Actinomycin D가 거세된 휜쥐 섭호선의 미세구조에 미치는 영향

최춘근,고기석,이재익 연세대학교 자연과학연구소 1985 學術論文集 Vol.15 No.-

정상인 흰쥐의 섭호선 조직과 거세를 시켜서 androgen의 영향을 억제시킨 흰쥐의 섭호선 조직, 그리고 거세시킨 후 actinomycin D를 투여하여 이와 같은 항생물질이 섭호선에 주는 미세구조의 변화를 관찰하고 위의 각 군에서 조직화학적인 방법을 이용하여 acid phosphatase의 반응을 전자 현미경으로 관찰하였다. 이 결과 거세시킨 흰쥐의 섭호선 세포에서 세포소기관의 소멸, 미세융모의 퇴화등 변화를 나타내었고, androgen의 영향이 없을 경우 세포의 대사이상을 나타내었고, actinomycin D를 처리하였을 경우 핵의 chromatin mass의 증가, 세포막의 파괴와 라이소좀이 증가되는 경향을 나타내었다. acid phosphatase의 반응은 거세된 흰쥐 세포에서 핵과 세포질에 분포하나 actinomycin D를 투여한 군에서는 주로 핵에 분포하는 경향을 나타내었다. Ultrastructural changes of prostates of the normal rats, castrated rats and actinomycin D treated castrated rats are studied with electron microscope. In addition, reaction of acid phosphatase is studied by histochemical method in each group. Disappearance of cell organells, (mitochondria, ER) degeneration of microvilli are characteristically observed in the castrated rat prostate. Increase of chromatin mass, destruction of cell membrane are seen in the actinomycin D treated castrated rat prostate. Reaction products of acid phosphatase are ubiquitous in nucleus and cytoplasm of the castrated rat prostate, but this reaction is predominant in nucleus of the actinomycin D treated castrated rat prostate.

Effect of Aralia elata Root Cutting Spacing on Growth and Yield

Ki Duk Park(박기덕),Su Jeong Heo(허수정),Hyo Young Lee(이효영),Nam Gil Lee(이남길),So hyeon Park(박소현),Jai Young Ko(고재영) 한국약용작물학회 2023 한국약용작물학회 학술대회논문집 Vol.2023 No.1

제진 댐퍼로서 WBK 의 적용가능성

고경득(Ko Gyeong-Deuk),주재황(Joo Jai-Hwang),황재승(Hwang Jae-Seung),강기주(Kang Ki-Ju) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

최근 개방형이고 규칙적인 다기능성 다공질 금속인 Wire-woven Bulk Kagome(WBK)가 소개되었다. 이번 논문은 건물의 지진 대비 진동제어 장치용 댐퍼로서 WBK 의 적용가능성을 조사는 것이 목적이다. WBK 의 에너지 소산능력을 조사하기 위해 전단 하중 아래에서 WBK 의 이력곡선은 실험적으로 측정하였고 실험결과와 비교를 위해서 3-D 유한요소해석에 의거하는 동일한 시뮬레이션 또한 수행하였다. 실험과 시뮬레이션 결과는 WBK 가 초기 연성후에 안정된 이력현상을 보여준다. Recently, multifunctional cellular metal with open and periodic structures, Wire-woven Bulk Kagome(WBK) has been introduced. The purpose of present work is to examine the feasibility of the WBK as an anti-seismic vibration control device for building structures. Hysteresis loop of the WBK under cyclic shear loading was experimentally measured to investigate the performance of WBK in the energy dissipation capacity and in parallel a numerical simulation based on the 3-D finite element analysis was also carried out for the verification of the experimental results. Both experimental and numerical simulation results show that the WBK has a stable hysteresis response after some initial softening.

巨大胸腺腫瘍의 一例 報告

李洙澤,高在起,李陽根 전북대학교 의과학연구소 1985 全北醫大論文集 Vol.9 No.1

Thymoma, one ot the most common neoplasms in the mediastinum, varies much in its size from patient to patient. The largest tumor reported in the previous references measured 34×18×16cm and weighed 5,700gm. The size of the present case measures 26×21×18cm and weighs 5,717gm. To our knowledge this is the largest one among the reported cases in the wold.

