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- 저자 : Das Abhijit (검색결과 8 건)
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Md Najmus Saadat,Sujit Das,Senjuti Nandy,Divya Pandey,Monojit Chakraborty,Usha Mina,Abhijit Sarkar 대한공간정보학회 2022 Spatial Information Research Vol.30 No.2
Air pollution is a serious concern with the developing economics in India and gets more severe when it has major cities ranked among the top 30 polluted cities worldwide. To find a solution, different programs and/or policies have been launched for air quality management country-wide. Unfortunately, no such plan could effectively solve the purpose rather than an unexpected COVID- 19 pandemic situation in India. Our study focused on the air pollution status and air quality index (AQI) in 42 cities (that includes 6 metros) representing North, South, East, West, Central, and North-East region of India during the pre-lockdown, four lockdowns and unlock phases. The results depict most of the pollutants except ozone (O3) were significantly reduced in the lockdown-1, and marginally increased in subsequent lockdown phases. Regarding the average AQI, its value was highest in North Indian cities (227), followed by East India (172), Central India (141), North-East India (130), West India (124), and South India (83) during the pre-lockdown. Due to COVID- 19 induced lockdown, North Indian cities observed the highest dip in average AQI (108), followed by Central India (113), East India (82), West India (73), South India (55), and North-East India (49) in the lockdown and unlock phases. Thus, the study gave a conspicuous vision on mitigation of air pollution under this pandemic; and, if strategic centralized policies are sensibly implemented and by involving the participation of people of India, then there is a feasibility of air pollution issue management.
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Seal Ishita,Sil Sidhanta,Das Abhijit,Roy Souvik 한국독성학회 2023 Toxicological Research Vol.39 No.2
Throughout the last decades flavonoids have been considered as a powerful bioactive molecule. Complexation of these flavonoids with metal ions demonstrated the genesis of unique organometallic complexes which provide improved pharmacological and therapeutic activities. In this research, the fisetin ruthenium-p-cymene complex was synthesized and characterized via different analytical methods like UV–visible spectroscopy, Fourier-transform infrared spectroscopy, mass spectroscopy, and scanning electron microscope. The toxicological profile of the complex was evaluated by acute and sub-acute toxicity. Additionally, the mutagenic and genotoxic activity of the complex was assessed by Ames test, chromosomal aberration test, and micronucleus based assay in Swiss albino mice. The acute oral toxicity study exhibited the LD50 of the complex at 500 mg/ kg and subsequently, the sub-acute doses were selected. In sub-acute toxicity study, the hematology and serum biochemistry of the 400 mg/kg group showed upregulated white blood cells, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, glucose and cholesterol. However, there was no treatment related alteration of hematological and serum biochemical parameters in the 50, 100, and 200 mg/kg group. In the histopathological analysis, the 50, 100, and 200 mg/kg groups were not associated with any toxicological alterations, whereas the 400 mg/kg group showed prominent toxicological incidences. Nevertheless, the treatment with fisetin ruthenium-p-cymene complex did not exhibit any mutagenic and genotoxic effect in Swiss albino mice. Thus, the safe dose of this novel organometallic complex was determined as 50, 100, and 200 mg/kg without any toxicological and genotoxic potential.
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Gautam Vishwakarma,Ravi Prakash Sanyal,Abhijit Shitre,D. A. Gadekar,Ajay Saini,Bikram Kishore Das 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.4
Stem rust resistance gene Sr2 is an important slow-rusting gene which has provided resistance against stem rust for many years. The Sr2 gene has durable resistance against all stem rust pathogens including the Ug99 group of races. It shows recessive inheritance and is linked with two phenotypic markers, Pseudo Black Chaff (PBC) and High Temperature-Induced Seedling Chlorosis (HTISC). However, direct screening as well as phenotypic marker-based screening for selection of Sr2 is difficult due to the effect of environmental factors and genetic background. Microsatellite marker Xgwm533 linked to Sr2 gene is useful for rapid screening of large populations. Here we report validation and use of Xgwm533 for screening 21 wheat lines and 24 wheat genotypes for the presence of the Sr2 gene. Furthermore, we also report the presence of a new, smaller allele (97 bp) of Xgwm533 locus in a few genotypes that was also confirmed by sequencing. We also demonstrate a new SYBR green dye, melt-curve/profile-based assay for convenient screening of the Xgwm533 locus, where the presence of different alleles can be differentiated in a gel-free manner.
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Cao Ming,Fan Bo,Zhen Tianchang,Das Abhijit,Wang Junling 한국독성학회 2023 Toxicological Research Vol.39 No.3
Lung cancer is the most often reported cancer with a terrible prognosis worldwide. Flavonoid metal complexes have exhibited potential chemotherapeutic effects with substantially low adverse effects. This study investigated the chemotherapeutic effect of the ruthenium biochanin-A complex on lung carcinoma in both in vitro and in vivo model systems. The synthesized organometallic complex was characterized via UV‒visible spectroscopy, FTIR, mass spectrometry, and scanning electron microscopy. Moreover, the DNA binding activity of the complex was determined. The in vitro chemotherapeutic assessment was performed on the A549 cell line through MTT assay, flow cytometry, and western blot analysis. An in vivo toxicity study was performed to determine the chemotherapeutic dose of the complex, and subsequently, chemotherapeutic activity was assessed in benzo-α-pyrene-induced lung cancer mouse model by evaluating the histopathology, immunohistochemistry, and TUNEL assays. The IC50 value of the complex in A549 cells was found to be 20 μM. The complex demonstrated significant apoptosis induction, enhanced caspase-3 expression and cell cycle arrest with downregulated PI3K, PPARγ, TGF-β, and TNF-α expression in A549 cells. The in vivo study suggested that ruthenium biochanin-A therapy restored the morphological architecture of lung tissue in a benzo-α-pyrene-induced lung cancer model and inhibited the expression of Bcl2. Additionally, increased apoptotic events were identified with upregulation of caspase-3 and p53 expression. In conclusion, the ruthenium biochanin-A complex successfully amelioratedlung cancer incidence in both in vitro and in vivo models through the alteration of the TGF-β/PPARγ/PI3K/TNF-α axis with the induction of the p53/caspase-3-mediated apoptotic pathway.
