대장게실질환의 수술적 치료에 대한 임상적 고찰

민승기,박재갑,최국진,김진복 대한대장항문학회 1994 Annals of Coloproctolgy Vol.10 No.3

구기자가루 첨가량에 따른 인절미의 품질특성

이효지,차경희,박진희 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.4

The purpose of this study was to investigate the quality characteristics of Kugija-Injeulmi by varying the ingredient ratio of Lycii fructus powder (4, 6 and 8%). According to sensory evaluation of Kugija-Injeulmi, as the ratio of Lycii fructus powder was increased, the bitterness, hardness and chewiness all increased. It was found that Kugija-Injeulmi made of glutinous rice was moistened and softened with the addition of more Lycii fructus powder, but it was rougher than Kugija-Injeulmi made of glutinous rice flour. As a result of textural analysis of Kugija-Injeulmi, the hardness, adhesiveness, gumminess and chewiness increased as the amount of Lycii fructus powder increased, whereas the cohesiveness decreased. Kugija-Injeulmi made of glutinous rice was moister than Kugija-Injeulmi made of glutinous rice flour. The overall-acceptability was negatively correlated with coarseness. The overall-acceptability of Kugija- Injeulmi made of glutinous rice was much higher than that made of glutinous rice flour. From the above results, the most advisable mixture ratio of Kugija-Injeulmi is as follows : Kugija-Injeulmi add 282g (94%) glutinous rice flour, Lycii fructus powder 18g (6%) and salt 3g. The moisture content was 42.22%.

백서에서 Chlorpromzaine,Haloperidol,Clozapine이 뇌파에 미치는 영향

정성훈,박영남,이만기,박진숙 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

To evaluate the differential elects of chlorpromazine, haloperidol, and clozapine on electroencephalographic (EEG) changes, EEG findings were compared in normal, relaxant, and schizophrenic animal models produced with MK-801 by using power spectral EEG analysis. Under pentobarbital anesthesia, the screw electrodes were implanted on the skull over the frontal cortex for EEG recording. The EEG was recorded before and after intraperitoneal administration of clozapine(5mg/kg), chlorpromazine(5mg/kg) and haloperidol(1mg/kg) in rats while awake(the normal group), rats pretreated with a relaxant pancuronium bromide(the relaxant group) and rats pretreated wish MK-801(0.2mg/kg, i.p., the MK-801 group). Spectrum analysis of the EEG was used to calculate the powers of each band (delta 1-4Hz; theta 4-8Hz; alpha 8-l3Hz; beta L 13-21Hz; beta H 21-30Hz; gamma 30-50Hz; and total 1-50Hz). The EEG activity was presented as the log value of the relative band power. In the relaxant group, clozapine increased the activity of the delta, theta and alpha bands. Chlorpromazine increased the activity of the betaL band as well as the delta, theta and alpha bands and it decreased the activity of the gamma band. However, haloperidol did not change the activity of all bands significantly. In the MK-801 group, clozapine increased the activity of the delta and gamma bands and chlorpromazine increased the activity of the delta, betah and gamma bands significantly, Haloperidol increased the activity of the alpha and betaL bands significantly. To evaluate the differential effects of antipsychotics on EEG between the groups, the ratio of power change after a drug as referenced to pre-drug power in each group was calculated and compared between the groups and was represented by star-like display. In the star-like display, clozapine showed the smallest change and caused a slight shift upwards and to the left, chlorpromazine showed irregular changes, haloperidol showed similar increases along each band.

Effect of Decreased Skeletal Muscle Index and Hand Grip Strength on Functional Recovery in Subacute Ambulatory Stroke Patients

Jin Gee Park,Kyeong Woo Lee,Sang Beom Kim,Jong Hwa Lee,Young Hwan Kim 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.5

Objective To investigate the effect of decreased Skeletal Muscle Index (SMI) and hand grip strength on functional recovery in subacute ambulatory stroke patients. Methods Subacute stroke patients who were referred to the rehabilitation center were recruited. Decreased SMI and hand grip strength were diagnosed according to the Asian Working Group on Sarcopenia. Diagnostic criteria were decreased SMI and decreased unaffected hand grip strength. SMI was measured by bioelectrical impedance analysis. Unaffected hand grip strength was measured with a hand dynamometer. Patients were divided into two groups, decreased group (DG) and not-decreased group (NDG), according to the presence of decreased SMI and hand grip strength. Both groups received conventional stroke rehabilitation for 3 weeks. All patients were evaluated at the baseline and at 3 weeks after treatment. Functional status was evaluated with 4-meter walk test (4MWT), 6-minute walk test (6MWT), Timed Up and Go test (TUG), and Modified Barthel Index (MBI). Results Both groups showed improvement in 4MWT, TUG, and MBI. NDG showed improvement in 6MWT. Comparing improvements between the two groups, NDG showed more improvement in 6MWT and TUG than DG. Conclusion The presence of decreased SMI and hand grip strength had negative effects on functional recovery in subacute ambulatory stroke patients.

