http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Peng Zhan,Xinyong Liu,Liu Wang,Hong Liu,Xuwang Chen,Xiao Li,Xin Jiang,Qiangqiang Zhang,Christophe Pannecouque,Lieve Naesens,Erik De Clercq,Ailin Liu,Guanhua Du 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
In continuation of our endeavor to develop new, potent, selective and less toxic antiviral agents, a novel series of 2-(2-amino/chloro-4-(2,4-dibromophenyl) thiazol-5-ylthio)acetamide derivatives was synthesized via an expeditious route and evaluated for their anti-HIV activities against wild-type virus and clinically relevant mutant strains, and for their anti-influenza virus activities against influenza A (H1N1 and H3N2) and influenza B in cellular assays. The selected active compounds were also assayed for their enzymic inhibitory activities. The results showed that some 2-chloro substituted thiazolylthioacetamide derivatives possessed potent activity against wild type HIV-1 and several key mutant strains (E138K, K103N, L100I) of HIV-1 in MT-4 cells with EC50 values in micromolar range. Two 2-amino substituted thiazole derivatives 8a7 and 8a8 displayed significant potency against influenza A/H1N1 in MDCK cells with EC50 values much lower than that of oseltamivir carboxylate, ribavirin, amantadine and rimantadine. Though the mechanism of actions is still unclear, these novel thiazolylthioacetamides might serve as original leads for further pharmacological investigations as potential therapeutic agents against HIV-1 or influenza virus.
Liu Peng,Liu Wen,Li Qiang,Yang Li,Duan Min,Dai Yue 보안공학연구지원센터 2014 International Journal of u- and e- Service, Scienc Vol.7 No.6
For the problem that the use effect of food processing information system is poor due to absence of knowledge acquisition measures and knowledge self-updating function, a knowledge acquisition approach based on rough set is put forward. First, the approach establishes a set of predicted samples for the relationship between food processing parameters and product quality; then uses the discretization of continuous attribute, attribute reduction and rule extraction algorithm of rough set to acquire automatically predicted knowledge from a large number of predicted sample sets, and then saves the predicted knowledge in the knowledge base of expert system; finally, realizes the extraction of knowledge of food processing process based on the inference engine, which greatly enhances the effectiveness and practicality of the acquired knowledge in online aided decision system of the food processing quality and safety.
AC/DC Side Split Capacitor Power Decoupling Circuit
Liu Peng,Fan Yue,Zhang Yong-gao,Ze Si-yuan 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4
Single-phase inverters have a wide range of applications in many fields, but there are inherent double frequency problems, and double frequency fluctuations can easily cause system instability. This paper proposes a mid-point common-mode injection power decoupling circuit. The advantage of this topology is that there are no additional switching devices and only the original DC side support capacitors and filter capacitors of the H-bridge inverter can be used to buffer the double frequency power. The half-bridge structure of this topology enables the AC side capacitors to operate positively and negatively, which can reduce the selection of the withstand voltage of the decoupling capacitor. Simulation and experimental results prove that the method can effectively suppress the secondary ripple on the DC side. The final data shows that the topology can effectively improve the system efficiency after decoupling.
( Peng Liu ),( Gaochao Xu ),( Kun Yang ),( Kezhi Wang ),( Yang Li ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.12
Mobile Edge Computing (MEC) and Wireless Power Transfer (WPT) are both recognized as promising techniques, one is for solving the resource insufficient of mobile devices and the other is for powering the mobile device. Naturally, by integrating the two techniques, task will be capable of being executed by the harvested energy which makes it possible that less intrinsic energy consumption for task execution. However, this innovative integration is facing several challenges inevitably. In this paper, we aim at prolonging the battery life of mobile device for which we need to maximize the harvested energy and minimize the consumed energy simultaneously, which is formulated as residual energy maximization (REM) problem where the offloading ratio, energy harvesting time, CPU frequency and transmission power of mobile device are all considered as key factors. To this end, we jointly optimize the offloading ratio, energy harvesting time, CPU frequency and transmission power of mobile device to solve the REM problem. Furthermore, we propose an efficient convex optimization and sequential unconstrained minimization technique based combining method to solve the formulated multi-constrained nonlinear optimization problem. The result shows that our joint optimization outperforms the single optimization on REM problem. Besides, the proposed algorithm is more efficiency.
