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- 저자 : Eun-Kyoung Koh (검색결과 307 건)
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박민경,서원석,박재옥,김창휘,고은석,임철완 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Tuberculous peritonitis is discovered from sixty to ninty percent of pulmonary tuberculosis patients. Clinical symptoms are nonspecific such as mild fever, weakness and malaise but show tenderness in right lower abdomen and abdominal distension. Diagnosis is confirmed by laparoscopic and pathologic findings. We report a case of tuberculous peritonitis in an 11-year-old boy who was hospitalized because of abdominal distension with pain on right lower abdomen which had developed one day before he came to hospital. Chest X-ray showed pleural effusion on both sides. We did laparoscopic examination and observed diffuse nodular infiltration. In biopsy specimen we observed osseous granuloma and acid-fast bacilli in AFB stain.
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육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고
김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-
Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.
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( Eun Sil Koh ),( Kyung Do Han ),( Mee Kyoung Kim ),( Eun Sook Kim ),( Min-kyung Lee ),( Ga Eun Nam ),( Hyuk-sang Kwon ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.4
Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients with type 2 diabetes. We examined whether weight changes early after new-onset diabetes have an impact on the clinical outcomes of diabetic nephropathy and retinopathy. Methods: Using the Korean National Health Insurance Service-National Health Screening Cohort database, 181,872 patients newly diagnosed with type 2 dia betes who were free of end-stage renal disease (ESRD) and proliferative diabetic retinopathy (PDR) during 2007 to 2012 were followed to the end of 2016. Weight change was defined as the difference in body weight from the time of diabetes di agnosis to 2 years later. Results: We identified 180 cases of ESRD and 780 cases of PDR followed up for a median of 5.5 years from the index year at 2 years after diagnosis. Those with 5% to 10% weight gain showed a significantly higher hazard ratio (HR) for ESRD, compared with those with ≤ 5% weight change after adjusting for several con founding factors, including the baseline estimated glomerular filtration rate (HR, 1.75; 95% confidence interval [CI], 1.14 to 2.70). Those with ≥ 10% weight loss showed the lowest HR for PDR (HR, 0.52; 95% CI, 0.33 to 0.83), whereas those with ≥ 10% weight gain showed the highest HR for PDR (HR, 3.20; 95% CI, 2.51 to 4.08). Conclusions: Weight gain after new-onset diabetes was associated with increased risk of ESRD and PDR whereas weight loss with decreased risk of PDR, but not ESRD.
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Eun Kyoung Koh(고은경),Young Ju Lee(이영주),Ji Eun Kim(김지은),Moon Hwa Kwak(곽문화),Jun Go(고준),Hong Joo Son(손홍주),Hee Seob Lee(이희섭),Young Jin Jung(정영진),Dae Youn Hwang(황대연) 한국생명과학회 2014 생명과학회지 Vol.24 No.6
미더덕껍질(Styela clava tunic, SCT)은 항염증 복합체, 창상필름, 골재생 유도 등을 포함한 다양한 의학적인 치료영역에 이용 되고 있다. 본 연구에서는 미더덕껍질 열수추출물(aqueous extract of Styela clava tunic, AE-SCT)의 H₂O₂에 의해 유발된 세포사멸의 보호 효과를 알아보기 위하여 세포 활성도의 변화에 관련된 요인을 측정하였다. 그 결과, AE-SCT는 3.3 mg/g의 플라보노이드와 32.3 mg/g의 페놀화합물을 포함하고 있었으며, HepG2 세포주에 독성을 유발하지 않았다. 또한, H₂O₂ 처리 후 AE-SCT를 처리하는 실험에서 AE-SCT는 H2O2에 의해 유발된 세포사멸을 개선하는 효과를 나타내지 않았다. 그러나, H₂O₂ 처리전에 AE-SCT를 사전 처리하는 예방효과 실험에서, 세포생존율은 H₂O₂만 처리한 그룹에 비하여 AE-SCT를 처리한 그룹에서 유의적으로 증가하였으며, 특히 AE-SCT를 50 μg/ml 처리한 농도에서 가장 높았다. 또한, FACS분석과 DAPI 염색에서도 사멸 세포의 수는 H₂O₂만 처리한 그룹에 비하여 AE-SCT를 처리한 그룹에서 유의적으로 감소하였다. 