감염성 질염에 대한 질내 산도측정, Amine 검사 및 현미경 검사의 진단적 가치

이태형,김기득,최재동,고민환,정원영 영남대학교 의과대학 1988 Yeungnam University Journal of Medicine Vol.5 No.2

1987년 5월 1일부터 9월 31일까지 5개월간 영남대학교의 의과대학 부속병원 산부인과 외래에 내원한 환자 549예를 대상으로 질내 pH 검사, 아민검사, 생리식염수 및 10% KOH습식도말현미경검사를 시행하였다. 질염과 관련된 임상증상 및 소견과 이를 기초로 한 이학적 진단과 비교분석한 결과 다음과 같은 성적을 얻었다. 1. 각 감염성 질염에서의 질산도 측정 및 아민검사와 생리식염수 습식도말검사성적은 세균성 질염 환자군에선 질 pH 5.0이상이 81.0%, 아민검사 양성이 62.8%, 유산균 감소 소견이 77.4%, 백혈구 감소가 70.1%이었으며, 트리코모나스 질염 환자군은 질 pH 5.0이상이 93.3%, 아민검사 음성이 90.0%, 유산균 감소 소견이 77.4%, 백혈구 감소가 70.1%이었으며, 트리코모나스 질염 환자군은 질 pH 5.0이상이 93.3%, 아민검사 음성이 90.0%, 유산균 감소가 90.0%, 백혈구 증가가 93.3%이었다. 진균성 질염 환자군은 질 pH 3.0 또는 4.0이 83.2%, 아민검사 음성이 100%, 정산유산균 소견이 89.7% 및 정상백혈구 소견이 72.4%이었다. 2. 생리식염수 및 10% KOH습식도말검사에 대한 이학적 진단이 정확도는 정상군이 77.6%, 세균성 질염균 26.3%, 진균성 질염군 47.5% 및 트리코모나스 질염군이 70.0%이었다. 질 Ph 측정 및 아민검사에 의한 진단의 정확도는 정상 및 진균성 질염군이 83.2%, 세균성 질염군이 60.6%, 트리코모나스 질염군이 83.3%이었다. 3. 세균성 질염군에서 질 pH 3.0 또는 4.0 및 아민검사 음성을 나타낸 23예의 질상피 세포에 대한 clue cell의 비율은 10.0%이하가 12예, 20.0% 및 30.0%가 5예, 50.0%가 4예, 그리고 50.0% 이상이 2예이었다. 이상의 성적으로 외래에서 손쉽게 시행할 수 있는 질내 산도측정과 아민검사는 각 감염성 질염의 감염여부에 대한 screening과 감별진단에 유용한 것으로 사료되며, 생리식염수 및 10% KOH습식도말검사에 이들 검사를 추가할 경우 진단의 신빙도를 높일 수 있을 뿐만 아니라 배양검사가 요구되는 환자의 선택에 있어서도 가치가 있을 것으로 추정되었다. Vaginitis is one of the most common disease in gynecologic field in recent days. About 90% of these patients suffer from the infection of the vagina caused by Gardnerella vaginalies. Candida, or Trichomonas, either alone or in combination. For the effective diagnosis and management, it is essential to get an accurate identification of the causative agent. Applying simple and easy diagnostic methods such as pH of vaginal discharge, amine test and microscopic examination of wet mount preparation of normal saline and 10% KOH to 549 cases of randomly selected patients visiting. Out-patient Department of Obstetrics and Gynecology of Yeung-nam University Hospital through May 1st to Sept 31st. 1987, the following results were obtained. 1. In the Gardnerella vaginities vaginal pH was more than 5.0 in 81.0% of total cases, positive amine test in 62.8%, decreased lactobacilli in 77.4% & decreased WBC counts in 70.1%. In the Trichomonas vaginitis vaginal pH more than 5.0 was noted in 93.3% of the cases. negative amine test in 90%, decreased lactobacilli in 90% & increased WBC counts in 93.3%, whereas Candida vaginitis and normal groups showed vaginal pH of 3.0~4.0 in 83.2%, negative amine test in 100%, normal distribution of lactobacilli in 89.7%, normal WBC counts in 72.4%. 2. The accuracy rates of physical diagnosis by wet mount preparation of normal saline and 10% KOH revealed 26.3%, 47.5%, 70.0% in Gardnerella vaginitis, Candida vaginitis, and Trichomonas vaginitis, respectively. The vagnal pH and amine test showed 83.2% of accuracy rate in Candida vagnities group. 60.6% in Gardnerella vagnitis group and 83.3% in Trichomonas vagnitis group. 3. In 23 cases of Gardnerella vagnitis showing vaginal pH of 3.0 or 4.0 and positive amine test, the clue cells were observed in 10% or less in 12 case 30% in 5 cases, 50% in 4 cases and 50% or more in 2 cases. In summary vaginal pH an amine test could be useful in screening and differentiating the different types of infectious vaginitis. Furthermore by adding microscopic examination of normal saline and 10% KOH wet mount preparation to them, they not only could obtain higher diagnostic accuracy rate but would be more valuable in selecting the patients requiring cultures to confirm the diagnoses.

