A Research of Hwang ji-young’s work - “Without people and people” performance

Ji-Young Hwang,Sung-ok Choi 한국콘텐츠학회 2019 한국콘텐츠학회 ICCC 논문집 Vol.2019 No.12

A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea

Yong Sung Choi,정성훈,김은선,Eun Sun Kim,Eunhee Lee,Euiseok Jung,So-Yeon Lee,이우령,Hye Sun Yoon,Yong Joo Kim,Ji Kyoung Park,Son Moon Shin,Ellen Ai-Rhan Kim 대한신생아학회 2022 Neonatal medicine Vol.29 No.1

Purpose: Pediatricians have a significant responsibility to educate mothers about the importance of breastfeeding. However, there have been minimal efforts in the courses of resident training in Korea. The purpose of this study is to evaluate the change in knowledge and attitude before and after a 4-week breastfeeding educational intervention among multicenter residents. Methods: Prospective interventional educational research was designed for residents at eight training hospitals in Korea. Institutional reviews were obtained in each hospital. The education curriculum consisted of 14 courses regarding breastfeeding theory and practice. These materials were used to teach pediatric residents for 4 weeks. Knowledge-based tests were administered before the course, and re-tests were administered after the course using different test items of similar levels. Test scores and survey responses were compared before and after the intervention. Results: A total of 73 residents (1st year 20, 2nd year 23, 3rd year 16, and 4th year residents 14) from eight training hospitals completed the intervention. Their average age was 30.3±2.9 years, 17 (23.3%) were male, 22 (30.1%) were married, and eight had more than one child of their own. The mean pre-test score was 61.8±13.4 and the mean post-test score was 78.3±7.5 (P<0.001). The inter-grade difference in the score was significant in the pre-test (P=0.005), but not significant in the post-test (P=0.155). There were more responses of obtaining confidence after the intervention (P<0.001). Conclusion: In our study, pediatric residents showed improvement in their knowledge and confidence level after 4 weeks of the breastfeeding curriculum. This will provide a basis for future policymaking in the training of pediatric residents regarding breastfeedReceived: 6 January 2022 Revised: 15 February 2022 Accepted: 15 February 2022 Correspondence to: Ellen Ai-Rhan Kim, MD Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3390 Fax: +82-2-3010-6978 E-mail: arkim@amc.seoul.kr A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea Yong-Sung Choi, MD,PhD1, Sung-Hoon Chung, MD, PhD2, Eun Sun Kim, MD, PhD3, Eun Hee Lee, MD4, Euiseok Jung, MD5, So Yeon Lee, MD, PhD5, Wooryoung Lee, MD6, Hye Sun Yoon, MD, PhD7, Yong Joo Kim, MD, PhD8, Ji Kyoung Park, MD, PhD9, Son Moon Shin, MD, PhD9, and Ellen Ai-Rhan Kim, MD, PhD5 1Department of Pediatrics, Kyung Hee University Hospital, Seoul, Korea 2Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea 3Department of Pediatrics, Kangwon National University Hospital, Chuncheon, Korea 4Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea 5Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 6Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea 7Department of Pediatrics, Nowon Eulji Medical Center, Eulji University, Seoul, Korea 8Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Korea 9Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 pISSN 2287-9412 . eISSN 2287-9803 Copyright(c) 2022 By Korean Society of Neonatology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Original Article 29 Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 ing in Korea.

