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전주홍,박기광,조경엽,이상대,송정록 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1
Bony defects of mandible caused by trauma, infection, or tumor resection have been reconstructed by autologous bone graftings. These reconstruction can restore facial contour and integrity of the oral cavity. However, it is often necessary to reduce the bulk of bone to allow soft tissue coverage of the graft. Therefore, the construction of removable dentures in this situation is fraught with frustation. The use of osseointegrated implants is a method to allow improved anchorage and support for the successful fabrication of dental protheses. We report two cases of the use of osseointegrated implants of the Branemark type(3i), in conjunction with bone grafting to the lower jaw.
윤석천,어수봉,김주일,이재엽 한국항공대학교 경영연구소 2000 경영연구 Vol.7 No.2
인터넷 취업알선은 디지털시대로의 변화에 따라 취업의 새로운 패러다임으로 대두되고 있다. 인터넷 취업알선의 대두를 거래비용이론의 접근에 따르면 탐색비용을 비롯한 거래비용은 줄어드는 대산 도덕적 해이와 역선택 비용은 증가하는 것으로 분석된다. 따라서 인터넷 취업알선이 확산되기 위해서는 두가지 방안이 제시될 수 있다. 단기적으로는 도덕적 해이와 역선택을 축소하기 위하여 개인정보 보호 및 보안 등을 비롯한 시장질서를 정립하는 것이며, 장기적으로는 새로운 비용의 증가분을 담보하는 신뢰의 구축을 위하여 채용부터 인사노무관리 및 해고에 이르기까지 전과정을 수행할 수 있는 인적자원 종합 기업을 육성하고 양성하는 것이다. The internet employment service becomes new paradigm of recruiting in the digital ages. Transaction cost approach explains that emergence of internet employment service results from the reduction of selection and recruiting cost. Because transaction cost is reduced utilizing internet tool, internet employment service becomes very popular. But that service increase the cost of moral hazard and adverse selection. The effective strategy of internet employment service enlargement make, shortly, a rule of internet employment market including solving the security and safety problems. The long term strategy i s developing the human resource firms with the integrated HRM functions in order to basically solve the moral hazard and adverse selection problem by the formation of trust.
( Ju Yup Lee ),( Na Young Kim ),( Yoon Jeong Choi ),( Ryoung Hee Nam ),( Yoon Jin Choi ),( Yong Hwan Kwon ),( Kichul Yoon ),( Hye Seung Lee ),( Dong Ho Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Helicobacter felis mouse model has been developed for the research regarding pathogenesis of chronic gastritis and gastric cancer. The aim of this study was to investigate long-term H. felis colonization in the stomachs of C57BL/6 mice and subsequent histologic fi ndings and infi ammatory reactions including pro-infi ammatory cytokines. Methods: Twenty-three female C57BL/6 mice at 4 weeks of age were gavaged with H. felis, and 13 control mice served as vehicle only. The mice were sacrifi ced at 4, 24, and 52 weeks after inoculation. The infection status and degree of infi ammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), tumor necrosis factor alpha (TNFa), and interleukin-1beta (IL-1ß) were measured by ELISA. Results: The overall infection rate was 100%, as determined by the culture and histology. At 4, 24, and 52 weeks, the neutrophil and monocyte scores were signifi cantly higher in infected mice than in control mice. At 24 weeks after inoculation, most of the infected mice showed mucosal atrophy with or without metaplasia, and a few showed focal dysplasia. Adenocarcinoma was observed in one mouse at 52 week post-infection (Table). Gastric mucosal MPO and IL-1ß levels were signifi cantly higher in infected mice than control mice at 24 and 52 weeks, however, the expression of gastric mucosal TNFa was not signifi cantly different between the infected and control mice at any time-point. Conclusions: Long-term H. felis-infection in C57BL/6 mice provoked a severe infi ammatory reaction and it progressed into atrophy, metaplasia, dysplasia and cancer. IL- 1ß might play an important role in the infi ammatory response of mice to Helicobacter species.
