흰쥐의 감각신경절세포에 대한 Methylmercuric chloride의 독성효과

鄭榮吉,白承和,韓斗錫,柳道坤,朴承澤 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

흰쥐의 배양 척수감각신경절세포에 대한 methylmercuric chloride(MMC)의 세포독성을 조사하기 위하여 여러 농도의 MMC가 포함된 배앙액에서 24시간 동안 배양한 후 MTI assay법에 의하여 세포의 생존율을 조사하였다. MMC는 농도에 비례하여 세포의 생존율을 감소시켰다. 또한 여러 농도의 MMC가 포함된 배앙액에서 흰쥐의 척수 감각신경절(dorsal root ganglion, DRG) 세포를 24시간 동안 처리한 결과 MTI_(50) 값이 25μM MMC에서 나타났다. MMC는 Borenfreund등(1988)의 독성판정기준에 의하여 흰쥐의 배앙 DRG 세포에 고독성인 것으로 나타났다. 이상의 결과는 MMC가 흰쥐의 배양 척수감각신경절세포에 강한 신경독성 효과가 있음을 제시하였으며 또한 배양신경세포는 약제의 효과를 검색하는데 효과적이었다. To examine the cytotoxic effect of methyl mercuric chloride(MMC) on the cultured rat spinal dorsal root ganglion(ORG) neurons, cell viability was measured by MTT assay after rat spinal ORG neurons were incubated with media containing various concentrations of MMC for 24 hours The results were as follows ; 1. MMC decresed cell viability of rat spinal ORG neurons in a dose-dependent manner. 2. MIT_(950) value was a 25uM MMC after spinal ORG neurons were cultured for 24 hours at various concentrations of MMC. 3. MMC was heighly toxic on the cultured ORG neurons by the toxic criteria of Borenfreund et al.(1988). From above the results, it is suggested that methylmercury involves in neurotoxicity by the decrease of cell viability in cultured rat spinal DRG neurons, and cultured neurons are effective in screening the putative agents.

유아에서 발생한 재발성 외음부 콘딜로마 1례의 치료

홍정희,문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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스쿼시 참가자의 참여동기와 만족도 관한 문화기술적 분석

김도호,한성유,허정석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This study attempts to investgate the aspects on the motives and the satsfactions of the participants of squash. This study is to analyze by ethnographic research method. The subjects in this study were 6 selected adult who were attending. The Data were collected through interviews during a period from october 2004 to december, 2004. The findings of this study were as below: First, In participating motives, casual squash participants showed participation continuous on account of health physical strength, activity motive, and accomplishment motive. Second, In participating motives, serious squash participants showed participation continuous on account of immersion motive, ostentation motive, activity motive. Third, In life satisfaction, casual squash participants felt satisfaction in physical part, psychological part. Fourth, In life satisfaction, serious squash participants felt satisfaction in physical part, social part.

Cyclosulfamuron이 벼의 생육과 Acetolactate Synthase 활성에 미치는 영향

지승환,송성도,정병룡 한국환경농학회 2003 한국환경농학회지 Vol.22 No.1

토양혼화실험을 동한 초장의 신장 억제틀 조사한 결과 초장이 50% 억제되었을 때의 cyclosulfamuron의 농도를 품종별로 비교하여 보면 동진벼, 화성벼, 일품벼의 경우 각각 6.3, 9.2, 146.8 mg/kg으로 동진벼가 제초제 cyclosulfamuron에 가장 민감하게 지상부의 생육이 억제되었다. 또한 cyclosulfamuron은 동일한 농도에서 지상부보다는 지하부의 생육을 더 크게 억제하였으며, 0.3 mg/kg 처리 수준에서 동진벼의 경우 건물 중의 억제정도는 지상부가 4.8% 정도이었으나 지하부는 38.9%이었다. 벼의 acetolactate synthase 활성을 cyclosulfamuron의 농도별로 검정한 결과 공시된 품종간에 큰 차이가 없었으며 50% 억제되는 농도는 화성벼, 동진벼 및 일품벼의 경우 각각 42.7, 32.7 및 56.7 μM이었다. Cyclosulfamuron, a herbicide of sulfonylurea type, is a relatively new compound which control broad leaves and perennial weeds in rice field. However, this herbicide has a minor disadvantage of decreasing rice plant growth, especially in early growth stage. Therefore, for introducing this cyclosulfamuron as a herbicide in rice field, it is important to minimize the suppression of early plant growth with maintaining weed control efficacy. This study was conducted to evaluate effects of cyclosulfamuron on early plant growth and acetolactate synthase activity of rice (Oryza sativa cv Dongjinbyeo, Hwasungbyeo, Ilpumbyeo). Rice growth was inhibited by cyclosulfamuron in their early growth stage. The concentrations required for 50% inhibition of Dongjinbyeo, Hwasungbyeo and Ilpwmbyeo growth were 6.3, 9.2 and 146.8 mg/kg, respectively. Inhibition effect of cyclosulfamuron on the root elongation was greater than the effect on the shoot growth. Concentrations required for 50% inhibition of acetolactate synthase activity from Dongjinbyeo, Hwasungbyeo, Ilpumbyeo were 42.7, 32.7 and 56.7 μM, respectively.

