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김병현 ( Byung Hyun Kim ),한건연 ( Kun Yeon Han ) 한국지리정보학회 2009 한국지리정보학회지 Vol.12 No.3
A lot of efforts have been made to resolve balancing problems between flux and source term and most finite volume models under development have been applied to simple channels such as imaginary and experimental channels. However, a number of numerical problems which can not be found in simple channels occur in the application to natural rivers and the problems should be resolved to apply finite volume models to natural rivers. In this study, 2D finite volume model which is applicable to natural rivers was developed and the accuracy of the developed model was validated through the application of partial dam break In addition, a simple and efficient 2D mesh generation method was suggested and the method can be accurately reflected to 2D mesh converted from surveyed cross sections in Han-river using GIS. The accuracy and applicability of the developed model on natural rivers were verified by performing simulation on Han-river using the generated mesh and comparing computed water elevation with measured water elevation.
Quinolone Alkaloids from Evodiae Fructus and Their Inhibitory Effects on Monoamine Oxidase
Han, Xiang-Hua,Hong, Seong-Su,Lee, Dong-Ho,Lee, Jung-Joon,Lee, Moon-Soon,Moon, Dong-Cheul,Han, Kun,Oh, Ki-Wan,Lee, Myung-Koo,Ro, Jai-Seup,Hwang, Bang-Yeon 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1 -methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-unde-cenyl]-4(1 H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.
유리간세포를 사용한 ANS 의 간내 이행에 관한 연구 : ANS 의 간내 이행과정에 단백질 매개 기구가 존재하는가 ?
한건,정연복,육동연 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.1
The hepatic uptake of an anionic fluorescence probe, 1-anilino-8-naphthalene sulfonate (ANS) was characterized using isolated rat hepatocytes. The initial uptake rate of ANS by isolated hepatocytes was determined. The uptake process of ANS was fitted well to the Michaelis-Menten equation with a saturable component. The V_(max) and K_m values were 2.9±0.1 n㏖/min/㎎ protein and 29.1±3.2 μM, respectively. The uptake clearance (CL_(up)) based on the ratio of V_(max) to K_m was 11.7 ㎖/min/g liver, revealing the good coincidence with that assessed from the analysis of the plasma disappearance curve in previous report. Forthermore, the effect of serum protein on the hepatic uptake of ANS into isolated hepatocytes was investigated. The permeability clearances (PS_(inf)) of ANS uptake were much higher than those predicted based on the unbound fractions in the presence of serum. These suggested that the hepatic uptake of extensively serum protein-bound ANS is mediated not only by the unbound form of ligand but also by the serum protein-mediated uptake mechanism.
유기 음이온계 약물의 간내 이행과정에 있어서 Cytoskeleton 의 역할에 관한 속도론적 연구
한건,정연복,육동연 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1
The effects of colchicine on the plasma elimination and biliary excretion of various organic anions in rats were examined. Elimination of indocyanine green (ICG) or rose bengal (RB) from plasma was significantly delayed when rats were treated with colchicine (3 ㎎/㎏ body weight) 3 hr prior to the administration of the dye. On the other hand, disappearance of sulfobromophthalein (BSP) or bromophenol blue (BPB) from plasma was not influenced by colchicine. The plasma disappearance and biliary excretion of organic anions were kinetically analyzed based on a compartment model, in which the deep compartment and the unknown disposition are incorporated. The transfer rate constants of ICG or RB, k_(23) (from the liver to the deep compartment) and k_(3B) (from the deep compartment to the bile), were decreased by colchicine, but those of BSP or BPB were not changed. A mechanism for the decrease in the k_(23) and k_(3B) values for ICG and RB might be explained by a inhibition of colchicine to the intracellular cytoskeleton. The hepatocellular distribution of RB or BPB was then determined. BPB mainly distributed to the cytosolic fraction, but RB distributed to each hepatocyte organelle. Taken together, it was suggested that ICG or RB is transported through hepatocytes into bile with the aid of the cytoskeleton, whereas BSP or BPB is handled by hepatocytes in a different way.
시판 지각으로부터 Hesperidin의 분리 및 함량분석
한두일,황방연,황석연,박정일,손건호,이승호,장승엽,강신정,노재섭,이경순 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Aurantii Fructus has been used in traditional medicine as a digestant, expectorant, and in the treatment of diarrhea, anal prolapse. For the quality control of this crude drug, hesperidin was isolated from the ethylacetate fraction of Citrus aurantium (Rutaceae) and identified by the spectroscopic evidences. A quantitative analysis of hesperidin using HPLC method exhibited that the average contents of hesperidin were 2.13±1.16% in 57 samples collected throughout the various regions of Korea.