Metabolizable Energy Values of Some Poultry Feeds Determined by Various Methods and Their Estimation Using Metabolizability of the Dry Matter

Han, I. K.,Hochstetler, H.W.,Scott, M.L. The Korean Society of Poultry Science 1976 韓國家禽學會誌 Vol.3 No.1

Metabolizable energy (M.E.) values of 12 U.S. feedstuffs and 10 Korean feed ingredients for poultry were determined both by the total collection method and by the chromic oxide indicator method. It was found that M.E. values of most poultry feedstuffs can be measured accurately by either method. Limitation of feed intake to almost maintenance level(approximately 60% of ad libitum) did not increase or decrease the M.E. value of the feeds. An attempt was made to establish a prediction equation to estimate the M.E. values based on the apparent metabolizability of dry matter (D.M.) in the feedstuffs. The results indicated that linear relationships do exist between D. M. metabolizability and M.E. values of carbohydrate-rich feedstuffs (grains and their by-products) or protein-rich feed ingredients (oil seed meals and animal protein feeds) or lipid-rich feeds (fats and oils) as follows: The prediction equation for carbohydrate-rich feedstuffs was Y = 0.0947x - 3.498 ($r^2\;=\;0.99$, Sy.x = 0.015); for protein-rich feed ingredients. it was Y = 0.1234x - 4.898 ($r^2\;=\;0.99$, Sy.x = 0.027); and for lipid-rich feedstuffs it was Y = 0.0844x + 0.774 ($r^2\;=\;0.99$, Sy.x = 0.032). where x = metabolizability of dry matter of feeds in %, and Y=metabolizable energy values in kcal./g. The errors attached to these estimations were relatively small. Thus these prediction equations may be very useful for estimation of the M.E. values from D.M. apparent metaboiizability of feeds, especially in areas of the world where calorimetry is not possible.

Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer

Han, S-W,Oh, D-Y,Im, S-A,Park, S R,Lee, K-W,Song, H S,Lee, N-S,Lee, K H,Choi, I S,Lee, M H,Kim, M A,Kim, W H,Bang, Y-J,Kim, T-Y Nature Publishing Group 2009 The British journal of cancer Vol.100 No.2

<P>This prospective study was conducted with the Korean Cancer Study Group to evaluate the efficacy and safety of cetuximab combined with modified FOLFOX6 (mFOLFOX6) as first-line treatment in recurrent or metastatic gastric cancer and to identify potential predictive biomarkers. Patients received cetuximab 400 mg m<SUP>−2</SUP> at week 1 and 250 mg m<SUP>−2</SUP> weekly thereafter until disease progression. Oxaliplatin (100 mg m<SUP>−2</SUP>) and leucovorin (100 mg m<SUP>−2</SUP>) were administered as a 2-h infusion followed by a 46-h continuous infusion of 5-fluorouracil (2400 mg m<SUP>−2</SUP>) every 2 weeks for a maximum of 12 cycles. Biomarkers potentially associated with efficacy were analysed. Among 38 evaluable patients, confirmed response rate (RR) was 50.0% (95% CI 34.1–65.9). Median time-to-progression (TTP) was 5.5 months (95% CI 4.5–6.5) and overall survival (OS) 9.9 months. Eleven patients having tumour EGFR expression by immunohistochemistry with low serum EGF and TGF-<I>α</I> levels showed a 100% RR compared to 37.0% in the remaining 27 patients (<I>P</I><0.001). Moreover, ligand level increased when disease progressed in seven out of eight patients with EGFR expression and low baseline ligand level. No patient exhibited EGFR amplification or K-ras mutations. Gastric cancer patients with EGFR expression and low ligand levels had better outcomes with cetuximab/mFOLFOX6 treatment.</P>

OGLE-2015-BLG-0196: GROUND-BASED GRAVITATIONAL MICROLENS PARALLAX CONFIRMED BY SPACE-BASED OBSERVATION

Han, C.,Udalski, A.,Gould, A.,Zhu, Wei,Szymań,ski, M. K.,Soszyń,ski, I.,Skowron, J.,Mró,z, P.,Poleski, R.,Pietrukowicz, P.,Kozłowski, S.,Ulaczyk, K.,Pawlak, M.,Yee, J. C.,Beichman, C. American Astronomical Society 2017 The Astrophysical journal Vol.834 No.1

