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Possible Role of Lysine Demethylase 2A in the Pathophysiology of Psoriasis
( Dong Ha Kim ),( Mi-ra Choi ),( Jae Kyung Lee ),( Dong-kyun Hong ),( Kyung Eun Jung ),( Chong Won Choi ),( Young Lee ),( Chang-deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.6
Background: Psoriasis is a common chronic inflammatory skin disease. The development of psoriasis is dependent on many intercellular events such as innate immunity and T cell-mediated inflammation. Furthermore, genetic factors are strongly implicated in the pathophysiology of psoriasis. Although a variety of susceptible genes are identified, it is likely that many important genes remain undisclosed. Objective: The aim of this study is to investigate the possible role of lysine demethylase 2A (KDM2A) in the pathophysiology of psoriasis. Methods: We examined the expression of KDM2A using a well established imiquimod-induced psoriasiform dermatitis model. Results: Immunohistochemistry analysis showed that expression of KDM2A was increased in imiquimod-induced psoriasiform dermatitis. Consistent with this result, KDM2A level was markedly increased in the epidermis of psoriatic patient. When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels. Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-α, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression. Finally, topical co-application of imiquimod and daminozide exacerbated the imiquimod-induced psoriasiform dermatitis. Conclusion: Together, these results suggest that KDM2A is increased to negatively regulate the inflammatory reaction of epidermal keratinocytes in psoriasis. (Ann Dermatol 32(6) 481∼486, 2020)
Won Il Choi(최원일),Day Sung Kim,Jung Hoon Kim,Dong Shik Choi,Yil Woo Kim,Jeung-Ho Kim,Seong-Kyu Kang 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
The work-related musculoskeletal disorders (WMSDs) have increased at the atypical work of the food & accommodation industry as well as at the regular work such as the manufacturing industry. However, most studies related to WMSDs have focused on the manufacturing industry. This paper investigates WMSDs, their prevention activities and problems in the food & accommodation industry. This study was performed for 160 restaurants/cafeterias or hotels in Gyeongsang province through interviews, document analysis, video analysis, etc., which included jobs of bellman, front-desk, room-maids and cook, etc. Based on the results, administrative or engineering measures for preventing WMSDs were suggested.
Possible role of lysine demethylase 2A (KDM2A) in the pathophysiology of psoriasis
( Dong Ha Kim ),( Mi-ra Choi ),( Jae Kyung Lee ),( Do Yeon Kim ),( Dong-kyun Hong ),( Kyung Eun Jung ),( Chong Won Choi ),( Young Lee ),( Chang-deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Psoriasis is a common chronic inflammatory skin disease. The development of psoriasis is dependent on many intercellular events such as innate immunity and T cell-mediated inflammation. Furthermore, genetic factors are strongly implicated in the pathophysiology of psoriasis. Although a variety of susceptible genes are identified, it is likely that many important genes remain undisclosed. Objectives: The aim of this study is to investigate the possible role of lysine demethylase 2A (KDM2A) in the pathophysiology of psoriasis. Methods: We examined the expression of KDM2A using a well established imiquimod-induced psoriasiform dermatitis model. Results: Immunohistochemistry analysis showed that expression of KDM2A was increased in imiquimod-induced psoriasiform dermatitis. Consistent with this result, KDM2A level was markedly increased in the epidermis of psoriatic patient. When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels. Poly(I:C) increased the expression of psoriasis-related cytokines including TNF-α, IL-8 and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression. Finally, topical co-application of imiquimod and daminozide exacerbated the imiquimod-induced psoriasiform dermatitis. Conclusion: Together, these results suggest that KDM2A is increased to negatively regulate the inflammatory reaction of epidermal keratinocytes in psoriasis.
Biomass를 위해 제조한 청목노상 callus로부터 Helicobacter pylori 억제물질의 분리 및 동정
Dong-Hyuck Yun(윤동혁),Won-Seup Cha(차원섭),Seon-Hon Lee(이선호),Bong-Jeun An(안봉전),Jeung-Hoan Kim(김정환),Sung-Sook Chun(천성숙),Jong-Ho Bae(배종호),Young-Je Cho(조영제) 한국생명과학회 2010 생명과학회지 Vol.20 No.3
청목노상 잎 시료로부터 spot 배양 후 bioreactor에서 배양된 청목노상 뽕잎callus 추출물을 이용하여 H. pylori균에 대한 항균활성을 측정한 결과, 높은 항균활성을 나타내는 것을 알 수 있었다. 배양된 청목노상 뽕잎 callus 추출물의 H. pylori 균에 대한 항균활성 물질을 정제하여 ¹H-NMR, <SUP>13</SUP><SUP></SUP>C-NMR, IR 및 FAB-MS spectrum 등을 활용하여 구조분석 한 결과 protocatechuic acid, chlorogenic acid, caffeic acid 및 rosemarinic acid로 동정하였으며, 단일물질 보다 혼합물질에 의한 synergy 효과에 의해 H. pylori 균에 대한 항균활성이 나타나는 것으로 판단되었다. The objective of this research was to evaluate the inhibitory activities of phenolic compounds isolated from Cheomoknosang callus on Helicobacter pylori. Total phenolic compounds of 80% ethanol extracts from callus were 15.3 ㎎/g. The activity of H. pylori inhibition at 80% ethanol extracts from Cheongmoknosang callus was determined as 14 ㎜ clear zone. Isolation of inhibitory compounds was carried out on Sephadex LH-20 and MCI-gel CHP-20 column chromatography using a gradient elution procedure of increasing MeOH in H₂O. The chemical structure of the inhibitory compound against Helicobacter pylori was confirmed as protocatechuic acid, chlorogenic acid, caffeic acid and rosemarinic acid by spectroscopic analysis of FAB-MS, NMR and IR spectrum.
