The Overall Survival of Hepatocellular Carcinoma after Resection According to the Cause of Liver Disease

( Eunseo Lee ),( Sunghwan Yoo ),( Sukhyeon Jeong ),( In-jung Kim ),( Sora Kim ),( Hye Young Chang ),( Jung Il Lee ),( Kwan Sik Lee ),( Hyun Woong Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Some studies have shown a poor prognosis for hepatocellular carcinoma (HCC) patients whose etiology is viral. This study is to evaluate the outcomes of the patients diagnosed to resectable HCC, according to the etiology of the disease due to the differences in prognosis between viral and non-alcoholic fatty liver disease (NAFLD). Methods: A total of 264 patients who received hepatectomy for the treatment of HCC between 2005 and 2019 were performed a review of medical records. They were divided into groups according to the cause of liver disease, followed by overall and disease-free survival analysis for comparison. Results: The cause of HCC consisted of 222 hepatitis B virus (HBV) (69.4%), 14 hepatitis C virus (HCV) (4.4%), and 28 non-alcoholic steatohepatitis (NASH) (7.9%). There was no statistically significant difference in the sex, tumor stage (BCLC and AJCC 7th) of the groups of patients divided according to the etiology of HCC. However, the mean age was higher in NAFLD (NAFLD 72 years, vs. HBV 62 years, HCV 68 years, P<0.001). The presence of liver cirrhosis was lower in NAFLD (NAFLD 14.3%, vs. HBV 51.8%, HCV 50%, P=0.001). Overall survival (OS) at five years of the patients with HBV, HCV and NAFLD were 88.2%, 74.1%, and 74.6%, respectively (P=0.031). Disease-free survival at five years of patients with HBV, HCV and NAFLD were 72.5%, 69.3%, and 77.9%, respectively (P=0.370). In multivariate analysis, age and baseline AFP were the significant prognostic factors of OS (hazard ratio [HR] for age; 0.938, confidential interval; 0.886-0.994, P=0.03, HR for AFP; 1.000; 1.000-1.000, P=0.001). Conclusions: Baseline age and AFP levels showed significant prognostic differences among the groups of HCC patients of the various etiologies. NAFLD induced HCC had shown slightly lower OS at five years than viral induced HCC.

A Study on the Bioplastic Material through the Biomimic Simulation of Malaria Parasite

EunSeo LEE,UnJung CHAE 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Determination of Noise Threshold from Signal Histogram in the Wavelet Domain

Eunseo Kim,Kamin Lee,Sejung Yang,Byung-Uk Lee 대한전자공학회 2014 전자공학회논문지 Vol.51 No.2

Thresholding in frequency domain is a simple and effective noise reduction technique. Determination of the threshold is critical to the image quality. The optimal threshold minimizing the Mean Square Error (MSE) is chosen adaptively in the wavelet domain; we utilize an equation of the MSE for the soft-thresholded signal and the histogram of wavelet coefficients of the original image and noisy image. The histogram of the original signal is estimated through the deconvolution assuming that the probability density functions (pdfs) of the original signal and the noise are statistically independent. The proposed method is quite general in that it does not assume any prior for the source pdf.

Catalytic enhancements in cytochrome P450 2C19 by cytochrome b5

Lee Gyu-Hyeong,Kim Vitchan,Lee Sung-Gyu,Jeong Eunseo,Kim Changmin,Lee Yoo-Bin,Kim Donghak 한국독성학회 2024 Toxicological Research Vol.40 No.2

Human cytochrome P450 2C19 catalyzes P450 enzyme reactions of various substrates, including steroids and clinical drugs. Recombinant P450 2C19 enzyme with histidine tag was successfully expressed in Escherichia coli and purified using affinity column chromatography. Ultra-performance liquid chromatography-tandem mass (UPLC-MS/MS) spectrometry showed that the purified P450 2C19 enzyme catalyzed 5-hydroxylation reaction of omeprazole. The purified enzyme displayed typical type I binding spectra to progesterone with a Kd value of 4.5 ± 0.2 μM, indicating a tight substrate binding. P450 2C19 catalyzed the hydroxylation of progesterone to produce 21-hydroxy (OH) as a major and 17-OH product as a minor product. Steady-state kinetic analysis of progesterone 21-hydroxylation indicated that the addition of cytochrome b5 stimulated a five-times catalytic turnover number of P450 2C19 with a kcat value of 1.07 ± 0.08 min− 1. The molecular docking model of progesterone in the active site of P450 2C19 displayed that the 21-carbon of progesterone was located close to the heme with a distance of 4.7 Å, suggesting 21-hydroxylation of progesterone is the optimal reaction of P450 2C19 enzyme for a productive orientation of the substrate. Our findings will help investigate the extent to which cytochrome b5 affects the metabolism of P450 2C19 to drugs and steroids.

