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고위험 자궁경부암의 수술 후 보조요법으로서 Paclitaxel 과 Carboplatin 동시 항암화학방사선요법의 효능과 안전성
조현일 ( Jo Hyeon Il ),김재원 ( Kim Jae Won ),박노현 ( Park No Hyeon ),송용상 ( Song Yong Sang ),강순범 ( Kang Sun Beom ),이효표 ( Lee Hyo Pyo ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.5
목적 : 일차적 치료로 수술을 받은 고위험 자궁경부암 환자에서 paclitaxel과 carboplatin 동시 항암화학방사선요법의 임상적 효과와 부작용을 평가하고자 하였다. 연구 방법 : 서울대학교병원 산부인과에서 진단받은 FIGO 병기 IB1-IIB 환자 중 2002년 2월부터 2002년 11월 사이의 기간동안 수술 후 보조요법으로 paclitaxel/carboplatin 동시 항암화학방사선요법을 받은 28명의 환자들이 후향적으로 조사되었다. 병리 소견상 림프절 전이가 있거나 또는 림프혈관 전이, 자궁경부 전층 침범, 종양 직경 4cm 이상의 위험인자 중 2가지 이상에 해당하는 환자를 동시 항암화학방사선요법의 대상으로 하였다. 항암화학요법은 4주 간격으로 2주기가 시행되었으며 paclitaxel 135 mg/m^2을 정주 후 carboplatin을 AUC 4.5의 용량으로 정주하였다. 방사선 치료는 항암화학요법 제 1일에 맞춰 시작되었다. 치료 효과는 부인과적 진찰, 자궁경부 세포진 검사, 골반 전산화 단층촬영, 종양표지자 검사 (SCCA)를 통해 재발의 유무로 판정되었다. 치료에 의한 부작용은 NCI-CTC version 2.0에 따라 분류되었다. 결과 : 연구에 포함된 28명의 환자들에게 총 56주기의 paclitaxel/carboplatin 항암화학요법이 방사선치료와 함께 시행되었다. 치료를 받은 환자 중 6-33개월의 (평균 12.5개월) 추적관찰 기간 중 자궁경부암의 진행이나 재발의 예는 없었다. 가장 중요하고 흔한 부작용은 혈액학적 독성이었으며 grade 3, 4의 호중구 감소증이 15예 Grade 1,2의 말초 신경 독성이 8예 (14.3%) 관찰되었다. 결론 : 고위험 자궁경부암환자에서 수술 후 보조요법으로 paclitaxel/carboplatin 동시 항암화학요법은 국소 재발 억제에 효과가 있으며 혈액학적 부작용이 문제가 되지만 수용 가능한 정도라고 사료된다. 그러나 장기 무병 생존율에 관한 좀 더 대규모의 전향적 무작위 임상연구가 필요하리라고 생각된다. Objective : To evaluate the efficacy and safety of concurrent chemotherapy of paclitaxel and carboplatin with standard pelvic radiotherapy as adjuvant therapy after primary surgery in high-risk cervical cancer. Methods : Twenty-eight patients with FIGO stage IB1-IIB cervical cancer who received adjuvant concurrent chemoradiotherapy with paclitaxel and carboplatin from February 2000 to November 2001 were analyzed retrospectively in this study. Adjuvant chemoradiotherapy was done if there were lymph node involvement or at least 2 positive findings among following risk factor; lymphovascular space invasion, full-thichness involvement of cervix and tumor size larger than 4 cm in diameter. Two cycles of paclitaxel 135 mg/m^2, followed by carboplatin with AUC of 4.5 were administered intravenously with an interval of at least 4 weeks. The radiotherapy was initiated concurrently at the first day of chemotherapy. The therapeutic results were evaluated by pelvic examination, Pap smear, SCCA (Squamous cell carcinoma antigen) and computed tomography (CT). The toxicities of the treatment were evaluated and graded by NCI-CTC version 2.0. Results : Total 56 cycles of paclitaxel/carboplatin chemotherapy with concomitant pelvic radiotherapy was delivered. None of the patients had a progressive or recurrent disease during the follow-up period ranging from 6 to 33 months (median: 12.5 months). Neutropenia was the most common and concerned toxicity. Fifteen cases of grade 3 and 4 neutropenia (26.8%) were observed. Non-hematologic toxicities were mild and mainly related to neurologic or gastrointestinal symptoms. Eight cases of grade 1 and 2 neurotoxicity were observed (14.3%). Conclusion : The adjuvant chemoradiotherapy with paclitaxel and carboplatin seems to be effective and well-tolerated for the treatment of high risk group cervical cancer after primary surgical therapy. But a large randomized study with longer duration of follow-up is needed to justify this conclusion.
