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Association among Working Hours, Occupational Stress, and Presenteeism among Wage Workers
Sung-Hwan Jeon,Jong-Han Leem,Shin-Goo Park,Yong-Seok Heo,Bum-Joon Lee,So-Hyun Moon,Dal-Young Jung,Hwan-Cheol Kim 대한직업환경의학회 2014 대한직업환경의학회지 Vol.26 No.-
Objectives: The purpose of the present study was to identify the association between presenteeism and long working hours, shiftwork, and occupational stress using representative national survey data on Korean workers. Methods: We analyzed data from the second Korean Working Conditions Survey (KWCS), which was conducted in 2010, in which a total of 6,220 wage workers were analyzed. The study population included the economically active population aged above 15 years, and living in the Republic of Korea. We used the chi-squared test and multivariate logistic regression to test the statistical association between presenteeism and working hours, shiftwork, and occupational stress. Results: Approximately 19% of the workers experienced presenteeism during the previous 12 months. Women had higher rates of presenteeism than men. We found a statistically significant dose?response relationship between working hours and presenteeism. Shift workers had a slightly higher rate of presenteeism than non-shift workers, but the difference was not statistically significant. Occupational stress, such as high job demand, lack of rewards, and inadequate social support, had a significant association with presenteeism. Conclusions: The present study suggests that long working hours and occupational stress are significantly related to presenteeism.
Leem, Dae-Ho,Choi, Kyeong-Hee,Han, Hye-Suk,Kim, Jun-Hee,Shin, Ji-Ae,Choi, Eun-Sun,Shim, Jung-Hyun,Kong, Gu,Min, Yong-Ki,Nam, Jeong-Seok,Oh, Seung Hyun,Kim, Kyoung-A,Kwon, Ki Han,Cho, Nam-Pyo,Cho, Sung Lippincott Williams Wilkins, Inc. 2010 EUROPEAN JOURNAL OF CANCER PREVENTION Vol.19 No.1
In a previous study, we demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in Korean patients having oral cancer. The goal of this study was to study whether KO-202125 (KO), a sauristolactam derivative in KB human oral squamous carcinoma cells, inhibits the activity of COX-2 enzyme and induces apoptotic cell death. In this study, it was shown that KO inhibited COX-2 mRNA and protein and its catalytic activity (prostaglandin E2), but not COX-1. The antiproliferative effect of KO on KB cells was also examined. The results showed that KO significantly decreased the number of viable cells and showed morphological changes in a concentration-dependent manner. The decrease in cell number was associated with apoptotic cell death evidenced by cleaved poly ADP ribose polymerase (PARP), nuclear fragmentation, sub-G1 population and annexin V positivity. Interestingly, KO is more potent than celecoxib, which is a well-known selective COX-2 inhibitor, although more studies are needed to prove it. Altogether, these results show that KO can act as a potent antioral cancer drug candidate by regulating COX-2 activity.
Relationship of serum lymphocyte with outcomes in chronic obstructive pulmonary disease
( Sung Woo Moon ),( Ah Young Leem ),( Young Sam Kim ),( Ji-hyun Lee ),( Tae-hyung Kim ),( Yeon Mok Oh ),( Sang Do Lee ),( Ji Ye Jung ),( Kold Study Group ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: The role of lymphocyte in the patients with chronic obstructive pulmonary disease (COPD) remains unclear. The purpose of this study was to evaluate the effect of the serum lymphocyte on several clinical parameters, such as lung function, exercise capacity, QOL, exacerbation and mortality in a Korean COPD cohort by repeated and simultaneous measurement of the serum lymphocyte and these clinical parameters. Methods: The study population comprised 451 patients with COPD from the KOLD cohort. Serum lymphocyte percentage (%) were measured every year along with various clinical parameters such as lung function, 6-min walking (6MW) distance, quality of life (CAT and SGRQ score), exacerbations and survival. Serum lymphocyte percentage less than 20% is considered as low lymphocyte. Follow-up data up to 9 years was used for analysis. Results: Among the 451 patients, 409 (90.7%) and 42 (9.3%) were the normal lymphocyte group and low lymphocyte groups at the time of enrollment, respectively. Clustered analysis showed that low lymphocyte group showed lower post-bronchodilator FEV1 (estimated mean=-5.70 % predicted; P=0.001), lower FVC (estimated mean=-5.63 % predicted; P=0.005), shorter 6MW distance (estimated mean=-41.31m; P<0.001), higher CAT score (estimated mean=2.62; P=0.013), and higher SGRQ score (estimated mean=10.10; P<0.001). However, serum lymphocyte % was not associated with frequent acute exacerbation and mortality. Conclusions: Patients with low serum lymphocyte showed low pulmonary function, low 6MW distance, and worse quality of life. Lymphocyte may be related with various conditions in COPD.
