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이재숙,조윤정,손정원,이갑노 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.3
To evaluate the relationship between c-myc amplification and leukemic transformation. The Southern hybridization was performed in 23 clinical leukemic samples(4 cases of ALL, 17 cases of ANLL, 1 case of CML, 1 case of CMMoL), 6 ATCC leukemic cell lines(ATCC CCL 213 Daudi;Burkitt lymphoma, ATCC CCL 243 K-562;chronic myelogenous leukemia, ATCC CRL 2582 Molt-4;T-cell acute lymphoblastic leukemia, ATCC CCL 240 HL-60; promyelocytic leukemia, ATCC CCL 246 KG-1;acute myeloblastic leukemia, ATCC CCL 246.1 KG-1a;acute myeloblastic leukemia), and 6 cases of nonleukemic bone marrow aspirates. The results were summarized as follows. 1. In leukemic cell lines, HL-60 showed marked c-myc amplification(6x) compared to negative control and KG1 showed mild amplification(2x). However, there was no c-myc amplification in K-562, KGla, and molt-4. 2. In leukemic samples, mild c-myc amplification(2x) was observed in 3 cases of 17 AML, but no amplification was observed in 4 ALLs, 1 CML, and 1 CMMoL. 3. In nonleukemic samples, one case of reactive marrow hyperplasia showed mild c-myc amplification (2x). From the above findings, it was concluded that the c-myc amplification was more common in acute nonlymphocytic leukemia than other types of leukemias, c-myc amplification appeared not only enough to transform hematopoietic cells but expression of other complicated oncogenes together with it cotributed the development of leukemia.
白血病에서의 c-myc 腫瘍蛋白의 發現樣相에 관한 硏究
조윤정,이갑노 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.3
To evaluate the relationship between the expression of c-myc oncoprotein and the development of leukemia, flow cytometric analysis (FACScan®) of c-myc oncoprotein using monoclonal antibody was performed in 23 clinical leukemic samples (4 cases of ANLL ; 15 cases of ALL; 3 cases of ALL in complete remission ; 1 case of chronic myelomonocytic leukemia).20 cases of control groups (non-leukemic bone marrow aspirates). & 4 ATCC leukemic cell lines(ATCC CCL 240 HL-60, acute promyelocytic leukemia ; ATCC CCL 213 Daudi, Burkitt lymphoma ; ATCC CCL 243 K-562. Chronic myelogenous leukemia in blast crises ; ATCC CRL 1582 Molt-4, acute T-cell leukemia). The results were summarized as follows. 1. The proportion of myelocytes, basophilic normoblasts. and polychromatophilic normoblasts of the bone marrow aspirate in control group showed weak, but significant correlation with the c-myc oncoprotein staining indices (% positivity of cell staining and/or corrected mean fluorescence intensity, CMFI) (r= 0.35, 0.35, 0.30 respectively). But the proportion of the other immature cells such as blasts, promyelocytes, pronormoblasts, and orthochromic nor-moblasts showed no correlation with the c-myc oncoprotein staining indices. 2. The difference of the percent positivity of c-myc staining in the cells among the immunologic classes of ALL was not significant. But the CMFI of B ALL is significantly higher than that of common ALL or T ALL (F ratio=3.85, p=0.05). 3. The extent of CDl3. CD33, CD34 expression in ANLL showed no correlation with the c-myc oncoprotein staining indices. But that of CD14 expression in ANLL showed negative correlation with CMFI (r= -1.0). 4. There is no significant differences in c-myc oncoprotein staining indices among ANLL, ALL. ALL in complete remission, CMMoL, leukemic cell lines, and control group. 5. The CMFI of c-myc protein staining is high in K-562, Molt-4, HL-60, and Daudi in a decreasing order. From the above findings, it was concluded that ; first, the malignant transformation of the hematopoietic cells require a complex phenomena in addition to the c-myc oncogene expression because the c-myc oncoprotein is present both in the malignant transformation and in the benign proliferation of hematopoietic cells. Secondly, in the hematopoietic malignancy c-myc oncogene expression is not only present in acute promyelocytic leukemia, but also in the other myeloid leukemia and lymphoblastic leukemia. Thirdly, c-myc oncogene expression is diminished in the terminal stage of monocytic differentiation.