고속도로 IC 및 JCT 주변 유휴부지의 물류시설 활용가능성 분석 : 수도권 및 지방광역시를 중심으로

양현지(Yang, Hyun-Ji),최재성(Choi, Jae-Sung) 한국물류학회 2021 물류학회지 Vol.31 No.2

최근 코로나 19 등의 감염병으로 인한 비대면 활동 증가로 인터넷, 모바일 등을 통한 이커머스 택배 이용건수가 증가하며 택배업체 등의 물류시설 부지 확보 수요가 점점 증가하는 추세이다. 업체별로 필요한 부지를 연도별 임계치 수준에서 수급하며 적게는1천 평에서 많게는 1만 평 이상의 부지가 추가적으로 필요하므로 부족한 부지를 현재와 같이 부동산업체 등을 통해 사적영역에서확보하는 것은 지속가능성의 한계에 직면할 것으로 보인다. 본 연구에서는 수도권(서울, 인천, 경기도) 및 지방광역시(대전, 대구, 광주, 울산, 부산)를 중심으로 공공 부문의 도시계획시설 측면에서 가장 넓은 유휴부지의 확보가 가능한 고속도로 IC/JCT 교통광장 유휴부지의 부지현황⋅활용가능성을 분석하였다. 분석방법 및 내용으로 다음 카카오맵의 로드뷰, 스카이뷰 등을 활용해 연구대상지의 유휴부지를 전수조사 후 사업지 내 이면도로 등의 존재 유무에 따라 단기 및 중⋅장기적 사업 우선순위화 분류, 국가물류통합정보센터 내 물류단지 건립계획을 이용해 택배업체의 허브 및 서브터미널 건설 시 예상 사업비 분석, 한국은행의 산업연관표를 적용해 경제적 파급효과 등의 결과를 도출하였다. 도출된 유휴부지를 택배업체 등에서 활용하기 위해서는 IC/JCT 교통광장대부분의 지역이 현재 ｢국토계획법 시행령 제71조｣에 의해 생산⋅자연녹지 용도지역인 상황을 고려하면 ｢건축법 시행령 별표1｣ 의 ‘18.창고시설 중 물류터미널’을 추가하는 방안, ｢도로법｣내 교통광장의 설치 및 관리에 관한 규정을 신설하거나 박성중 의원등 10인이 제안하여 위원회 심사 중인 ｢도로공간의 입체개발에 관한 법률안｣의 본회의 통과를 통한 입법화를 완료해 법적 근거마련이 필요한 상황으로 보인다. 향후 법제도 개선을 통해 고속도로 IC/JCT의 유휴부지(총 183만평-수도권 140만평, 지방광역시43만평) 중 수도권은 약 12%, 지방광역시는 약 10% 정도만이라도 활용 가능하다면‘19년 한국통합물류협회의 18개 택배사업자가제시한 물류시설 구축을 위한 유휴부지 마련 수요를 충족시켜 부지확보의 어려움이 일정 부분 해소될 수 있을 것으로 추정한다. As contact-free activities have increased due to infectious diseases such as COVID-19, the number of delivery-related services has also increased through the rise of e-commerce. As such, the demand for securing sites for logistics facilities is rising as well. Each delivery company keeps supply and demand in balance at the annual threshold level, which means that they require additional land ranging from 3,300m2 (1,000 pyeong) to as much as 33,000m2 (10,000 pyeong). However, it is unreasonable to continuously secure land to meet demands from private areas through real estate companies, as is the current standard procedure done by delivery companies. This study analyzes the feasibility of securing unused land in its current state, focusing on unused sites in expressways IC/JCT, where the widest unused land, in terms of urban planning facilities can be found, mainly in the capital region (Seoul, Incheon, Gyeonggi-do) and provincial metropolitan cities (Daejeon, Daegu, Gwangju, Ulsan, Busan). Full-scale inspection of unused land near expressways is first conducted using Kakao Map’s Road View and Sky View, and the results, such as short-term or mid to long term business priorities, are derived depending on whether backside roads exist or not. Estimated business expenses are calculated using information of logistics center from the National Logistics Integrated Information Center, and economic effects of building hubs and sub-terminals for delivery companies in the unused land are also drawn, applying the Leontief input-output table from the Bank of Korea. Most unused land such as those surrounding roundabouts near expressways IC/JCT is considered as productive green areas and natural green areas in accordance with Article 71 of ｢Enforcement Decree of the National Land Planning and Utilization Act｣, so clause 18, which states “logistics terminal amongst storage facility field”, of schedule 1 in ｢Enforcement Decree of Building Act｣ should be added to the Article to loosen restriction on construction in areas surrounding roundabouts. Also, regulations on the installation and management of roundabouts in the ｢Road Act｣ should be established to allow delivery company to utilize the unused land derived through this analysis. Preparation of a legal basis is deemed necessary by passing legislation through the plenary session for ｢The Bill on the Development of Three-dimensional Road Space｣ under examination made by 10 lawmakers, including Park Sung-joong. If approximately 12% of the total unused land in expressways IC/JCT in the capital region and approximately 10% in provincial metropolitan cities are made available by improving the legal system in the future, demand of 18 delivery companies from Korea Logistics Association will be met. Through this, it is estimated that the difficulty of securing sites for logistics facility construction would be partially resolved.

