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A Novel Spectral Matching LED Lighting Source for Plant
Fan Cao,Ailin Chen,Zhisheng Wang,Xiaoyang He,Nianyu Zou 한국조명·전기설비학회 2017 조명·전기설비학회논문지 Vol.31 No.8
This paper deals with the spectral matching optimization by a group of narrowband high power LEDs to achieve the target spectrum required by plant growing, the correlation index is a key evaluation criteria, higher value of which is often difficult to achieve because of the poor performance of spectral matching algorithm. The bat algorithm is proposed as a spectral matching algorithm. Parameters of bat algorithm under high correlation index are selected by observing the parameter variation tendency in the spectral matching simulation. In the experimental verification, 2 kinds of control circuit are used to match the target spectrum. Experimental results shows that appropriate parameter groups of bat algorithm must select based on their relationship with the correlation index. In practical experiment, the optimal correlation index is 0.70±0.05 under conditions of 3 selected bat algorithm parameter groups. It is of significance to plant lighting in the engineering practice exploratory.
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Allergen-Dependent Differences in ILC2s Frequencies in Patients With Allergic Rhinitis
Dachuan Fan,Xiangdong Wang,Min Wang,Yang Wang,Liang Zhang,Ying Li,Erzhong Fan,Feifei Cao,Koen Van Crombruggen,Luo Zhang 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.3
Purpose: Group 2 innate lymphoid cells (ILC2s) are a novel population of lineage-negative cells that induce innate type 2 responses by producing the critical Th2-type cytokines IL-5 and IL-13 in response to IL-25 and IL-33 stimulation. ILC2s accumulation in the peripheral blood of patients with allergic rhinitis (AR) is controversial; the precise role of ILC2s in the immunopathogenesis of AR is still not clear. We investigated the role of ILC2s in phenotypic AR sensitized to distinct allergens. Methods: Flow cytometric analysis of the peripheral blood of 7 healthy controls (HCs), 9 patients monosensitized to house dust mite (HDM), and 8 patients monosensitized to mugwort was performed to quantify ILC2s frequency. Peripheral blood mononuclear cells (PBMCs) were isolated from HDM-AR and mugwort-AR patients, and Lineage- and Lineage+ cells were separated using a fluorescence-activated cell sorter (FACS). IL-5 and IL-13 levels in the supernatants of PBMCs, and Lineage- and Lineage+ cells stimulated with IL-25 and/or IL-33 combined with IL-2 in vitro were assessed using the Milliplex magnetic bead kit. Results: The percentage of ILC2s was significantly elevated in HDM-AR patients compared to mugwort-AR patients and HCs, while no significant difference was found between mugwort-AR patients and HCs. IL-33±IL-25 plus IL-2 induced a significantly greater release of IL-5 and IL-13 in the PBMCs of HDM-AR patients compared to PBMCs of mugwort-AR patients. IL-25 plus IL-2 also induced a significantly greater release of IL-13 in the PBMCs of HDM-AR patients compared to PBMCs of mugwort-AR patients. Stimulation with IL-33 and/or IL-25 combined with IL-2 also induced a significantly greater IL-5 and IL-13 release from Lineage- cells compared to Lineage+ cells. Conclusions: AR patients sensitized to HDM or mugwort allergen have distinct phenotypic and functional profiles in ILC2s frequencies. ILC2s mediate major type 2 immunity in the development of HDM-AR and may be a potential therapeutic target.
