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백지원(Ji-Won Baek),구보경(Bo-Kyung Koo),김규종(Kyu-Jong Kim),이연경(Yeon-Kyung Lee),이성국(Sung-Kook Lee),이혜성(Hye-Sung Lee) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.4
본 연구는 우리나라 장수노인들의 식품섭취상태를 분석 평가하고 건강한 장수를 위한 식생활 지침의 설정을 위한 기초자료를 얻고자 수행되었다. 연구 대상은 경상북도 성주군에 거주하는 85세 이상 고령노인 중에서 일상 생활에 문제가 없는 224명이었으며 이들을 대상으로 반복 24시간 회상법을 이용하여 1년간 4회의 계절별 식품 섭취 조사를 실시하였으며 결과를 요약하면 다음과 같다. 계절별 식품군별 섭취량에 있어서 남자노인은 감자류의 섭취량이 여름철에 유의적으로 높고, 버섯류의 섭취량이 가을철에 유의하게 높은 것을 제외하고는 모든 식품군의 섭취량에 있어 계절별 차이가 나타나지 않았다. 여자노인의 경우 곡류, 당류, 두류, 채소류, 과일류, 조미료류, 음료 및 주류, 육류, 우유류, 어패류의 섭취량이 겨울철에 유의하게 높았으며, 종실류, 해조류, 난류의 섭취량은 계절에 따른 차이가 없었다. 조사 대상자들의 연평균 1일 총 식품 섭취량은 594.4±186.1 g이었으며 이 중에서 513.5±161.2 g(86.4%)는 식물성 식품군으로부터 섭취하였고 79.3±56.7 g(13.3%)는 동물성 식품군으로부터 섭취하였다. 섭취량이 가장 높았던 식품군은 곡류였으며그 다음이 채소류, 과일류, 어패류, 음료 및 주류, 조미료류, 두류, 육류, 우유류, 감자류 등의 순이었다. 장수 노인대상자들의 음식별 섭취빈도는 밥류에 있어서는 쌀밥의 섭취비율이 80.1~89.2%로 가장 높았으며 국과 찌개류에서는 쇠고기국, 된장국, 된장찌개의 섭취 비율이 높았다. 어육류 식품의 경우 조기구이의 섭취비율(9.4~12.7%)이 높았으며, 해조류 식품의 경우 김구이의 섭취비율(7.4~20.5%)이 높았고, 각 계절마다 계절식품의 섭취비율이 높았다. 김치류의 경우 배추김치의 섭취비율이 4계절 모두 70% 이상으로 높게 나타났다. 일품요리류는 손쉽게 조리할 수 있는 라면과 국수의 섭취비율이 높았다.<br/> 본 연구의 결과에서 경북 성주지역 장수 노인들의 계절별 식품 섭취량에 있어 겨울철의 식품 섭취량이 다른계절에 비해 유의하게 높았으며, 남자노인보다는 여자노인이 식품섭취에 계절에 의한 영향을 더욱더 많이 받는 것으로 나타났다. 또한 장수 노인들은 가공식품보다는 계절마다 제철에 생산되는 자연 식품의 섭취비율이 높았다. 전반적으로 장수노인들은 소식의 경향을 보였으며 이와 같은 소식습관과 신선한 식물성 식품들의 일상 섭취가 건강한 장수에 영향을 미쳤을 가능성도 있을 것으로 사료된다. The purpose of this study was to estimate food intakes of the long-lived elderly and to obtain the data for establishing dietary guidelines that may be recommended for the general population for the sake of longevity. The subjects of the study were 224 elderly people of age over 85 years living in Kyungpook Sung-Ju area who have no problem in daily living. The food consumption survey was carried out seasonally by the repeated 24-hr recall method for one year. The subject group for this study was composed of 58 males and 166 females, the average age being 87 years old. Food intakes of the winter were more than any other seasons. The mean daily total food intake per capita was 594.4 g, 513.5 g (86.4%) from plant foods and 79.3 g (13.3%) from animal foods. The sequence of high intakes of food groups were cereals, vegetables, fruits, fishes, legumes and meats. Boiled white rice, beef soup, soybean paste soup, soybean paste stew, broiled yellow croaker, kimchi, ra myon and broiled noodles were consumed most frequently. In conclusion, the subjects consumed much more plants foods than animal foods and consumed more natural and seasonal foods than processed foods and also showed food habits of eating small meals. Dietary habits of eating small meals containing abundant amount of fresh plant foods might partially contribute to the longevity of the subjects.
Analysis of serum IgE level and omalizumab response
( Ji Su Lee ),( Young Ah Cho ),( Sung Min Kim ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Chronic spontaneous urticaria (CSU) can be treated with several drugs such as antihistamines, cyclosporine, and doxepin. In recent years, the monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab, has been considered to be an effective treatment option in refractory CSU cases. Since omalizumab is an IgE antibody, it can be hypothesized that the treatment effect of omalizumab may be related to the patient's serum IgE levels. Objectives: We aimed to investigate the association between demographic, clinical, biological characteristics, focusing on serum IgE levels and omalizumab efficacy in CSU patients. Methods: We retrospectively analyzed 68 patients with CSU treated with omalizumab from June 2018 to June 2020. The relationship between the result of blood test and the response to omalizumab was analyzed. Results: The good response for omalizumab treatment was significantly associated with female sex (p=0.040), and young age (p=0.034). However, there was no correlation between the serological characteristics (IgE, hemoglobin, white blood cell, platelet levels and eosinophil, basophil percentage) and treatment response. Conclusion: The correlation of omalizumab response and serologic traits including serum IgE levels were not identified. Additional research is needed to clarify objective factors related to drug response.
( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: There are various treatment options of psoriasis, including phototherapy, systemic oral agents and, recently, biologics. These therapies include immune regulation, so it is necessary to confirm the risk of malignancy and infections. Objectives: To evaluate the risk of malignancies and hospitalized infectious disease (HID) in patients with psoriasis by treatments, comparing with general population (GP). Methods: The study population consisted of 159,423 patients for malignancies and 272,475 patients for HID during 2005 to 2018 from the National Health Insurance Service (NHIS). Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of mild (ML), phototherapy (PH), oral systemics (OR) and biologics (BI) cohort were evaluated. Results: For HID, the results (aHRs; CIs) were ML (1.12; 1.11-1.14), PH (1.05; 1.00-1.09), OR (1.19; 1.15-1.24) and BI (0.85; 0.62-1.17). For tuberculosis (Tb), a particular infectious disease, the results (aHRs; CIs) were ML (1.11; 1.06-1.16), PH (1.11; 0.96-1.28), OR (1.21; 1.08-1.36) and BI (8.83; 6.62-12.5). For malignancies, the results (aHRs; CIs) were ML (1.12; 1.10-1.15), PH (1.20; 1.12-1.29), OR (1.15; 1.08-1.21) and BI (1.47; 0.93-2.43). Conclusion: Patients with psoriasis showed a significantly higher risk of malignancies and HID than GP. Biologics were not seemed to be a significant risk factor for these diseases, but appeared to increase the risk of Tb. Therefore, in choosing a treatment for psoriasis, these risks should be considered.
Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats
Ji-Eun Kim,Young-Ju Lee,Moon-Hwa Kwak,Go Jun,Eun-Kyoung Koh,Sung-Hwa Song,Ji-Eun Seong,Ji Won Kim,Kyu-Bong Kim,Suhkmann Kim,Dae-Youn Hwang 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.1
Loperamide has long been known as an opioid-receptor agonist useful as a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease as well as to induce constipation. To determine and characterize putative biomarkers that can predict constipation induced by loperamide treatment, alteration of endogenous metabolites was measured in the serum of Sprague Dawley (SD) rats treated with loperamide for 3 days using ¹H nuclear magnetic resonance (¹H NMR) spectral data. The amounts and weights of stool and urine excretion were significantly lower in the loperamide-treated group than the Notreated group, while the thickness of the villus, crypt layer, and muscle layer was decreased in the transverse colon of the same group. The concentrations of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatinine (Cr) were also slightly changed in the loperamide-treated group, although most of the serum components were maintained at a constant level. Furthermore, pattern recognition of endogenous metabolites showed completely separate clustering of the serum analysis parameters between the Notreated group and loperamide-treated group. Among 35 endogenous metabolites, four amino acids (alanine, glutamate, glutamine and glycine) and six endogenous metabolites (acetate, glucose, glycerol, lactate, succinate and taurine) were dramatically decreased in loperamide-treated SD rats. These results provide the first data pertaining to metabolic changes in SD rats with loperamide-induced constipation. Additionally, these findings correlate the changes in 10 metabolites with constipation.
( Sang-ha Kim ),( Sae Byol Kim ),( Beomsu Shin ),( Ji-ho Lee ),( Seok Jeong Lee ),( Myoung Kyu Lee ),( Won-yeon Lee ),( Suk Joong Yong ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Chronic obstructive pulmonary disease (COPD) requires regular follow-up visits and maintained inhaler medication use. This study was to determine the effect of medication adherence on acute exacerbation in patients with COPD, using healthcare claim data. Methods: Patients with COPD who were at age >40 and had started using the long acting inhaler were observed as the study subjects for about 6 months from January to June 2016. Patients who had ever hospitalized or visited to emergency room (ER) for COPD before they were prescribed long acting inhaler were excluded from the study. General characteristics of and medication adherence in subjects were defined as independent variables; medication adherence was indirectly measured by medication possession ratio (MPR) and evaluated as divided into >80% adherence group and <80% adherence group. Analysis was conducted by using hospitalization or admission to ER as the endpoints to determine acute exacerbation of COPD. Results: Subjects were total 3,959 patients consisting of 60.4% of adherence group and 39.6% of non-adherence group. The result of analysis on the effect of inhaler adherence on COPD exacerbation (hospitalization or ER visit) was statistically significant as 1.68 (95% confidence interval 1.33-2.14) in non-adherence group compared to adherence group and confirmed that good adherence positively influenced decrease in acute exacerbation. Conclusions: Risk of acute exacerbation of COPD requiring hospitalization or visit to ER was low in long acting inhaler adherence group, determining that medication adherence has positive effect on decease in acute exacerbation.