Duplication or deletion of chromosome 17p11.2-p12 in CMT1 and HNPP peripheral neuropathy patients

Kim, Hyo-Sun,Jang, Young-Eun,Chung, Ki-Wha 公州大學校 基礎科學硏究所 2003 自然科學硏究 Vol.10 No.-

CMT와 HNPP 말초신경증은 가장 흔하게 발병하는 운동 및 감각 말초신경계의 선천성 질환이다. CMT1과 HNPP의 유전적 원인으로는 염색체 17p11.2-p12의 1.5 Mb 지역의 중복과 결실이 각각 50%이상과 70% 이상을 차지하는 것으로 알려졌다. 본 연구에서 한국인 CMT1 및 HNPP 환자를 대상으로 중복 및 결실을 조사하였는데, 31 CMT1 가족 중 13 가족에서 중복을 보였으며 (42%), 24 HNPP 가족 중 19 가족에서 결실을 보였다 (79%). 17p11.2-p12 중복을 보이는 CMT1A 환자가 HNPP 결실환자보다 발병 연령, 발병 기간, 근육 이양성 및 족 기형성에서 훨씬 심한 증상을 보였다. Charcot-Marie-Tooth disease (CMT) and hereditary neuropathy with liability to pressure palsies (HNPP) are most common inherited motor and sensory peripheral neuropathies. The majority of CMT1 patients have a 1.5 Mb duplication in chromosome 17p11.2 while most HNPP patients have a deletion of the same region. In the analysis of Korean CMT1 and HNPP patients, each HNPP deletion and CMT1A duplication was observed from 79% (19 families) among 24 HNPP families and 42% (13 families) among 31 CMT1 families. CMT1A duplication patients showed more severe clinical symptoms than HNPP deletion patients, when we examined oneset age, disease duration, muscular atrophy, foot deformity and scoliosis.

Korean English Teacher's Disempowerment in English-only Classes

Sung-Sam Hwang,Hyo-Sun Seo,Tae-Young Kim 한국사회언어학회 2010 사회언어학 Vol.18 No.1

Hwang, Sung-Sam, SeD, Hyo-Sun, Kim, Tae-Young. 2010. Korean English Teacher's Disempowerment in English-only Classes: A Case Study Focusing on Korea-specific Cultural Aspects. The Sociolinguistic journal of Korea 18(1). In this case study, we have focused on the disempowerment of a Korean English teacher (KET) in English-only classrooms. Six English as a foreign language (EFL) classrooms in a Korean high school were observed and analyzed by using interpretive discourse analysis. Out of the six classes, three representative classrooms were both video- and audio-taped. The results show that the English-only classes could weaken the KETs' power via three mechanisms: (a) calling the KETs' last name for choral greetings at the beginning of the class, (b) students' group solidarity and peer pressure between classmates, and (c) the students' excessively collaborative approach to peer assistance. It is argued that the exclusive English-only instruction disempowers the KETs' status and dismantles their vocational identity. In order to remedy the current situation, within a scaffolding supported by the eclectic use of first language where necessary for effective class management, KETs are empowered and overcome constraints imposed by the limited L2 oral competence of some non-native English teachers.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

졸·겔法에 의한 TiN 薄膜 製造에 關한 硏究

宣孝任,姜泰範,李奭鎬 상명대학교 논문집 1993 상명대학교논문집 Vol.31 No.-

The polymeric sols were prepared by hydrolysis and polymerization of titanium tetraisopropoxide in diethanolamine. TiO_2 coating films prepared by dip coating of alumina substrate with polymeric sols were heated at various temperature for 7 hours in NH_3 gas. TiN thin films obtained from TiO_2 were investigated by XRD. TiO_2 coating film on alumina substrate was converted into the TiN thin film by nitridation under the flow of NH_3 gas at 1100℃ for 7 hours.

