Optimizing the Hospital Blood Bank Stock in Korea: A Comparative Analysis of the Uniform 5-Day Stock Index and a Novel Blood Stock Index

Park Seo-Jin,Lim Young Ae,Kim Kyung-Hee 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.3

Background: Maintaining optimal blood inventory levels in hospitals is important to prevent blood shortage and wastage. We aimed to provide an efficient blood inventory management strategy for hospital blood banks nation-wide by comparing the current use of 5-day issuable stock (IS) with Lim’s IS as a novel target IS. Methods: The average and CV of daily usage (DU) were calculated from information entered into Korea’s Blood Management System by 194 participating hospitals in 2019 and 2020. Using these data, Lim’s IS was calculated by determining the simulated annual average blood shortage day nearest to 1 for each blood group in each hospital. The 5-day IS (5IS) was estimated by multiplying the average DU in 2018 by five to count the shortage days in 2019. Results: The average DU (0.3–231.3 units) and corresponding CV (0.33–7.14) in the participating hospitals were inversely proportional (r=–0.699 to –0.695). The hypothetical averages of 5IS and Lim’s IS were 27.0±41.2 and 24.7±20.8, respectively (P=0.006). The shortage days for 5IS and Lim’s IS were 8.9±22.7 and 1.0±1.9, respectively (P<0.001). Conclusions: While 5IS was unacceptable for universal application, Lim’s IS remained near one shortage day and is considered more efficient than 5IS. Hospitals should implement indicators that consider DU and its variations. This is the first study to introduce Lim’s IS as an indicator of optimal blood inventory, and the data are expected to provide guidance for effective blood inventory management nationwide, particularly during blood shortages.

마이크로에멀젼과 이의 응용

임경희,김홍운,이종문 한국유화학회 2004 한국응용과학기술학회지 Vol.21 No.2

熱環境의 理論的 背景에 관한 硏究

林晩澤,朴京甲,鄭圭福,鄭碩熙 조선대학교 국토개발연구소 1993 국토개발연구 Vol.13 No.1

The design ranges of human-environmental system can be divided into seven kinds, water, thermal, air, light, acoustic, color, psychology and environment. This study aims at clarifying the theoretical background of thermal environment is what point of view is historically. Thermal environment developed based on the thermal comfort index, standard and law establishment etc. To constitute the amenity of thermal environment and to control it, it needs to prediction and adaptability.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_(2) at 37°C. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KC1, 60 mM HEPES, pH 7.9, 25 mM MgCl_(2), 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2μg of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

소금으로 팽화시킨 유과바탕 및 쌀엿강정용 팽화쌀의 품질

임경려,이경희,강순아 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.6

This study was performed to improve the quality and extend the shelf life of Yukwa and Salyeotgangjung, traditional Korean cookies, by using fine hot salt instead of oil as the popping medium. Yukwa and Salyeotgangjung were popped with fine salt, and the size, sensory evaluation, color values, and textural properties were then compared with those popped in oil. The results showed that the Yukwa base with salt was popped the most at 140C and the rice was popped at 240C. The Yukwa base in salts was smaller in size and larger in density than in oil but the popped rice in salts had a similar size and a smaller density than that popped in oil. In the sensory test, the Yukwa base and popped rice expanded in the salts were preferred to those popped in oil but there was little difference in only popped rice. In terms of color, there was a difference between those popped in salt and in oil. In terms of texture, only popped rice expanded in the salts was harder than in oil, and the Yukwa popped in oil was more cohesive than in the salts. In brittleness, there were no differences between in salt and in oil.