<P>In this paper, we present an analysis of the binary gravitational microlensing event OGLE-2015-BLG-0196. The event lasted for almost a year, and the light curve exhibited significant deviations from the lensing model based on the rectilinear lens-source relative motion, enabling us to measure the microlens parallax. The ground-based microlens parallax is confirmed by the data obtained from space-based microlens observations using the Spitzer telescope. By additionally measuring the angular Einstein radius from the analysis of the resolved caustic crossing, the physical parameters of the lens are determined up to the twofold degeneracy, u(0) < 0 and u(0) > 0, solutions caused by the well-known 'ecliptic' degeneracy. It is found that the binary lens is composed of two M dwarf stars with similar masses, M-1 = 0.38 +/- 0.04M(circle plus) (0.50 +/- 0.05M(circle plus)) and M-2 = 0.38 +/- 0.04M(circle plus) (0.55 +/- 0.06M(circle plus)), and the distance to the lens is D-L = 2.77. +/- 0.23 kpc (3.30 +/- 0.29 kpc). Here the physical parameters outside and inside the parentheses are for the u(0) < 0 and u(0) > 0 solutions, respectively.</P>

OGLE-2014-BLG-0257L: A MICROLENSING BROWN DWARF ORBITING A LOW-MASS M DWARF

Han, C.,Jung, Y. K.,Udalski, A.,Gould, A.,Bozza, V.,Szymań,ski, M. K.,Soszyń,ski, I.,Poleski, R.,Kozłowski, S.,Pietrukowicz, P.,Skowron, J.,Ulaczyk, K.,Wyrzykowski, Ł. American Astronomical Society 2016 The Astrophysical Journal Vol.822 No.2

<P>In this paper, we report the discovery of a binary composed of a brown dwarf (BD) and a low-mass M dwarf from observation of the microlensing event OGLE-2014-BLG-0257. The resolution of the very brief caustic crossing combined with the detection of subtle continuous deviation in the lensing light curve induced by the Earth's orbital motion enable us to precisely measure both the Einstein radius theta(E) and the lens parallax pi(E), which are the two quantities needed to unambiguously determine the mass and distance to the lens. It is found that the companion is a substellar BD with a mass of 0.036 +/- 0.005 M-circle dot (37.7 +/- 5.2 M-J) and it is orbiting an M dwarf with a mass of 0.19 +/- 0.02 M-circle dot. The binary is located at a distance of 1.25 +/- 0.13 kpc toward the Galactic bulge and the projected separation between the binary components is 0.61 +/- 0.07 au. The separation scaled by the mass of the host is 3.2 au/M-circle dot. Based on the assumption that separations scale with masses, the discovered BD is located in the BD desert. With the growing sample of BDs in various environments, microlensing will provide a powerful probe of BDs in the Galaxy.</P>

Tritium Concentrations of Tritiated Water Vapor and Tritiated Hydrogen in the Atomosphere in Taejon