효율적인 컴포넌트 개발을 위한 확장 객체지향 분석 및 설계

왕기철,박경우,고형대 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-

Component Based Development(CBD) is an emerging paradigm of software development. Its goal is composing an application with plug & play software components on the frameworks. This CBD requires existing software analysis and design approaches to be reconsidered. In this paper. we present the extended method from Object-Oriented Analysis and Design. To provide a clear separation of component specification form its design and implementation. we add interface design step and component implementation design step to the process of Object-Oriented Methodology. To provide a method of tracking each step in the development process, we add "use case-behavior-control object-interface mapping table", "component-interface-implementation class mapping table", and "interface-implementation class-integrated implementation class mapping table" to the Object-Oriented Models. Object-Oriented Models could be easily re-engineered to Component System Models by the proposed method. Component System Models also could be easily back tracked by the proposed method.

中寒冷環境에서 艾灸刺戟 期間 및 形態가 CD4 T세포에 미치는 영향

吳寄男,朴東錫,高炯均 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1999 東西醫學硏究所 論文集 Vol.1999 No.-

Purpose; This Study was aimed to Investigate the different effects according to the form and term of moxibustion therapy on the depression of the immune response induced by cold stress in rats. Methods, The control group and the Sample groups were also exposed to cold stress and they were redivided into 1, 2, 3, 4 day-group by total term of time exposed to cold stress. The sample group were classified into sample I (direct moxibustion therapy), sample I (Bongrae-moxibustion therapy) according to the form of moxibustion, To all of sample groups, each moxibustion therapy were peformed 2 times a day on the loci corresponding Bi-su(BL20) of Human body and Blank loci. Experimental studies frere performed for the observation of the No. of RBC, WBC and Lymphocyte in blood CD4+ T helper cell count, spleen CD4? T helper cell count, axillary lymph node CD4? T helper cell count, and Thymus CD4+T helper cell count in rats exposed to cold stress. Results ; 1. The CD4? T ce11 count in blood was increased statistically significant in all of the sample I (1, 2, 3, 4-day group) as compared with the control group. And in the sample II only 2-day group gained the statistical significance as compared with the control group. 2. The CD4? T cell count in axillyary lymph node was increased statistically significant in all of the sample I (1, 2, 3, 4-day group) compared with the control group. But all of the sample II were increased without the statistical significance compared with the control group. 3. The CD4? cell count in Spleen was increased with the statistical nonsignificance in all of the sample I (1, 2, 3, 4-day group) as compared with the control group. And in the sampleII only 1-day group gained the statistical significance as compared with the control group. all of the sample I (1, 2, 3, 4-day group) as compared with the control group. And in the sample II only 1-day group gained the statistical significance as compared with the control group. 4. The CD4? T cell count in Thymus was increased with the statistical non significance in the Conclusions ; On the depression of the immune response induced by cold stress in rats, direct moxibustion therapy is more effective than Bongrae-moxibustion therapy for the recovery of immune response.