産後 心不症에 對한 臨床的 硏究

姜聲貴,趙炳權,高在起 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1

Heart failure developing abruptly during the last month of pregnancy or within a few weeks following delivery has been observed in the absence of any known preexisting cafdiac lesion, and a clinical entity called "post-partal heart disease" has been described. Twenty-four of the postpartum heart failure were studied clinically at the Jeonbug University Hospital during the period three years and nine months, from Jannary, 1976 to October, 1979. 1. Postpartum heart failure showed the peak incidence of age in their second decade and primipara. 2.Among the 24 cases of postpartum heart failure, the symptoms during the first week after delivery developed 8 cases, and 2nd week 6 cases, and 8 week 3 cases. 3. In the spring, postpartum heart failure showed the peak incidence but 5 cases in the summer and winter, respectively. 4.At the damission, chief complains were dyspnea, cough, generalized edema and orthopnea. Physical findings revealed cardiomegaly, pulmonary rales, hepatomegaly, systolic murmur, hypertension and gallop rhythm in frequency. 5.The chest X-ray film showed the cardiomegaly in 18 cases(75%), pulmonary edema in 18 cases(75%) and pleurisy with effusion in 4 cases(16.7%). 6.Electrocardiograms revealed 17 cases(70.8%) sinus tachycardia, 17 cases(70.8%) STT changes, 8 cases left ventricular hypertrophy and 2 cases low voltage in frequency.

Textural and geochemical characteristics of Fe-Mn crusts from four seamounts near the Marshall Islands, western Pacific

Jonguk Kim,Kiseong Hyeong,Chan Min Yoo,Jai-Woon Moon,Ki-Hyune Kim,Young-Tak Ko,Insung Lee 한국지질과학협의회 2005 Geosciences Journal Vol.9 No.4

Textural and geochemical properties of ferroman-ganese crust (Fe-Mn crust) samples from four adjacent seamountsnear the Marshall Islands were investigated to delineate the pale-oceanographic condition on their growth history. The Fe-Mn crustsamples of this study show four distinct layers (layers 1 to 4 fromtop to bottom). The uppermost layer 1 is massive and black, andis enriched in hydrogenetic elements such as Mn, Co, Ni, and Mo.The next layer 2 is porous and filled with sediment. Detrital (Al,Rb, and Ti) and biogenic (Cu, Zn, and Ba) elements are enrichedin layer 2. The layers 3 and 4 are phosphatized layers which areimpregnated with carbonate fluorapatite (CFA), and thereforetheir primary mineralogy and geochemistry were not preserved.The property of layer 2 suggested that this layer had grown underthe condition of high biogenic and detrital flux. Such a conditionmay be met in the Inter-tropical Convergence Zone (ITCZ) wherethe northeast and southeast trade winds met. Considering thehave formed when these seamounts were beneath the ITCZ. On theother hand, layer 1 may have started to grow after the seamountsmoved out of the ITCZ with the northwestward movement of thePacific plate. Our study indicates that the Fe-Mn crusts can beused to trace the paleolocation of ITCZ when precise age determi-nation and information on the plate movement are provided.

뇌실내 Calcitonin 투여로 인한 위산분비 억제에 대한 뇌내 신경전달체의 역할

장우익(Woo Ick Jang),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),고창만(Chang Mann Ko),현재헌(Jae Hun Hyun),김상태(Sang Tae Kim),이상인(Sang In Lee),최흥재(Heung Jai Choi),김경환(Kyung Hwan Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.5

N/A Peptides that are common to the brain and gut are thought to play intermediary roles as neurotransmitters or neuromodulators in the regulation of gut function. Calcitonin is a polypeptide hormone of 32 amino acid residues. Recently, much evidence has been accumulated to suggest that calcitonin may inhibit gastric acid secretion by a central action, but the neurohumoral pathways mediating the antisecretory effects of calcitonin in rats are not well elucidated. In the present study, using a gastric perfusion technique, the effects of ICV administration of calcitonin on gastric acid secretion stimulated by baclofen were investigated in rats. We also investigated whether the serotonergic system is involved in calcitonin's effect of gastric acid secretion. The results obtained were as follows: 1) ICV administration of baclofen stimulated gastric acid secretion in a dose-dependent manner. Central administration of baclofen was approximately 200-400 times more sensitive than subcutaneous administration. 2) Baclofen-induced gastric acid secretion was partially suppressed by bilateral vagotomy. 3) Gastric acid secretion stimulated by baclofen was markedly suppressed by ICV administration of calcitonin. 4) Depletion of brain serotonin with the neurotoxin 5, 7-dihydroxytryptamine did not influence calcitonin-induced gestric acid suppression. In this study it was demonstrated that centrally- administered calcitonin suppresses baclofen-induced gastric acid secretion. Also. it is suggested that the serotonergic system is not involved in calcitonin-induced gastric acid suppression.

