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김찬우,이동건,강승훈,조지현,이수진,조동환,김정기 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2
Objectives : Risperidone and olanzapine, which are atypical antipsychotics. are widely used in the treatment of schizophrenia as the 1st line drug, proving their effectiveness for both positive and negative symptoms. They also have many advantages even from the side effects. However, they show differences with the chemical structure and pharmacokinetics and they work differently to receptors. Researchers have studied the effect and side effect during the acute phase of schizophrenia as an open prospective study. Methods : Forty subjects with DSM-IV schizophrenia or schizoaffective patients including 1) 1st onset schizophrenia patient, 2) patient who has been treated by the prior antipsychotics and not improved or even worse to be admitted again, were assigned to receive risperidone or olanzapine for 6 weeks. Psychopathology, adverse effect. weight change, fasting serum glucose, and drug cost were compared within and across groups. Results : After 6 weeks later both treatment groups showed the significant decrease in PANSS positive, general psychopathology and total score while they did not show any significant difference between two groups. Risperidone group, however. showed the significant decrease in PANS negative score, which olanzapine group did not. In terms of adverse effect risperidone group showed more extrapyramidal symptom than olanzapine group. Body weight rised significantly after Gweeks, but no significant difference between two treatment groups. There were no significant indrease of fasting serum glucose level. Conclusions : Risperidone and olanzapine are effective drugs which can be used during the acute phase of schizophrenia. Risperidone is expected to shorten the admission day and remission of the symptom of acute phase, mile olarizapine is more advantage in a neurologic side effect than rispendone.
정용진,서권일,이기동,윤광섭,강미정,김광수 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.1
To utilize deteriorated sweet persimmon effectively, response surface methodology(RSM) was used to determine the optimal vinegar fermentation conditions and monitored by a divided two stage fermentation. The optimum conditions for maximum alcohol content were obtained when the first stage (alcohol fermentation) was carried out with an initial sugar concentration of 18.5°Brix, agitation rate of 140.8 rpm, fermentation time of 127.6 hr. When sugar concentration was 14°Brix, maximum alcohol content(7.1%) was predicted at fermentation conditions of 160 rpm in agitation rate, 140 hr in fermentation time. The optimum conditions for maximum acidity were obtained when second stage(vinegar fermentation) was carried out 249.5 rpm in agitation rate, 148.8 hr in fermentation time. Predicted values at the optimum conditions were similar to experimental values.
Lee Tae-Gee,Yeum Dong-Min,Kim Young-Sook,Yeo Saeng-Gyu,Lee Yong-Woo,Kim Jin-Soo,Kim In-Soo,Kim Seon-Bong The Korean Society of Fisheries and Aquatic Scienc 2005 Fisheries and Aquatic Sciences Vol.8 No.2
A peptide that inhibits angiotensin-converting enzyme (ACE) was isolated from a hydrolysate of Manila clam (Ruditapes philippinarum) proteins prepared with thermolysin. Amino acid sequence of the peptide was determined to be Leu-Leu-Pro. Chemically synthesized Leu-Leu-Pro had an $IC_{50}\;value\;of\;158\;\mu{M}$. Peptides related to the Manila clam-derived peptide were synthesized to study the structure-activity relationships. The tetrapeptide, Leu-Leu-Pro-Pro, had a very weak effect on the enzyme. However, Leu-Leu-Pro-Asn showed no inhibitory activity.
Population Structure of Fusarium graminearum from Maize and Rice in 2009 in Korea
Lee, Seung-Ho,Lee, Jung-Kwan,Nam, Young-Ju,Lee, Soo-Hyung,Ryu, Jae-Gee,Lee, Theresa The Korean Society of Plant Pathology 2010 Plant Pathology Journal Vol.26 No.4
We performed diagnostic PCR assays and a phylogenetic analysis using partial sequences of TEF1 (translation elongation factor-1) to determine the trichothecene chemotypes and genetic diversity of F. graminearum isolates from maize and rice samples collected in 2009 in Korea. PCR using a species-specific primer set revealed a total of 324 isolates belonging to the putative F. graminearum species complex. PCR with trichothecene chemotypespecific primers revealed that the nivalenol (NIV) chemotype was predominant among the fungal isolates from rice (95%) in all provinces examined. In contrast, the predominant chemotype among the corn isolates varied according to region. The deoxynivalenol (DON) chemotype was found more frequently (66%) than the NIV chemotype in Gangwon Province, whereas the NIV chemotype (70%) was predominant in Chungbuk Province. Phylogenetic analysis showed that all DON isolates examined were clustered into lineage 7, while the NIV isolates resided within lineage 6 (F. asiaticum). Compared with previous studies, the lineage 6 isolates in rice have been predominantly maintained in southern provinces, while the dominance of lineage 7 in maize has been evident in Gangwon at a slightly reduced level.