[논문]반응성 골재의 입자 크기와 입도가 모르타르의 알칼리-실리카 반응 팽창에 미치는 영향

전쌍순,이효민,진치섭 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

골재의 알칼리-실리카 반응성을 판정하는 방법으로 모르타르 바 법 (Mortar-Bar method) 이 일반적으로 사용되고 있다. 본 연구에서는 알칼리 골재 반응성을 판정하는 모르타르 바 법 중에서 촉진시험법인 ASTM C 1260 시험방법을 이용하여 반응성 골재를 판별하고l 판별된 반응성 골재의 입자 크기와 입도가 모르타르의 알칼리-실리카 반응 팽창에 미치는 영향에 관하여 검토하였다. 그 결과I 반응성 골재의 입자 크기 및 입도에 상관없이 반응성 골재의 총표면적이 커질수록 팽창률도 증대하여,알칼리-실리카 반웅에 의한 팽창과 반웅성 골재의 총표면적과의 사이에는 상관관계가 있는 것을 확인할 수 있었다.

[논문]재생골재의 광물학적 및 화학적 특성과 동결융해 저항성

전쌍순,이효민,진치섭 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

급속한 산업화와 인구증가 및 대량소비에 따른 페기물에 의하여 초래되는 지구 환경오염을 위한 사회시스템의 구축이 필요함을 암시한다고 볼 수 있다. 본 연구에서는 지금까지 주로 저급재료로 사용되던 재생골재의 구성광물,화학조성 및 물리화학적 특성과 알칼리-골재 반응성 여부를 조사하고, 재생굵은골재의 대체율에 따른 콘크리트 강도와 동결융해 저항성을 검토하여 재생골재의 재활용을 위한 기초자료를 제시하고자 한다. 본 연구에 사용된 재생골재는 천연골재에 비교하여 공학적 기초 물성치에서 현저히 큰 차이는 나타내지 않았으며, 이를 사용한 재생콘크리트의 공학적 특성도 보통 콘크리트의 기준에 근접하는 것으로 나타났다.

고등학생의 자기표현과 자아존중감 향상을 위한 독서요법효과분석

선효원,심혜숙 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-

The purpose of this study is determine effects of the reading therapy program on the self-expression and self-esteem of boy students of academic high schools. For the purpose, this researcher surveyed 2nd-grade boy students of academic high schools located in Busan. All of the surveyed students, 170 in number, were asked to receive self-expression and self-esteem tests before the program is applied. Out of them, 30 who were low in both self-expression and self-esteem were selected. Then out of the thirty, 20 who wanted to participate in the program wore finally selected. Those 20 participants were divided into experimental and control groups, each consisting of 10 members. The reading therapy program used here was first developed by Watson(1994), and adapted by this researcher appropriately. The program was applied on the basis of 2 hours(120 min.) a session. Group activities under the program were made over 10 sessions totally, with 2 session a week based. The control group was not treated in any way over the same sessions. In the study, the following research questions were given. 1. Will the reading therapy program increase self-expression? 2. Will the reading therapy program improve self-esteem? Scales by Rakos & Schroeder were used as a device for measuring the subjects' self-expression. And Coopersmith's scale(1969) was applied to the measurement of the subjects' self-esteem. For data collected here, means of scores obtained from self-expression and self-esteem tests before the application of the program, similarities between the experimental and control groups, means of scores from such tests after the program and differences between the two groups were all processed through t-test. Results of the study can be summarized as follows. 1. The self-expression of the experimental group which participated in the reading therapy program was significantly higher than that of the control group, at the significance level of P < .05. 2. The self-esteem of the experimental group significantly improved more than that of the other group, at the significance level of P < .05. In conclusion, the reading therapy program improved self-expression and self-esteem significantly. This study was carried out on 2nd-grade boy students of academic high schools, so its results are difficult to be generalized. In future, therefore, it is needed to examine effects of the program on the self-expression and self-esteem o high schools for male, female and the both sexes and compare results of the examination.