다발성 외상 환자에서 Emergency Room Transfusion Score (ETS)를 이용한 응급수혈의 예측인자
조현규 ( Hyeon Kyu Jo ),박용진 ( Yong Jin Park ),김선표 ( Sun Pyo Kim ),김성중 ( Seong Jung Kim ),조수형 ( Soo Hyung Cho ),조남수 ( Nam Soo Cho ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.1
Purpose: The purposes of this study are finding the elements for a fast determination of the need for a transfusion to a multiple trauma patient arriving at this clinic in the initial stage establishing objective bases for a doctor in an emergency department to determine the need for a transfusion immediately after a patient has arrived at the emergency department, and providing treatment by considering various factors based on the nine criteria suggested in the emergency room transfusion score (ETS). Methods: This study was conducted on 375 multiple-trauma patients who visited the Chosun University Hospital Emergency Medical Center and activated the Emergency Trauma Team from January 2010 to December 2013. The patients were divided into the transfused group and the non-transfused group by retrospectively analyzing their medical records. Subsequently, the medical records were examined using the nine items suggested by the ETS and the results were analyzed. Results: Three hundred seventy-five patients with multiple traumas visited the Chosun University Hospital Emergency Medical Center and activated the Emergency Trauma Team. Among them, 258 died and 117 recovered and left the hospital. The deceased patients consisted of 182 males and 76 females with an average age 45. Of the 375, 165 were transferred from other hospitals, and 245 were blunt trauma patients. One hundred sixty-nine patients were injured in traffic accidents, and 119 of those 169 who had systolic blood pressure less than 90 mm Hg died. Two hundred twenty-six (60.3%) out of the 375 patients with multiple traumas receivedan emergency blood transfusion and their average age was 48. The 375 patients consisted of 156 males, 151 who had been transferred from other hospitals, 218 who presented with blunt trauma, 134 who had been injured in traffic accidents, 156 who had a systolic blood pressure less than 90 mm Hg, 134 who scored higher than 9 points on the GCS, and 162 who had a stable pelvic fracture of these 143 died. Conclusion: During this study, 226 (60.3%) out of the patients with multiple traumas received an emergency blood transfusion. After analyzing the results related to emergency blood transfusion by using ETS, we found that an emergency blood transfusion had to be prepared quickly when patients were transferred from other hospitals when the systolic blood pressure was less than 90 mmHg. when abnormalities had been detected by ultrasonography and when the patient presented with a stable pelvic fracture. [ J Trauma Inj 2015; 28: 1-8 ]
Choi Da Hyeon,Kang Seong Ki,Lee Kyeong Eun,Jung Jongsun,Kim Eun Ju,Kim Won-Ho,Kwon Young-Guen,Kim Kwang Pyo,Jo Inho,박윤신,Park Sang Ick 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.6
BACKGROUND: Beating cardiomyocyte regeneration therapies have revealed as alternative therapeutics for heart transplantation. Nonetheless, the importance of nitric oxide (NO) in cardiomyocyte regeneration has been widely suggested, little has been reported concerning endogenous NO during cardiomyocyte differentiation. METHODS: Here, we used P19CL6 cells and a Myocardiac infarction (MI) model to confirm NO-induced protein modification and its role in cardiac beating. Two tyrosine (Tyr) residues of b2-tubulin (Y106 and Y340) underwent nitrosylation (Tyr-NO) by endogenously generated NO during cardiomyocyte differentiation from pre-cardiomyocyte-like P19CL6 cells. RESULTS: Tyr-NO-b2-tubulin mediated the interaction with Stathmin, which promotes microtubule disassembly, and was prominently observed in spontaneously beating cell clusters and mouse embryonic heart (E11.5d). In myocardial infarction mice, Tyr-NO-b2-tubulin in transplanted cells was closely related with cardiac troponin-T expression with their functional recovery, reduced infarct size and thickened left ventricular wall. CONCLUSION: This is the first discovery of a new target molecule of NO, b2-tubulin, that can promote normal cardiac beating and cardiomyocyte regeneration. Taken together, we suggest therapeutic potential of Tyr-NO-b2-tubulin, for ischemic cardiomyocyte, which can reduce unexpected side effect of stem cell transplantation, arrhythmogenesis.
포스터 전시 : 췌담도 ; 간이식후 합병된 Biliary cast syndrome에 의한 폐쇄성 황달 1예
백상현 ( Baeg Sang Hyeon ),최호순 ( Choe Ho Sun ),조경란 ( Jo Gyeong Lan ),김종표 ( Kim Jong Pyo ),이오영 ( Lee O Yeong ),손주현 ( Son Ju Hyeon ),한동수 ( Han Dong Su ),함준수 ( Ham Jun Su ),이민호 ( Lee Min Ho ),이동후 ( Lee Dong 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<서론> 간이식후에 발생될 수 있는 담도계의 합병증은 16~35% 정도로 보고되고 있다. 가장 빈도가 높은 합병증으로는 담즙누수(Bile leak), 문합부 협착 등을 들 수 있으며, 그 외에도 T-관 누수, 담석증, biliary cast sydrome 등을 들 수 있다. 특히 biliary cast syndrome은 간이식후 생기는 후기 담도계 합병증으로 드물게 세계적 보고는 있었으나 국내보고가 미흡한 실정이다. 대개 내시경적 역행성 담도 조영술을
남궁현,이임표,이조웅,NamGung, Hyeon,Lee, Im Pyo,Lee, Jo Ung Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.11
The dipolar effect of neighboring protons that are not directly bonded to the carbon of interest on coupled carbon-13 relaxation in a simple organic molecule has been studied by comparing the relaxation behaviors of labeled carbon-13 in $Br13CH_2COOH$ with those in $BrCH_213COOH.$ Various pulse sequences, such as coupled inversion recovery pulse sequence, J-negative and J-positive pulse sequence, and nonselective and selective proton ${\pi}pulse$ sequence, were employed to perform the required coupled spin relaxation experiments. To gain information on various spectral densities, including that of dipolar-CSA cross correlation, the experiments were performed on two different spectrometers, operating, respectively, at 50.31 and 125.51MHz for 13C. The magnitude of CH dipolar spectral densities for $BrCH_213COOH$ was found to be about 8% of those for $Br13CH_2COOH$, which means the effect due to the protons not directly bonded to the carbon of interest is small but not completely negligible.