Kim,K.H.,Han,M.J.,Kim,C.K. 대한방사선 방어학회 1997 방사선방어학회지 Vol.22 No.2

대기중 삼중수소에 대한 국내 기초 준위를 파악하기 위하여 1995년 3월부터 12월 까지 대전지역 대기중 수증기상태의 삼중수소(HTO) 및 가스상태의 삼중수소(HT)의 농도를 측정하였다. 대기시료는 삼중수소 포집장치를 이용하여 3주간 계속적으로 체취하였으며, 대기중 삼중수소는 액체섬광계수기(Liquid scintillation counter)를 이요하여 계측하였다. 대기중 HTO의 농도는 3.2-36 mBq m-3(평균 : 16.2 mBq m-3)이었으며, 여름철에 높고 겨울철에 낮은 농도를 나타내었다. 이러한 경향은 대기중 절대습도의 변화와 유사하였다. 한편, 대전지역 대기 수분중 삼중수소의 비방사능 농도는 0.62-3.82 BqL-3 범위의 값을 나타내었으며, 대기중 HT는 35.7-48.9 mBq m-3(평균 : 41.1 mBq m-3)의 농도범위를 나타내었다. During the period of March 1995 to December 1995, tritium concentrations of tritiated water vapor (HTO) and tritiated hydrogen (HT) in the atmosphere in Taejon were measured to evaluate present background levels of tritium in the atmosphere. Air samples were collected continuously for three weeks with a sampling system for tritium in the atmosphere and were analyzed by a liquid scintillation counting system. The range of the atmospheric HTO concentrations was 3.2 - 36 mBq m3 with a mean value of 16.2mBq m3. The atmospheric HTO concentrations were the highest in summer and the lowest in winter. This trend was similar to the variation of atmospheric absolute humidity. The specific activities of tritium in atmospheric water vapor in Taejon ranged from 0.62 Bq L-1 to 3.82 Bq L-1 with a mean value of 2.04 Bq L-1. The atmospheric HT concentrations were in the range of 35.7 mBq m3 to 48.9 mBq m3 with a mean value of 41.1 mBq ??.

Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis

Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5

<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. 
Acta Neurol Scand: 2011: 123: 325–331. 
© 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>

Isolation and partial characterization of a bacteriocin produced by <i>Pediococcus pentosaceus</i> K23-2 isolated from Kimchi

Shin, M.S.,Han, S.K.,Ryu, J.S.,Kim, K.S.,Lee, W.K. Blackwell Publishing Ltd 2008 Journal of Applied Microbiology Vol.105 No.2

<P>Abstract</P><P>Aims: </P><P>Screening and partial characterization of a bacteriocin produced by <I>Pediococcus pentosaceus</I> K23-2 isolated from Kimchi, a traditional Korean fermented vegetable.</P><P>Methods and Results: </P><P>A total of 1000 lactic acid bacteria were isolated from various Kimchi samples and screened for the production of bacteriocin. Pediocin K23-2, a bacteriocin produced by the <I>Pediococcus pentosaceus</I> K23-2 strain, showed strong inhibitory activity against <I>Listeria monocytogenes</I>. The bacteriocin activity remained unchanged after 15 min of heat treatment at 121°C or exposure to organic solvents; however, it diminished after treatment with proteolytic enzymes. The bacteriocin was maximally produced at 37°C, when the pH of the culture broth was maintained at 5·0 during the fermentation, although the optimum pH for growth was 7·0. The molecular weight of the bacteriocin was about 5 kDa according to a tricine SDS-PAGE analysis.</P><P>Conclusions: </P><P><I>Pediococcus pentosaceus</I> K23-2 isolated from Kimchi produces a bacteriocin, which shares similar characteristics to the Class IIa bacteriocins. The bacteriocin is heat stable and shows wide antimicrobial activity against Gram-positive bacteria, especially <I>L. monocytogenes</I>.</P><P>Significance and Impact of the Study: </P><P>Pediocin K23-2 and pediocin K23-2-producing <I>P. pentosaceus</I> K23-2 could potentially be used in the food and feed industries as natural biopreservatives, and for probiotic application to humans or livestock.</P>

MOA-2010-BLG-073L: AN M-DWARF WITH A SUBSTELLAR COMPANION AT THE PLANET/BROWN DWARF BOUNDARY

Street, R. A.,Choi, J.-Y.,Tsapras, Y.,Han, C.,Furusawa, K.,Hundertmark, M.,Gould, A.,Sumi, T.,Bond, I. A.,Wouters, D.,Zellem, R.,Udalski, A.,Snodgrass, C.,Horne, K.,Dominik, M.,Browne, P.,Kains, N.,Br IOP Publishing 2013 The Astrophysical journal Vol.763 No.1