Three-dimensional functional unit analysis of hemifacial microsomia mandible-a preliminary report

Choi, Ji Wook,Kim, Byung Hoon,Kim, Hyung Soo,Yu, Tae Hoon,Kim, Bong Chul,Lee, Sang-Hwy Korean Association of Maxillofacial Plastic and Re 2015 Maxillofacial Plastic Reconstructive Surgery Vol.37 No.-

Background: The aim of this study was to present three-dimensional (3D) structural characteristics of the mandible in the hemifacial microsomia. The mandible has six distinct functional units, and its architecture is the sum of balanced growth of each functional unit and surrounding matrix. Methods: In order to characterize the mandibular 3D architecture of hemifacial microsomia, we analyzed the mandibular functional units of four hemifacial microsomia patients using the 3D reconstructed computed tomography (CT) images. And we compared the functional unit size between affected and non-affected side. Results: The length of condyle and angle showed significant differences between affected and non-affected sides. However, the length of mandibular body showed insignificant differences. The size differences between affected and non-affected side were observed at the condyle, angle, and body in descending order. Conclusions: This preliminary study suggests that the main etiopathogenic units are condyle and angle in the hemifacial microsomia mandible. Further investigation with the increased number of subjects will be helpful to establish treatment modality by etiopathogenic targeting of hemifacial microsomia.

Role of cytochrome P450 enzymes in fimasartan metabolism <i>in vitro</i>

Choi, Young Jae,Lee, Ji-Yoon,Ryu, Chang Seon,Chi, Yong Ha,Paik, Soo Heui,Kim, Sang Kyum Elsevier 2018 Food and chemical toxicology Vol.115 No.-

<P><B>Abstract</B></P> <P>Fimasartan (FMS), an angiotensin II receptor antagonist, is metabolized to FMS S-oxide, FMS N-glucuronide, oxidative desulfurized FMS (BR-A-557), and hydroxy-n-butyl FMSs. The purpose of this study was to characterize enzymes involved in NADPH-dependent FMS metabolism using recombinant enzymes such as cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO), as well as selective chemical inhibitors. The results showed that CYP, but not FMO, plays a major role in FMS metabolism. CYP2C9, CYP3A4, and CYP3A5 were involved in the formation of FMS S-oxide, which was further metabolized to BR-A-557 by CYP3A4/5. CYP2C9 played an exclusive role in n-butyl hydroxylation. The specificity constant (kcat/Km) values for S-oxidation by CYP2C9, CYP3A4, and CYP3A5 were 0.21, 0.34, and 0.19 μM-1∙min-1, respectively. The kcat/Km values of hydroxylation at the 1-, 2-/3-, and 4-n-butyl group in CYP2C9 were 0.0076, 0.041, and 0.035 μM-1∙min-1, respectively. The kcat and Km values provide information for the prediction of FMS metabolism in vivo. In addition, simultaneous determination of the FMS metabolites may be used to evaluate CYP2C9 and CYP3A4/5 activity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CYP but not FMO played the major role in the NADPH-dependent fimasartan (FMS) metabolism. </LI> <LI> CYP2C9, CYP3A4 and CYP3A5 were involved in the formation of FMS <I>S</I>-oxide, a major FMS metabolite. </LI> <LI> The value of the k<SUB>cat</SUB>/K<SUB>m</SUB> of <I>S</I>-oxidation by CYP2C9, CYP3A4 or CYP3A5 was 0.21, 0.34 or 0.19 μM<SUP>−1</SUP>·min<SUP>−1</SUP>, respectively. </LI> <LI> FMS <I>S</I>-oxide was further metabolized to oxidative desulfurated metabolite, BR-A-557 by CYP3A4/5. </LI> <LI> CYP2C9 played an exclusive role in the <I>n</I>-butyl hydroxylations of FMS. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Angle-tolerant linear variable color filter based on a tapered etalon