( Ju Yup Lee ),( Nayoung Kim ),( Ji Hyun Park ),( Jeong Eun Yu ),( Yun Jeong Song ),( Jung Won Yoon ),( Dong Ho Lee ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1
Background/Aims Overlap functional gastrointestinal disorder (FGID) is associated with more severe gastrointestinal symptoms and lower quality of life. The aim of this study is to evaluate clinical features of non-erosive reflux disease (NERD), functional dyspepsia, irritable bowel syndrome, their overlap in terms of sex and gender, and to assess the risk factors, including genetic polymorphisms. Methods A total of 494 FGIDs and 239 controls were prospectively enrolled between 2004 and 2020. FGIDs were diagnosed based on the Rome III criteria and symptoms were evaluated using a questionnaire. Follow-up questionnaires were conducted to determine the change of symptoms during the 75.8-month mean observation period. Risk factors including genetic polymorphisms in neurotransmitter receptor (SLC6A4 5-HTTLPR, GNB3, ADRA2A, CCKAR, and TRPV1) and cytokine (TNFA and IL10 ) genes. Results NERD was more prevalent in men, and functional dyspepsia in women. Overlap FGIDs (n = 239) were more prevalent than nonoverlap FGIDs (n = 255) in women (P = 0.019). Anxiety and depression scores were higher in the overlaps (P = 0.012 and P < 0.001, respectively). Symptoms were more frequent and severe in the overlap FGIDs than in the non-overlaps (P < 0.001). During followup, symptoms progressed more frequently in the overlap FGIDs, especially in patients with the L/S genotype of SLC6A4 5-HTTLPR and anxiety/depression. Conclusions Overlap FGID patients need attention given their association with anxiety/depression and more severe symptoms, especially in women. Genetic polymorphisms also may be associated with certain symptoms of overlap FGIDs. (J Neurogastroenterol Motil 2022;28:145-158)
( Ju Yup Lee ),( Sung Kook Kim ),( Kwang Bum Cho ),( Kyung Sik Park ),( Joong Goo Kwon ),( Jin Tae Jung ),( Eun Young Kim ),( Byung Ik Jang ),( Si Hyung Lee ),( Daegu-gyeongbuk Gastrointestinal Study 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.2
Background/Aims We aim to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rates according to the Los Angeles classification for esomeprazole alone, and esomeprazole plus mosapride. Methods A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at weeks 4 and 8. The primary endpoint was the endoscopic healing rate of ERD after 8 weeks of treatment. Results Endoscopic healing rates according to the Los Angeles classification was 32 (66.7%) in the E+M group and 26 (60.5%) in the E only group, but there was no statistically significant difference between the groups. Only at 4 weeks, the total GERD symptom score changes relative to the baseline significantly improved in the E+M group than that of the E only group (-13.4 ± 14.7 vs -8.0 ± 12.3, P = 0.041), and upper abdominal pain and belching score changes showed significantly improved in the E+M group than that of the E only group (P = 0.018 and P = 0.013, respectively). Conclusions The combination of a proton pump inhibitor with mosapride shows a tendency for upper abdominal pain, belching, and total GERD symptoms scores to improve more rapidly. This suggests that combination therapy with esomeprazole and mosapride will be useful for rapid improvement of specific GERD symptoms, such as upper abdominal pain and belching in ERD patients. (J Neurogastroenterol Motil 2017;23:218-228)
Ju Yup Lee,김나영,남령희,Yoon Jeong Choi,서지형,이혜승,Jane C Oh,이동호 대한암예방학회 2014 Journal of cancer prevention Vol.19 No.2
Background: Previous studies on Helicobacter pylori infection in mice have contributed to better understanding of the pathogenesis of chronic gastritis and gastric carcinoma. The aim of this study was to evaluate H. pylori colonization and subsequent inflammatory responses in the stomachs of C57BL/6 mice depending on inoculation number and the presence of high-salt diet. Methods: Eighty-four female mice with 4 weeks age were used in this study. The infected mice were gavaged with H. pylori strain Sydney-1 (SS1), and the uninfected mice were dosed with vehicle. In each of these groups, half of the mice were fed ona basal diet (0.25% salt) and the other half were fed on a high-salt diet (7.5% salt). The infected mice were inoculated 4 or 5 times, and infection status and degree of inflammation were checked by culture and histopathology, respectively, after 4 weeks. Gastric mucosal myeloperoxidase and tumor necrosis factor-alpha were measured by ELISA. Results: The overall infection rate was 95.2%; the infection rate after 5 inoculations (100%) was greater than that after 4 inoculations (91.3%). However, no differences in the degree of inflammation were found between 2 groups. The bacterial density was also significantly increased in mice that were on the high-salt diet and had been inoculated 5 times, respectively. Mean neutrophil infiltration in the infected group was 1.7±0.6 (1, minimal; 2, mild; 3, moderate; 4, marked). However, the high-salt diet was not increase the inflammatory grade in the infected group. Gastric mucosal myeloperoxidase and tumor necrosis factor-alpha levels did not increased by the high-salt diet and increased the number of inoculation. Conclusions: In spite of well colonization of H. pylori in the stomachs of C57BL/6 mice, the degree of subsequent inflammation was irrelevant to high-salt diet and frequent (5 times) inoculations.