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Drought stress-induced changes of microRNAs in diploid and autotetraploid Paulownia tomentosa
Guoqiang Fan,Xibing Cao,Lin Cao,Minjie Deng,Zhenli Zhao,Suyan Niu,Zhe Wang,Yuanlong Wang 한국유전학회 2017 Genes & Genomics Vol.39 No.1
Drought stress adversely affects plant productivity. Growth and timber production of Paulownia trees are limited under drought stress. Changes in gene expression patterns and miRNA in different ploidy of Paulownia tomentosa have been investigated. However, the responses of P. tomentosa to drought stress at the microRNA (miRNA) level have not been reported so far. To identify miRNA candidates and their target genes involved in the drought stress response in diploid and tetraploid P. tomentosa, four small RNA and four degradome libraries from diploid and autotetraploid P. tomentosa under normal and drought stress conditions were constructed and sequenced. A total of 41 conserved and 90 novel miRNAs were identified. Among these miRNAs, 67 (26 conserved and 41 novel) and 53 (six conserved and 47 novel) were significantly differentially expressed in response to drought stress in diploid and autotetraploid P. tomentosa, respectively. Degradome analysis identified 356 candidate miRNA target genes that encoded proteins with functions that included plant defense, transcriptional regulation, and hormone metabolism. In particular, miR4 and miR156 were identified only in autotetraploid P. tomentosa under drought stress. These results will help us build a foundation for future studies of the biological functions of miRNAmediated gene regulation in P. tomentosa.
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SEDs and Beaming Effect for Fermi Blazars
Jun-Hui Fan,Jiang-He Yang,Yi Liu,Yu-Hai Yuan,Cao Lin,Hu-Bing Xiao 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.2
In this work, based on our previous calculations of spectral energy distributions for a sample of Fermi blazars (Fan et al. 2015a), we calculated the radio loudness and performed correlation analyses. Our analysis results show that radio loudness is closely anti-correlated with synchrotron peak frequency and positively correlated with gamma-ray luminosity, suggesting that the gamma-ray emissions are strongly beamed.
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Cao Ming,Fan Bo,Zhen Tianchang,Das Abhijit,Wang Junling 한국독성학회 2023 Toxicological Research Vol.39 No.3
Lung cancer is the most often reported cancer with a terrible prognosis worldwide. Flavonoid metal complexes have exhibited potential chemotherapeutic effects with substantially low adverse effects. This study investigated the chemotherapeutic effect of the ruthenium biochanin-A complex on lung carcinoma in both in vitro and in vivo model systems. The synthesized organometallic complex was characterized via UV‒visible spectroscopy, FTIR, mass spectrometry, and scanning electron microscopy. Moreover, the DNA binding activity of the complex was determined. The in vitro chemotherapeutic assessment was performed on the A549 cell line through MTT assay, flow cytometry, and western blot analysis. An in vivo toxicity study was performed to determine the chemotherapeutic dose of the complex, and subsequently, chemotherapeutic activity was assessed in benzo-α-pyrene-induced lung cancer mouse model by evaluating the histopathology, immunohistochemistry, and TUNEL assays. The IC50 value of the complex in A549 cells was found to be 20 μM. The complex demonstrated significant apoptosis induction, enhanced caspase-3 expression and cell cycle arrest with downregulated PI3K, PPARγ, TGF-β, and TNF-α expression in A549 cells. The in vivo study suggested that ruthenium biochanin-A therapy restored the morphological architecture of lung tissue in a benzo-α-pyrene-induced lung cancer model and inhibited the expression of Bcl2. Additionally, increased apoptotic events were identified with upregulation of caspase-3 and p53 expression. In conclusion, the ruthenium biochanin-A complex successfully amelioratedlung cancer incidence in both in vitro and in vivo models through the alteration of the TGF-β/PPARγ/PI3K/TNF-α axis with the induction of the p53/caspase-3-mediated apoptotic pathway.
