http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Seo, Ju-Hee,Leem, Jong-Han,Ha, Eun-Hee,Kim, Ok-Jin,Kim, Byung-Mi,Lee, Ji-Young,Park, Hye-Sook,Kim, Hwan-Cheol,Hong, Yun-Chul,Kim, Young-Ju Blackwell Publishing Ltd 2010 Paediatric and perinatal epidemiology Vol.24 No.2
<P>Summary</P><P>Seo J-H, Leem J-H, Ha E-H, Kim O-J, Kim B-M, Lee J-Y, Park H-S, Kim H-C, Hong Y-C, Kim Y-J. Population-attributable risk of low birthweight related to PM<SUB>10</SUB> pollution in seven Korean cities. <I>Paediatric and Perinatal Epidemiology</I> 2010; <B>24:</B> 140–148.</P><P>To understand the preventable fraction of low birthweight (LBW) deliveries due to maternal exposure to air pollution during pregnancy in Korea, it is important to quantify the population-attributable risk (PAR). Thus, we investigated the association between maternal exposure to air pollution during pregnancy and LBW, and calculated the PAR for air pollution and LBW in seven Korean cities. We used birth records from the Korean National Birth Register for 2004. A geographic information system and kriging methods were used to construct exposure models. Associations between air pollution and LBW were evaluated using univariable and multivariable logistic regression, and the PAR for LBW due to air pollution was calculated.</P><P>Of 177 660 full-term singleton births, 1.4% were LBW. When only spatial variation of air pollution was considered in each city, the adjusted odds ratios unit of particulate matter <10 µm in diameter (PM<SUB>10</SUB>) for LBW were 1.08 [95% confidence interval [CI] 0.99, 1.18] in Seoul, 1.24 [95% CI 1.02, 1.52] in Pusan, 1.19 [95% CI 1.04, 1.37] in Daegu, 1.12 [95% CI 0.98, 1.28] in Incheon, 1.22 [95% CI 0.98, 1.52] in Kwangju, 1.05 [95% CI 1.00, 1.11] in Daejeon and 1.19 [95% CI 1.03, 1.38] in Ulsan.</P><P>The PARs for LBW attributable to maternal PM<SUB>10</SUB> exposure during pregnancy were 7%, 19%, 16%, 11%, 18%, 5% and 16% respectively. Because a large proportion of pregnant women in Korea are exposed to PM<SUB>10</SUB>– which is associated with LBW – a substantial proportion of LBW could be prevented in Korea if air pollution was reduced.</P>
( Ok-hee Kim ),( Hyojung Kim ),( Jinku Kang ),( Dongki Yang ),( Yu-hoi Kang ),( Dae Ho Lee ),( Gi Jeong Cheon ),( Sang Chul Park ),( Byung-chul Oh ) 생화학분자생물학회 2017 BMB Reports Vol.50 No.1
Accumulation of tissue macrophages is a significant cha-racteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified age-dependent macrophage accumulation in the bone marrow, showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10. BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and thera-peutic clues. [BMB Reports 2017; 50(1): 43-48]
Paenibacillus hordei sp. nov., isolated from naked barley in Korea.
Kim, Jeong Myeong,Lee, Se Hee,Lee, Seung Hyeon,Choi, Eun Jin,Jeon, Che Ok N.V. Swets en Zeitlinger 2013 Antonie van Leeuwenhoek Vol.103 No.1
<P>A Gram-staining positive, facultative aerobic bacterium, designated strain RH-N24(T), was isolated from naked barley in South Korea. Cells of the isolate were observed to be motile rods by means of peritrichous flagella and showed catalase-positive and oxidase-negative reactions. Growth of strain RH-N24(T) was observed at 4-40?C (optimum: 35-37?C) and at pH 5.0-9.0 (optimum: pH 6.0-7.0). Chemotaxonomic data (major isoprenoid quinone: MK-7; DNA G?+?C content: 53.5?mol?%; cell wall type: A1γ-meso-diaminopimelic acid; major fatty acids: anteiso-CB(15:0) and CB(16:0B)) supported the affiliation of the isolate to the genus Paenibacillus. The major cellular polar lipids were identified as phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol and two unidentified polar lipids. Phylogenetic analysis based on 16S rRNA gene sequences also supported the conclusion that strain RH-N24(T) belonged to the genus Paenibacillus. Comparative 16S rRNA gene sequence analysis showed that strain RH-N24(T) was most closely related to Paenibacillus hunanensis FeL05(T) and Paenibacillus illinoisensis NRRL NRS-1356(T) with similarities of 94.64 and 94.54?%, respectively. On the basis of phenotypic and molecular properties, strain RH-N24(T) represents a novel species within the genus Paenibacillus for which the name Paenibacillus hordei sp. nov. is proposed. The type strain is RH-N24(T) (=KACC 15511(T)?=?JCM 17570(T)).</P>
Close Relationship Between SARS-Coronavirus and Group 2 Coronavirus
Kim, Ok-Ju,Lee, Dong-Hun,Lee, Chan-Hee The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.1
The sudden appearance and potential lethality of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) in humans has resulted in a focusing of new attention on the determination of both its origins and evolution. The relationship existing between SARS-CoV and other groups of coronaviruses was determined via analyses of phylogenetic trees and comparative genomic analyses of the coronavirus genes: polymerase (Orflab), spike (S), envelope (E), membrane (M) and nucleocapsid (N). Although the coronaviruses are traditionally classed into 3 groups, with SARS-CoV forming a $4^{th}$ group, the phylogenetic position and origins of SARS-CoV remain a matter of some controversy. Thus, we conducted extensive phylogeneitc analyses of the genes common to all coronavirus groups, using the Neighbor-joining, Maximum-likelihood, and Bayesian methods. Our data evidenced largely identical topology for all of the obtained phylogenetic trees, thus supporting the hypothesis that the relationship existing between SARS-CoV and group 2 coronavirus is a monophyletic one. Additional comparative genomic studies, including sequence similarity and protein secondary structure analyses, suggested that SARS-Co V may bear a closer relationship with group 2 than with the other coronavirus groups. Although our data strongly suggest that group 2 coronaviruses are most closely related with SARS-CoV, further and more detailed analyses may provide us with an increased amount of information regarding the origins and evolution of the coronaviruses, most notably SARS-CoV.