An Improved Differential Buck Circuit with Power Decoupling
Liu Peng,Fan Yue,Zhang Yong-gao,Ze Si-yuan 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Single-phase inverters have inherent double frequency problems, which are likely to cause system instability. In this paper, it does not add additional switching devices while retaining the four switching devices of the H-bridge. This topology only needs to split the original filter capacitor on the AC side into two symmetrical connections and can cancel additional DC side support capacitors. For this topology, the fundamental frequency common-mode voltage injection is used to avoid additional low-frequency harmonics derived from the DC side. Theoretical analysis and experiment explain the working principle of the topology. And the superiority of this topology is explained in terms of decoupling accuracy and the number of switches. The result proves that this topology can effectively buffer the double frequency of the system without additional switching devices.
Peng Liu,Tingmei Wang 한국물리학회 2008 Current Applied Physics Vol.8 No.1
Poly(hydroethyl acrylate) (PHEA) was grafted from ZnO nanoparticles via the copper-mediated surface-initiated atom transfer rad-ical polymerization (SI-ATRP) technique with the bromo-acetamide modied ZnO nanoparticles (BrA-ZnO) as macroinitiators with thecatalysts of 1,10-phenanthroline and Cu(I)Br in water. Graft reaction was rst order kinetic with respect to the polymerizing time in thefrom the elemental analysis results. The product, poly(hydroethyl acrylate) grafted ZnO nanoparticles (PHEA-ZnO) were also charac-terized with Fourier transform infrared spectroscopy (FT-IR), UVvis spectroscopy, thermogravimetric analysis (TGA), X-ray photo-electron spectroscopy (XPS) and transmission electron microscopy (TEM).
Analytical modeling of axial stiffness of tensile bolted joints under concentric external load
Peng He,Jiaxin Liu,Chengyuan Zhang,Zhansheng Liu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.11
Stiffness of bolted joints is a critical parameter for determining deformations and natural frequencies of assemblies. In this study, the effect of external load on axial stiffness of bolted joints is clarified theoretically for the first time. The stiffness of stress zones between and beyond load planes is derived on the basis of the strain energy method and used to formulate the stiffness of bolted joints. The influence of the distance between the load planes of the external load, axial positions of the external load, and difference in the material of the clamped parts on the stiffness of the bolted joints are investigated by applying the proposed formulations and finite element method. Comparisons with finite element results indicate that the proposed formulation can accurately predict the stiffness of the bolted joints.
Liu Chunlei,Li Peng,Ao Xiang,Lian Zhengnan,Liu Jie,Li Chenglong,Huang Minjun,Wang Liang,Zhang Zhongmin 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Ligamentum flavum hypertrophy (LFH) is a major cause of lumbar spinal canal stenosis (LSCS). The pathomechanisms for LFH have not been fully elucidated. Isobaric tags for relative and absolute quantitation (iTRAQ) technology, proteomics assessments of human ligamentum flavum (LF), and successive assays were performed to explore the effect of clusterin (CLU) upregulation on LFH pathogenesis. LFH samples exhibited higher cell positive rates of the CLU, TGF-β1, α-SMA, ALK5 and p-SMAD3 proteins than non-LFH samples. Mechanical stress and TGF-β1 initiated CLU expression in LF cells. Notably, CLU inhibited the expression of mechanical stress-stimulated and TGF-β1-stimulated COL1A2 and α-SMA. Mechanistic studies showed that CLU inhibited mechanical stress-stimulated and TGF-β1-induced SMAD3 activities through suppression of the phosphorylation of SMAD3 and by inhibiting its nuclear translocation by competitively binding to ALK5. PRKD3 stabilized CLU protein by inhibiting lysosomal distribution and degradation of CLU. CLU attenuated mechanical stress-induced LFH in vivo. In summary, the findings showed that CLU attenuates mechanical stress-induced LFH by modulating the TGF-β1 pathways in vitro and in vivo. These findings imply that CLU is induced by mechanical stress and TGF-β1 and inhibits LF fibrotic responses via negative feedback regulation of the TGF-β1 pathway. These findings indicate that CLU is a potential treatment target for LFH.