An investigation on the identification and definition of user experience constructs

Eunseo Lee(이은서),Philjun Moon(문필준),Yoonjin Lee(이윤진),Seoyeon Yoon(윤서연),Younghee Song(송영희),Woojin Park(박우진) 대한인간공학회 2023 대한인간공학회 학술대회논문집 Vol.2023 No.5

Effects of smart speaker’s visual feedback modality on user experience during multitasking situation

Eunseo Lee(이은서),Woojin Park(박우진) 대한인간공학회 2022 대한인간공학회 학술대회논문집 Vol.2022 No.10

여자코일을 이용한 멀티레벨 무선전력전송 시스템의 공진 토폴로지 분석

최은서(Eunseo Choi),이재홍(Jaehong Lee),이승환(Seung-Hwan Lee) 전력전자학회 2021 전력전자학술대회 논문집 Vol.2021 No.7

MZ세대 소비자의 SNS 능동 적 참여도를 높이기 위한 인스타그램 및 유튜브 활용 전략 - 편의점 3사(CU, GS25, 7ELEVEN)를 중심으로 -

이희정 ( Lee Heejung ),박지인 ( Park Jiin ),김해찬 ( Kim Haechan ),김우진 ( Kim Woojin ),이규성 ( Lee Gyuseong ),노은주 ( Noh Eunju ),최은서 ( Choi Eunseo ) 한국고객만족경영학회 2021 고객만족경영연구 Vol.23 No.4

4차 산업혁명시대가 도래함에 따라 빅데이터의 중요성이 더욱 강조되고 있으며, 정보기술의 발전과 함께 데이터의 중요성은 갈수록 높아지고 있고 빅데이터의 활용은 기업의 핵심가치가 되었다. 코로나 19 사태로 인해 온라인 기반의 비대면(untact) 활동이 급격하게 증가하면서 디지털 경제로의 전환이 가속화되어 기업들은 디지털을 활용한 소비자와의 소통이 어느때 보다 더 중요해졌다. 특히 MZ세대는 트랜드를 주도하는 주요 소비자층으로 자리 잡고 있으며, SNS 매체 등 디지털 환경을 기반으로 활발하게 소비활동을 하고 있어 기업은 이들을 소구하기 위해서 SNS를 적극적으로 활용하는 방안이 절실하게 필요한 시점이다. 편의점은 일상생활에 대한 영향력과 비중이 지속적으로 확대되고 있으며, 특히 편의점 간편식은 젊은 세대와 가구들을 중심으로 폭발적 인기를 누리고 있다. 따라서 편의점을 이용하는 소비자들의 구매행동에 영향을 미칠 수 있는 SNS 마케팅은 기업의 중요한 전략으로 떠오르고 있다. 본 연구는 혼합적 연구분석 방법(mixed methodology)을 사용하여 설문조사 방법 뿐만 아니라 소비자들의 소리를 체계적으로 분석하기 위해 비정형 데이터 분석을 함으로써 보다 더 현실적으로 소비자들의 의견을 파악하고자 하였고 이를 바탕으로 향후 편의점 산업이 어떻게 MZ세대 소비자들의 SNS 능동적 참여도를 이끌어 낼 수 있는지에 대해 전략을 제안하고자 한다. 설문조사를 통해 20~30대 소비자들이 기업 SNS에 능동적으로 참여하도록 유도하기 위한 소셜미디어를 사용하는 중요한 동기를 파악하였고, 주로 사용하는 SNS 매체, 즉 유튜브와 인스타그램에 따라서 소비자의 이용동기가 다를 것인지를 확인하였다. 또한 이와 동시에 비정형 데이터, 즉 텍스트 데이터를 분석하고자 뉴스미디어 자료 및 인스타그램, 유튜브에 올라온 댓글을 분석함으로써 현재 소비자들이 소셜미디어 매체를 어떻게 활용하고 있는지를 살펴보았다. 텍스트 마이닝을 통해 시장의 소리를 파악해 봄으로써 향후 유통산업이 어떻게 MZ 소비자들을 대상으로 효율적인 SNS 전략을 구사할 수 있을 것인지를 제안하였다. The importance of big data is becoming more emphasized, and with the development of information technology, the use of big data has become the core value of companies. The rapid increase in online-based untact activities has accelerated the transition to the digital economy, leading communication skills more important than ever for companies to interact with consumers using digital tools. In particular, the MZ generation is a major consumer base leading the trend and is actively engaged in consumption activities utilizing digital environments such as SNS media, so it is critical for marketers to actively use SNS to appeal for them. Convenience stores continue to expand their influence and weight on daily life, and instant foods are enjoying explosive popularity, especially among the young customers. Therefore, SNS marketing of convenience stores is critical tool to appeal for MZ generation. This study attempted to investigate the significant SNS usage motivations that can attract MZ generation by utilizing mixed methods. Based on results, we suggest strategies on how the convenience store industry can attract active SNS participation for young generation. Through the survey, we identified important motivations of using social media and suggest the effective ways to encourage consumers in their 20s and 30s to actively participate in corporate SNS. Also we investigate whether consumers' usage of YouTube and Instagram is different in the context of usage and SNS participation. We analyzed news media data, Instagram, and comments posted on YouTube in order to examine how consumers are currently using social media. By grasping the voice of the consumers through text mining, it was suggested how the distribution industry is able to utilize efficient SNS strategies for MZ consumers.

