가족 등록 환자 관리 프로그램 개발

전계록,김윤진,장용훈 대한의료정보학회 1996 Healthcare Informatics Research Vol.2 No.1

일측성 질폐쇄 및 동측 신장 무발생을 동반한 중복자궁 2예

윤일영,여소진,김형문,김정식,김태희,이해혁,남계현,이권해,김준모,김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Uterus didelphys with unilateral obstructed hemivagina and ipsilateral renal agenesis usually presents after menarch with progressive abdominal pain during menses secondary to hematocolpos, and indeed a very rare congenital anomaly due to Mullerian duct malformation. An accurate and prompt diagnosis is of importance to permit treatment and to assure the future fertility of the patient. Pelvic ultrasound, physical examination and pelvic MRI established a diagnosis of hematometracolpos secondary to uterus didelphys with unilateral imperforate hemivagina. An incision in the vaginal septum allowed drainage of the hematocolpos, providing relief of the patients symptoms. We report two case of uterus didelphys with obstructed hemivagina with brief review of the literature.

SMEDDS를 이용한 난용성 약물의 용출율 향상

김계현,이윤석,배준호,지상철,박은석 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

ABSTRACT-A self-microemulsifying drug delivery system (SMEDDS) was developed to enhance the solubility and dissolution rate of poorly water soluble drug, biphenyl dimethyl dicarboxylate, DDB. The system was optimized by evaluating the solubility of DDB and the microemulsion existence range after the preparation of microemulsions with varying compositions of triacetin and surfactant-cosurfactant mixtures (Labrasol as surfactant (S) and the combination of Transcutol, Cremophor RH 40 and Plurol oleique as cosurfactant (CoS)). SMEDDS in this study markedly improved the solubility of DDB in water up to 10 mg/ml and the size of the o/w microemulsion droplets measured by dynamic light scattering showed a narrow monodisperse size distribution with an average diameter less than 50nm. The microemulsion existing range is increased proportional to the ration of S/CoS, however, it decreased remarkably as the oil content was more than 20%. In vitro dissolution study of SMEDDS showed a significantly increased dissolution rate of DDB in water (>12 fold over DDB powder), and SMEDDS also had significantly greater permeability of DDB in Caco-2 cell compared to powders.

도시 폐수처리장의 활성 슬러지로부터 분리된 aniline 분해세균의 특성

조윤석,오계헌,전효정 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1

Activated sludge samples were collected from a municipal sewage treatment plant and used for enrichment of mixed cultures with aniline as the sole carbon and nitrogen source. Several aniline-degrading bacteria were obtained, and two strains which had the excellent aniline degradability were isolated, and designated as HJ-1 and HJ-2, respectively. Morphological observation and various physiological characterization were performed for the isolates. In order to understand the degradative pathway of aniline by the isolates, catechol was sprayed on the individual colonies grown on solid mineral media containing aniline. As the result, color was changed to yellow, and this indicated that the isolates degraded aniline by a meta fission mechanism.

오염된 토양으로부터 분리된 세균에 이한 2,4-Dinitrotoluene과 2,6-Dinitrotoluene의 생물학적 제거

오계현,조윤석,이명석 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

Dinitrotoluenes (e.g., 2.,4-Dinitrotoluene and 2,6-Dinitrotoluene) are the major impurity resulting from the manufacture of 2,4,6-trinitrotoluene(TNT) and are primary starting materials for the synthesis of toluenediisocyanate which are used in the production of polyurethane foam. Both 2,4-DNT(2,4-dinitro- toluene) and 2,6-DNT(2,6-dinitrotoluene) are recalcitrant and have been shown to be toxic to aquatic and terrestrial organisms in the environment. Because little information is available for the biological degradation of DNTs, they have has not been evaluated for the possible treatment processes of industrial waste streams where DNTs may represent a serious disposal problem. In the present work, we explored the feasibility using a bacterium for DNTs degradation, with the ultimate aim of application for the industrial treatment. A DNTs-degrading bacterium was isolated from soil samples collected from an explosive contaminated area. Complete degradation of 2,4-DNT at the initial concentration of 50 ㎎ 2,4-DNT per liter was achieved within 10 days of incubation in bench-scale bioreactors, whereas 2,6-DNT degraded completely within 14 days under the same conditions, respectively. The bacterium was able to utilize DNTs as the sole nitrogen source. Co-substrate was essential for the bacterial growth and DNTs degradation in the medium. Neither bacterial growth nor DNTs degradation were observed in the absence of co-substrate. The detection of the parent substrates and their intermediates were based on HPLC and GC-MS methodology.

퍼지 데이터를 이용한 불량률(Ρ) 관리도의 설계

김계완,서현수,윤덕균 한국품질경영학회 2004 품질경영학회지 Vol.32 No.2

Using the p chart is not adequate in case that there are lots of data and it is difficult to divide into products conforming or nonconforming because of obscurity of binary classification. So we need to design a new control chart which represents obscure situation efficiently. This study deals with the method to performing arithmetic operation representing fuzzy data into fuzzy set by applying fuzzy set theory and designs a new control chart taking account of a concept of classification on the term set and membership function associated with term set.