한국의 SOC와 물류 합리화 방안

이효선 단국대학교 1998 論文集 Vol.32 No.-

In the sight of economic development stage. SOC in Republic of Korea has been requested quantitatively as well as qualitatively. But the lack of SOC and structural fragility transportation cost and trafic expenses, causing the weakness of our industrial competition, and functioning as the decrease of the quality of life. Like this, the cause of much transportation cost and traffic expense is the lack of investment and divers financial deficiency. If we survey the cause of the difficulty, we can point out the worst standard of traffic and transportation structure(29 among 41 countries) as foundational stock accumulation for 30 years. Also, because investment financial resources depend on government, constant investments cannot be formed safety. The result was formed unbalanced investments for practical necessary parts. Also, because traffic facilities management and operation was maintained by government, the efficiency of traffic facilities was obstructed greatly. For the solution of traffic difficulties, the emphasis on the goal of traffic and transportation parts in the future 2011 is oftening the good traffic and transportation service which bear comparison with developed countries. The emphasis on traffic and transportation service which satisfy rapidly, stability as well as the increase of quantitative facilities as public goods. By 2011, domestic transportation will estimate 1,2 doubles, freights 1.7 doubles. Because of the expansion of the international interchange, passengers will estimate 4 doubles, freighs 6 doubles. From 1996 to 2011, gross investment will estimate about 364 billion : the financial share 15 billion 2000 million the private share 121 billion. Expect for the anticipation of new investment of transportation parts, the transportation facilities in the early 1960's will advent the time of exchange. For example, by 2011, yearly investment will increase about 10 percentage. Except for new investment, we must consider new additional investment and maintainable investment. Accordingly, we must excape from the past investment from which only depend on finance must find out diverse investment resource.

조리학 전공 대학생들의 인턴쉽 기대와 만족에 관한 연구

정효선,윤혜현 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.3

This study investigated the degree of expectation and satisfaction with internship program of undergraduates majoring in culinary studies, and suggested improvements in satisfaction for training programs. Differences between expectation and satisfaction were significant in all 21 items including pay for internship program, rest spaces, and break time during working. Expectation questions were extracted to five factors. Factor 1 circumstances of kitchen Factor 2 staff's ability and attitude Factor 3 working environment Factor 4 working hours and pay and Factor 5 rotation, period, and placement of jobs. Five factors were also obtained from factor analysis of satisfaction. Factor 1 working hours and rest Factor 2 staff's attitude and pay Factor 3 facilities and sanitation Factor 4 circumstances of kitchen and Factor 5 period and placement of jobs. Overall satisfaction values showed significant differences depending on gender, school-year system, grade, age, and school. The working hours and rest factor had the most significant influence on the overall satisfaction with internship program of undergraduates majoring in culinary studies.

전통 떡류에 대한 대학생들의 이용 현황에 관한 연구

정효선,서경화,신민자 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.1

The purpose of this study was to investigate the consumption patterns of traditional Korean rice cake among college students. Self administered questionnaires were collected from 512 college students in the Seoul, Kyunggi, Chungchung, Kyungsang, Junla and Gangwondo areas. The data were statistically analysed using frequency analysis, chi-squared and t-tests and a one-way ANOVA. By examining the results of the student's perceptions of traditional Korean rice cake, it was found that most knew little, or only a moderate amount, about this type of food. Meanwhile, more than half the students liked traditional Korean rice cake, as this type of food satisfied their need for a traditional Korean taste, while the reason for disliking was that they were more familiar with western-style confectionary. Most students answered that they only ate traditional Korean rice cake on special occasions, such as big holidays or ceremonies for the dead ancestors. Most answered that they bought those foods at conventional markets, the mile in the neighborhood, (Eds note: I don't understand, do you mean, "within a mile of their neighborhood"?) or atbig malls. The factor they considered the most important at the time of purchase was the quality(taste), which demonstrates the need for the development of traditional Korean rice cakes, with new tastes and shapes, which still satisfy the Korean's taste, whilemaintaining the traditional taste. For the questions that asked about the problems faced by the traditional Korean rice cake manufacturing industry, and the reasons for low consumption, the students responded that buying this type of food was difficult as the outlets selling themwere not easy to find. Our results seem to suggest that there are almost no specialty stores for the sale of traditional Korean rice cake compared to the other types of cakes that are scattered all over the country. (Eds note: this is only my opinion, and I maybe wrong, but I would have though that trying to market traditional Korean rice cakes at local convenience stores, rather than specially stores, would make them more available to the general public. Their marketing at speciality stores will maintain the status quo, i.e. people will go to the speciality stores to purchase product for holidays and special occasions, wheras they will go to the local convenience stores to buy general everyday snacks etc.)