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Objectives: The incidence of lung cancer has been on the increase despite the decreasing rate of smoking, And the possible curative approach to lung cancer is surgical resection. Although the remnant lung function is very important due to postoperative well-being, we often failed to notice of its significance and carried on only few studies. The exercise pulmonary function test has been widely applied for objective measurement of work capacity, and can be extremely helpful for investigating exertional dyspnea. The present investigation was designed to evaluate the factors such as FEV₁, FVC, V_(E)max, Vo₂max, anaerobic threshold, heart rate reserve, breathing reserve 4 weeks after resection in lung cancer patients. And now, we will understand the changes of lung function and the consequence of work capacity after surgical resection. Methods: Ten healthy subjects and twenty patients with lung malignancy underwent progressively incremental exercise test to symptom-limited stage. In patient group, the above incremental exercise test also was done at 4 weeks after surgical resection. Measurement were made of metabolic, cardiorespiratory, blood gases, and symptoms during exercise test. Results: 1) There were significant decreases in FEV₁, FVC, V_(E)mas, Vo₂max in the postresection group. These decreases were more marked in the postpeumonectomy group than in the postlobectomy group. 2) In postpeumonectomy group, there were more decreases in FEV₁, FVC₁, VO₂max without significance, but fall in V_(E)max with significance. 3) There was no significant correlation between the decrease of FEV and Vo₂max in either patient group. Conclusion: There were significant decreases in FEV₁, FVC, V_Emax, Vo₂max in postresection group. And there was no significant correlation between the decrease of FEV₁and Vo₂max in either resection group. This reveals that change in FEV₁is a poor predictor of change in exercise capacity after lung resection.
The association of malignant tumors with various glomerulopathies is well known. The most common clinical finding of glomerulopathies has been the nephrotic syndrome and the most frequently associated neoplasms are Hodgkin's disease, various carcinomas, non-Hodgkin's lymphoma and leukemia in the order. Association between lung malignancy and glomerulopathy has been reported, as a paraneoplastic syndrome. The most frequent renal leison in patients with glomerulopathy associated with lung malignancy is membranous glomerulonephrities. Rare reports have been seen in the literature on IgA- associated glomerulonephritis and lung malignancy. We report a case of lgA nephropathy associated with bronchial squamous cell carcinoma with a review of the literature.