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Stromal CD10 expression and relationship to the E-cadherin/&bgr;-catenin complex in breast carcinoma
Kim, Hyun-Soo,Kim, Gou Young,Kim, Youn Wha,Park, Yong-Koo,Song, Jeong-Yoon,Lim, Sung-Jig Blackwell Publishing Ltd 2010 Histopathology Vol.56 No.6
<P>Kim H-S, Kim G Y, Kim Y W, Park Y-K, Song J-Y & Lim S-J(2010) <I>Histopathology</I> <B>56,</B> 708–719Stromal CD10 expression and relationship to the E-cadherin/&bgr;-catenin complex in breast carcinoma</P><P>Aims: </P><P>Previous investigations have indicated that stromal CD10 expression, and altered levels of both E-cadherin and &bgr;-catenin, are associated with the biological aggressiveness of human carcinoma. The aim was to evaluate stromal CD10 expression and the association of stromal CD10 with E-cadherin and &bgr;-catenin in breast carcinoma.</P><P>Methods and results: </P><P>The expression of CD10, E-cadherin and &bgr;-catenin was immunohistochemically analysed in tissue microarrays containing 104 cases of invasive ductal carcinoma (IDC) and 10 cases of ductal carcinoma <I>in situ</I> (DCIS). Stromal CD10 was detected in 49.5% (50/101) of the IDC. No immunoreactivity was identified in the stromal cells of normal breast, DCIS or intraductal components of IDC. Accumulation of the cytoplasmic &bgr;-catenin was found in 87.0% (87/100) of the IDC. Stromal CD10 expression in IDC was significantly correlated with tumour size (<I>P</I> = 0.027), stage (<I>P</I> < 0.001) and histological grade (<I>P</I> = 0.006), the presence of nodal (<I>P</I> = 0.048) and distant (<I>P</I> = 0.015) metastases, oestrogen receptor-negative status (<I>P</I> = 0.016), cytoplasmic &bgr;-catenin accumulation (<I>P</I> = 0.031) and lower overall survival rate (<I>P</I> = 0.041).</P><P>Conclusions: </P><P>Stromal CD10 expression in IDC may constitute an important prognostic marker. Stromal CD10 expression with associated aggressive features might be related to aberrant &bgr;-catenin expression.</P>
Giant superficial angiomyxoma of the vulva: a case report and review of the literature
Kim, Hyun-Soo,Kim, Gou Young,Lim, Sung-Jig,Ki, Kyung-Do,Kim, Hyun Cheol Blackwell Publishing Ltd 2010 Journal of cutaneous pathology Vol.37 No.6
<P>Superficial angiomyxomas (SAMs) are rare, benign cutaneous tumors frequently involving the subcutis. Only 15 cases of SAM involving the vulva have been reported, ranging from 0.9 to 4 cm in diameter. A 26-year-old woman presented with a 7-year history of a large, pedunculated cutaneous mass on the left labium major, measuring 12.5 × 11 × 10.5 cm and mimicking a soft tissue sarcoma. The mass was relatively well-circumscribed, but unencapsulated and multilobulated. Microscopically, the mass showed a conglomerate of moderately-to-sparsely cellular angiomyxoid lobules. Each lobule consisted of scattered spindle-shaped or stellate tumor cells set in an abundant myxoid stroma. Thin-walled, small-to-medium-sized blood vessels were distributed diffusely throughout the stroma. Scattered stromal neutrophils were also observed. No large vessels or plexiform capillaries were apparent. There was no perivascular accentuation of stromal cells or smooth muscle bundles. The tumor cells constantly expressed vimentin, CD34, CD44 and S-100, but none expressed estrogen receptors (ERs) and progesterone receptors (PRs), desmin or cytokeratin. Together, these findings were diagnostic of a SAM. Giant SAMs of the vulva can mimic aggressive angiomyxomas (AAMs) and angiomyofibroblastomas (AMB), as well as soft tissue sarcomas. Giant SAMs should be included in the differential diagnosis of vulvar soft tissue tumors.</P><P>Kim H-S, Kim GY, Lim S-J, Ki K-D, Kim HC. Giant superficial angiomyxoma of the vulva: a case report and review of the literature.</P>
이건(Gun Lee),장영운(Young Woon Chang),김수영(Su Young Kim),한요셉(Yo Seb Han),김영희(Yong Hee Kim),김교영(Gou Young Kim),이동근(Dong Keun Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byung Ho Kim),이정일(Jung Il Lee),이주희(J 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Granulomatous appendiceal disease is uncommon. Since the first report by Meyerding in 1953, about 150 cases of presumed isolated appendiceal Crohn's disease have been documented worldwide. However, none of appendiceal Crohn's disease has been reported in Korea. We experienced 27-year-old woman and 42-year-old man with isolated appendiceal Crohn's disease, which was diagnosed after surgical operation. It was presumed as acute appendicitis with periappendiceal abscess preoperatively. The pathologic finding of appendectomy specimen showed transmural inflammation with giant cell and lymphocyte infiltration, and non-caseous epitheloid granuloma. (Korean J Gastroenterol 2001;38:381-384)
Yun, Seok Joong,Jeong, Pildu,Kang, Ho Won,Kim, Ye-Hwan,Kim, Eun-Ah,Yan, Chunri,Choi, Young-Ki,Kim, Dongho,Kim, Jung Min,Kim, Seon-Kyu,Kim, Seon-Young,Kim, Sang Tae,Kim, Won Tae,Lee, Ok-Jun,Koh, Gou-Yo Korean Continence Society 2015 International Neurourology Journal Vol.19 No.2