Whole genome analysis for liver metastasis gene signatures in colorectal cancer
Ki, Dong Hyuk,Jeung, Hei-Cheul,Park, Chan Hee,Kang, Seung Hee,Lee, Gui Youn,Lee, Won Suk,Kim, Nam Kyu,Chung, Hyun Chul,Rha, Sun Young Alan R. Liss, Inc 2007 International journal of cancer Vol.121 No.9
<P>Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular events involved in tumor progression and metastasis. We performed experiments using a cDNA microarray containing 17,104 genes with the following tissue samples: paired tissues of 25 normal colorectal mucosa, 27 primary colorectal tumors, 13 normal liver and 27 liver metastasis, and 20 primary colorectal tumors without liver metastasis. To remove the effect of normal cell contamination, we selected 4,583 organ-specific genes with a false discovery rate (FDR) of 0.0067% by comparing normal colon and liver tissues using significant analysis of microarray, and these genes were excluded from further analysis. We then identified and validated 46 liver metastasis-specific genes with an accuracy of 83.3% by comparing the expression of paired primary colorectal tumors and liver metastases using prediction analysis of microarray. The 46 selected genes contained several known oncogenes and 2 ESTs. To confirm that the results correlated with the microarray expression patterns, we performed RT-PCR with WNT5A and carbonic anhydrase II. Additionally, we observed that 21 of the 46 genes were differentially expressed (FDR = 2.27%) in primary tumors with synchronous liver metastasis compared with primary tumors without liver metastasis. We scanned the human genome using a cDNA microarray and identified 46 genes that may play an important role in the progression of liver metastasis in CRC. © 2007 Wiley-Liss, Inc.</P>
Kim Dong-Hwan,Lim Soobin,Chung Kyoung-Jae,Hwang Yong-Seok,Kim Han-Sung,Dang Jeong-Jeung,Lee Seung-Hyun,Choe Kyumin,Jung Won-Hyeok,Kwon Hyeok-Jung 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.12
We have studied the feasibility of automatic and fast control of the low energy beam transport section in the newly developed radio-frequency quadrupole at KOMAC (Korea Multipurpose Accelerator Complex) by combining a simple neural network model with a beam profile monitor. Extensive beam dynamics simulations on the proton injector with varying beam transport parameters are performed to generate the training set for the machine learning and to obtain optimization model for the injector. These datasets are well-trained and show good ability to estimate the beam parameters at position under consideration. These results can be a steppingstone to develop an auto-tuning or feedback control system based on artificial intelligence for a high-intensity accelerator. This paper presents the calculation conditions and the training process in detail, as well as the cross-validation of the trained neural network model by using the results obtained by beam dynamics code.
면적강우량 결정방법에 따른 병렬저수지의 하류부 유출 특성분석 - 홍수조절 능력이 없는 저수지의 경우 -
이증석 ( Jeung-seok Lee ),원동철 ( Dong-chul Won ),박동일 ( Dong-il Park ),안승섭 ( Seung-seop Ahn ) 한국환경기술학회 2013 한국환경기술학회지 Vol.14 No.2
본 연구에서는 중소규모의 하천유역에서 수문에 의해 인위적인 조절 없이 자연 방류되는 저수지의 저감효과를 검토하고 홍수조절에 따른 하류부의 영향을 검토함으로써, 자연하천에 대한 효율적인 치수방안 마련에 활용하고자 한다. 50년 빈도의 홍수가 유입할 경우 화금지에서는 저수지조절로 첨두홍수량 3㎥/s(8.3%)를 감소시키고 성곡지에서는 11 ㎥/s(6.5%)를 저감시키는 효과를 보이고 있는 것으로 검토되었으나, 두 저수지가 모두 수문이 없는 자연조절식 여수로 이므로 풍각천과 현리천 합류지점 하류에서는 지체된 홍수가 중첩되어 홍수량이 17 ㎥/s 증가하는 것으로 나타나 조절 효과에 대한 불확실성이 우려되므로 치수적인 측면에서 자연 조절되는 저수지의 경우 강우 및 유역상황에 따라 치수안전성을 저해하는 요인으로 나타날 수 있으므로, 치수대책 수립에 주의를 요해야 한다. This study is aimed at the evaluation of reservoir flood regulation effect in small river basin. Reservoir decrease flood damage and supply of water in the downstream areas. This study basin is Punggak Stream at the Chungdo Gyeongbuk. In this study, rainfall frequency analysis, runoff and reservoir regulation is carried out. Though the regulation of reservoir, peak flow is reduced in Hwagum reservoir 3% and Sunggok reservoir 5%, respectively. But Peak flow increased 17 ㎥/s by flood delay at punggak estuary.