속립성 (粟粒性) 간결핵 (肝結核)

박재홍,백홍선,고재기,이양근,이중열,안득수 ( jai Hong Park,Hong Sun Baek,Jai Ki Ko,Yang Kun Lee,Jung Yeol Rhee,Deuk Soo Ahn ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1

Miliary t:;!'oerculosis of the liver is not often considered as a cause in obscure illness, fever of ur.determir.ed origin or hepatomegaly. A 3p year-old man had suffered from unL.nown fever and chillness, nausea and weight loss for 1p months and had a history of tuberculous pleurisy, confirmed by pleural biopsy in 25 year-old of his age. In local clinic, because of high fever, he had received treatment under the impression of typhoid fever but no improvement vas noted. Physical exaniination on admission revealed that blood pressure was 1ZO/80 mmHg, respira- tion 20/minute, the pulse 100/minute, temperature Rg'C. General appearance was chronic ill and hepato..iegalv and splenomegaly were noted on palpation. On laboratory data showed persistent leukopenia (2,200/mm to 3,400/mm), but bone marrow biopsy was within normal range. Liver scan sliowed hepatospenomegaly and multiple cold area noted. Liver biopsy revealed multiple tubercle with caseous necrotic lesion and large gi,..; cells around the tubercle noted.

Mirror Syndrome Resulting from Metastatic Congenital Neuroblastoma to Placenta

( Sung Hyeon Park ),( Jung-man Namgoong ),( Kyeong Nam Ko ),( Chong Jai Kim ),( Pil-ryang Lee ),( Euiseok Jung ),( Byong Sop Lee ),( Ki-soo Kim ),( Ellen Ai-rhan Kim ) 대한주산의학회 2018 Perinatology Vol.29 No.4

Congenital neuroblastoma is a rare disease. Placental metastasis is extremely rare and poor prognosis has been reported in neonates. Mirror syndrome could occur in mother with placental metastasis with possibilities of hypertension and edema. We report a case of detection of left suprarenal mass in fetus at 31⁺⁵ weeks’ gestation. Mother presented with palpitation, edema, headache, and hypertension. Maternal 24 hours urine vanillylmandelic acid (VMA) and normetanephrine (NME) level at 34 weeks’ gestation were elevated. Consequently, emergent cesarean section was done. Based on abdominal ultrasonography and whole body magnetic resonance imaging, left adrenal tumor with liver metastasis was suspected. Neuroblastoma was confirmed by liver and placenta biopsy. Chemotherapy was started with Pediatric Oncology Group 9243 at day 7 and changed into Children's Oncology Group 3961 due to cholestasis and poor response during 2nd cycle. Plasma exchange was done for aggravated direct hyperbilirubinemia. The baby expired at 73 days due to multi-organ failure. Maternal symptoms were completely resolved in 2 weeks after delivery along with normalization of the elevated level of VMA and NME. We report a first case of mirror syndrome in Korean mother and fetus resulting from metastatic congenital neuroblastoma to placenta.

PEMFC에서 전극과 전해질 막의 열화 가속 시험

송진훈 ( Jin Hoon Song ),김세훈 ( Sae Hoon Kim ),인병기 ( Byung Ki Ahn ),고재준 ( Jai Joon Ko ),박권필 ( Kwon Pil Park ) 한국화학공학회 2012 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.50 No.5

Until a recent day, degradation of PEMFC MEA (membrane and electrode assembly) has been studied, separated with membrane degradation and electrode degradation, respectively. But membrane and electrode were degraded coincidentally at real PEMFC operation condition. Therefore in this work, AST (Accelerated Stress Test) of MEA degradation was done at the condition that membrane and electrode were degraded simultaneously. There was interaction between membrane degradation and electrode degradation. Membrane degradation reduced the decrease range of catalyst active area by electrode degradation. Electrode degradation reduces increase range of the hydrogen crossover current and FER (Fluoride Emission Rate) by membrane degradation.