Lee Chang-Soo,Kim Eun-Mi,Lee Sang-Ho,KIm Min-Soo,Kim Yong-Kweon,Kim Byug-Gee The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.3
Desorption/ionization on silicon mass spectrometry (DIOS-MS) is a relatively new laser desorption/ionization technique for mass spectrometry without employing an organic matrix. This present study was carried to survey the experimental factors to improve the efficiency of DIOS-MS through electrochemical etching condition in structure and morphological properties of the porous silicon. The porous structure of silicon structure and its properties are crucial for the better performance of DIOS-MS and they can be controlled by the suitable selection of electrochemical conditions. The fabrication of porous silicon and ion signals on DIOS-MS were examined as a function of silicon orientation, etching time, etchant, current flux, irradiation, pore size, and pore depth. We have also examined the effect of pre- and post-etching conditions for their effect on DIOS-MS. Finally, we could optimize the electrochemical conditions for the efficient performance of DIOS-MS in the analysis of small molecule such as amino acid, drug and peptides without any unknown noise or fragmentation.
Lee, Chang-Soo,Lee, Ji-Hye,Kang, Kyoung-Ku,Song, Hwan-Moon,Kim, In-Ho,Rhee, Hyun-Ku,Kim, Byung-Gee Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.2
In this study, mesoporous silicate was applied as a matrix for the analysis of various molecules from small molecules to medium sized peptides in laser desorption/ionization mass spectrometry. In contrast with conventional matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), the proposed approach, desorption/ionization on mesoporous silicate mass spectrometry (DIOM-MS), significantly reduces the problem of matrix interference in low mass region and can be applied to the analysis of versatile chemicals including amino acids, synthetic drugs, peptides and others. In addition, distinctive advantage of DIOM-MS showed higher salt tolerance and could be applied to identify the proteins from the analysis of tryptically digested peptides. DIOM-MS has several availabilities such as easy sample preparation, rapid analysis of small molecules without noise, peptide analysis without organic matrix, high salt tolerance, versatile coupling with other separation techniques, and high throughput manner.
Fabrication of Disposable Protein Chip for Simultaneous Sample Detection
Lee, Chang-Soo,Lee, Sang-Ho,Kim, Yun-Gon,Oh, Min-Kyu,Hwang, Taek-Sung,Rhee, Young-Woo,Song, Hwan-Moon,Kim, Bo-Yeol,Kim, Yong-Kweon,Kim, Byung-Gee The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.5
In this study, we have described a method for the fabrication of a protein chip on silicon substrate using hydrophobic thin film and microfluidic channels, for the simultaneous detection of multiple targets in samples. The use of hydrophobic thin film provides for a physical, chemical, and biological barrier for protein patterning. The microfluidic channels create four protein patterned strips on the silicon surfaces with a high signal-to-noise ratio. The feasibility of the protein chips was determined in order to discriminate between each protein interaction in a mixture sample that included biotin, ovalbumin, hepatitis B antigen, and hepatitis C antigen. In the fabrication of the multiplexed assay system, the utilization of the hydrophobic thin film and the microfluidic networks constitutes a more convenient method for the development of biosensors or biochips. This technique may be applicable to the simultaneous evaluation of multiple protein-protein interactions.
Lee, Gwang-Soo,Cukur, Deniz,Yoo, Dong-Geun,Bae, Sung Ho,Kong, Gee-Soo Elsevier 2017 QUATERNARY INTERNATIONAL Vol.459 No.-
<P><B>Abstract</B></P> <P>High-resolution seismic data (Chirp and Sparker profiles) were used to investigate the sequence stratigraphy and evolution of the continental shelf of the South Sea, Korea, since the Last Glacial Maximum (LGM). Approximately 1950 km of chirp and sparker profiles were acquired. Along with seismic profiling, 30 piston core samples were collected and two previous long drill cores (SSDP-103 and 104) were tied to the seismic data. Our data show nine types of seismic facies on the basis of seafloor morphology and sub-bottom acoustic characters. Based on the analysis of seismic profiles, shelf deposits of the South Sea accumulated after the onset of the LGM can be divided into five sedimentary units; S1 to S5, from top to bottom. Correlation between sediment cores and seismic data suggests that Unit S5 is an incised channel fill formed by fluvial or coastal sediments during the early transgressive stage, accompanied by backstepping of the shoreline. Unit S4 is a transgressive sand layer reflecting the deposition of coarse sediments due to the strong currents and tides, following the rapid retreat of the coastline. Unit S3 represents paleo channel- and basin-fill deposits formed in estuary or delta environments near the inner continental shelf. Unit S2 forms an inner shelf transgressive sand layer including sand ridges. Unit S1 is interpreted as the most recent mud formed during the sea level highstand stage when the sea-level rise ended. Our results show that the sedimentary evolution of the continental shelf of the South Sea, since the LGM, has been closely related to the sea-level changes. The distribution of paleo-channels is associated with the paleo-Seomjin River, local sediment supply, and continental shelf erosion.</P>