임신 제 일삼분기와 제 이삼분기 초음파의 태아기형 진단의 유용성에 대한 고찰

최승도,최규연,이정재,정성윤,이임순,이권해 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Objective: Ultrasonographic screening between 9 and 13 weeks for fetal structural abnormalities using transvaginal sonography in unselected population. Visualization of detailed fetal anatomy in the first trimester has improved as a result of technological progress in ultrasound machines and the introduction of transvaginal sonography(TVS). Our study aims to evaluate the accuracy of TVS as a screening tool for detecting fetal malformations in a nonselected population of pregnant women. For this purpose we compared the results obtained by using second trimesster TA scanning with those obtained using TVS at 9-14 weeks' gestation. Methods: From March 2001 to February 2003, 620 unselected consecutive pregnant women were recruited at their initial visit at Soonchunhyang university hospital, department of obstetrics and gynecology and offered a TVS scan at the average gestational age of 9-13 weeks in addition to the TA screening usually performed between 22-26 weeks. To fulfill the technical requirements of a screening test, ultrasonographic examinations were performed by skillful operators with different degrees of experienced using adequate instruments Aloka SSD 5500 (Aloka Co. Ltd., Tokyo, Japan) provided with either a 3.5-5MHz TA probe or a 5-7.5MHZ TV probe) in a fixed scanning time of maximum 30 min, generally considered sufficient for a complete fetal anatomic survey. Results: During the study period we found in our unselected population an overall prevalence of target abnormalities of 2.2%(24 malformed fetuses out of 600 screened). In the fetuses examined by TVS, 16 abnormalities were detected whereas 8 were not; of these, 6 were detected at transabdominal rescreening at 22-26 weeks and the remaining 2 were observed after birth. A nuchal region abnormality was the most frequent type of malformation detected in the early scan, including six cases of nuchal edema, two cases of cystic hygroma associated with hygroma associated with hydrops, three cases of hydronephrosis, one case of fetal neck teratoma, one case of cleft lip. Conclusion: This study has demonstrated the potential of screening a low risk population for fetal abnormalities at 9-13 weeks of gestation using transvaginal sonography and rescreened via transabdominal sonography at 22-26 weeks. Larger studies are required to establish the clinical value of the first trimester scan.

감응성막의 전기적 성질을 이용한 유기 가스 반응 특성

김도균,이준호,유승엽,장정수,권영수 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The electrical properties of Maleate copolymer (C_(18)MA-VE_(2)) and Itaconate copolymer (C_(18)ITA-VE_(2)) Langmuir-Blodgett (LB) films for in-plane were investigated to develop the gas sensor. The C_(18)MA-VE_(2) and C_(18)ITA-VE_(2) were used as sensitive materials and deposition on the slide-glass substrate using LB method which could control the thickness in the molecular order (Å). The current-voltage (I-V) characteristics were measured to investigated the response characteristics in chloroform, acetone, ethanol and methanol gases. The conductivity of sensitive films were 10^(-)7[S/cm] for an in-plane. The change of conductivity was occurred by behavior of organic gases, which mean that the behavior of organic gases could be analyzed using conductivity change and application to gas sensor. In the experimental results, the relation between sensitive films and organic gases could be divided by three-type. Thus, we could analyze the modeling of the response characteristics of organic gases using the conductivity change of sensitive films.