광장공포증 유무에 따른 공황장애 환자의 공존병리와 증상 심각도의 비교 연구

임경희,장은진,김정범 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

연구목적 : 본 연구에서는 광장공포증을 동반하지 않은 공황장애 환자들(이하 비광장공포증군)과 광장공포증을 동반한 공황장애 환자들(이하 광장공포증군)의 공존병리와 증상의 심각도를 조사하여 두 질환의 본질을 규명하고 치료계획을 세우는데 도움을 얻고자 한다. 방 법 : 연구대상은 1998년 3월부터 2001년 7월까지 계명대학교 동산의료원 정신과에서 외래치료를 받아온 환자들로 비광장공포증군 26명, 광장공포증군 44명으로 구성된 총 70명이다. 평가도구는 9개의 증상차원을 평가하는 90문항으로 구성된 간이정신진단검사(SCL-90-R)와 공황장애의 필수적이고 전반적인 7가지 영역의 심각도를 평가하는 한국판 공황장애 심각도 척도를 사용하였다. 통계적 분석은 ANOVA, Chi-square test, student t-test, person correlaiton을 시행하였고, 통계적 유의수준은 p<.05로 하였다. 결 과 : 1) 광장공포증군의 광장공포증적 두려움과 회피의 정도는 경도에서 중등도 사이에 해당되는 것으로 나타났다(PDSS점수 : 1.46±0.94). 2) 인구통계학적 특성에 대해 광장공포증군과 비광장공포증군을 비교해 보면, 연령, 성별, 교육정도, 직업유무, 병력, 발병연령에서는 두 집단 간에 유의한 차이가 없었다(표 1). 3) 세 집단의 공존병리의 유형을 분석해 본 결과, 광장공포증군은 모든 증상차원에서 정상대조군 집단보다 유의하게 높은 점수를 얻었다. 비광장공포증군은 불안, 공포불안, 정신증 척도에서 정상대조군 집단 보다 유의하게 높은 점수를 얻었다(표2). 4) 광장공포증군은 비광장공포증군에 비해 신체화, 강박증, 적대감, 공포불안, 편집증척도에서 유의하게 높은 점수를 보였다(표 2). 5) 광장공포증군과 비광장공포증군의 심각도 비교에서는 내적감응적 두려움과 회피, 직무수행의 장해/고통, 사회적 기능의 장해/고통에서는 두 집단 간에 유의한 차이를 보이지 않았느아, 심각도 총점, 복합점수, 공황발작의 빈도, 공황발작 동안의 고통, 예기불안, 광장공포증적 두려움과 회피에서는 광장공포증군이 비광장공포증군에 비해 유의하게 높은 점수를 보였다(표 3). 6) 광장공포증군내에서 광장공포증적 두려움과 회피항목은 SCL-90-R의 정신증 척도를 제외한 신체화, 강박증, 대인민감성, 우울, 불안, 적대감, 공포불안, 편집증 척도와 유의한 정적상관관계를 보였다(표 4). 결 론 : 광장공포증군이 비광장공포증군에 비해 대부분의 필수증상의 심각도가 높을 뿐만 아니라 더 다양한 공존병리를 가지고 있음이 밝혀져 기본적으로 더 심한 질환임이 시사된다. 따라서 공황장애의 치료와 평가에 있어서 공존병리와 증상의 심각도를 함께 고려하고 공황장애에서 광장공포증이 동반되는 경우 이에 대한 더 적극적이고 집중적인 치료가 필요하겠다. Objectives : In this research comorbidity and severity of symptom of patients that have panic disorder without agoraphobia(PD) and with agoraphobia(PDA) were examined in order to study their nature more closely and also to help set up therapy plans. Method : 70 patients were diagnosed with PD(N=26) and PDA(N=44) by DSM-Ⅳ. SCL-90-R was administered to panic subjects and normal control subjects. PDSS were administered to panic subjects, the statistical analysis was conducted using ANOVA, Chi-square test, student t-test, Pearson Correlation analysis. statistical signifi-cance was p<.05. Results : 1) The degree of agoraphobic fear/avoidance of PDA indicated the level to from moderate(PDSS score 1.46 0.94). 2) There was no significant difference between the two groups(PD/PDA) in there sex, age, education level, occupation, duration of illness, onset of age. 3) After analyzing the comorbidity pattern of the three groups, PDA was significantly higher score than normal control group in all symptom level. PD had higher score than normal control groups in anxiety, phobic anxiety and psychotism. 4) PDA showed much a significantly higher score in Somaatization, Obsessive-Compulsive, Hostility, Phobic Anxiety, Paranoid Ideation when compared to PD. 5) There was no significant difference between the two groups(PD/PDA) in there interoceptive fear/avoidance, PDA had significantly higher scores than PD. 6) The agoraphobic fear/avoidance item within PDA had significant correlation with Somatization, Obsessive-Compulsive, Interpersonal Sensitivity, Depression, Anxiety, Hostility, Phobic Anxiety, Paranoid Idation except significant correlation with psychoticism. Conclusion : As it is shown clearly in all the results, PDA had a higher level of severity than PD. It was also clarified that PDA had a variety of comorbidity. Therefore when evaluating the treatment of Panic Disorder, One has to consider the comorbidity and severity. A more positively and concentrated treatment will be needed when panic disorder is accompanied by agoraphobia.

