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전주홍,박기광,조경엽,이상대,송정록 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1
Bony defects of mandible caused by trauma, infection, or tumor resection have been reconstructed by autologous bone graftings. These reconstruction can restore facial contour and integrity of the oral cavity. However, it is often necessary to reduce the bulk of bone to allow soft tissue coverage of the graft. Therefore, the construction of removable dentures in this situation is fraught with frustation. The use of osseointegrated implants is a method to allow improved anchorage and support for the successful fabrication of dental protheses. We report two cases of the use of osseointegrated implants of the Branemark type(3i), in conjunction with bone grafting to the lower jaw.
Yu, Kyung-Rok,Yang, Se-Ran,Jung, Ji-Won,Kim, Hyongbum,Ko, Kinarm,Han, Dong Wook,Park, Sang-Bum,Choi, Soon Won,Kang, Soo-Kyung,Schö,ler, Hans,Kang, Kyung-Sun Wiley (John WileySons) 2012 Stem Cells Vol.30 No.5
<P>CD49f (integrin subunit α6) regulates signaling pathways in a variety of cellular activities. However, the role of CD49f in regulating the differentiation and pluripotency of stem cells has not been fully investigated. Therefore, in this study, human mesenchymal stem cells (hMSCs) were induced to form spheres under nonadherent culture conditions, and we found that the CD49f-positive population was enriched in MSC spheres compared with MSCs in a monolayer. The expression of CD49f regulated the ability of hMSCs to form spheres and was associated with an activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. Furthermore, the forced expression of CD49f modulated the proliferation and differentiation potentials of hMSCs through prolonged activation of PI3K/AKT and suppressed the level of p53. We showed that the pluripotency factors OCT4 and SOX2 were recruited to the putative promoter region of CD49f, indicating that OCT4 and SOX2 play positive roles in the expression of CD49f. Indeed, CD49f expression was upregulated in human embryonic stem cells (hESCs) compared with hMSCs. The elevated level of CD49f expression was significantly decreased upon embryoid body formation in hESCs. In hESCs, the knockdown of CD49f downregulated PI3K/AKT signaling and upregulated the level of p53, inducing differentiation into three germ layers. Taken together, our data suggest that the cell-surface protein CD49f has novel and dynamic roles in regulating the differentiation potential of hMSCs and maintaining pluripotency.</P>