An EV optimal routing problem considering non-linear charging time and variable speeds

Jerimi Lee,Yoona Kang,Ohjae Kwon,Eunseo Ko,Chungmok Lee 한국경영과학회 2022 한국경영과학회 학술대회논문집 Vol.2022 No.6

초등 과학교육의 저작도구 활용 능력기반 교수학습환경 효과분석

이은서 ( Eunseo Lee ),이명근 ( Myung Geun Lee ) 한국교육공학회 2017 교육공학연구 Vol.33 No.3

4차 산업혁명 시대의 중요한 교육목표 중 하나는 능력 중심 인재를 양성하는데 있다. 특히 고도의 기술과 결합된 복잡한 삶의 문제를 해결할 수 있는 과학적 사고력을 기르는 교육은 어느 때보다 더 강조되고 있다. 이 연구는 초등학교 과학수업에서 학습자들의 과학적 사고력 및 과학적 태도를 기르기 위한 효과적인 교수학습 환경을 설계하는 방안으로서 저작도구 활용 능력기반 교수학습 환경의 효과를 분석 하였다. 먼저 초등 과학교육에서의 구성주의 교수학습 환경 설계의 필요성을 검토하였다. 이어 구성주의 교수학습 환경 구현을 위해 발견학습 원리를 토대로 능력기반 교수학습을 계획하고, 대표적인 학습환경 자원으로 저작도구인 StarLogo를 인지 촉진 도구로 활용하는 능력기반 교수학습 환경 모형을 도출하였다. 이를 토대로 세부 교수학습 활동을 설계하고, 인천광역시 소재 초등학교 6학년 학급 중 사전 과학적 사고력 및 태도가 동질한 두 집단을 선정하여 저작도구 활용 능력기반 교수학습 환경을 적용한 수업의 효과를 분석하였다. 연구결과 첫째, 저작도구 활용 능력기반 교수학습 환경을 적용한 실험집단과 적용하지 않은 통제집단 간 과학적 사고력에 통계학적으로 유의한 차이가 있었다. 특히 과학적 사고력의 하위영역인 연역적 영역과 비판적 영역, 창의적 영역에서 유의한 차이가 있었다. 둘째, 집단 간 과학적 태도에도 통계학적으로 매우 유의한 차이가 있었고, 특히 과학적 태도의 하위영역인 감정적, 행동의도적, 유용성 인식도 요소 모두에서 유의한 차이가 있었다. 이상에서 볼 때, 저작도구 활용 능력기반 교수학습 환경은 초등학교 과학교육에서 과학적 사고력 및 태도를 향상시키는 데 효과적인 방안이라 할 수 있다. 이는 학습자의 과학적 사고력 및 태도를 효과적으로 향상시키고, 나아가 4차 산업혁명 시대에 필요한 문제해결능력을 가진 창의적 인재를 길러내기 위해 저작도구 활용 능력기반 교수학습 환경을 적용한 교육을 적극적으로 도입할 필요가 있다는 것을 시사한다. This study developed a model of competency-based instruction-learning environment for elementary school science classes and analyzed the effects of the instruction-learning environment using an authoring tool on learners` scientific thinking ability and attitude. To this end, the whole research was conducted in three phases: first, a competency-based instruction-learning environment model was designed, which was suitable for elementary science classes on the basis of principles of constructivist learning environment and discovery learning with detailed resources and activities planned around the model using authoring tools such as StarLogo. Second, two homogeneous groups with regard to scientific thinking ability and attitude were formed out of sixth grade students of an elementary school in Incheon, and an experiment was carried out upon the groups. Third, statistical analyses were conducted to identify the effects of the model on scientific thinking ability and attitude towards science. Two major results from the study were as follows: first, a statistically significant difference was observed on the scientific thinking ability between the experimental group and the control group. This difference was especially noticeable in such subdomains of thinking ability as deductive, critical and creative thinking ability. Second, the attitude toward science were also distinguished between the two groups. The attitude subdomains that showed significant differences were affection, behavioral intention and usability awareness. Based on the results of the study, competency-based instruction-learning environment using a authoring tool such as StarLogo in elementary science classes can be said to be an effective strategy to develop learners` scientific thinking ability and attitude toward science.