Detection of MicroRNA-21 Expression as a Potential Screening Biomarker for Colorectal Cancer: a Meta-analysis

Jiang, Jian-Xin,Zhang, Na,Liu, Zhong-Min,Wang, Yan-Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: Colorectal cancer (CRC) is a major cause of cancer-related death and cancer-related incidence worldwide. The potential of microRNA-21 (miR-21) as a biomarker for CRC detection has been studied in several studies. However, the results were inconsistent. Therefore, we conducted the present meta-analysis to systematically assess the diagnostic value of miR-21 for CRC. Materials and Methods: Using a random-effect model, the pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to evaluate the diagnostic performance of miR-21 for CRC. A summary receiver operating characteristic (SROC) curve and an area under the curve (AUC) were also generated to assess the diagnosis accuracy of miR-21 for CRC. Q test and I2 statistics were used to assess between-study heterogeneity. Publication bias was evaluated by the Deeks' funnel plot asymmetry test. Results: A total of 986 CRC patients and 702 matched healthy controls from 8 studies were involved in the meta-analysis. The pooled results for SEN, SPE, PLR, NLR, DOR, and AUC were 57% (95%CI: 39%-74%), 87% (95%CI: 78%-93%), 4.4 (95%CI: 2.4-8.0), 0.49 (95%CI: 0.32-0.74), 9 (95%CI: 4-22), and 0.83 (95%CI: 0.79-0.86), respectively. Subgroup analyses further suggested that blood-based studies showed a better diagnostic accuracy compared with feces-based studies, indicating that blood may be a better matrix for miR-21 assay and CRC detection. Conclusions: Our findings suggest that miR-21 has a potential diagnostic value for CRC with a moderate level of overall diagnostic accuracy. Hence, it could be used as auxiliary means for the initial screening of CRC and avoid unnecessary colonoscopy, which is an invasive and expensive procedure.

A Novel Mutation p.L461P in KRT5 Causing Localized Epidermolysis Bullosa Simplex

( Xin Jiang ),( Yingyu Zhu ),( Huihui Sun ),( Feng Gu ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.1

Background: Epidermolysis bullosa (EB) is a rare genetic disease with widely different clinical manifestations, but the relationship between genotype and phenotype is not fully understood. In the present study, we recruited a Chinese family in which two members had been diagnosed with localized EB simplex (EBS), with clinical manifestation, including blisters and erosions on the soles of the feet since infancy. Objective: To identify and confirm the genetic variation in a Chinese family diagnosed as localized EBS. Methods: Our study included two patients, other healthy members of the family, and 100 normal controls. Genomic DNA samples were isolated from each participant, and then polymerase chain reaction (PCR) direct sequencing was performed. Results: The results of PCR direct sequencing revealed a novel heterozygous missense mutation in codon 461 of exon 7 of KRT5 (c.1382T>C), which led to an amino acid change (p.L461P) in the patients with EBS but was absent in unaffected family members and 100 unrelated control samples. Conclusion: The present study broadens the mutational spectrum of EBS, and this knowledge could be harnessed for prenatal screening, gene diagnosis, and gene therapy for localized EBS. (Ann Dermatol 33(1) 11∼17, 2021)

Batch Auditing for Multi-client Dynamic Data in Multi-cloud Storage

Xin Liu,Yujia Jiang 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6

Cloud storage introduces many challenges due to the security and integrity threats toward user’s outsourced data. Many auditing protocols have been proposed, but the majority of them could only serve in single cloud environment. This paper proposes an efficient auditing protocol, which supports batch auditing for multiple data files in multi-cloud environment. By utilizing the bilinear map, the proposed protocol achieves full stateless and transparent verification. By constructing a Merkle Hash Tree, the proposed protocol can resist the replace attack and support dynamic operation of data. In addition, our protocol protects the position information of the data blocks by generating fake data blocks to confuse the organizer. The performance analysis demonstrates the efficiency of the protocol.

Perseveration in Sufferings: A Study on the Contribution of Su Shi to Chinese Food Culture

Xin Jiang 한국식생활문화학회 2017 한국식생활문화학회학술대회논문집 Vol.2017 No.11

An Optimal Inspection Policy for Protection Devices of Electronic Equipment Using Delay Time Model

Jiang Xin-liang,Zhao Jian-min,Li Zhi-wei 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.8

In order to reduce or eliminate the consequences of the electronic equipment malfunction, some important electronic equipment were installed protection devices. Failures of protection devices are of hidden feature, and can only be found by inspections. Protection device failing to system malfunctioning has a delay characteristic. According to this delay characteristic, an inspection policy was proposed based on delay time model. An inspection model was developed to minimize the average cost per unit time with constraint of availability. Based on the model, optimal inspection interval can be determined to meet the objective of the opti

FgIlv3a is crucial in branched-chain amino acid biosynthesis, vegetative differentiation, and virulence in Fusarium graminearum

Xin Liu,Yichen Jiang,Yinghui Zhang,Mingzheng Yu,Hongjun Jiang,Jianhong Xu,Jianrong Shi 한국미생물학회 2019 The journal of microbiology Vol.57 No.8

