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( Young Sok Ji ),( Min Sung Lee ),( Chang Wook Min ),( Seong Kyu Park ),( Se Hyung Kim ),( Jina Yun ),( Hyun Jung Kim ),( Kyoung Ha Kim ),( Chan Kyu Kim ),( Kyu Taek Lee ),( Jong Ho Won ),( Dae Sik Ho 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.4
Background/Aims: There is controversy about the prophylactic effect of anti-thymocyte globulin (ATG) on graft versus host disease (GVHD) in the setting of matched related-donor hematopoietic stem cell transplantation (HSCT). This study assessed the inf luences of ATG on the incidences of acute and chronic GVHD and other clinical outcomes in matched related-donor HSCT. Methods: Sixty-one patients received allogeneic HSCT from human leukocyte antigen-matched, related donors. Patients received busulfan/fludarabine conditioning regimens and standard GVHD prophylaxis with or without additional ATG. Results: There was no significant difference in the cumulative incidences of overall acute GVHD, grade II to IV acute GVHD at day 100, and chronic GVHD during the follow-up period between the ATG and non-ATG groups. Three-year overall survival rates were very similar, but three year disease-free survival of the non-ATG group was higher than that of the ATG group (56.2% for ATG vs. 63.1% for non-ATG, p = 0.597). Relapse rate at 3 years in the ATG group was slightly higher than that of the non-ATG group (37.5% vs. 20%, p = 0.29). Non-relapse mortality rate at 3 years was lower in the ATG group (6.25% vs. 15.6%, p = 0.668). Conclusions: Although the addition of ATG doesn’t guarantee a reduction in the incidences of acute and chronic GVHD, pre-transplantation ATG may result in lower non-relapse mortality in the context of matched related-donor HSCT with a busulfan/fludarabine conditioning regimen. However, caution is needed when using ATG because of a possibility to increase relapse rate.
A change of the risk of infectious complication before and after the renovation of laminar flow room
( Young Sok Ji ),( Se Hyung Kim ),( Jina Yun ),( Hyun Jung Kim ),( Kyoung Ha Kim ),( Chan Kyu Kim ),( Seong Kyu Park ),( Jong-ho Won ),( Dae Sik Hong ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: In general, Allogeneic HSCT recipients are likely to benefit from protective isolation measures (that is, a protective environment), including HEPA filtration and/or laminar air flow, to reduce exposure to environmental fungi and reduce transplant-related mortality. HSCT centers should follow published guidelines for hospital isolation practices, including Centers for Disease Control (CDC) guidelines for preventing health-care-associated infections. However, theefficacy of specific isolation precautions in preventing health-care-associated infections among HCT recipients has not been evaluated. Hospital construction and renovation may result in an increased risk of health-care-associated invasive mold infection, particularly aspergillosis. Methods: We evaluated the incidence of infectious complications of HSCT recipients before and after the renovation of laminar air flow room. Total 180 patients were enrolled. Results: The incidence of febrile episodes after therenovation was lower than before (21%; 17 events of 81 cases versus 33.3%; 33 events of 99 cases, respectively). However, the duration of antibiotic therapy was similar (11 days versus 10 days, respectively). Cases received empiric anti-fungal therapy after the renovation were more rare than before the renovation (1 case versus 5 cases). There was no case to received preemptive antifungal therapy after the renovation. The most common pathogen was gram positive cocci before the renovation, and gram negative rod after the renovation. Non-relapse mortality within 100 days after HSCT was not different before and after the renovation (8.6%; 7 cases versus 8.1%; 8 cases, respectively). Conclusions: Therefore, the active efforts including close monitoring of air quality, hand hygiene, and sterilized equipments are critical to minimize the risk of pathogen transmission during the renovation. These activities may guarantee the safety for transplant recipients.