Ni1-xCdxFeAlO₄계의 Mossbauer 스펙트럼 연구

홍성락,고정대,백승도 濟州大學校 基礎科學硏究所 1998 基礎科學硏究 Vol.11 No.2

Ni1-xCdxFeAlO₄계의 Mossbauer스펙트럼은 x가 0.2이하인 경우에는 초상자성 이완현상을, x가 0.3~0.5인 경우에는 준강자성에 의한 sextet를 x가 0.7, 0.8인 경우에는 강자성 이완현상, x가 0.8이상인 경우에는 상자성에 의한 doublet가 나타난다. x가 0.2이하인 시료에서 치환된 Cd²이온은 주로 A-site의 Al³이온을 B-site로 이동시키고, 계속적인 Cd²이온의 증가에 따라 A-site의 Fe³+ 이온도 B-site로 이동하게 된다. Ni1-xCdxFeAlO₄계의 초상자성 이완 현상은 A-site의 Al³이온에 의한 것으로 강자성 이완현상은 치환된 Cd²+이온에 의한 것으로 설명할 수 있고, Yafet-Kittel자기구조에 따라 Ni1-xCdxFeAlO₄계의 자기적 성질을 해석할 수 있다. The Mossbauer spectra of the Ni1-xCdxFeAlO₄system were investigated with the Cd content X at room temperature. The spectra of the samples exhibit various patterns as follows 1) superparmagnetic relaxation for 0≤x≤0.2, 2)ferrimagnetic sextet for 0.3≤x≤0.5, 3) ferromagnetic relaxation for x=0.6, 0.7, 4)paramagnetic doublet for 0.8≤x≤1, with the Cd content x. In the samples with X values from O to 0.2, the substituted Cd²+ ions transfer the Al³+ ions from A-site to B-site mainly. The superparamagnetic relaxation effect and the ferromagnetic relaxation effect are derived from the Al³,Cd²respectively. The magnetic structrue of the Ni1-xCdxFeAlO₄system was explained by the Yafet-Kittel model.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

시각장애인의 유산소성 운동이 체력에 미치는 영향

박재성,김주혁,황영성,김도호,이수판,한성유,허정석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This research fulfilled the program of aerobic exercise for living during 6 months with seven men and women who are disabled people with visual impairment, The program consists or gym, swimming, aerobic and running, During 6 months, all exercises were executed 1 hours, twice a week for 6 weeks. Each exercise had self-servant and was carried out 60 minutes with teaching method of special directors in every weep Physique by height, weight, condition of exercise ability by the capacity of the lungs of the heart and lung endurance and intake of the maximum oxygen, muscular strength of stomach, grasping power, pliability by forward bending with the upper part of the body, instantaneous force of muscle in a sudden jump, muscular endurance by put-up and sit-up, agility by side-step and response of the whole body, and balance by one leg standing while closing eyes as using Helmas (sewoo systems korea) were measured. The Results, 1.There is a significant difference for both men and women in the capacity of the lungs and the heart and lung endurance, However only women have a significant difference in intake of the maximum oxygen. 2. Both men and women have a significant difference in muscular strength of stomach and grasping power to measure muscular strength. 3. Both men and women have a significant difference in forward bending with the upper part or the body to measure flexibility. 4. Sudden jump to measure instantaneous force of muscle, sit-up, and push-up to measure muscular endurance show that both men and women have a significant difference.(p<.01) 5. Side-step and response of the whole body to measure agility show that both men and women have a significant difference. 6. One leg standing with closing eyes to measure balance show that both men and women have a significant difference.

雲達山의 植物相

閔雄基,張珍成,全正壹,金輝,崔道烈,金承昆 서울대학교 수목원 2001 서울大學校 樹木園 硏究報告 Vol.- No.21

This study was carried out to investigate the flora of Mt. Undal (alt. 1,097.2m) located on the northwestern side of province Gyeongsangbuk-do, near Myngyeong-si city, from April 2000 to Sept. 2000. Total number of vascular plants discovered in Mt. Undal were 70 families, 154 genera, and 243 taxa(including species, subspecies, varieties and forma). Major vegetation was Acer pictum var. mono - Quercus mongolica - Carpinus laxiflora community. The overall forest stand age of this area was 40 to 50 years, and occasionally ca 70 years old Abies holophylla trees were found. Although, there were no rare and endangered speices, we found two species of level IV by the Ministry of Environment - Anemone koraiensis Nakai, Anemone reflexa. Steph. et Willd.