<P><B>Purpose:</B></P><P>MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of the study was to identify and validate urinary cell-free miRNAs that can segregate patients with PCa from those with BPH. </P><P><B>Methods:</B></P><P>In total, 1,052 urine, 150 serum, and 150 prostate tissue samples from patients with PCa or BPH were used in the study. A urine-based miRNA microarray analysis suggested the presence of differentially expressed urinary miRNAs in patients with PCa, and these were further validated in three independent PCa cohorts, using a quantitative reverse transcriptionpolymerase chain reaction analysis. </P><P><B>Results:</B></P><P>The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. In particular, herpes simplex virus (hsv)-derived hsv1-miR-H18 and hsv2-miR-H9-5p showed better diagnostic performance than did the serum prostate-specific antigen (PSA) test for patients in the PSA gray zone. Furthermore, a combination of urinary hsv2-miR-H9-5p with serum PSA showed high sensitivity and specificity, providing a potential clinical benefit by reducing unnecessary biopsies. </P><P><B>Conclusions:</B></P><P>Our findings showed that hsv-encoded hsv1-miR-H18 and hsv2-miR-H9-5p are significantly associated with PCa and can facilitate early diagnosis of PCa for patients within the serum PSA gray zone.</P>
Kim, Young Mee,Seo, Jawon,Kim, Yung Hee,Jeong, Jaeho,Joo, Hye Joon,Lee, Dong-Hee,Koh, Gou Young,Lee, Kong-Joo 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18
Angiogenesis is an essential process in physiological and pathological processes and is well-regulated to maintain the cellular homeostasis by balancing the endothelial cells in proliferation and apoptosis. Angiopoietin-1 (Ang1) regulates angiogenesis as a ligand of Tie 2 receptor tyrosine kinase. however, the regulation pathways are not well-understood. To date, only a few of the signaling molecules involved in the Tie 2 receptor tyrosine kinase-mddiated angiogenesis have been identified. In this study, we systematically identified tyrosine-phosphorylated proteins in Ang1-induced signaling cascade in human umbllical vein endothelial cells (HUVECs), employing proteomic analyses combining two-dimensional gel electrophoresis, Western analysis using phosphotyrosine antibody and mass spectrometry (MALDI TOF MS and nanoLC-ESI-q-TOF tandem MS). We report here the identification, semiquantitative analysis, and kinetic changes of tyrosine-phosphorylated proteins in response to Ang1 in HUVECs and identified 66 proteins among 69 protein spots showing significant changes. Of these, P54nrb was validated as a molecule involved in cell migration. These results suggest that Ang1 induces stabilization of neo-vessel network by regulating thel phosphorylations of metabolic and structural proteins.
IgA 신병증 환자에서 Angiotensin Converting Enzyme 과 Endothelial Nitric Oxide Synthase유전자 다형성
김원,김현철,박성배,김인희,이광영,박성광,강성귀,고규영,이대열 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.3
To evaluate the association between ACE gene I/D polymorphism and ecNOS gene a/b polymorphism in IgA nephropathy, 158 IgA nephropathy patients and 121 control subjects were examined. In genotype distribution of the ACE gene I/D polymorphism, there was no significant difference in genotype distribution between controls and IgA nephropathy patients. We also examined the association between ACE genotype and clinical characteristics in the patients with IgA nephropathy. The incidence of hypertension in patients with DD genotype was higher than that of other genotypes. There were no significant association between I/D polymorphism distribution and chronic renal failure, nephrotic range proteinuria, and glomerular sclerosis in IgA nephropathy. In genotype distribution of ecNOS gene a/b polymorphism, there was no significant difference between IgA nephropathy patients and controls. There was no significant difference in frequency of chronic renal failure, hypertension, nephrotic range proteinuria and glomerular sclerosis among ecNOS genotypes. In addition, we failed to detect any significant association between the ACE and ecNOS gene-polymorphis ms and the decline of renal function in IgA nephropathy. A further study with larger number of patient population would be necessary.
SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling
Kim, Kangsan,Kim, Il-Kug,Yang, Jee Myung,Lee, Eunhyeong,Koh, Bong Ihn,Song, Sukhyun,Park, Junseong,Lee, Sungsu,Choi, Chulhee,Kim, Jin Woo,Kubota, Yoshiaki,Koh, Gou Young,Kim, Injune Grune & Stratton 2016 Circulation research Vol.119 No.7
<P>Rationale: Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback is well known, the positive feedback control for augmenting VEGF signaling remains poorly understood. Transcription factor Sox17 is indispensable for angiogenesis, but its association with VEGF signaling is largely unknown. The contribution of other Sox members to angiogenesis also remains to be determined. Objective: To reveal the genetic interaction of Sox7, another Sox member, with Sox17 in developmental angiogenesis and their functional relationship with VEGF signaling. Methods and Results: Sox7 is expressed specifically in endothelial cells and its global and endothelial-specific deletion resulted in embryonic lethality with severely impaired angiogenesis in mice, substantially overlapping with Sox17 in both expression and function. Interestingly, compound heterozygosity for Sox7 and Sox17 phenocopied vascular defects of Sox7 or Sox17 homozygous knockout, indicating that the genetic cooperation of Sox7 and Sox17 is sensitive to their combined gene dosage. VEGF signaling upregulated both Sox7 and Sox17 expression in angiogenesis via mTOR pathway. Furthermore, Sox7 and Sox17 promoted VEGFR2 (VEGF receptor 2) expression in angiogenic vessels, suggesting a positive feedback loop between VEGF signaling and SoxF. Conclusions: Our findings demonstrate that SoxF transcription factors are indispensable players in developmental angiogenesis by acting as positive feedback regulators of VEGF signaling.</P>