원저 : NC/Nga 마우스에서의 아토피피부염 병변에 대한 신나무 잎 추출물의 효과
김지영 ( Ji Young Kim ),정미숙 ( Mi Sok Jeong ),최선은 ( Sun Eun Choi ),김지윤 ( Ji Yoon Kim ),박귀영 ( Kui Young Park ),박관희 ( Kwan Hee Park ),이도익 ( Do Ik Lee ),주성수 ( Seong Soo Joo ),이정수 ( Chung Soo Lee ),방효원 ( Hyo 대한피부과학회 2010 대한피부과학회지 Vol.48 No.11
Background: Atopic Dermatitis (AD) is a chronic relapsing inflammatory skin disease that is usually observed in patients with an individual or familial history of atopic diseases, and AD is precipitated by environmental factors, including mite antigens. AD is known to be generated by an imbalance of both Th1 and Th2 cytokines. However, the exact etiology of AD is unclear. The leaves of Acer ginnala (AGL) have been demonstrated to have an anti-oxidant effect. Objective: We wanted to investigate the effect of AGL on AD-like skin lesions and the other factors related to an immune response. Methods: The AGL was applied to the AD-like skin lesions on the backs of NC/Nga mice. The efficacy of AGL in the NC/Nga mice was evaluated by the changes of severity of the skin lesions (a modified SCORAD). Blood was collected from the retro-orbital area and the abdominal vena cava. The levels of eosinophils, immunoglobulin (Ig) E and Th2-related cytokines in the blood were measured. Results: The topical application of AGL suppressed the development of AD-like skin lesions. The percent of blood eosinophils was decreased after treatment with AGL. The serum IgE and Th2-related cytokine levels were decreased after treatment with AGL compared with those treated with base cream (the vehicle treated AD group). The IL-4, IL-5 and IL-13 levels were lower than those of the vehicle treated AD group. Conclusion: The findings suggest that AGL may exert an inhibitory effect on atopic dermatitis. (Korean J Dermatol 2010;48(11):913∼918)
Na, Ji-Young,Kim, Sok-Ho,Song, Ki-Bbeum,Lim, Kyu-Hee,Shin, Gee-Wook,Kim, Jong-Hoon,Kim, Bum-Seok,Kwon, Young-Bae,Kwon, Jung-Kee The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.3
Chondrocyte apoptosis has been recognized as an important factor in the pathogenesis of osteoarthritis (OA). Hydrogen peroxide ($H_2O_2$), which produces reactive oxygen species, reportedly induces apoptosis in chondrocytes. The ginsenoside $Rb_1$ (G-$Rb_1$) is the principal component in ginseng and has been shown to have a variety of biological activities, such as anti-arthritis, anti-inflammation, and anti-tumor activities. In this study, we evaluated the effects of G-$Rb_1$ on the mitochondrial permeability transition (MPT) and caspase-3 activity of chondrocyte apoptosis induced by $H_2O_2$. Cultured rat articular chondrocytes were exposed to $H_2O_2$ with or without G-$Rb_1$ and assessed for viability, MPT, Bcl-xL/Bax expression, caspase-3 activity, and apoptosis. The co-treatment with G-$Rb_1$ showed an inhibition of MPT, caspase-3 activity, and cell death. Additionally, the levels of the apoptotic protein Bax were significantly lower and the levels of the anti-apoptotic protein Bcl-xL were higher compared with $H_2O_2$ treatment alone. The results of this study demonstrate that G-$Rb_1$ protects chondrocytes against $H_2O_2$-induced apoptosis, at least in part via the inhibition of MPT and caspase-3 activity. These results demonstrate that G-$Rb_1$ is a potentially useful drug for the treatment of OA patients.
LC-MS/MS Profiling-Based Secondary Metabolite Screening of Myxococcus xanthus
( Ji Young Kim ),( Jung Nam Choi ),( Pil Kim ),( Dai Eun Sok ),( Soo Wan Nam ),( Choong Hwan Lee ) 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.1
Myxobacteria, Gram-negative soil bacteria, are a well-known producer of bioactive secondary metabolites. Therefore, this study presents a methodological approach for the high-throughput screening of secondary metabolites from 4 wild-type Myxococcus xanthus strains. First, electrospray ionization mass spectrometry (ESI-MS) was performed using extracellular crude extracts. As a result, 22 metabolite peaks were detected, and the metabolite profiling was then conducted using the m/z value, retention time, and MS/MS fragmentation pattern analyses. Among the peaks, one unknown compound peak was identified as analogous to the myxalamid A, B, and C series. An analysis of the tandem mass spectrometric fragmentation patterns and HR-MS identified myxalamid K as a new compound derived from M. xanthus. In conclusion, LC-MS/MS-based chemical screening of diverse secondary metabolites would appear to be an effective approach for discovering unknown microbial secondary metabolites.