Regulation of Proinflammatory Mediators via NF- <i><i>κ</i></i> B and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea <i>Lonicera japonica THUNB</i>

Park, Kwang-Il,Kang, Sang-Rim,Park, Hyeon-Soo,Lee, Do Hoon,Nagappan, Arulkumar,Kim, Jin A,Shin, Sung Chul,Kim, Eun Hee,Lee, Won Sup,Chung, Hyon-Jong,An, Su Jin,Kim, Gon Sup Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-

<P><I>Lonicera japonica THUNB.</I>, which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because of the anti-inflammation properties. This study aimed to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea <I>L. japonica T.</I> by nuclear factor-kappaB (NF-<I><I>κ</I></I>B) and mitogen-activated protein kinases (MAPKs) pathway. Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2, as well as mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1<I><I>β</I></I>, and IL-6. Moreover, polyphenols inhibited nuclear translocation of NF-<I><I>κ</I></I>B p65, phosphorylation/degradation of the inhibitor of <I><I>κ</I></I>B, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected. These results indicate that polyphenol components isolated from Korea <I>L. japonica T.</I> should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-<I><I>κ</I></I>B and p38 MAPK activity.</P>

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

자기포화흡수에 의한 비선형흡수계수 측정

김일곤,유동선 昌原大學校 基礎科學硏究所 1996 基礎科學硏究所論文集 Vol.8 No.-

양자구슬에 구속된 엑시톤의 양자구속효과에 의해서 양자구슬의 선형 흡수스펙트럼은 청색전이를 일으킨다. 양자구슬을 포함하는 유리에 조사하는 광량이 증가하면 흡수단이 단파장 쪽으로 이동하며, 흡수율이 감소하는 비선형흡수 현상을 볼 수 있다. 본 논문에서는 평균반경이 3.4nm 인 양자구슬을 포함한 유리와 3.5nm와 4.4nm의 양자구슬을 동시에 갖고 있는 유리의 흡수율을 자기포화방법을 이용하여 400 - 411nm 범위에서 측정하였다. Z₁,₂absorption line of CuBr quantum dots was shifted toward the short wavelength region and the shifted energy was inversely proportional to the square of effect radius. If the input intensity increase, the absorption peak moves toward the short wavelength region and the absorption decrease. By the self saturation method, we measure the nonlinear absorption coefficient of aluminoborosilicate glass including CuBr quantum dots, the average redius is 3.4nm, 3.5nm, 4.4nm.