더불어, H₂O₂의 처리에 의해 유도된 Bax/Bcl-2 발현비율은 AE-SCT처리에 의해 농도의존적으로 감소되었다. 이러한 연구 결과는 AE-SCT가 H₂O₂에 의해 유발된 세포사멸을 예방하는 우수한 효과를 가지고 있음을 제시하고 있어 향후 다양한 항산화 제품 개발을 위한 기초자료로 사용될 수 있을 것으로 사료된다. Styela Clava tunic (SCT) has found some applications in many areas of medical treatment including as an anti-inflammatory compound, a wound healing film, in guided bone regeneration, and as a food additive. The protective effect of SCT aqueous extract (AE-SCT) on cell death induced by H₂O₂ treatment was investigated by measuring the changes in cell viability in HepG2 cells after AE-SCT treatment. High concentrations of antioxidant compounds including flavonoids (3.3 mg/g) and phenolics (32.3 mg/g) were detected in AE-SCT but no significant cytotoxicity was observed in HepG2 cells treated with AE-SCT. The viability of HepG2 cells was also not changed by treatment with different concentrations of AE-SCT after H₂O₂ treatment. However, cell viability was significantly increased in cells treated with three different concentrations of AE-SCT before H₂O₂ treatment. The greatest increase in cell viability was observed in the group treated with 50 μg/ml AE-SCT, when compared with vehicle-treated group. FACS and DAPI staining analysis indicated that the decrease in number of dead cells was dependent on the concentration of AE-SCT. Alterations in the Bax/Bcl-2 ratio after H₂O₂ treatment were significantly restored by treatment with different concentrations of AE-SCT. These results indicate that AE-SCT, which contains high levels of antioxidants, may protect cells against death induced by H₂O₂ treatment.
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Eun Kyoung Kim,Min Ku Chon,Hyun-Sook Kim,Yong Hyun Park,Sang Hyun Lee,Ki Seok Choo,Hyung Gon Je,Dae-Hee Kim,Tae Oh Kim,Yoon Seok Koh,Jae Hyeong Park,Jae-Hwan Lee,Young Jin Choi,Eun Seok Shin,Hyuck Jun 대한심장학회 2025 Korean Circulation Journal Vol.55 No.1
Background and Objectives: Among various emerging catheter-based treatments for severe tricuspid regurgitation (TR), the spacer device can reduce the regurgitation orifice without manipulating the valve leaflet. However, its clinical application has been hampered by traumatic anchoring to the myocardium and the coaxial alignment of the balloon resulting in insufficient TR reduction. This study aimed to evaluate the early-stage safety, technical feasibility, and preliminary efficacy of the novel atraumatic vertical spacer in patients with isolated severe TR. Methods: All procedures were guided by fluoroscopy and transthoracic echocardiography. The maximum device placement time with an inflated balloon was 24 hours. Changes in the amount of TR, right ventricular function, and patient hemodynamics were measured during balloon deployment. Results: A total of 7 patients (median age 74), underwent successful device implantation without procedure-related complications. During balloon inflation (median 25 minutes), there were no symptoms or signs indicative of TR intolerance. TR was reduced by 1 grade or greater in all patients, with 2 patients exhibiting a reduction of 3 grades, from torrential TR to a moderate degree. Mild TR after balloon inflation was achieved in 3 patients with baseline severe TR. The TR reduction observed during initial balloon deployment was sustained during the subsequent balloon maintenance period. Conclusions: The Pivot-balloon procedure was safe, technically feasible, and effective in reducing TR in patients with severe TR. No periprocedural complications or adverse cardiovascular events were reported during device placement with TR reduction observed in all patients. However, longer-term follow-up is needed to confirm safety and treatment effect.