Enhancement of recombinant human EPO production and glycosylation in serum-free suspension culture of CHO cells through expression and supplementation of 30Kc19.

Park, Ju Hyun,Wang, Zesong,Jeong, Hee-Jin,Park, Hee Ho,Kim, Byung-Gee,Tan, Wen-Song,Choi, Shin Sik,Park, Tai Hyun Springer International 2012 Applied microbiology and biotechnology Vol.96 No.3

<P>We previously reported that the expression of Bombyx mori 30Kc19 gene in CHO cells significantly improved both the production and sialylation of recombinant human EPO (rHuEPO) in adhesion culture mode. In this study, the effects of 30Kc19 expression and supplementation of 30Kc19 recombinant protein on the productivity and glycosylation pattern of rHuEPO were investigated in the serum-free suspension culture mode. Especially, glycosylation pattern was examined in detail using a quantitative MALDI-TOF MS method. The expression of 30Kc19 increased the EPO production by 2.5-folds and the host cells produced rHuEPO with more complex glycan structures and a larger content of sialic acid and fucose. The glycan structures of rHuEPO in the 30Kc19-expressing cell consisted of bi-, tri-, tetra-, and penta-antennary branching (35, 18, 33, and 14 %, respectively), while the control cells produced predominantly bi-antennary branching (70 %). About 53 % of the glycans from rHuEPO in the 30Kc19-expressing cell was terminally sialylated, while no obvious sialylated glycan was found in the control cells. The percentage of fucosylated glycans from the 30Kc19-expressing cell culture was 77 %, whereas only 61 % of the glycans from the control cell were fucosylated glycans. We also examined whether these effects were observed when the recombinant 30Kc19 protein produced from Escherichia coli was supplemented into the culture medium for CHO cells. In the control cell line without the 30Kc19 gene, EPO production increased by 41.6 % after the addition of 0.2 mg/mL of the recombinant 30Kc19 protein to the culture medium. By the Western blot analysis after two-dimensional electrophoresis (2-DE) of isoforms of EPO, we confirmed that 30Kc19 enhanced the sialylation of EPO glycans. These results demonstrated that both 30Kc19 gene expression and the recombinant 30Kc19 protein addition enhanced rHuEPO productivity and glycosylation in suspension culture. In conclusion, the utilization of 30Kc19 in CHO cell culture holds great promise for use in the manufacturing of improved biopharmaceutical glycoproteins.</P>

Update on Stroke Rehabilitation for Non-Motor Impairment

Park Jin Gee 대한뇌신경재활학회 2022 뇌신경재활 Vol.15 No.2

Various interventions exist to treat non-motor impairments caused by stroke. Adjuvant treatments such as non-invasive brain stimulation, virtual reality, computer-assisted training, neurostimulation, and biofeedback are being investigated and applied in the areas of cognitive dysfunction, language problems, visual disorders, dysphagia, mood disorders, and post-stroke pain. Most of these treatments have shown efficacy and symptom improvement, but further investigation is required to fully clarify their effects.

Application of a Contiunous Wavelet Transform to the Impact Location Estimation in Plate Type Structures

Jin-Ho Park,Jeong-Han Lee,Gee-Yong Park 한국소음진동공학회 2004 한국소음진동공학회 학술대회논문집 Vol.2004 No.11

The Xeno-glycomics database (XDB): a relational database of qualitative and quantitative pig glycome repertoire

Park, Hae-Min,Park, Ju-Hyeong,Kim, Yoon-Woo,Kim, Kyoung-Jin,Jeong, Hee-Jin,Jang, Kyoung-Soon,Kim, Byung-Gee,Kim, Yun-Gon Oxford University Press 2013 Bioinformatics Vol.29 No.22

<P><B>Summary:</B> In recent years, the improvement of mass spectrometry-based glycomics techniques (i.e. highly sensitive, quantitative and high-throughput analytical tools) has enabled us to obtain a large dataset of glycans. Here we present a database named Xeno-glycomics database (XDB) that contains cell- or tissue-specific pig glycomes analyzed with mass spectrometry-based techniques, including a comprehensive pig glycan information on chemical structures, mass values, types and relative quantities. It was designed as a user-friendly web-based interface that allows users to query the database according to pig tissue/cell types or glycan masses. This database will contribute in providing qualitative and quantitative information on glycomes characterized from various pig cells/organs in xenotransplantation and might eventually provide new targets in the α1,3-galactosyltransferase gene-knock out pigs era.</P><P><B>Availability:</B> The database can be accessed on the web at http://bioinformatics.snu.ac.kr/xdb.</P><P><B>Contact:</B> byungkim@snu.ac.kr or ygkim@ssu.ac.kr</P><P><B>Supplementary information:</B> Supplementary data are available at <I>Bioinformatics</I> online.</P>

CuII-M(M=Zn, Al 및 Fe) 산화-환원반응에서 활성 금속 및 음이온의 효과

박진희(Park, Jin-Hee),류경주(Rhu, Gyeung-Ju),김유빈(Kim, You-bin),박지현(Park, Ji-Hyeun),지유진(Gee, You-Jin),김봉곤(Kim, Bong-Gon) 한국과학영재교육학회 2018 과학영재교육 Vol.10 No.1