교정력이 흰쥐의 치아이동량과 치근흡수에 미치는 영향

김일곤,김광원,윤영주 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.5

본 연구는 치아를 실험적으로 이동시킬 때, 교정력의 크기와 적용방법에 따른 치아이동 양상의 차이가 존재하는 지의 여부와 치근흡수와의 관련 여부에 대하여 평가하고자 하였다. 300g 전후의 건강한 수컷 흰쥐 24마리를 세 군으로 나누고 상악 제 1대구치와 상악중절치 사이에 NiTi closed coil spring을 장착하여, 각 군당 50g(A군), 100g(B군), 25g(C군)을 적용하였고 C군의 경우에는 교정력을 적용한 지 4일째 50g으로 힘을 증가하였다. 15일간 교정력을 적용하는 동안 매일 ehter로 흡입 마취를 시행하고 치아이동거리를 digital caliper로 측정하고 15일간의 실험기간 종료 후 상악 제1대구치 치근부의 조직표본을 제작하여 광학 현미경으로 관찰한 바 다음과 같은 결과를 얻었다. 1. 각 군별 15일간 총 치아이동거리는 B군에서 가장 컸고, 그 다음 C군, A군의 순이었으나 통계학적으로 유의성 있는 차이는 없었다. 2. A, B, C군 모두 전형적인 치아의 이동양상을 보여주었으며 치아이동 지체기가 끝난 날은 C, B, A군의 순서로 각각 7, 8, 9일째 끝났으나 통계학적으로 유의성있는 차이는 없었다. 3. A, B, C군 모두에서 치근의 흡수양사을 관찰할 수 있었고, 특히 B군에서 가장 심한 치근흡수양상을 보여주었고, C 군에서 치근흡수의 양상이 가장 적었다. 이상을 종합해볼 때, 교정력이 크다고 하여 더 바른 치아이동이 일어난다고 볼 수 없으며 교정력이 클수록 초자양변성대가 광범위하게 형성되어 오히려 치근의 흡수도 증가하므로 교정력을 적용할 때 초기 교정력을 보다 적게 적용하여 초자양변성대 형성범위를 줄인 뒤 교정력을 증가시키는 방법이 치근흡수를 최소화하면서 효과적인 치아이동을 얻을 수 있을 것으로 생각된다. This study was undertaken to investigate the relation between orthodontic force magnitude and the amount of tooth movement. And more light force application for reducing root resorption. Twenty-four rats were divided into three experimental groups(A,B,C) based on force magnitude and application method. Springs of 50g force were applied to A group, springs of 100g force were applied to B group and springs of 25g force were applied to C group initially, and after 4 days springs of C group were changed to springs of 50 force. Two kinds of sentalloy (GAC U.S.A) closed coil spring, 50g and 100g, were used. And we made 25g springs by heat treatment process of 50g springs. Each spring was inserted between the maxillary central incisor and the maxillary left first molar. Amounts of tooth movement were measured every day by digital caliper(Digimatic, Mitutoyo, Japan) under inhalation anesthesia for 15days. After 15days, all rats were sacrificed and histological samples were obtained with Hematoxyline-Eosin stain and Masson's trichrome stain. Following conclusion were made ; 1. Group B showed the mean cumulative tooth movement of 2.19±0.41㎜ at 15th day, which was greatest among three groups, followed by group C(2.06±0.10㎜), group A(1.90±0.49㎜) respectively. However, there was no statistically difference among three groups. 2. All groups showed general tooth movement pattern and A, B, C group finished lag phase at 9th, 8th, 7th day, but there was no statistical significance. 3. Group A, B, C showed root resorption and especially group B showed the most severe root resorption and group C showed milder root resorption than other groups. According to the above results, large initial force with the development of a fairly widespread hyalinized zone may cause severe root resorption, so initial force should be applied lightly to reduce hyalinized area and eventually root resorption and increased force will induce efficient tooth movement.

양자구슬의 홀버닝과 여기광량의 관계

김일곤,유동선 昌原大學校 基礎科學硏究所 2001 基礎科學硏究所論文集 Vol.13 No.-

We have measured the absorption spectrum of CuBr quantum dots at 8.5K. Z1.2 exciton peak moves toward the shorter wavelength relative to the bulk CuBr. After a selective excitation by the dye laser, we could find the spectral hole in the absoprption spectrum. The depth and width of spectral hole depends on the optical fluence of dye laser. There are two process in the hole burning of quantum dots. The rising times of hole depth are 1.2 sec and 250 sec respectively. We think that the fast process is the result of the reduction of quantum dots which have the specific mean diameter, the second process is caused by the variation of a environment of matrix.

다중박막 반사경의 제작

김일곤,심훈 國立昌原大學校 基礎科學硏究所 1990 基礎科學硏究所論文集 Vol.2 No.-

농산물시장 근로자의 작업강도 분석

김일곤 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The study was intended to analyze the work intensity by duties in the agricultural market. Of the male personnel in the agricultural market in D metropolitan city, 16 managers, 21 brokers, and 35 deliverers, a total of 72. workers were selected, and their maximum and minimum average work intensity, metabolism at rest, and calorie consumption per minute per weight were measured. The findings were as follows. 1. Maximum work intensity by duties was 58.40±4.99% in delivery, 21.65±2.94% in brokerage, and 9.97±2.00% in management (p<.001). Minimum work intensity at work was 21.83±6.73% in delivery, 6.80±4.04% in brokerage, and 2.86±1.64% in management(p<.001). 2. Average work intensity was 38.67±7.11% in delivery, 12.83±3.51% in brokerage one, and 6.70±2.49% in management (p<.001). Mean of the work intensity of all 3 kinds of works was 24.03±15.47%. 3. Average metabolism at rest was 1468.14±78.63Kcal in management, 1408.25±51.20Kcal in brokerage, and 13.14.06±65.65Kcal in delivery (p<.001), Mean of the total metabolism at rest of all 3 kinds of works was 1375.77±90.67Kcal. 4. Calorie consumption per minute per weight was 0.090±0.010Kcal in delivery, 0.066± 0.003Kcal in brokerage, and 0.060±0.005 Kcal in management (p<.001). Mean of calories consumption of all 3 kinds of works was 0.076±o.ol5Kcal per minute per weight. Average work intensity during the 6 hours of work a day by duties in the agricultural market was 24%, which was lower than the maximum intensity of 33% recommended by National institute for Occupational Safety and Health. Work intensity in delivery, however, as found in the study, was 39%, very high. Thus, it is required to make alternatives for delivery job, like identifying working environment, making improvements in terms of human engineering, and increasing the personnel.