Ji, Peng,Park, Chul-Soon,Gao, Song,Lee, Sang-Shin,Choi, Duk-Yong The Optical Society 2017 Optics express Vol.25 No.3

Nutrient compositions of <i>Bombyx mori</i> mature silkworm larval powders suggest their possible health improvement effects in humans

Ji, Sang-Deok,Kim, Nam-Suk,Kweon, HaeYong,Choi, Bo Hye,Yoon, Sun Mi,Kim, Kee-Young,Koh, Young Ho 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.7 No.1

<P>The nutrient components of 3 differently prepared white jade silkworm (also known as Baek Ok Jam) larval powders (WJSLPs) were examined. A proximate analysis of 3 WJSLPs revealed that steamed and freeze-dried mature silkworm larval powder (SMSP) had the highest protein contents among the 3 WJSLPs. In addition, the ASP, SER, GLY, ALA, TYR, and THR contents in SMSP and freeze-dried mature silkworm larval powder (FMSP) significantly increased compared to those in freeze-dried 3rd day of 5th instar silkworm larval powder (FDSP). Even though SMSP and FMSP had reduced mineral contents compared to those of FDSP, the essential minerals, such as Ca, Mg, K, Na, P, S, Zn, Fe, Mn, and Cu, were highly enriched in SMSP and FMSP. The second most enriched nutrient in the 3 WJSLPs was crude lipids. The 3 WJSLPs showed high contents of Omega-3 (n-3) fatty acids, which are one of the most popular health improvement supplements. We recently showed that SMSP could extend the lifespan and prevent the onset and progression of Parkinson's disease in Drosophila models (Nguyen et al., 2016). Thus, further studies in the functionalities of the 3 WJSLPs will reveal their unknown health improvement effects. (C) 2016 Published by Elsevier B.V. on behalf of Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society.</P>

Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites

Choi, Yeon Jung,Zhou, Yuanyuan,Lee, Ji-Yoon,Ryu, Chang Seon,Kim, Young Ho,Lee, Kiho,Kim, Sang Kyum Elsevier 2018 Food and chemical toxicology Vol.112 No.-

<P><B>Abstract</B></P> <P>This study was designed to characterize lauric acid metabolism to facilitate the establishment of cytochrome P450 4A11 (CYP4A11) inhibition assay. Three metabolites (2-, 11-, and 12-hydroxylauric acids) were identified in pooled human liver microsomes based on comparisons with authentic standards. Reaction phenotyping using 14 recombinant CYPs showed that ω-hydroxylation was mediated dominantly by CYP4A11 and marginally by CYP4F3B. CYP2B6 played an exclusive role in the formation of 2-hydroxylauric acid. The production of 11-hydroxylauric acid was mediated by CYP2E1, CYP2C9, CYP2B6, CYP1A2, CYP3A4, and CYP4A11. The IC<SUB>50</SUB> values of HET0016, a well-known pan-CYP4 inhibitor, against the formation of 12-, 11-, and 2-hydroxylauric acid were 1.0, 1.0, and 0.009 μM, respectively. Among the 50 natural compounds examined, plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) inhibited the formation of 12-, 11-, and 2-hydroxylauric acid with IC<SUB>50</SUB> values of 1.7, 2.3, and 2.7 μM, respectively. In the selectivity study, HET0016 inhibited CYP2B6 with an IC<SUB>50</SUB> of 9.2 nM, as well as CYP1A2, CYP2C19, and CYP2E1 with IC<SUB>50</SUB> values of 1–2 μM. Plumbagin inhibited all CYP enzymes tested with IC<SUB>50</SUB> values of 1.7–3.0 μM. These methods can be used as tools to develop CYP4A11 inhibitors; simultaneous determination of the hydroxylauric acid metabolites provides further information on selectivity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ω-Hydroxylation of lauric acid was mediated dominantly by CYP4A11 and marginally by CYP4F3B. </LI> <LI> CYP2B6 played an exclusive role in the formation of 2-hydroxylauric acid. </LI> <LI> Production of 11-hydroxylauric acid was mediated by CYP2E1, CYP2C9, CYP2B6, CYP1A2, CYP3A4, and CYP4A11. </LI> <LI> Simultaneous determination of the hydroxylauric acid metabolites provides information on selectivity. </LI> <LI> Formation of 12-, 11-, and 2-hydroxylauric acid was inhibited by plumbagin with IC<SUB>50</SUB> values of 1.7, 2.3, and 2.7 μM. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Significant Domains of Life Satisfaction That Affect Suicidal Behavior in Adolescents