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Lipopolysaccharide로 활성화된 RAW264.7세포에서 염증반응사이토카인 발현에 대한 Epigallocatechin gallate의 억제효능연구
서은지(Eun Ji Seo),고준(Jun Go),김지은(Ji Eun Kim),고은경(Eun Kyoung Koh),송성화(Sung Hwa Song),성지은(Ji Eun Sung),박찬규(Chan Kyu Park),이현아(Hyun Ah Lee),김동섭(Dong Seob Kim),손홍주(Hong Joo Son),이충열(Cung Yeoul Lee),이희섭(Hee 한국생명과학회 2015 생명과학회지 Vol.25 No.9
Epigallocatechin gallate (EGCG)는 녹차(Camellia sinensis, green tea)에 포함되어 있는 대표적인 카테킨(Catechin)으로, 당뇨(diabetes), 신경퇴행성 질환(neurodegenerative disorders), 암(cancer), 심혈관계 질환(cardiovascular disease), 비만(obesity) 등의 다양한 임상질환에 우수한 치료효과를 나타내는 것으로 알려왔다. 본 연구에서는 EGCG가 LPS (Lipopolysaccaride)로 자극된 RAW264.7 세포의 염증억제과정에서 Nitric oxide (NO)관련인자와 사이토카인 발현에 미치는 영향을 분석하기 위해, NO농도, inducible NO synthase (iNOS) 발현량, TNF-α, IL-1β, IL-6, IL-10 사이토카인의 발현량을 분석하였다. 먼저, EGCG (100-400 μM)를 처리한 Raw264.7 세포에서 특이적인 독성이 나타나지 않음을 확인하였으며, 이후 Raw264.7 세포에 4가지 다른 농도(0.1, 0.5, 1.0, 5.0 ㎍/ml)의 LPS를 처리한 후 MTT분석, NO농도분석, IL-6농도분석을 실시하여, 염증을 유발할 수 있는 최적 LPS 농도를 1 ㎍/ml로 설정하였다. NO농도를 분석한 결과, LPS를 처리한 그룹이 No그룹에 비하여 급속히 증가하여 63 μ㏖/l까지 증가하였으나 400 μM EGCG를 처리한 그룹에서만 68.2% 정도 감소하였으며, 동시에 iNOS 발현 양상은 200, 400 μM EGCG/LPS 처리 그룹에서 각각 12.3%, 17.4% 감소하였다. 또한, 감소비율에는 차이가 있었으나, anti-inflammatory 사이토카인(IL-1β, TNF-α)과 pro-inflammatory 사이토카인(IL-10)의 발현은 EGCG/LPS 처리에 따라 유의적으로 감소하였다. 그러나, IL-6단백질과 mRNA 농도는 Vehicle/LPS 처리 그룹과 EGCG/LPS 처리 그룹에서 유의적인 차이를 나타내지 않았다. 따라서, 본 연구의 결과는 EGCG가 LPS의 자극에 의해 활성화된 Raw264.7 세포를 효과적으로 억제하는 효능을 나타냄을 제시하고 있으며, 이러한 과정에 사이토카인들이 서로 다르게 특이적 반응을 중계함을 제시하고 있다. Epigallocatechin gallate (EGCG), the main catechin in green tea, has been shown to have some beneficial effects against various human diseases, including diabetes, neurodegenerative disorders, cancer, cardiovascular disease and obesity. To investigate the mechanism of the suppressive effects of EGCG on inflammatory response in macrophages, alterations on the levels of nitric oxide (NO) regulatory factors and inflammatory cytokines were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells. No significant toxicity was detected in RAW264.7 cells treated with 100?400 μM EGCG. Moreover, the optimal concentration of LPS was determined to be 1 ㎍/ml based on the results of cell viability assay, NO assay and IL-6 enzyme-linked immunsorbent assay (ELISA). Furthermore, NO levels decreased significantly by 68.2% in the 400 μM EGCG/LPS treated group, while the level of inducible nitric oxide synthase (iNOS) expression decreased by 12-17% in the 200 and 400 μM EGCG/LPS treated group. A significant decrease in transcription of pro-inflammatory cytokines (TNF-α and IL-1β) and anti-inflammatory cytokine (IL-10) was also detected in the EGCG/LPS treated group. However, IL-6 transcript and protein was maintained at a constant level when in the LPS treated group relative to the EGCG/LPS treated group. Overall, these results suggest that the differential regulation of inflammatory cytokines is an important factor influencing the suppressive effects of EGCG against LPS-activated inflammatory response in RAW264.7 cells.
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