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Fan Chen,Anye Cao,Linming Dou,Guangcheng Jing 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.5
The occurrence of coal bursts affects the safety of coal mines while coal burst hazard evaluation exerts a guiding influence preventing future coal bursts. Therefore, a method for quantitatively evaluating coal burst hazard was proposed based on zone division and an analytic hierarchy process (AHP). On this basis, by considering the distribution of influence factors of coal bursts in coal mining face (CMF) and means of influencing weight changes, the research aimed to enhance the accuracy and pertinence of coal burst hazard evaluation. By investigating the LW250204 of Yanbei Coal Mine in Gansu Province, China, it can be speculated that the CMF was influenced by various factors (including extra-thick coal seam, syncline and anticline tectonics, mining-induced disturbance, dip angle of coal seams, and mining depth) and thus suffered significant threat of coal burst. The results revealed the following three points: firstly, the degree of coal burst hazard had a positive correlation with the thickness of the coal seams, the mining depth, and mining-induced disturbance, while it exhibited a negative correlation with syncline and anticline tectonics. Moreover, it showed a parabolic correlation with the dip angle of the coal seams. Secondly, the zone division of the CMF was carried out according to the range of influence and changes in various factors. Based on AHP and the degree of influence of different factors on coal burst hazard, an evaluation matrix for the weights of influence factors driving coal bursts was established to quantify the differences between weights of various influence factors. Thirdly, based on the evaluation matrix for weights of influence factors, the relative coal burst hazard index was constructed to quantify the coal burst hazard in a given zone. Through testing, the goodness of fit between the distribution of the global relative coal burst hazard indices of the LW250204 and mininginduced tremors (MITs), as located, reached 90.8%, which validated the accuracy of the evaluation results. The research can provide a reference for quantitative evaluation of coal burst hazard in coal mines.
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Cao, Yan,Zandi, Yousef,Rahimi, Abouzar,Fan, Qingming,Bai, Yu,Guo, Junde,Fu, Leijie,Khadimallah, Mohamed Amine,Jameel, Mohammed,Assilzadeh, Hamid Techno-Press 2021 Advances in nano research Vol.11 No.3
The rotor disk produces an azimuthal velocity component in the space between the rotor and stator of a turbine disk, also known as the rim seal cavity. As part of an empirically study, the rim seal cavity is subjected to a test aimed to count the number of unstable structures and evaluate their rotational speed. An Electronic Control Unit (ECU) has a leak test aperture that is sealed by a sealing device that is selectively disposed in the leak test aperture. Designing pump and compressor machines and units requires the development of dependable seal assemblies that maintain tightness over a long period of time and in a wide variety of pressures and temperature. In the field of electrochemical machining (ECM), heat-resistant and high-strength materials may be machined into complicated forms using this well-known technology. ECM presents some issues as the electrochemical copying of grooves, insulating groove features, slots and mini-holes can cause water leakage due to the poor sealing device of the closed integral structure turbine disk. Sealing devices of rotor turbine disks are heavy components with low-cycle fatigue analysis to their life curves. However, there is rare analysis to detect their defects in various rotor regions (temperature, considering stress, mission profile). This study by use of hydro-thermal loading has attempted to focus on the mechanical seals rings and basic productive and operating requirements. Taking the damage and wear, the clearance has been altered that cause a raising in leakage. Generally, the leakage grows more rapidly than linearly with the after-damage clearance. Also, damage and wear were related to the labyrinth seal itself, resulting that the bending curvature and the percentage of bent tooth length were also relevant in defining the leakage in the case of bending damage.
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Buckling of axial compressed cylindrical shells with stepwise variable thickness
Fan, H.G.,Chen, Z.P.,Feng, W.Z.,Zhou, F.,Shen, X.L.,Cao, G.W. Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.1
This paper focuses on an analytical research on the critical buckling load of cylindrical shells with stepwise variable wall thickness under axial compression. An arctan function is established to describe the thickness variation along the axial direction of this kind of cylindrical shells accurately. By using the methods of separation of variables, small parameter perturbation and Fourier series expansion, analytical formulas of the critical buckling load of cylindrical shells with arbitrary axisymmetric thickness variation under axial compression are derived. The analysis is based on the thin shell theory. Analytic results show that the critical buckling load of the uniform shell with constant thickness obtained from this paper is identical with the classical solution. Two important cases of thickness variation pattern are also investigated with these analytical formulas and the results coincide well with those obtained from other authors. The cylindrical shells with stepwise variable wall thickness, which are widely used in actual engineering, are studied by this method and the analytical formulas of critical buckling load under axial compression are obtained. Furthermore, an example is presented to illustrate the effects of each strake's length and thickness on the critical buckling load.
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