무선을 통한 데이터 방송 시스템에서의 배터리를 절약하는 인덱싱 기법

왕기철(Gi-cheol Wang),오병균(Hyung-dae Koh),고형대(Byeong-kyun Oh) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.1B

이동 컴퓨팅 환경에서의 가장 큰 문제점중의 하나는 배터리 문제이다. 이동 컴퓨팅 환경에서의 데이터 접근은 반드시 배터리를 소모하게 된다. 더구나 배터리의 수명은 향후 10년간 20% 정도 밖에 증가되지 않을 전망이다. 따라서 데이터를 방송형태로 전달하든지 아니면 주문형태로 전달 하든지 배터리를 최대한으로 절약하는 효율적인 데이타 처리방법이 필수적으로 필요하다. 사실 방송형태의 데이터 처리는 이동 컴퓨팅의 특성으로 볼 때 가장 자연스러운 것으로 볼 수 있으며 방송 데이터의 인덱싱에 관한 많은 연구결과들이 나와 있다. 본 논문은 이 연구결과들을 바탕으로 개선된 인덱싱 기법과 인덱스 구조 그리고 인덱스 추적 알고리즘을 제공한다.

Poster Session : PS 0759 ; Rheumatology ; Epidemiology of Polymyalgia Rheumatica

( In Young Kim ),( Gi Hyeon Seo ),( Seul Kee Lee ),( Hye Min Jeong ),( Hyung Jin Kim ),( Jea Joon Lee ),( Eun Mi Koh ),( Hoon Suk Cha ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Polymyalgia rheumatica (PMR) is a chronic infi ammatory disease affecting people older than 50 years of age. The diagnosis is made based on clinical features, and the current standard of treatment is low-dose glucocorticoids. PMR is more commonly reported in Caucasians and females. However, epidemiological studies in Asia are scarce, and no such studies have been conducted in Korea. We estimated incidence and prevalence of PMR in Korea. Methods: This study was conducted by reviewing National Health Insurance and Health Insurance Review and Assessment databases. We verifi ed all claims data for population aged over 50 years between 2007 and 2012. PMR cases were defi ned by diagnostic and prescription codes. Cases were included when the PMR ICD-10 code (M 35. 3) was recorded more than twice, and glucocorticoids were prescribed for more than 30 days. Results: We identifi ed 1,463 newly diagnosed cases of PMR during the 5 years. Among them, 992 (67. 8%) were female, and mean age at diagnosis was 66. 9 years old. Thesex and age adjusted annual incidence rate was estimated to be 2. 06 per 100,000 individuals aged over 50 years. The prevalence rate was 8. 21 per 100,000 individuals in 2012. Incidence and prevalence appeared to increase with age, peaking at about 70 years old. Prednisolone was the most commonly prescribed glucocorticoid. In half of the patients, the starting dose was 5-15 mg daily. Of the 1,453 PMR cases, only 1. 2% had a diagnostic code for giant cell arteritis simultaneously. Conclusions: This is the fi rst study to investigate the epidemiology of PMR in Korea. The incidence and prevalence of PMR appeared to be considerably lower than those in Western populations. Both genetic and environmental factors might infi uence disease occurrence. The actual incidence may have been underestimated due to a lack of awareness of PMR in clinical practice.

아기 상태에 따른 스마트 요람 시스템 개발

고원희(Won-Hee Koh),김동준(Dong-Joon Kim),박주형(Joo-Hyung Park),송민기(Min-Gi Song),윤준수(Jun-Su Youn),강태구(Tae-Koo Kang) 대한전기학회 2019 대한전기학회 워크샵 Vol.2019 No.7

봉독약침요법(蜂毒藥鍼療法)이 항염(抗炎), 진통작용(鎭痛作用)에 미치는효능(效能)에 관(關)한 실험적연구(實驗的硏究)

권기록,고형균,Kwon Gi-Lok,Koh Hyung-Kyun 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2