Ji Soo Kim,Seo-Hyun Choi,Sang-Eun Lee,Chai Won Lee,Won-Hyoung Kim,Jae Nam Bae,Jeong Seop Lee,Seri Maeng,Jisung Son,Hyeyoung Kim 대한소아청소년정신의학회 2021 소아청소년정신의학 Vol.32 No.3

Objectives: Adolescent suicide is a serious national issue in Korea. Recently, life satisfaction has been recognized as a major factor related to this issue. The main purpose of this study was to identify the domains of life satisfaction that affect suicidal behavior in adolescence. Methods: Data were collected from eight middle schools in Incheon, Korea. A total of 1297 students answered questions regarding their demographic characteristics, happiness, self-related life satisfaction domains (appearance, leisure time, physical health, and mental health), depressive symptoms, and suicidal behavior. Results: In the Spearman correlation analysis, female sex, perceived socioeconomic status (SES), happiness, and all four self-related satisfaction scores showed significant correlations with depression and suicidality. Multivariate regression analysis suggested that suicidality was significantly affected by perceived SES, satisfaction with appearance, mental health satisfaction, and depression. Finally, depression was identified as a partial mediator of the association between mental health satisfaction and suicidality, and a complete mediator of the association between female sex and suicidality. Conclusion: Perceived SES, satisfaction with appearance, and mental health satisfaction significantly affected students’ suicidality, with or without the effect of depression. Health authorities, educators, and family members must be aware of this to identify adolescents at suicide risk earlier.

Effect of NaCl/Monosodium Glutamate (MSG) Mixture on the Sensorial Properties and Quality Characteristics of Model Meat Products

Ji Yeon Chun,Byong Soo Kim,Jung Gyu Lee,Hyung Yong Cho,Sang Gi Min,Mi Jung Choi 한국축산식품학회 2014 한국축산식품학회지 Vol.34 No.5

Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on. Therefore, this study was carried out to investigate the effect of monosodium glutamate (MSG) as a salty flavor enhancer on the quality and sensorial properties of the NaCl/MSG complex and actual food system. For characterizing the spray-dried NaCl/MSG complex, surface dimension, morphology, rheology, and saltiness intensity were estimated by increasing MSG (0-2.0%) levels at a fixed NaCl concentration (2.0%). MSG levels had no effect of the characteristics of the NaCl/MSG complex, although the addition of MSG increased the surface dimension of the NaCl/MSG complex significantly (p<0.05). Furthermore, the effect of MSG on enhancing the salty flavor was not observed in the solution of the NaCl/ MSG complex. In the case of an actual food system, model meat products (pork patties) were prepared by replacing NaCl with MSG. MSG enhanced the salty flavor, thereby increasing overall acceptability of pork patties. Replacement of NaCl with MSG (<1.0%) did not result in negative sensorial properties of pork patties, although quality deterioration such as high cooking loss was found. Nevertheless, MSG had a potential application in meat product formulation as a salty flavor enhancer or a partial NaCl replacer when meat products were supplemented with binding agents.