http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hyeon-Suk Ham(함현숙),Se-Yeul Lee(이세열),Dong-Wan Lee(이동완),Jong-Hwan Seong(성종환),Han-Soo Kim(김한수),Dong-Seob Kim(김동섭),Young-Guen Lee(이영근) 한국생명과학회 2012 생명과학회지 Vol.22 No.9
비파 잎의 항산화 활성을 탐색하고 활성물질을 분리하여 규명하기 위하여, 동결 건조한 비파 잎을 마쇄하여 n-hexane, ethyl acetate (EtOAc)와 methanol (MeOH)로 용매 분획하였다. 각 추출물에 대하여 정량적으로 DPPH 소거활성, SOD 유사활성을 측정하고, 페놀 화합물과 플라보노이드 함량을 측정하였으며, 각 용매에 따른 추출물 중 비교적 활성이 강한 EtOAc 추출물과 MeOH 추출물에 대하여 column chromatography를 이용하여 얻은 분획물들 중 강한 활성을 보인 각 1개의 분획물에서 3개의 화합물을 분리하였으며, GC/MS 분석에서 phytol, β-sitosterol 및 (-)-Loliolide으로 동정하였다. To investigate potential medicinal or functional uses of Eriobotrya japonica, this study focused on the isolation and identification of antioxidant compounds from Eriobotrya japonica leaves. Various solvents were extracted from the leaves, and their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals was measured, in addition to their superoxide dismutase-like activity, polyphenol compounds, and flavonoid content. Ethyl acetate extract exhibited the strongest scavenging effect in a 0.2 mM solution of DPPH (63.24±2.20%, 81.83±2.10%, and 93.15±2.31% in 0.3, 0.7, and 1.0 mg/ml sample concentrations, respectively). The antioxidant effect of the ethyl acetate extract and methanol extract were generally stronger than that of n-hexane extract. The extracts were further purified by repeated silica gel column chromatography. The antioxidant compounds were identified as phytol, β-sitosterol, and (-)-loliolide using GC/MS.
( Hyeon Joo Ham ),( In Jun Yeo ),( Seong Hee Jeon ),( Jun Hyung Lim ),( Sung Sik Yoo ),( Dong Ju Son ),( Sung-su Jang ),( Haksup Lee ),( Seung-jin Shin ),( Sang Bae Han ),( Jae Suk Yun ),( Jin Tae Hon 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.1
Recently, increasing evidence suggests that neuroinflammation may be a critical factor in the development of Parkinson’s disease (PD) in addition to the ratio of acetylcholine/dopamine because dopaminergic neurons are particularly vulnerable to inflammatory attack. In this study, we investigated whether botulinum neurotoxin A (BoNT-A) was effective for the treatment of PD through its anti-neuroinflammatory effects and the modulation of acetylcholine and dopamine release. We found that BoNT-A ameliorated MPTP and 6-OHDA-induced PD progression, reduced acetylcholine release, levels of IL-1β, IL-6 and TNF-α as well as GFAP expression, but enhanced dopamine release and tyrosine hydroxylase expression. These results indicated that BoNT-A had beneficial effects on MPTP or 6-OHDA-induced PD-like behavior impairments via its anti-neuroinflammation properties, recovering dopamine, and reducing acetylcholine release.
( Suk Hyeon Jeong ),( Su Young Kim ),( Hyun Lee ),( Jun Soo Ham ),( Keum Bit Hwang ),( Subin Hwang ),( Sun Hye Shin ),( Myung Jin Chung ),( Seung Heon Lee ),( Sung Jae Shin ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.
Jeong, Suk Hyeon,Kim, Su-Young,Lee, Hyun,Ham, Jun Soo,Hwang, Keum Bit,Hwang, Subin,Shin, Sun Hye,Chung, Myung Jin,Lee, Seung Heon,Shin, Sung Jae,Koh, Won-Jung The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.
〈속보논문〉 가공 송전 철탑기초 설계 및 시공 방법 연구
張石漢(Suk-Han Jang),金熙光(Hee-Kwang Kim),李康現(Kang-Hyeon Lee),韓炅洙(Kyung-Soo Han),咸邦郁(Bang-Wook Ham),丁沂善(Ki-Sun Chung) 대한전기학회 2007 전기학회논문지 Vol.56 No.6
Electric transmission lines pass through a variety of area. Foundation supporting the conductors and tower are selected properly in accordance with external load, for example dead load, wind load, snow load, construction load etc, and topography and geology condition. Typical types of foundation are as follows: pad foundation for small load and hard soil or rock in mountainous area, pile foundation for medium or large load and soft soil in plain field area. This paper introduced cylindrical foundation design & construction for large load and mountainous area. This foundation failure mode against pulling-out show splitting failure by tensile force toward circumferential direction.