Purpose: In order to study the anti-inflammatory and analgesic effects of Bee Venom Therapy, writhing syndrome, carrageenin induced edema, and complete adjuvant induced arthritis were experimented. Methods: 1. We used rats of writhing syndrom induced by acetic acid injection. Group I was treated with Acupuncture therapy. Group II was treated with Bee Venom thearpy. we compared with Group I, II and the control group. 2. We used rats of paw edema induced by carrageenin injection. Group I Was treated with Acupuncture therapy, Group II was treated with Bee Venom thearpy we compared with Group I, II and the control group. 3. We used rats of arthritis induced by Freud's complete adjuvant injection. Group I was treated with Acupuncture therapy, Group II was treated with Bee Venom thearpy we compared with GroupI,II and the control group. Results: 1. Analgesic effects on writhing syndrome induced by acetic acid injection showed statistical significance in Bee Venom treated group as compared with the control group. 2. The paw edema induced by carrageenin injection was decreased with statistical significance in Bee Venom treated group as compared with the control group. 3. The arthritis induced by Freud's complete adjuvant injection wasn't significant. Conclusion: Bee Venom Therapy was effective on inflammatory disease.

봉약침요법의 면역반응에 관한 임상적 연구

권기록,고형균,Kwon, Gi-Rok,Koh, Hyung-Kyun 대한침구의학회 2000 대한침구의학회지 Vol.17 No.1

The immune response of Bee Venom Therapy is commonly appear in clinics. It is whole body delayed allergy type and generally like fatigue. Therefore, in order to analysis the clinical form, we have observed immune response of 100 patients who visited Sangji University Oriental Medical Hospital and treated Bee Venom Therapy over 10 times from November 1998 to October 1999. The results were summarized as follows. 1. The distribution of Sex was 60 females, 40 males, and the average of patients age was $50.6{\pm}1.5years$. 2. The distribution of disease was degenerative arthritis, HIVD of L-spine, RA, etc. 3. The total treated time is 2765 and is observed 361 immume responses. 4. The average of keeping time in immume response is $11.8{\pm}0.6(hr)$, and the cases of over 24hrs is occupied 24.0%. 5. In the correlation between treated times and immume response is generally in inverse proportion. 6. The general aspect of immume response is chilling, heating, powerless, headache, dizziness, etc. 7. $M{\ddot{u}}ller$ Grade II-III was observed only 1%.

초기 류마티스 관절염에서 적혈구 침강속도, 혈청 C-반응성 단백과 방사선학적 진행의 상관관계

고재현 ( Jay Hyun Koh ),김재형 ( Jae Hyung Kim ),이창근 ( Chang Keun Lee ),전찬홍 ( Chan Hong Jeon ),서기현 ( Gi Hyeon Seo ),안홍준 ( Hong Joon Ahn ),차훈석 ( Hoon Suk Cha ),김진석 ( Jin Seok Kim ),안중모 ( Joong Mo Ahn ),고은미 ( 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.4

Objective: To investigate the clinical usefulness of serial measurement of erythrocyte sediment rate(ESR) and C-reactive protein(CRP) for monitoring the radiological progression in early rheumatoid arthritis(RA). Methods: Thirty one patients with RA according to the 1987 ACR criteria, with joint symptoms for less than one year, and who had not previously received disease modifying antirheumatic drugs(DMARDs) were assessed from Oct. 1994 to Aug. 1998 in retrospective study. Area under curve(AUC) of ESR and CRP were calculated in these patients. Joint damage in the hands was assessed by modified Sharp`s method. Results: Male to female ratio was 1: 3.4. Median age of this group was 45.8±13.2 years. Patients who had positive rheumatoid factor were 82%. Mean duration until first visit was 271.9±145.8 days. At the first clinic visit, mean ESR and CRP were 50mm/hr and 2.0mg/dL. Mean erosions and joint space narrowing score by modified Sharp`s method were 55.2 and 12.4, respectively. Correlation analysis showed that ESR AUC and CRP AUC were significantly associated with radiologic progression. Conclusions: Elevated over-time ESR and CRP provide a convenient short term correlation with radiologic outcome(i. e. erosions). Elevated over-time ESR and CRP can be used as a guide for therapy.

제주도 염지하수열 에너지 활용 파일럿 연구(I)

박승혁(Seunghyuk Park),김형권(Hyung-Kweon Kim),김윤식(Yun-Shik Kim),고기원(Gi-Won Koh),문수형(Soo-Hyung Moon),김태형 (Tae-Hyung Kim),문덕철(Deok-Cheol Moon) 대한지질학회 2017 대한지질학회 학술대회 Vol.2017 No.10