연구의 목적은 중학교 과학영재학생들의 R & E 프로그램으로, Cu (II) -M (M=Zn, Al, Fe)의 산화-환원반응에서 생성물의 형상과 반응속도에 미치는 구리(II) 이온의 농도, 활성 금속 (M) 및 음이온(spectator ion)의 영향에 대한 연구를 수행하는데 있다. 본 연구를 수행한 결과, 다음과 같은 결론을 얻었다. 첫째, CuSO4-Zn 산화-환원반응에서 0.5 M 황산구리 수용액 보다 진한 농도와 표면적이 큰 아연 분말을 사용하였을 때, 환원 생성물은 빠르게 붉은색 구리로 환원됨을 확인 하였다. 불균일 반응계인 Cu(II)-M의 산화-환원반응은 반응물의 농도가 증가하면 구리의 핵형성 속도가 증가하므로 초기 형성된 검은색 구리가 빠르게 붉은색으로 변화되는 것을 알 수 있었다. 산화-환원반응의 진행에 따른 생성물의 형상 변화는 0.2 M CuSO4 수용액에서 가장 쉽게 확인할 수 있었다. 둘째, 환원 생성물인 구리의 형상은 사용하는 활성 금속의 종류에 따라 다른 것을 확인하였다. 반응성이 큰 아연(Zn)과 알루미늄(Al)은 반응초기에 검은색 구리가 석출되지만, 철(Fe)을 사용하면, 철 표면에 환원된 구리가 도금되는 현상을 쉽게 관찰할 수 있었다. 이처럼 철을 사용하면 새로운 지적 호기심은 감소되지만 형상에 따른 색변화에 따른 학생들의 오개념 형성을 방지할 수 있을 것으로 생각된다. 셋째, 활성 금속(M)의 종류에 따른 Cu(II) -M 산화-환원 반응의 반응속도는 Zn > Al > Fe 순으로 얻어졌다. 이는 환원된 구리의 핵형성 속도가 수소기체의 생성과 관련이 있고, 환원된 구리의 흡착속도 차이를 의미한다. 넷째, 음이온에 의한 Cu(II)-Zn 치환 반응의 반응 속도는 Cl- > SO42- > NO3- 순서로 얻어졌다. 질산 구리(NO3-)와 금속 아연을 반응시켰을 경우, 초기 생성물은 다른 음이온과 같이 검은색 생성물이 얻어졌으나, 2시간 후 다공성의 녹청색 생성물을 확인할 수 있었다. 이 프로그램의 특징은 페트리 접시를 이용한 산화-환원 반응의 실험으로 거시적 현상을 저 비용과 친환경적으로 학생들이 화학 변화를 직접 관찰할 수 있기 때문에, 과학 영재 학생의 지적 호기심과 탐구력을 자극하고 과제 집중력을 높일 수 있었다. 또한, 이 프로그램의 부분적 수정으로 고등학교 과학 영재교육에 적용될 것으로 기대된다. The aims of in this study is to investigate the effects of the reactants concentration, kinds of active metal (M) and the anion (spectator ion) on the morphology and the rate constants of Cu(II)-M’substitution reaction as the R&E programs of science (chemistry) gifted students. As a result of this study, the following conclusions were obtained. First, in the CuSO4-Zn substitution reaction, it was confirmed that most of the product was red copper when using an aqueous solution of copper sulfate that is thicker than 0.5 M or using a zinc powder having a large surface area. As the concentration of the reactants increases, the nucleation rate of copper is increased and red copper is obtained. However, the concentration at which the change of metal surface was observed was 0.2 M CuSO4 aqueous solution. Second, it was confirmed that the morphology of copper as a reduction product varies depending on the kinds of the active metal. Although zinc (Zn) that generates hydrogen gas has black copper precipitate, iron (Fe) has a morphology and color similar to that of metallic copper. Third, the reaction rate of Cu(II)-M substitution reaction according to the kind of active metal(M) was shown in order of Zn, Al, and Fe. This indicates that the rate of nucleation of the reduced copper is related to the generation of hydrogen gas and the adsorption capacity of copper reduced to the surface of the active metal. Fourth, the reaction rate of Cu(II)-Zn substitution reaction by anions was decreased by Cl-, SO42-, and NO3- order. However, in the case of NO3-, the product was found to be a mixture of various types. The experimental methods of the redox reaction using Petri dishes are economical, environmentally friendly, and can directly observe the chemical changes as macroscopic phenomena. Also, applying this program to middle school students, we were able to stimulate intellectual curiosity and inquiry ability of science gifted students, and to increase task concentration ability. We expect that some modifications of this program will be applicable to high school science gifted education.

CANDU 핵연료 채널에 대한 동특성 및 결함증상 해석

박진호(Jin-Ho Park),이정한(Jeong-Han Lee),김봉수(Bong-Soo Kim),박기용(Gee-Yong Park) 한국소음진동공학회 2003 한국소음진동공학회 학술대회논문집 Vol.2003 No.11