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Hayeon Kim(Hayeon Kim),Bumhee Park(Bumhee Park),Shin-Young Kim(Shin-Young Kim),Jiyea Kim(Jiyea Kim),Bora Kim(Bora Kim),Kyu-In Jung(Kyu-In Jung),Seung-Yup Lee(Seung-Yup Lee),Yerin Hyun(Yerin Hyun),Bung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents. Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6−9, 10−13, and 14−17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis. Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6−9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10−13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14−17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation. Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.
북한의 외국어로서 조선어 교육과정 연구 - 유학생 A의 학습 경험을 중심으로 -
김지예 ( Kim Jiyea ),조염정 ( Zhao Yanting ),최유진 ( Choi Yu-jin ) 한성대학교 한성어문학회 2019 漢城語文學 Vol.41 No.-
The purpose of this study is to check the aspects of Joseon language education of North Korea because it has the value to research as one sector of Korean education conducted for foreigners. To achieve it, autobiographical writing and in-depth interview were conducted for A foreign student who experienced Joseon language education in Kim Ilseong Univ. of North Korea. Also, completion of this research was additionally promoted by analyzing Joseon language education related real materials and precedent researches. Therefore, this thesis could reorganize the program of Joseon language education of North Korea, especially, trainee educational program of Chinese scholarship student. About 60 Chinese scholarship students of each year are dispatched to Kim Ilseong Univ. or Kim Hyungjik College of Education in North Korea for 7 months. North Korean curriculum had goals of linguistic education and system propaganda at the same time and managed diverse subjects other than Joseon language. Joseon language education was conducted for 180~270 minutes per day and used 7 kinds of Joseon language materials developed by Kim Ilseong Univ. Lecture classes focusing on teachers were conducted and main practice was recite. In the curriculum, achievement evaluation was conducted 1 time at the end of the term. Foreign student A looked back that studying in North Korea enriched his or her life.
Kim, Hyemin,Kim, Yejin,Bae, Seyeon,Lim, Seung Hyeon,Jang, Mirim,Choi, Jiyea,Jeon, Jane,Hwang, Young-il,Kang, Jae Seung,Lee, Wang Jae Mary Ann Liebert 2015 ANTIOXIDANTS AND REDOX SIGNALING Vol.23 No.16
<P>Aims: The developing brain of a neonate is particularly susceptible to damage by vitamin C deficiency because of its rapid growth and immature antioxidant system. Cognitive impairment and sensory motor deficits are found in the adult brain upon vitamin C deficiency. Therefore, the aim of this study was to clarify the role of vitamin C in its own right and its related mechanisms in Gulo(-/-) mice incapable of synthesizing vitamin C. Results: When vitamin C supplementation was ceased for 2 weeks until delivery, stillbirths and a significant reduction in neonatal mice were observed and the growth of neonates was remarkably decreased. In addition, intraparenchymal hemorrhages were found in most of the brains, especially in the stillborn neonates. In addition, the levels of malondialdehyde (MDA) and 8-isoprostanes were increased and structural abnormalities were found in the cortex, hippocampus, and cerebellum. Especially, vitamin C deficiency caused the failure of or a delay in the formation of cerebellar fissures accompanied by abnormal foliation and altered Purkinje cell alignment. In the developed adult brains from vitamin C-deficient Gulo(-/-) mice, the levels of glutathione, MDA, nitrate, IL-6, TNF-, and Bax were increased and the expression of the GABRA6 and calbindin-28k was decreased. Due to atrophy of the granule and Purkinje cells, the motor behavior of vitamin C-deficient Gulo(-/-) mice declined. Innovation and Conclusion: Vitamin C deficiency during gestation induces intraparenchymal hemorrhages and severe defects in the development of the cerebellum. In fully developed brains, it induces the functional impairment by altering the cellular composition in the cerebellum. Antioxid. Redox Signal. 23, 1270-1283.</P>
Won Kim,Seyeon Bae,Hyemin Kim,Yejin Kim,Jiwon Choi,Sun Young Lim,Hei Jin Lee,Jihyuk Lee,Jiyea Choi,Mirim Jang,Kyoung Eun Lee,Sun G,Chung,Young-il Hwang,Jae Seung Kang,Wang Jae Lee 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.4
The L-gulono-γ-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo-/- mice under conditions of ascorbic acid insufficiency, we investigated the effect of ascorbic acid insufficiency on factors related to bone metabolism in Gulo-/- mice. Four groups of mice were raised for 4 weeks under differing conditions of ascorbic acid insufficiency, namely, wild type; ascorbic acid-sufficient Gulo-/- mice, 3-week ascorbic acid-insufficient Gulo-/- mice, and 4-week ascorbic acid-insufficient Gulo-/- mice. Four weeks of ascorbic acid insufficiency resulted in significant weight loss in Gulo-/- mice. Interestingly, average plasma osteocalcin levels were significantly decreased in Gulo-/- mice after 3 weeks of ascorbic acid insufficiency. In addition, the tibia weight in ascorbic acid-sufficient Gulo-/- mice was significantly higher than that in the other three groups. Moreover, significant decreases in trabecular bone volume near to the growth plate, as well as in trabecular bone attachment to the growth plate, were evident in 3- or 4-week ascorbic acid-insufficient Gulo-/-. In summary, ascorbic acid insufficiency in Gulo-/- mice results in severe defects in normal bone formation, which are closely related to a decrease in plasma osteocalcin levels.