COVID-19 상황에서 태권도 운동지속 모색 : 지도자 인식에 대한 계층구조분석
유현상 ( Yoo Hyeon-sang ),이석용 ( Lee Suk-yong ),함은주 ( Ham Eun-ju ),한동욱 ( Han Dong-wook ) 국기원 2022 국기원태권도연구 Vol.13 No.2
목적 본 연구는 COVID-19 상황에서 태권도 운동지속을 위한 지도방안의 우선순위를 도출하여, 태권도 지도자들에게 의미있는 자료제공과 함께 태권도장의 활성화를 위한 지도방안을 제공하는데 목적이 있다. 방법 본 연구는 측정항목 및 계층구조 설정을 위해 전문가 5인과 함께 선행연구 및 문헌 검토 후 쌍대비교가 가능한 설문지를 도출하였으며, 지도자를 대상으로 직접방문 또는 이메일 통하여 총 40부의 설문을 진행하였다. 자료 분석을 위해 SPSS Win Ver. 27.0과 Microsoft Office Excel 2016을 사용하였다. 결과 첫째, 평가요인의 상대적 중요도 분석 결과, 지도방법, 프로그램, 지도자의 특성 순으로 나타났다. 둘째, 평가요인별 상대적 중요도 분석 결과, 지도자 특성은 지도자의 이미지, 지도방법은 동기부여, 프로그램은 수련 내용, 온·오프라인 수련은 오프라인 수련, 방역은 소독 및 체온, 홍보는 SNS 홍보, 시설은 접근성이 가장 높은 상대적 중요도를 가진 것으로 나타났다. 마지막으로, 복합가중치의 경우 동기부여, 수련내용, 명확한 설명 순으로 나타났다. 결론 지도자가 인식하는 운동지속을 위한 요인은 동기부여와 수련내용이며, 지도자는 다양한 수련 내용을 통해 수련생의 태권도에 대한 몰입과 흥미를 유도해야 하며, 자율성을 지지하는 동기부여를 통해 학습참여를 유도하면 긍정적인 결과가 나타날 것으로 사료된다. Purpose The purpose of this study is to derive the priority of the guidance plan for continuing the Teakwondo movement in the COVID-19 situation, and to provide meaningful data to Teakwondo leaders and to provide guidance plans for the revitalization of the Teakwondo gym. Method In this study, to establich measurement items and hierarchical structure, after reviewing previous studies and literature with 5 experts, a questionnaire was drawn that enables pairwise comparison. SPSS WIN Ver. 27.0 and Microsoft Office Excel 2016 were used for data process. Results First, as a result of analyzing the relative importance of evaluation factors, guidance methods, programs, and characteristics of leaders appeared in order. Second, as a result of analyzing the relative importance of sub-factors by evaluation factor, it was found that the leader’s image, motivation in guidance method, training content in programs, offline training in on/offline training, disinfection and body temperature in quaratine, SNS promotion in promotion, and accessibility in facilities. Lastly, the composite weight were higher in the order of motivation, training conternt and clear explanation. Conclusion The factors for continuation of exercise by the leader are motivation and training contents. The leader should induce the trainees’ immersion and interest in Taekwondo through various training contents, and induce learning participation through motivation that supports autonomy. It is believed that this will lead to positive result.
함시영,성숙환,김주현,Ham, Si-Yeong,Seong, Suk-Hwan,Kim, Ju-Hyeon 대한흉부심장혈관외과학회 1987 Journal of Chest Surgery (J Chest Surg) Vol.20 No.4
From Nov. 1980 to Jun. 1987, 270 primary lung cancer patients were operated on at the department of Thoracic & Cardiovascular Surgery, Seoul National University Hospital. There Were 223 males & 47 females with 55.5 years of mean age. There were 151 [55.9%] squamous cell ca., 43 [18.8%] adenoca., 8 [3.5%] undiff. large cell, 9 [3.9%] undiff. small cell ca. & 18 [7.9%] mixed type, and also composed of 65 [28.3%] stage I, 31 [13.5%] stage II and 133 [58.1%] of stage III cases. They received 78 [34.1%] lobectomies, 62 [27.1%] pneumonectomies and 60 [26.2%] exploratory thoracotomies with 70% resectability rate. The five year actuarial survival rate of all patients was 37%. According to TNM stage, five year survival rate of the patients in stage I was 71%, those of stage II was 29% and of stage III 21%. According to histological cell type, five year actuarial survival rate of the squamous cell ca. was 35%, of adenoca. 49%, of undiff. large cell. 22%, 2 year survival rate of undiff. small cell was 31% and 3 year survival rate of mixed type was 47%. Hospital death was 2 case with a 1.3% early postop. mortality rate.
혈액종양 : 다발성 전이를 동반한 설암 환자의 골격근전이와 β-HCG 상승 1예
함준수 ( Jun Soo Ham ),황금빛 ( Keum Bit Hwang ),황수빈 ( Subin Hwang ),정숙현 ( Suk Hyeon Jeong ),이지윤 ( Ji Yun Lee ),이세훈 ( Se Hoon Lee ),박근칠 ( Keunchil Park ) 대한내과학회 2015 대한내과학회지 Vol.89 No.6
Metastases to skeletal muscle and paraneoplastic syndromes involving β-human chorionic gonadotropin (HCG) production are an extremely rare manifestation of head and neck squamous cell carcinoma. We report a patient with a β-HCG-secreting squamous cell carcinoma of the tongue with diffuse metastases involving skeletal muscle. A 47 year old female, who was being treated heavily with palliative chemotherapy for metastatic tongue cancer, was admitted with a palpable thigh mass and pain. A magnetic resonance image showed an intramuscular metastasis in the thigh. Ultrasound-guided biopsy of the thigh mass confirmed metastatic squamous cell carcinoma. She was scheduled for enrollment into a clinical trial; however, a positive serum β-HCG test was noticed. There was no evidence of pregnancy or a trophoblastic or non-trophoblastic tumor secreting β-HCG. Finally, she was revealed to have a paraneoplastic syndrome with diffuse metastases and was ultimately referred for palliative care. We review the literature of previously reported cases of an increase of β-HCG in patients with head and neck cancer. (Korean J Med 2015;89:719-722)