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Anamika Roy,Mamun Mandal,Sujit Das,Manoj Kumar,Robert Popek,Amit Awasthi,Balendu Shekher Giri,Kartick Chandra Mondal,Abhijit Sarkar 대한환경공학회 2023 Environmental Engineering Research Vol.29 No.3
Recent regulations on exhaust emissions have led to an increase in non-exhaust emissions, which now surpasses exhaust emissions. Non-exhaust emissions are mainly generated from brake and tire particle abrasion, road wear, and re-suspended road dust. In Asia, non-exhaust emissions have increased significantly over the past 50 years, resulting in almost 92% of the population breathing polluted air, which accounts for 70% of air pollution related-deaths. Most Asian countries with poor air quality are developing or underdeveloped. Taking this into consideration, the current study aims to shed light on particulate pollution from non-exhaust emissions in the Asian context to assess the current status and its health consequences and provides technological solutions. The study is based on an in-depth analysis of existing reviews and research concerning non-exhaust emissions and their health impacts in Asia to pinpoint knowledge gaps. The study found that particulate pollutants had exceeded WHOs standards in many Asian countries, bringing deleterious health consequences among children and the elderly. The findings underscore the significance of future researchers efforts to devise solutions that curtail non-exhaust emissions, ultimately reducing air pollution, augmenting air quality, fostering better health outcomes, and paving way for a more sustainable future before it is too late.
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Joydeep Purkayastha,Pritesh Rajeev Singh,Abhijit Talukdar,Gaurav Das,Jitin Yadav,Srinivas Bannoth 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.3
Purpose: Locally advanced colorectal cancer may require an en bloc resection of surrounding organs or structures to achieve complete tumor removal. This decision must weigh the risk of complications of multivisceral resection against the potential survival benefit. The purpose of this study is to review a single-center experience of feasibility of en bloc multiv- isceral resections for locally advanced colorectal carcinoma and to examine the effect of surgical experience on immediate outcome and rate of R0 resections. Methods: This is a study of 27 patients who underwent multivisceral resection for locally advanced colorectal carcinoma which was performed at our institute from January 2016 to December 2019. Among the 27 patients aged between 21 and 76 years (mean age, 48.67±7.3 years), 13 were males and 14 were females. Overall 18 patients had primary colon carci- noma and 9 had primary rectal carcinoma. All rectal cancer patients received neoadjuvant chemoradiation. All patients underwent surgery with curative intent. All patients underwent open surgery of which 66.7% underwent colectomy, 14.8% underwent anterior resection, 11.1% underwent Miles procedure, and 7.4% underwent pelvic exenteration. Results: The mean operative time was 268.14±72.2 minutes and the median amount of blood units transfused was 2.07 units. The mean hospital stay was 13.67±3.4 days. Histologically, 44.4% of patients had well-differentiated adenocarci- noma and 55.6% had moderately differentiated adenocarcinoma. The final histopathological examinatio n revealed ma- lignant infiltration of the adjacent organs in 19/27 patients (70.4%). Pathological complete response was seen in 2 patients. R0 resection rate achieved was 96.3%. Lymph node metastasis was seen in 66.7% of patients with colon cancer and 11.1% with rectal cancer with overall mean number of harvested lymph nodes being 12.44±3.01. Postoperative complications were identified in 7 patients (25.9%), while mortality was seen in 2 (7.4%). Conclusion: Multivisceral resection for advanced colorectal cancer invading into the adjacent organ may be performed with acceptable morbidity and mortality.
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Sanath Krishna Muliya,Anukul Nath,Gandla Chethan Kumar,Avinash Visvanathan,Melvin Selvan,Raghuram Gowda,Vishal Santra,Abhijit Das 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.2
Delineating species distribution comprising information on habitat suitability is vital for developingconservation strategies. Like many other snake species, Lycodon flavicollis is a poorly studied peninsularIndian endemic species known only from few locality records. We used MaxEnt following the smallsampling approach to determine the probable distribution of the species. We found that the majority ofthe predicted area falls under Deccan Peninsular (Central Plateau and Deccan South) region of Indiafollowed by parts of Western Ghats. Isothermality and mean temperature of wettest quarter hadconsiderable influence on the predicted distribution range of the species. The findings of the presentwork show that our modelling approach may help in identifying new areas where this species may occur. We discussed the usefulness of this approach in determining potential distribution of data deficientspecies such as L. flavicollis. Additionally, we have also provided significant information on morphologyand natural history to enrich our current knowledge on the species.
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