現代中國語法과 句子

林慶姬 단국대학교 중어중문학과 1982 中國文學報 Vol.- No.5

진폐증 환자의 결핵진단을 위한 중합효소연쇄반응법의 임상적응용

임철재,이경혜,박재희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Recent development in thepolymerase chain reaction(PCR) has brought an extraordinary opportunity for the rapid detection of M. tuberculosis in clinical specimens for the diagnosis of tuberculosis. Pneumoconiosis is a sort of pulmonary fibrosis consequent to inhalation of the respirable dust. The association between pulmonary tuberculosis and pneumoconiosis is well recognized. There is a 10-fold increase in the tuberculosis risk among the workers who have pneumoconiosis demonstrated by chest roentgenogram. The physicians managing the patients with pneumoconiosis have to maintain a high index of suspicion for the development of mycobacterial infection, since the diagnosis of tuberculosis is often difficult. Mycobacterium tuberculosis is a very slow growing organism and acid-fast bacillus(AFB) staining frequently shows false negative results, and therefore PCR would be a very rapid, easy and sensitive diagnostic method for the diagnosis of Mycobacterium tuberculosis in pneumoconiotic patients. To compare the PCR method with the conventional methods in diagnosing Mycobacterium tuberculosis in sputum, we used the sputa of 115 pneumoconiosis patients in Munkyeong Cheil Hospital. Of 32 pulmonary tuberculosis in the pneumoconiosis patients, 29 were PCR positive and were higher than 28, 20 positive by culture and AFB stain. Overall sensitivity, specificity, and which were 90.6, 91.5% respectively for the PCR assay ; 87.5, 100% for the culture method : 62.5, 98.7% for the AFB stain. The PCR assay is a rapid, efficient, sensitive method which can detect M. tuberculosis in pneumoconiosis patients, and further study should be followed for the development of the easier method.

中國語 動詞謂語句의 主語判別

林慶姬 단국대학교 1994 論文集 Vol.28 No.-

Subject is one of the principal component in Chinese. In Chinese, content of the sentence is determined by word order basically because it has no morphological change compared with Western language. However, lots of controversies might be brought because of determination of subjective criterion since there is no indication representing subject in change of basic word orter. The criteria to determine subject in Chinese are word order and meaning. Verb-predicate sentences of SVO morphology corresponds with the above two standards, but when 0 is followed by S or V, the different results can be mad depending on which criterion of word order meaning on choose. The purpose of this thesis is to recognize the disputed issue and to approach resolution of the problem througuh examination of study results on subject on far. Concerning the study method, the extreme way has been carefully avoided which one should simple choose word order or meaning as determination criterion of subject in the past. Instead, the method selected in this thesis is to apply concordantly emphasizing relationship between order meaning. Following are the result of analysis of concrete sentence with the basis of the above principal. 1. Judgment of Inverted Object and Sentences with subject-predicate predicate. a. 這本書我看完了, 什마事情他度做, 車他騎走了 b. 我這本書看完了, 他什마事情都做, 他車騎走了 Since the word which was originally placed in object in a view of meaning comes the first inteh sentence, it is considerede that the function of object has been lost and taken role of subject which is the content descriptive in predicates. To support this logic, comprehensive definition has been adopted that the subject is the theme(principal subject) of one sentences and also is the object of the statement. 2. Existensial Sentence a. Component "台上" in "台上坐着主席團" Because the distinction of the existential sentence is circumstance description for certain place, not statement for activity, it is considered that "台上" can be determinded as subject according to the extraordinary emphasis of the position. b Component "一幅畵" and "一個人" in "牆上掛着一幅畵" and "前面來了一個人" Although "一幅畵" and "一個人" are placed in object, however, on the ground of structural distinction of predicate part, it is considered inverted subject of predicate part since it shows the function of subject rather than that of object. 3. Sentences with Passive Subjects "錢" can be determined as subjects without controversy because "錢花完了" is the sentence as expressing passive meaning without "被". 4. Non-subject Sentences In the sentence pattern like "下雨了", it is considered non-subject sentence which has no subject originally according to acknowledgement of the sentence used conventionally because it is difficult to present positive basis due to indistinct agent-passive relation of noum.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_2 at 37℃. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KCI, 60 mM HEPES, pH 7.9, 25 mM MgCI_2, 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2 ㎍ of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.