오염된 토양으로부터 분리된 Burkholderia cepacia에 의한 2,4-D의 미생물학적 분해

오계헌,조윤석 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1

Mixed cultures capable of utilizing 2,4-D (2,4-dichlorophenoxyacetic acid) as the sole carbon and energy source were enriched from contaminated soils which had a previous history of annual 2,4-D application. Among six strains isolated from the mixed cultures, the isolate which had an excellent 2,4-D degradability was selected. Morphological observation and various physiological characterization were performed for the isolate. MIS (microbial identification system) was used for the identification of the isolate, and assigned as Burkholderia cepacia. Complete degradation of 2,4-D was achieved in the experiment within 28 hours of incubation. 2,4-DCP(2,4-dichlorophenol) was produced as a metabolite during 2,4-D degradation. For the analyses of 2,4-D and 2,4-DCP, HPLC and UV-spectrophotometer were used in this study.

운동선수들의 고통 대처 반응에 관한 연구

이계윤,문윤제 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

The purpose of this study was to investigate 1) the validity and reliability of Sports Inventory for Pain(SIP) when used Korean athletes 2) the effect according to gender, injury-potential, performance levels, grade. The participants were 485 athlete's in elementary, middle?igh school and university. The SIP was developed by Meyers et al(1992) and translated into Korean by 2 Ph.D sport psychologist, head coaches. Factor analytic procedure was used to determine SIP factors. Major SIP factors included direct copy, cognitive, catastrophizing, avoidance, body awareness. MANOVAs indicated significant gender(F5,475=2.67, p<.05), injury-potential(F5,475=2.20, p<.05), performance levels(F5,475=2.65, p<.05). Findings demonstrate that the SP can be used to differentiate between gender, injury-potential, performance, thus providing partial confirmation of construct validity of the SIP. These findings may be used as a starting point for continued research delineating and contrasting pain coping response in sport athletes.

운동선수들의 스트레스와 사회적 지원, 대처기술에 따른 운동상해 효과

이계윤 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.3

본 연구는 운동스트레스, 사회적 지원, 대처기술과 운동상해의 빈도나 정도간에 어떠한 인과 관계가 있는지 알아보고자 하였다. 이러한 목적을 수행하기 위하여 광주·전남 지역의 전국체전 대표선수로 선발된 377명을 운동스트레스, 사회적 지원, 대처기술, 운동상해의 빈도와 정도를 조사하였다. 그 결과 운동스트레스와 대처기술만이 유의한 상관(p<.05)이 나왔고, 다른 변인간에는 상관이 없었다. 그리고 세변인 즉, 운동스트레스, 사회적 지원, 대처기술이 운동상해의 빈도를 설명하는 전체 변량은 1.6%(R2)이었고, 상해 정도를 설명하는 변량은 2.5%(R2) 이었다. 마지막으로 운동스트레스를 독립변인, 사회적 지원과 대처기술을 매개변인, 운동상해의 빈도와 정도를 종속변인으로 설정하여 각 변인별 인과분석(경로 분석)을 한 결과 운동스트레스와 대처기술만이 인고관계가 있었고, 다른 변인간에는 관계가 없는 것으로 나타났다. 따라서, 상해 발생원인을 찾는 향후 연구에서는 기술적인 병인학과 분석적인 병인학에 관심을 가지고 접근하는 것이 더 합리적인 것으로 판단된다. The purpose of this study was to investigate the relationship between the sport stress, social support and coping skills, on the severity of injury and number of days missed from training and competition due to injury. The participants consisted of 377 provincial sport athletes who selected in Gwangju·Chonnam, and investigated psychosocial variables of sport stress, social support, coping skills, on the severity of sport injury and frequency of sport injury. The results were as follows. In the analysis of correlations, there were significant(p < .05) correlations between sport stress and coping skills, whereas significant relationships were not found between other variables. The frequency of sport injury accounted for 1.6%(R^2) of the total variance in psychsocial variables(sport stress, social support, coping skills), and severity of sport injury accounted for 2.5%(R^2) of the total variance in psychsocial variables. In the analysis of path(sport stress: independent variables, social support·coping skills: extraneous variables, frequency and severity of sport injury: dependent variables), there were significant(p < .05) relationships between sport stress and coping skills, whereas significant relationships were not found between other variables. The results of this study were not consistent with past research that reported a relationship between psychosocial variables and sport injury. It was probably due to attempt of only analytical epidemiology. Future research should examine using methods of descriptive epidemiology and analytical epidemiology to find occurrence of athletic injury in epidemiology.

TNT-분해세균인 Stenotrophomonas maltophilia에 의한 s-Triazine계 제초제인 Atrazine의 미생물학적 분해

오계헌,조윤석,이명석 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

The agricultural use and relative persistence of s-triazine herbicide such as atrazine have led to increasing concern about environmental contamination. Stenotrophomonas maltophilia capable of utilizing TNT as sole nitrogen source has been isolated from contaminated soils and the bacterium showed excellent degradability for several-triazine herbicides including atrazine. Complete depletion of atrazine was achieved within 30 hours of incubation. Atrazine was catabolized in the presence of different supplemented carbons. Among the co-substrates used in this experiment (e.g., glucose, fructose, starch, succinate, acetate), fructose was the best co-substrate. However, no atrazine degradation was monitored without the supplemented co-substrates in the cultures. The relationships between atrazine degradation by S. maltophilia and several relevant physicochemical parameters (e.g., N-sources, yeast extract) were examined. High performance liquid chromatographic methodology was used to measure this substrate and it also resolved unknown intermediates.