<P>We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the source was previously known to be photometrically variable. Analyzing the pre-event source light curve, we demonstrate that it is an irregular variable over timescales >200 days. Its dereddened color, (V - I)(S),(0), is 1.221 +/- 0.051 mag, and from our lens model we derive a source radius of 14.7 +/- 1.3 R-circle dot, suggesting that it is a red giant star. We initially explored a number of purely microlensing models for the event but found a residual gradient in the data taken prior to and after the event. This is likely to be due to the variability of the source rather than part of the lensing event, so we incorporated a slope parameter in our model in order to derive the true parameters of the lensing system. We find that the lensing system has a mass ratio of q = 0.0654 +/- 0.0006. The Einstein crossing time of the event, t(E) = 44.3 +/- 0.1 days, was sufficiently long that the light curve exhibited parallax effects. In addition, the source trajectory relative to the large caustic structure allowed the orbital motion of the lens system to be detected. Combining the parallax with the Einstein radius, we were able to derive the distance to the lens, D-L = 2.8 +/- 0.4 kpc, and the masses of the lensing objects. The primary of the lens is an M-dwarf with M-L,M-1 = 0.16 +/- 0.03 M-circle dot, while the companion has M-L,M-2 = 11.0 +/- 2.0 M-J, putting it in the boundary zone between planets and brown dwarfs.</P>

Proposed mechanism in the change of cellular composition in the outer medullary collecting duct during potassium homeostasis.

Park, E-Y,Kim, W-Y,Kim, Y-M,Lee, J-H,Han, K-H,Weiner, I D,Kim, J Gutenberg 2012 HISTOLOGY AND HISTOPATHOLOGY Vol.27 No.12

<P>Potassium depletion (K?-D) induces hypertrophy and hyperplasia of collecting duct cells, and potassium repletion (K?-R) induces regression of these changes. The purpose of this study was to examine the time courses of the changes in cellular composition, the origin of intercalated cells (ICs) and the mechanism responsible for these changes. SD rats received K?-depleted diets for 1, 7, or 14 days. After K?-D for 14 days some of the rats received normal diets for 1, 3, 5, or 7 days. In the inner stripe of the outer medulla, K?-D increased significantly the number and proportion of H?-ATPase-positive ICs, but decreased the proportion of H?-ATPase-negative principal cells (PCs). However, proliferation was limited to H?-ATPase-negative PCs. During K?-R, the cellular composition was recovered to control level. Apoptosis increased during K?-R and exclusively limited in H?-ATPase-negative PCs. Double immunolabeling with antibodies to PC and IC markers identified both cells negative or positive for all markers during both K?-D and K?-R. Electron microscopic observation showed that ultrastructure of AE1-positive some cells were similar to AE1-negative some cells during K?-R. LC3 protein expression increased significantly and autophagic vacuoles appeared particularly in PCs on days 14 of K?-D and in ICs on days 3 of K?-R. These results suggest that PCs and ICs may interconvert in response to changes in dietary K+ availability and that autophagic pathways may be involved in the interconversion.</P>

유우개량을 위한 유단백질의 유전적 다형에 관한 연구 Ⅰ. αS1 - Casein 및 K - Casein 의 유전적 변이체

한상기(Sang K . Han),이기만(Khy M . Lee),정의용(Eui Y . Chung),장경진(Kyung J . Jang) 한국축산학회 1984 한국축산학회지 Vol.26 No.3

Genetic variants of αs₁-casein (αs₁-Cn) and K-casein (k-Cn) in milk proteins from 138 individual Holstein cattle in Korea were investigated by means of strach-gel-urea electrophoresis and the appearance of phenotypes, gene frequencies and genetic similarities were compared with those of foreign Holstein and of her breeds. The results are summarized as follows: 1. The milk proteins in cattle were controlled by codominant autosomal allelic genes of 9αs₁-Cn^A and αs₁-Cn^B(2 types), and K-Cn^A and K-Cn^B (2 types). 2. The distribution of phenotypes in each milk protein loci was αs₁-Cn BB 124, BC 14; K-Cn AA 76 Ab 49, BB 13. The number of phenotypes coxesponded closely to expectation of Hardy-Weinberg equilibrium (αs₁-Cn:0.7 $gt;P$gt;0.5, k-Cn;0.7$gt;P$gt;0.5). 3. Gene frequencies for genetic variants of the milk protein loci were analyzed. By the predominant allele in αs₁-Cn was αs₁-Cn B with a frequency of 0.949, whereas αs₁-CnC was in low gene frequency (0.051). Among the two alleles for K-Cn, K-Cn A gene showed to occur in high frequency (0.728). However, the Kin B was in low gene frequency (0.272).