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Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Seo, Ju-Hee,Leem, Jong-Han,Ha, Eun-Hee,Kim, Ok-Jin,Kim, Byung-Mi,Lee, Ji-Young,Park, Hye-Sook,Kim, Hwan-Cheol,Hong, Yun-Chul,Kim, Young-Ju Blackwell Publishing Ltd 2010 Paediatric and perinatal epidemiology Vol.24 No.2
<P>Summary</P><P>Seo J-H, Leem J-H, Ha E-H, Kim O-J, Kim B-M, Lee J-Y, Park H-S, Kim H-C, Hong Y-C, Kim Y-J. Population-attributable risk of low birthweight related to PM<SUB>10</SUB> pollution in seven Korean cities. <I>Paediatric and Perinatal Epidemiology</I> 2010; <B>24:</B> 140–148.</P><P>To understand the preventable fraction of low birthweight (LBW) deliveries due to maternal exposure to air pollution during pregnancy in Korea, it is important to quantify the population-attributable risk (PAR). Thus, we investigated the association between maternal exposure to air pollution during pregnancy and LBW, and calculated the PAR for air pollution and LBW in seven Korean cities. We used birth records from the Korean National Birth Register for 2004. A geographic information system and kriging methods were used to construct exposure models. Associations between air pollution and LBW were evaluated using univariable and multivariable logistic regression, and the PAR for LBW due to air pollution was calculated.</P><P>Of 177 660 full-term singleton births, 1.4% were LBW. When only spatial variation of air pollution was considered in each city, the adjusted odds ratios unit of particulate matter <10 µm in diameter (PM<SUB>10</SUB>) for LBW were 1.08 [95% confidence interval [CI] 0.99, 1.18] in Seoul, 1.24 [95% CI 1.02, 1.52] in Pusan, 1.19 [95% CI 1.04, 1.37] in Daegu, 1.12 [95% CI 0.98, 1.28] in Incheon, 1.22 [95% CI 0.98, 1.52] in Kwangju, 1.05 [95% CI 1.00, 1.11] in Daejeon and 1.19 [95% CI 1.03, 1.38] in Ulsan.</P><P>The PARs for LBW attributable to maternal PM<SUB>10</SUB> exposure during pregnancy were 7%, 19%, 16%, 11%, 18%, 5% and 16% respectively. Because a large proportion of pregnant women in Korea are exposed to PM<SUB>10</SUB>– which is associated with LBW – a substantial proportion of LBW could be prevented in Korea if air pollution was reduced.</P>
Kim, Woo-Jin,Shin, Eun-Ha,Kong, Hee Jeong,Nam, Bo-Hye,Kim, Young-Ok,Jung, Hyungtaek,An, Cheul Min The Korean Society of Fisheries and Aquatic Scienc 2013 Fisheries and Aquatic Sciences Vol.16 No.4
Microsatellite markers are important for gene mapping and for marker-assisted selection. Sixty-five polymorphic microsatellite markers were developed with an enriched partial genomic library from olive flounder Paralichthys olivaceus an important commercial fish species in Korea. The variability of these markers was tested in 30 individuals collected from the East Sea (Korea). The number of alleles for each locus ranged from 2 to 33 (mean, 17.1). Observed and expected heterozygosity as well as polymorphism information content varied from 0.313 to 1.000 (mean, 0.788), from 0.323 to 0.977 (mean, 0.820), and from 0.277 to 0.960 (mean, 0.787), respectively. Nine loci showed significant deviation from the Hardy-Weinberg equilibrium after sequential Bonferroni correction. Analysis with MICROCHECKER suggested the presence of null alleles at five of these loci with estimated null allele frequencies of 0.126-0.285. These new microsatellite markers from genomic libraries will be useful for constructing a P. olivaceus linkage map.
Ok Hee Choi,Jin Hyeuk Kwon,Yong Sik Min,Jin Woo Kim The Korean Society of Mycology 2011 Mycobiology Vol.39 No.1
Stem rot was found for the first time on the Asiatic dayflower plant (Commelina communis L.) in Korea. A detailed description of this Korean specimen is given, along with its rDNA internal transcribed spacer sequence. The fungus was identified as Sclerotium rolfsii Saccardo based on mycological characteristics and molecular data.
A Scintigraphic Study of the Pyramidal Lobe of the Thyroid
Kim, Ok Hwa,Lee, Seong Yong,Lee, Myung Hee,Lee, Han Jin,Bahk Yong Whee CATHOLIC MEDICAL CENTER 1982 Bulletin of the Clinical Research Institute Vol.10 No.1
The authors reviewed 200 consecutive cases of thyroid scintigrams in order to seek the incidence and morphological characteristics of pyramidal lobe (PL). The results were as follows. 1) The incidence of PL was 104 (52%) out of 200 cases, and PL was located in the left lobe of the gland in 50 (48.1%), in the isthmus portion in 33 (31.7%) and in the right lobe in 21 (20%). 2) PL was rod shaped in 57 cases (54.8%), triangular or cone shaped in 42 (40.0%) and dumbbell or club shaped in 5 (4.8%). 3) The length of PL was 1 to 2 cm in 44 cases (42.3%), 2 to 3 cm in 36 (34.6%) and less than 1 cm in 12 (10.4%) and more than 3 cm in 13 (12.5%). The width of PL was 0.5 to 1 cm in 18 cases (75%), less than 0.5 cm in 12 (11.5%) and more than 1 cm in 14 (13.5%). 4) To evaluate the histopathologic relationship between the thyroid gland proper and PL, we measured the length of PL in 54 cases of normal group and in 21 cases with diffuse goiter, retrospectively. The mean and standard deviation in the former was 1.64±0.66 cm and in the latter 1.77±0.67 cm. The difference between the normal and goitrous group was not significant statistically suggesting that the biological behaviour of PL is not probably parallel to that of the thyroid gland proper.