Evaluation of Changes in Serum Thyroid Hormone Levels in Patients with Hepatitis B Infection
윤혁준,Kyeung Jung,임인수,Kap No Lee,Jae Kyung Kim 국제문화기술진흥원 2023 International Journal of Advanced Culture Technolo Vol.11 No.2
Purpose: We aimed to determine the differences in the levels of serum thyroid hormone (free T4 [FT4]) and thyroid stimulating hormone [TSH]) as biomarkers for hepatitis B virus (HBV) infection status, with respect to age and sex. Methods: We retrospectively analyzed serum samples from 200 patients who underwent HBV testing from August 2022 to September 2022. Serum samples were collected from patients suspected of having HBV infection who visited this hospital. Thyroid hormone levels were measured, and patients were grouped according to age and sex. Results: Differences in TSH and FT4 levels in the serum of patients in the HBV-positive and -negative groups were not significant. Among the HBV-positive patients in the younger age group (<60 years), TSH and FT4 levels were 1.78 ± 0.09 µIU/mL (normal: 0.4–5.0 µIU/mL) and 1.24 ± 0.02 ng/mL (normal: 0.8–1.9 ng/mL), respectively, whereas among the HBV-positive patients in the older age group (≥60 years), TSH and FT4 levels were 2.22 ± 0.17 µIU/mL and 1.24 ± 0.07 ng/mL, respectively. Conclusions: The presence of HBV did not markedly affect serum thyroid hormone levels. Our findings shed light on the conflicting evidence on the association between thyroid hormone levels and HBV infection. We, Hyeokjun Yun and Bo Kyeung Jung are co-first authors which made substantial contribution equally to the conception and designed of this work. Jae Kyung Kim, In soo Rheem and Kap No Lee made significant contributions to the acquisition and analysis of the data.
金蕙慶,李甲魯 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.1
The purpose of this investigation was to evaluate the antigenic level and functional activity of protein C, protein S and free protein S in various thrombogenic disease states. Also, the study on the reference values of protein C and protein S in normal Korean adults was included. The results were summarized as follows ; 1. The antigenic level and functional activity of protein C in normal Korean male were 100±20.9% (mean±2SD), 99.9±22.8% and those in female 97.4±18.4%, 97.4±24.2%. Those of the female appeared to be lower than those of the male but it was statistically of no difference. The average antigenic level and functional activity of normal Korean adults were respectively 99.0±20.1% and 98.9±23.6%. The antigenic level and functional activity of protein S in normal Korean male were 102.8±23.7%, 104.6±16.2%, and those in female 99.5±26.7%, 99.3±31.3% The female showed significantely lower value than male (p<0.05). The average were 100.7±25.4%, 102.6±28.6%. Free protein S antigenic level were 42.4±11.4% in normal male and 40.3±12.3% in normal female. The female showed little lower value than the male, but it was not statistically different. The average was 41.5±12.1%. 2. Protein C antigenic level and functional activity decreased very significantly in toxemia (84.8±8.5%, 80.6±15.3%), chronic liver diseases (44.6±19.3%, 43.6±19.0%), disseminated intravascular coagulopathy (54.7±19.4%, 53.3±19.1%), hepatoma, acute and chronic myelogenous leukemia, malignant lymphoma and lung cancer (66.9±58.6%, 65.7±62.2%) (p<0.001), but showed no change in acute lymphoblastic leukemia, stomach, colon and ovarian cancers. Protein S antigenic level and functional activity decreased very significantly in normal pregnancy (67.9±18.6%, 50.1±22.4%), toxemia (66.3±8.5%, 61.7±25.3%), chronic liver diseases (62.8±12.2%, 62.9±12.9%), disseminated intravascular coagulopathy (67.2±13.1%, 67.5±11.7%), toxemia, acute and chronic myelogenous leukemia, malignant lymphoma, lung cancer (p<0.001), and significantly decreased in acute lymphoblastic leukemia (94.5±30.9%, 96.2±35.1%), but showed no change in stomach, colon and ovarian cancers. Free protein S antigenic level very significantly decreased in normal pregnancy (21.9±9.2%), toxemia (24.8±14.6%), chronic liver diseases (22.4±5.0%), disseminated intravascular coagulopathy (22.7±4.2%), hepatoma, acute and chronic myelogenous leukemia, malignant lymphoma and lung cancer (33.3±24.1%) (p<0.001), but showed no change in stomach, colon and ovarian cancers. 3. There was good correlation between protein C antigenic level and functional activity, and between protein S antigenic level and functional activity (r>0.6). Our results showed the decreased antigenic level and functional activity of protein C and S, and free protein S antigenic level in various thrombogenic disease states except few non-hematologic malignancy. Such results might be helpful to understanding the pathogenesis of thrombogenic phenomena in various diseases and might be useful guide to therapeutic management.