각형강관을 이용한 스틸콘크리트 단위벽체의 축내력에 관한 실험적 연구

김곤묵,홍석일,이대현,김호수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The steel house, one of new construction methods, has been mainly adapted to a lot of housing and developed in construction skill. But the disadvantage of steel house system is that the system is limited to small housing because it is composed of light gauge steel. Therefore, in order to solve it, this study presents the new system which is made of a carbon steel square for general structural purpose. The framed wall system which is presented in this study is composed of the steel stud members by using the carbon steel square and is reinforced by the horizontal members called runner. So, this system has more sufficient strength and axial load capacity than the steel house wall system. Besides, this system gives us the improved effects of the adiabatic and sound insulation by filling up the autoclaved lightweight concrete. Accordingly, this study evaluates on the axial capacity of unit wall of the system through the experimental study according to the experimental variable and analysis on the structural performance of the framed wall system using carbon steel square.

CuBr 양자구슬에서 Z₁,₂여기자에너지의 온도의존성

김일곤 昌原大學校 基礎科學硏究所 1997 基礎科學硏究所論文集 Vol.9 No.-

CuBr이 고루 분산된 aluminoborosilicate유리를 열처리하면 평균반경이 수nm인 양자구슬을 석출할 수 있다. 양짜구슬의 석출여부는 유리의 흡수스펙트럼을 측정하여 확인할 수 있다. 양자구슬의 반경이 큰 경우는 2차 열처리를 통하여 β-CuBr로 변환시킬 수 있으나 5nm보다 작은 경우는 γ-CuBr만이 석출되었다. 결정의 하였다. 열처리온도와 방법에 따라서 형태가 다른 두 종류의 CuBr양자구슬을 얻을 수 있음을 알았다. 그리고 β-CuBr에서는 여기자에너지가 온도에 선형적으로 비례하여 변화하나, γ-CuBr에서는 0.00027T²/(T+b)의 형태로 변하였다. QD which average radius is several nm is precipitated by the annealed glass that CuBr semiconductor is uniformly dispersed. We can confirm the precipitataion of QD by a measurement of absorption spectrum. When the radius of QD is larger than 5nm, β-CuBr is obtained through the 2nd heat-treatment of the samples. γ-CuBr is only precipitated as the radius is smaller than 5nm. For γ-CuBr the temperature dependence of exciton energy is nonlinear, that is, 0.00027T²/(T+b) but its of β-CuBr is linear.

관절원판 유착을 동반한 악관절 내장증 환자의 수술후 증상의 변화

김형곤,남광현,박광호,허종기,김일수,최희수 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Purpose: The aim of this study was to find the clinical characteristics of the patients who had temporo-mandibular joint internal derangement(ID) with disc adhesion(adhesion group) compared to only disc displacement without disc adhesion, perforation, hyperemia, and so on(ID group) . Materials and methods: Thirty seven joints were included in adhesion group and 54 joints in ID group of all 174 patients(174 joints) treated surgically and had been checked periodically over 12 months at TMJ clinic of Yongdong Severance Hospital, Yonsei University, between 1992 and 1997. Mouth opening range, pain during mouth opening and biting, headache, neck/shoulder pain and TMJ sound were checked his/her every visit before and after surgery. Results: The maximum mouth opening was improved significantly after postoperative 3 months in two groups(p<0.01), but adhesion group was less improved. Pain during mouth opening was improved significantly over 3 months after surgery in adhesion group(p<0.01), but in ID group 1 month after surgery. Biting pain was improved and maintained it after surgery and not significant difference between two groups. Headache and neck/shoulder pain were much improved after surgery(p<0.01) , but slight relapse was found in adhesion group after 12 months. TMJ sound was more found in adhesion group after 1 month(p<0.05), but after 3 months, no significant difference was found between two groups. Conclusions: The postoperative results of adhesion group were worse than ID group. Therefore, it is considered more carefully to diagnose and treat in cases of internal derangement with adhesion.