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Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
Byun, S.H.,Lee, J.H.,Jung, N.C.,Choi, H.J.,Song, J.Y.,Seo, H.G.,Choi, J.,Jung, S.Y.,Kang, S.,Choi, Y.S.,Chung, J.H.,Lim, D.S. Pergamon Press 2016 Biochemical pharmacology Vol.115 No.-
<P>Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which serves diverse biological functions. A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. Rosi-DCs were generated by treating immature DCs with TNF-alpha, type II collagen, and rosiglitazone. CIA mice then received subcutaneously (s.c.) two injections of Rosi-DCs. The severity of arthritis was then assessed histopathologically. The phenotypes of the DC and regulatory T (Treg) cell populations in CIA mice were determined by flow cytometry and the effect of Rosi-DCs on the secretion of autoimmunity-inducing cytokines was examined by ELISA. Rosi-DCs expressed lower levels of DC-related surface markers than mature DCs. Histopathological examination revealed that the degree of inflammation in the paws of Rosi-DC-treated mice was much lower than that in the paws of PBS-treated CIA mice. Taken together, these results clearly show that rosiglitazone-mediated DCs ameliorate CIA, most likely via the induction of antigen-specific Treg cells. (C) 2016 Elsevier Inc. All rights reserved.</P>
鄭元采,盧載榮,安長憲,卞珠燮 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
This works has been carried out in order to study the influence of different condition of soil moisture on the growth and yield of tobacco leaves. It was investigated the soil moisture on the cultivating farm of tobacco for the study on the variation in soil moisture. The results are summarized as follow; 1.In the deficient supply of soil moisture, S1 treatment at the setting stage caused the delay of growth, and S3 treatment at the period vigrous growth influenced eriousely on the yield. Dry leaf weight decreased gradually in order S1>S6>S2>S3>S5>S4. 2.The dry leaf weight was decreased according to the increase of treatment duration, the results showed as T1=T2=T3<C 3.In the excessive supply of soil moisture, 90% (maximum water holding capacity) treatment during 10~20 days was damaged at early stage more than latter stage treatment in the growth. 4.In the deficient or excessive supply of soil moisture, excessive supply treated plots in long period and the replication plots in the deficient supply treated influenced on the yields.
Hwang, S.R.,Seo, D.H.,Al-Hilal, T.A.,Jeon, O.C.,Kang, J.H.,Kim, S.H.,Kim, H.S.,Chang, Y.T.,Kang, Y.M.,Yang, V.C.,Byun, Y. Elsevier Science Publishers 2012 Journal of controlled release Vol.163 No.3
The regulation of angiogenesis is an interesting area to consider for novel therapeutic approaches to rheumatoid arthritis (RA). Chemically modified heparins have been developed as possible candidates for angiogenesis inhibitor; however, they have a major clinical drawback in exhibiting poor oral bioavailability. Here, orally absorbable O-desulfated low molecular weight heparin (ODS-LMWH) derivatives were newly synthesized by conjugating 2-O- or 6-O-desulfated LMWH with deoxycholic acid (DOCA) or bisDOCA (a dimer of DOCA), and their physicochemical properties, antiangiogenic potency and pharmacokinetic profiles were assessed. After selecting the best candidate among those derivatives, its therapeutic efficacy on arthritis was investigated in a murine collagen antibody-induced arthritis (CAIA) model. ODS-LMWH derivatives significantly inhibited the capillary-like tube formation of human umbilical vein endothelial cells (HUVECs) and basic fibroblast growth factor (bFGF)-induced angiogenesis in the Matrigel plug assay. Among all the compounds, 6ODS-LHbD showed the highest oral bioavailability in rats (19.3%). In the CAIA mouse model, 6ODS-LHbD (10mg/kg, p.o., S.I.D.) significantly inhibited neovascularization in the joint, the increase of hind-paw thickness, and the structural damage in the bone. Therefore, 6ODS-LHbD would be a promising candidate for an orally active drug for the treatment of RA.
IMx Glycated Hemoglobin측정법에 관한 연구
황성준,박종성,이승관,이창규,류정록,변대훈,박은병 高麗大學校 倂設 保健大學 保健科學硏究所 1994 保健科學論集 Vol.20 No.1
Percent glycated hemoglobin(%GHb) is an indirect measure of the mean blood glucose level in an individual over the previous two to three months. A fully automated assay for quantitating %GHb in human whole blood has been developed using the Abbot IMx R analyzer. The assay is accomplished by specific solution phase tagging of glycated hemoglobin by a soluble polyanionic affinity reagent, and subsequent capture of the anionic complex by a cationic solid phase matrix. Both glycated hemoglobin(GHb) and total hemoglobin(Hb) are quantitated by measuring quenching of the fluorescence from an added dye by home. A correlation study was conducted accross IMx R instruments with fully automated HPLC (Hi-Auto A_(IC TM), Kyoto Daiiclii co.) as the reference assay. The correlation statistics obtained for 20 diabetic specimens were: IMx=0.84 HPLC+1.75, correlation coefficient= 0.969. Studies from linear relationship statistics had showed that there ere no evidence for difference between two methods. IMx glycated hemoglobin assay was don-sidered to be compatible with HPLC method.