Dihydroxyacid dehydratase (DHAD), encoded by ILV3, catalyses the third step in the biosynthetic pathway of branchedchain amino acids (BCAAs), which include isoleucine (Ile), leucine (Leu), and valine (Val). Enzymes involved in BCAA biosynthesis exist in bacteria, plants, and fungi but not in mammals and are therefore attractive targets for antimicrobial or herbicide development. In this study, three paralogous ILV3 genes (FgILV3A, FgILV3B, and FgILV3C) were identified in the genome of Fusarium graminearum, the causal agent of Fusarium head blight (FHB). Deletion of FgILV3A alone or combined with FgILV3B or FgILV3C indicated an important role for FgILV3A in BCAA biosynthesis. FgILV3A deletion mutants lost the ability to grow on medium lacking amino acids. Exogenous supplementation of 1 mM Ile and Val rescued the auxotrophy of ΔFgIlv3A, though 5 mM was required to recover the growth defects in ΔFgIlv3AB and ΔFgIlv3AC strains, indicating that FgIlv3b and FgIlv3c exhibit redundant but accessory roles with FgIlv3a in BCAA biosynthesis. The auxotrophy of ΔFgIlv3A resulted in pleiotropic defects in aerial hyphal growth, in conidial formation and germination, and in aurofusarin accumulation. In addition, the mutants showed reduced virulence and deoxynivalenol production. Overall, our study demonstrates that FgIlv3a is crucial for BCAA biosynthesis in F. graminearum and a candidate fungicide target for FHB management.

Effect of Externality in Multiplex Networks on One-layer Synchronization

Xin Jiang,Meng Li,Zhiming Zheng,Yifang Ma,Lili Ma 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.11

Synchronization phenomenon plays an important role in the dynamic process on complex networks. In this letter, we consider synchronization under multiplex structures and explore the effect of external parts on the multilayered Kuramoto model with positive correlation between frequencies and degree. We show that large and strong mixing parts of the external layer may put off synchronization while the coupling strength of external layers has an accelerating, but limited, influence on synchronization. In particular, an explosive synchronization can be obtained by weakening the co-evolution coupling strength. The transition tends to be smooth when the co-evolution coupling strength increases. Our findings indicate that externality from multiplex networks, especially the mixing parts, and the co-evolution coupling strength should be of importance for synchronization on one certain layer.

Exploring computer vision and artificial intelligence-based distance measurement tools for the standing long jump

Cheng Jiang(강성),Jia-Qi Sun(손가기),Ke-Xin Qi(기가심),Xue Jiang(강설),Xiangchuan Jin(김향천),Xuanshang Jin(김현상) 한국체육측정평가학회 2022 한국체육측정평가학회지 Vol.24 No.1

이 연구에서 제자리 멀리뛰기의 측정 범위에 대한 핵심 기술은 주로 두 가지의 단계를 거친다. 첫 번째 단계는 환경 초기화 단계로, 주로 제자리 멀리뛰기의 필드, 카메라 및 인체의 핵심 지점의 정량적 식별을 포함한다. 두 번째 단계는 범위 설정 단계로 카메라의 점프 프레임과 착지 프레임의 적정 세트를 추출하고 발가락과 발뒤꿈치 영역 또는 범위의 핵심 포인트를 식별하는 것으로 구성된다. 이 연구의 목적을 달성하기 위해서 총 20회의 제자리 멀리 뛰기 동작을 측정하였으며 정확도를 평가한 결과 측정 오차는 0.58cm, 표준편차는 0.24로 나타났다. 따라서 이 연구는 제자리 멀리뛰기 동작의 결과에 대한 오차를 1㎝ 이내로 조절할 수 있다는 것이 입증되었으며, 이는 곧 높은 정확도를 지닌 도구로서 판단된다. 또한 이 연구는 일반적인 웹캠을 사용하기 때문에 다른 제자리 멀리뛰기 검사 방식에 비해 장비의 가격이 저렴하고, 유지비용 또한 부담을 덜어줌과 동시에 높은 지능을 가지고 있는 도구라는 장점이 있다. 따라서 이 연구 결과를 통해 널리 보급되는 것을 기대할 수 있다. The key technology of standing long jump ranging in this study are mainly manifested in two stages: the first stage is the environment initialization stage, which mainly includes the quantitative identification of standing long jump field, camera and human body key points; the second stage is the ranging stage, which consists of extracting the set of jump frame and landing frame and identifying the key points of toe and heel. After the evaluation of test accuracy, the measurement is conducted 20 times, the error is 0.58cm, and the standard deviation is 0.24. It is proved that this study can control the error of standing long jump test results within 1cm, which shows that the research results have high test accuracy. Because this study uses an ordinary webcam, compared with other standing long jump test methods, it has the advantages of higher intelligence, low price and low maintenance cost. The research results are easy to be widely popularized.

Efficient Coupling-Driven Track Assignment Algorithms

Meng-Xin Jiang,Yih-Lang Li 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.2

A multi-scale model linking microstructure and macro electric behaviors of ferroelectric field effect transistor

Limei Jiang,Xin Feng,Hao Ming,Qiong Yang,Jie Jiang,Min Liao 한국물리학회 2020 Current Applied Physics Vol.20 No.3

A multi-scale model linking microstructure and macro electric properties of ferroelectric field effect transistor (FeFET) is established based on the phase field method and Maxwell's total current law. The simulation results confirm that the channel current of FeFET is modulated by local interface ferroelectric domains which are easily affected by the microstructure. Using the developed transistor model, we investigate the effects of location of dislocation sites on hysteresis behavior of ferroelectric film and electric behavior of FeFET. Interfacial dislocations have strong effects on hysteresis behavior than internal dislocations since the former can induce imprint behavior while the latter only reduce the coercive field. However, due to the c-domains at the interface, the effects of interfacial and internal dislocations on FeFET electrical properties are the exact opposite. The interfacial dislocations just increase the voltage required to toggle the channel while the internal dislocations can induce disappearance of the FeFET memory window.