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( Jun Hou ),( Xiangmo Zhao ),( Fei Hui ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
High peak-to-average power ratio (PAPR) of transmitted signals is a major drawback in Multicarrier modulation (MCM) systems. Companding transform is a well-known method to reduce the PAPR without restrictions on system parameters such as the number of subcarriers, frame format and constellation type. In this paper, a novel adaptive companding scheme, mainly focuses on compressing the large signals into the desirable distribution, is proposed to reduce the PAPR with low implementation complexity. In addition, formulas to calculate its PAPR and bit error rate (BER) performance are also derived. Simulation results confirm that the proposed scheme can achieve an effective tradeoff between PAPR reduction and BER performance by carefully choosing the companding parameter.
Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory
Zhao, Ming-Gao,Toyoda, Hiroki,Lee, Yong-Seok,Wu, Long-Jun,Ko, Shanelle W.,Zhang, Xue-Han,Jia, Yongheng,Shum, Fanny,Xu, Hui,Li, Bao-Ming,Kaang, Bong-Kiun,Zhuo, Min Elsevier 2005 Neuron Vol.47 No.6
<P><B>Summary</B></P><P>Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD induction in the hippocampus. However, LTP in the prefrontal cortex is less well characterized than in the hippocampus. Here we report that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol. Furthermore, pharmacological or genetic blockade of the NR2B subunit in the cingulate cortex impaired the formation of early contextual fear memory. Our results demonstrate that the NR2B subunit of the NMDA receptor in the prefrontal cortex is critically involved in both LTP and contextual memory.</P>
A newly recorded genus Tanvia Solovyev & Witt, 2009 from China (Lepidoptera: Limacodidae)
Jun Wu,Ting-Ting Zhao,Hui Lin HAN 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.1
A genus Tanvia Solovyev & Witt, 2009, belonging to family Limacodidae, is reported for the first timefrom Yunnan province, China, with redescription of a newly recorded species: T. zolotuhini Solovyev &Witt, 2009. In this study, illustrations of adults and genitalia of the species and the distribution areprovided.
Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases
Zhao, Xinxia,Ni, Wei,Chen, Chuangfu,Sai, Wujiafu,Qiao, Jun,Sheng, Jingliang,Zhang, Hui,Li, Guozhong,Wang, Dawei,Hu, Shengwei Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3
Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass in sheep. The objectives were to investigate whether myostatin gene can be edited in sheep by transcription activator-like effector nucleases (TALENs) in tandem with single-stranded DNA oligonucleotides (ssODNs). We designed a pair of TALENs to target a highly conserved sequence in the coding region of the sheep MSTN gene. The activity of the TALENs was verified by using luciferase single-strand annealing reporter assay in HEK 293T cell line. Co-transfection of TALENs and ssODNs oligonucleotides induced precise gene editing of myostatin gene in sheep primary fibroblasts. MSTN gene-edited cells were successfully used as nuclear donors for generating cloned embryos. TALENs combined with ssDNA oligonucleotides provide a useful approach for precise gene modification in livestock animals.
Analysis of deliverability data in shale gas reservoirs: pseudo-pressure and pressure employed
Zhao, Chaojie,Li, Jun,Zhang, Hui 한국자원공학회 2019 Geosystem engineering Vol.22 No.4
Forecasting deliverability in shale gas reservoirs accurately has received much attention in the industry in recent years. Most wells in shale gas reservoirs are horizontal with multiple fractures, and it has been widely recognized that the dominant early flow regime is usually long-duration transient flow. The most popular method for analyzing linear flow is the plot of rate-normalized pressure versus square root of time, where the pseudo-pressure is employed for gas. However, the pseudo-pressure employed approach is difficult to handle by hand than the pressure employed approach. The purpose of this work is to evaluate the accuracy of pseudo-pressure employed method for analyzing gas rate in shale gas reservoirs, and establish which method is the most simple and accurate for reserve estimation. Based on a number of numerically simulated cases, comparisons between the pseudo-pressure and pressure employed methods for estimating gas rate are made. It is shown that the pressure employed method yields the gas rate that not quite accurately match the simulated values, however, as the same general parameters, the pseudo-pressure employed method really does not improve this inaccuracy. Accordingly, the pressure employed approach is a good and simple method for forecasting gas rate. In addition, depending on the simple hand method, a modification approach is proposed by incorporating constant factors to forecast the gas rate with more confidence. This work will provide an efficient guidance to assist analysts in evaluating hydrocarbon deliverability rapidly and efficiently in shale gas reservoirs.
Hui-wen Xiao,Yuan Li,Dan Luo,Jia-li Dong,Li-xin Zhou,Shu-yi Zhao,Qi-sheng Zheng,Hai-chao Wang,Ming Cui,Sai-jun Fan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In the present study, we found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine. Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure. Additionally, high-throughput sequencing showed that hydrogen-water oral gavage resulted in retention of the TAI-shifted intestinal bacterial composition in mice. Collectively, our findings suggested that hydrogen-water might be used as a potential therapeutic to alleviate intestinal injury induced by radiotherapy for abdominal and pelvic cancer in preclinical settings.
Controllable tuning of the electronic transport in pre-designed graphene nanoribbon
Hui Zeng,Jun Zhao,Jianwei Wei,Dahai Xu,J.-P. Leburton 한국물리학회 2012 Current Applied Physics Vol.12 No.6
We make use of ab initio density functional theory calculation to explore the electronic and transport properties of zigzag-edged graphene nanoribbon (ZGNR) with peculiar designed electronic transport channels by tailoring the atomic configuration of the nanostructure. Tailoring the atomic structure has significant influences on the electronic transport of the defective nanostructure, and eventually the metal-semiconducting transition are identified with the increasing number of missing atoms. Our results demonstrate that pre-designed graphene nanoribbon by selective tailoring with high precision is expected to be served as the basic component for nanoelectronic device.
Hui Sun,Qing Chang,Ya-Shu Liu,Yu-Ting Jiang,Ting-Ting Gong,Xiao-Xin Ma,Yu-Hong Zhao,Qi-Jun Wu 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1
Purpose The evidence of adherence to cancer prevention guidelines and endometrial cancer (EC) risk has been limited and controversial. This study summarizes and quantifies the relationship between adherence to cancer prevention guidelines and EC risk. Materials and Methods The online databases PubMed, Web of Science, and EMBASE were searched for relevant publications up to June 2, 2020. This study had been registered at PROSPERO. The registration number is CRD42020149966. Study quality evaluation was performed based on the Newcastle-Ottawa Scale. The I2 statistic was used to estimate heterogeneity among studies. Egger’s and Begg’s tests assessed potential publication bias. Summary hazard ratios (HRs) and 95% confi dence intervals (CIs) for the relationship between adherence to cancer prevention guidelines score was assigned to participants by summarizing individual scores for each lifestyle-related factor. The scores ranged from least healthy (0) to most healthy (20) and the EC risk was calculated using a random-effects model. Results Five prospective studies (four cohort studies and one case‑cohort study) consisted of 4,470 EC cases, where 597,047 participants were included. Four studies had a low bias risk and one study had a high bias risk. Summary EC HR for the highest vs. lowest score of adherence to cancer prevention guidelines was 0.54 (95% CI, 0.40 to 0.73) and had a high heterogeneity (I2=86.1%). For the dose-response analysis, an increment of 1 significantly reduced the risk of EC by 6%. No signifi cant publication bias was detected. Conclusion This study suggested that adherence to cancer prevention guidelines was negatively related to EC risk.
Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.