김지예 ( Jiyea Kim ) 사단법인 아시아문화학술원 2019 인문사회 21 Vol.10 No.4
본고는 이론적 고찰을 바탕으로 한국어 듣기 교육 연구를 분석하여 그에 따른 연구과제를 제시하는 것을 목적으로 한다. 듣기 교육 연구사는 여러 번 검토되기는 하였으나 연구의 지향점에 대해서는 명확히 제시되지 못하고 있다. 이는 듣기 교육의 이론적 고찰 없이 연구 동향만을 분석하였기 때문으로 보인다. 이에 본고는 한국어 듣기 교육의 이론적 고찰을 바탕으로 315편의 듣기 교육 논문을 분석하였다. 그 결과, 듣기의 특성이나 듣기 능력, 듣기 과정 등에 관한 이론적 연구의 필요성과 함께 듣기교육체계, 듣기학습법, 듣기학습자료, 듣기평가에 학습자 중심, 맥락, 과제 중심, 실제성, 숙달도의 원리가 반영되어야 함도 고찰하였다. 이를 바탕으로 연구에 있어 학습자의 요구와 특성을 고려해야 하며, 듣기 교육 연구가 발전적인 방향으로 나아가기 위해서는 이론적 연구의 필요와 교수 원리를 반영할 구체적인 방안이 제시되어야 함을 제안하는 바이다. This study aims to review the subject area of Korean listening education research and to present future research topics. Researches describing the history of Korean listening education have been conducted constantly, but the direction for future studies is not clearly presented since they analyzed researches without a theoretical review. This study analyzed 315 research papers based on theoretical background. The results of analysis are as follow. First, a study based on theoretical consideration of the nature of listening, listening competence, and the process of listening will be required. Second, principles of learner-oriented, context, task-oriented, authenticity, and proficiency need to be reflected on listening education system, listening learning method and evaluation. Based on the results, this study suggests that a theoretical review and specific measures of teaching principles should be reflected in further studies on Korean listening education.
자동화된 해석기법 적용을 통한 차량 에어백 설계 시스템 개발
김수일(Sooil Kim),배지예(Jiyea Bae),이우주(Woojoo Lee),김동철(Dongchoul Kim) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11
An automated design system of an airbag is presented, which autonomously correlates airbag finite element simulation and the optimization process. Current airbag correlation is achieved through the manual application of trial-and-error procedures implemented by skilled engineers. The developed system successfully correlates a baseline model automatically and reduces the time and skill required for correlation and increase repeatability.
GSK3B induces autophagy by phosphorylating ULK1
Ryu Hye Young,Kim Leah Eunjung,Jeong Hyeonjeong,Yeo Bo Kyoung,Lee Ji-Won,Nam Hyeri,Ha Shinwon,An Hyun-Kyu,Park Hyunhee,Jung Seonghee,Chung Kyung Min,Kim Jiyea,Lee Byung-Hoon,Cheong Heesun,Kim Eun-Kyou 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast kinase Atg1, has an essential role in autophagy induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. We previously identified glycogen synthase kinase 3 beta (GSK3B) as an upstream regulator of insulin withdrawal-induced autophagy in adult hippocampal neural stem cells. Here, we report that following insulin withdrawal, GSK3B directly interacted with and activated ULK1 via phosphorylation of S405 and S415 within the GABARAP-interacting region. Phosphorylation of these residues facilitated the interaction of ULK1 with MAP1LC3B and GABARAPL1, while phosphorylation-defective mutants of ULK1 failed to do so and could not induce autophagy flux. Furthermore, high phosphorylation levels of ULK1 at S405 and S415 were observed in human pancreatic cancer cell lines, all of which are known to exhibit high levels of autophagy. Our results reveal the importance of GSK3B-mediated phosphorylation for ULK1 regulation and autophagy induction and potentially for tumorigenesis.