( Ju Yup Lee ),( Nayoung Kim ),( Ji Hyun Park ),( Ryoung Hee Nam ),( Sun Min Lee ),( Chin-hee Song ),( Geun Kim ),( Hee Young Na ),( Yoon Jin Choi ),( Jin Joo Kim ),( Dong Ho Lee ) 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims Emerging evidence shows that the mechanism of irritable bowel syndrome (IBS) is associated with neurotrophic factors and tight junction proteins (TJPs). It is known that there are sex differences in the pathophysiology of IBS. The aim of the present study is to determine expression levels of neurotrophic factors, TJPs, and cytokines according to IBS subtype and sex. Methods From 59 IBS (33 IBS-constipation, 21 IBS-diarrhea, and 5 IBS-mixed) and 36 control patients, colonic mucosa mRNA expression levels of transient receptor potential vanilloid-1 (TRPV1), nerve growth factor (NGF), glial cell-derived neurotrophic factor (GDNF), and various TJPs were assessed by real-time polymerase chain reaction. Western blot was performed to determine levels of zonular occludens-1 (ZO-1). Serum levels of cytokines were measured by enzyme-linked immunosorbent assay. Results TRPV1, GDNF, and NGF mRNA levels were significantly increased in those with IBS-constipation compared to those in controls (all P < 0.05). However, they showed no significant difference between those with IBS-diarrhea and controls. Expression level of TRPV1 correlated with that of GDNF (r = 0.741, P < 0.001) and NGF (r = 0.935, P < 0.001). ZO-1 RNA expression levels were lower (P = 0.021) in female IBS-diarrhea than those in controls, although they showed no significant differences between male IBS-diarrhea and controls. Serum IL-1β levels in female IBS were significantly higher than those of male IBS, especially in IBS-constipation (P < 0.001). Conclusion Our results suggest that neurotrophic factors and IL-1β are closely related to IBS-constipation and that decrease of ZO-1 is an important factor in female with IBS-diarrhea.
Lee, Jaehee,Lee, So Yeon,Choi, Keum Ju,Lim, Jae Kwang,Yoo, Seung Soo,Lee, Shin Yup,Cha, Seung Ick,Park, Jae Yong,Kim, Chang Ho The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.4
Background: Thoracoscopic pleural biopsy is often required for rapid and confirmative diagnosis in patients with suspected pleural tuberculosis (PL-TB). However, this method is more invasive and costly than its alternatives. Therefore, we evaluated the clinical utility of the chest computed tomography (CT)-based bronchial aspirate (BA) TB-polymerase chain reaction (PCR) test in such patients. Methods: Bronchoscopic evaluation was performed in 54 patients with presumptive PL-TB through diagnostic thoracentesis but without a positive result of sputum acid-fast bacilli (AFB) smear, pleural fluid AFB smear, or pleural fluid TB-PCR test. Diagnostic yields of BA were evaluated according to the characteristics of parenchymal lesions on chest CT. Results: Chest radiograph and CT revealed parenchymal lesions in 25 (46%) and 40 (74%) of 54 patients, respectively. In cases with an absence of parenchymal lesions on chest CT, the bronchoscopic approach had no diagnostic benefit. BA TB-PCR test was positive in 21 out of 22 (95%) patients with early-positive results. Among BA results from 20 (37%) patients with patchy consolidative CT findings, eight (40%) were AFB smear-positive, 18 (90%) were TB-PCR-positive, and 19 (95%) were culture-positive. Conclusion: The BA TB-PCR test seems to be a satisfactory diagnostic modality in patients with suspected PL-TB and patchy consolidative CT findings. For rapid and confirmative diagnosis in these patients, the bronchoscopic approach with TB-PCR may be preferable to the thoracoscopy.