Sang Won Choi,Yeon Jeong Jang,Yu Jin Lee,Hyun Hee Leem,Eun Ok Kim 한국식품영양과학회 2013 Preventive Nutrition and Food Science Vol.18 No.4
Four functional constituents, oxyresveratrol 3"-O-β-D-glucoside (ORTG), oxyresveratrol (ORT), t-resveratrol (RT), and moracin (MC) were isolated from the ethanolic extract of mulberry (Morus alba L.) twigs by a series of isolation procedures, including solvent fractionation, and silica-gel, ODS-A, and Sephadex LH-20 column chromatographies. Their chemical structures were identified by NMR and FABMS spectral analysis. Quantitative changes of four phytochemicals in mulberry twigs were determined by HPLC according to cultivar, producing area, and heat processing. ORTG was a major abundant compound in the mulberry twigs, and its levels ranged from 23.7 to 105.5 mg% in six different mulberry cultivars. Three other compounds were present in trace amounts (<1 mg/100 g) or were not detected. Among mulberry cultivars examined, "Yongcheon" showed the highest level of ORTG, whereas "Somok" had the least ORTG content. Levels of four phytochemicals in the mulberry twigs harvested in early September were higher than those harvested in early July. Levels of ORTG and ORT in the “Cheongil” mulberry twigs produced in the Uljin area were higher than those produced in other areas. Generally, levels of ORTG and ORT in mulberry twigs decreased with heat processing, such as steaming, and microwaving except roasting, whereas those of RT and MC did not considerably vary according to heat processing. These results suggest that the roasted mulberry twigs may be useful as potential sources of functional ingredients and foods.
Relationship between occupational sunlight exposure and the incidence of renal cancer
Hyun-Suk Jang,Jong-Han Leem,Seong Soo Jeon,Shin-Goo Park,Sangyoon Lee,Yangwon Kang,Go Choi,Hyung Doo Kim,Hyeonwoo Ju,Sung Wook Jang,Youna Won,Hwan-Cheol Kim 대한직업환경의학회 2019 대한직업환경의학회지 Vol.31 No.-
Background: The risk factors for renal cancer include smoking, obesity, hypertension, and exposure to trichloroethylene. Recent studies have shown that low sunlight exposure increases the risk of developing a range of cancers, including renal cancer. Given that most of the daytime is spent at work, a lack of occupational sunlight exposure can be a risk factor for renal cancer. Therefore, this study examined the relationship between occupational sunlight exposure and the incidence of renal cancer. Methods: This was a university hospital-based case-control study on renal cancer. Of the 706 newly diagnosed patients with renal cell carcinoma (RCC), 633 cases were selected; 73 who had no occupational history were excluded. In addition, 633 controls were selected from the general population after 1:1 matching with respect to sex, age (within 5 years), and residential area (constituency-level). Information on sunlight exposure by the occupational group was referred to data from France. To estimate the association between occupational sunlight exposure and the RCC risk, the odds ratios (ORs) were calculated using conditional logistic regression analysis. Results: Sunlight exposure was divided into quartiles and the risk of RCC was analyzed. The adjusted OR of RCC (OR: 0.664, 95% confidence interval: 0.449–0.983) was significantly lower for the Q4 group than Q1 group but the Q2 and Q3 groups did not show significant results. The risk of RCC tended to decrease with increasing exposure to sunlight (p for trend < 0.028). Conclusions: Higher occupational sunlight exposure reduces the risk of RCC.