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송명준(MJ Song),송성선(SS Song) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.11
원발성 난관 융모상피암이 복강내에 전이된 경우는 드문질환으로 본병원 산부인과에서는 원발성 난관융모상피암이 심한 복강내에 전이된 예를 경험하였기에 이의 증례 및 간단한 문헌고찰과 함께 보고하는 바이다. A case of tubal choriocarcinoma metastatized to abdominal cavity, that was arosed from the tube and extended to the uterus, and then, tubal rupture and abdominal metastasis were occured. At operation, grossly metastatic mass was removed but the patient was expired due to hemoperitoneum and multiple metastasis.
송찬호,양영호,김세광,박용원,조재성,김미순,정미정 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.7
1. 샘플링의 적응증은 모성연령 증가(advanced maternal age)가 전체의 31.2%로 가장 많았으며, 염색체이상의 아이를 분만한 기왕력이 26.1%, 그밖의 선천성 기형아를 분만한 기왕력이 19.4% 등의 순서였다. 2. 융모막 융모샘플링의 성공률은 총 510예중 496예로 97.3%로 나타났다. 3. 임신주수는 7-12주에 시행하였으며, 이중 9-10주가 56.3%로 가장 많았고, 11-12주가 38.0%,7-8주 가 5.7%였다. 4. 융모막 융모샘플링 횟수는 1회가 62.4%, 2회가 28.6%, 3회가 7.5%, 4회가 1.6%였다. 5. 재취된 융모의 양은 0-4mg이 14예, 5-10mg이 186예,11-20mg이 190예, 21-30mg이 88예, 31-40mg이 23예, 41-50mg이 9예있었다. 6. 한 개의 side당 metaphase수는 5-10mg이 10.4개, 11-20mg이 16.9개, 21-30mg이 18.0개, 31-40mg, 20.4개, 41-50mg이 20.5개로 채취된 융모의 양이 많을수록 metaphase 수도 다소 증가하였으나 융모의 양은 많아도 형태가 불완전 했던 2예에서 metaphase수가 적었고, 5mg미만의 적은 양으로도 양질의 충분한 metaphase를 얻은 등의 예외가 발견되기도 하였다. 7. 염색체 이상은 11예로서 2.2%였다. 8. 샘플링 후의 자연유산율은 총 510예중 14예로 2.7%였다. 이상의 연구결과를 종합하면, 임신초기 융모막 융모샘플링에 의한 산전 유전 검사방법은 비교적 안 전하고 진단에 신뢰성이 있으므로 현재 양수천자에 대치되어 사용되고 있으며 한국에서 점차 정착되어가고 있음을 알 수 있다. We report here our initial experience with 510 cases of Chorionic Villus Sampling(CVS)for first-trimester diagnosis of fetal genetic disorders at the YUMC in Kores. Five hundred and ten ongoing pregnant women underwent chorionic villus sampling(494 cases with transcervical and 16 cases with transabdominal)between 7-12gestational weeks. Advabcde maternal age was the most common indication for CVS(31.2%). The success rate of CVS was 97.3%. Majority of cases(91.0%)required one or two aspirations. The cytogenetic analysis routinely used was the direct overnight and long-term culture methods. Abnormal karyotype in 11 cases(2.2%)were found. Fetal loss rate was 2.7%. To date,375 of the women have been delivered and all infants are doing well and the remaining95 pregnancies are continuing uneventfully. There was no fetal anomaly related to CVS. We concluded that chorionic villus sampling is an acceptably safe and reliable procedure and its use has become standardized in Korea, in place of amniocentesis, for prenatal genetic diagnosis.
흰쥐에서 난소제거가 Follocle Stimulating Hormone (FSH) 분비와 FSHβ Subunit mRNA에 미치는
송찬호,김재욱,박기현,조동제,유경자,이병석,윤미정,김창미 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.8
Follicle stmulating hormone ( FSH ) consist of α and β subunits, which are encoded by se-parate genes. Pituitary release of FSH appears to be regulated by the hypothalamic GnRH and the gonadal steroid hormones. In addition , inhibin and follistatin produced by the gonad have been known to inhibit FSH secretion selectively. However , little is known about their regulation of the biosynthesis of FSH subunits at transcriptional and posttranscriptional levels. In the pre-sent study , we studied the time course of changes in α and FSHβ subunit mRNA concentrati-ons after castration and the effects of ovarian steroids of changes in α and FSHβ subunit mRNA concentrations after castration and the effects of ovarian steroids on α and FSHβ subunit mRNA in ovariectomized rats in order to determine Whether FSH subunit synthesis is modulated at the pretranslational levels, and whether synthesis and secretion are differently regulated. Results are as follows: 1. The time course of the rise in the steady state α subunit and FSHβ subunit mRNA levels were observed after ovariectomy, which paralleled the increases in serum and pituitary FSH concentrations. The time course experiments revealed differences in the patterns of α and FSHβ subunit mRNA responses , the rise in FSHβ subunit mRNA levels being more pro- minent than the rise in α subunit mRNA. 2. FSHβ mRNA levels were negatively regulated by the single injection of progesterone but not by estradiol , suggesting that FSHβ subunit mRNA seemed to be more sensitive to ne-gative feedback by progesterone than estradiol. Similar results were obtained by the continuous treatment of ovarian steroids for 1∼4 days , but inhibition was more prominent with continuous treatment. It is , therefore , concluded that estradiol and progesterone inhibit the synthesis of FSH at the pretranslational level by modulating the steady state levels of α and FSHβ subunit mRNA , progesterone effect being more promiment than that of estradiol and α and FSHβ subunit are regulated in a different manner.
김명자(MJ Kim),송태섭(TS Song),김홍택(HT Kim) 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.11
10회의 정상분만을 경험한 Rh 부적합부부의 증례를 보고하는 바이다. The Rh-negative blood type is extermely rare among Koreans. Its occurrence is 0.15% according to Dr. Won. An Rh-negative woman(50 years of age, para:10-0-1-7, pheno-and geno-type of Rh-subgroups: CcdEe, Cde/cde, respectively, titration of anti-D: negative, gynecological diagnosis: carcinoma in situ of the cervix) is presented with a brief case history and a revies of literatures on it.
한세준,송창훈,이만종,홍성기 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.5
Endodermal sinus tumor, being one of the germ cell tumor is rare and highly malignant. It characteristically develops in young women. This tumor is extremely virulent and the mortality is very high, regardles of mode of treatment, including combined chemotherapy. The authors present a case of Left Ovarian Endodermal Sinus Tumor in 59-year old woman with a brief review of the literatures.
정택상(TS Chung),송명준(MJ Song),이희동(IS Lee) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.10
저자 등은 충남대학 부속병원 산부인과에서 난소유피종에 병발된 편평상피세포암 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. An ovarian dermoid cyst combined with wquamous cell carcinima was presented. A 57 year old woman complaining of abdominal pain and lower abdominal mass was taken laparotomy. Left ovary was measured 10*15*7cm, 650gm in size. Ascites, adhesion and other gross abnormalities were not found. Gross appearance and cut surface of tumor revealed typical dermoid cyst except a small portion of inner wall directed to the mesoovarium which was found to be moderately differentiated squamous cell carcinoma. Some invasions to the left tube and outerwall of left uterus were noted.