情報技術과 政府

李忠雄 서울대학교 사회과학연구소 1985 社會科學과政策硏究 Vol.7 No.4

관순법에 의한 휜-관 열교환기의 성능 해석

이태환,유충웅 진주산업대학교 1999 論文集 Vol.38 No.-

A cross-flow finned tube heat exchanger was investigated using a tube-by-tube method. The refrigerant R22 flows inside tubes while the air passes outside the finned tube. A self-constructed refrigerant circuitry was adopted. The refrigerant enthalpy at the exit of each tube and the average condensate layer thickness are investigated as a measure of the heat transfer and the observation with the quantity of condensation phenomenon respectively. The dependence of refrigerant enthalpy and the average condensate layer thickness on the refrigerant circuitry was also observed. It was confirmed that this method could be applied to the analysis of finned tube heat exchanger with condensation.

보조권선을 이용한 SRM의 소음진동저감 운전에 관한 연구

이종근,유충웅,최태완 진주산업대학교 1999 論文集 Vol.38 No.-

The main vibration source of SRM drive is generated by rapid variation of radial force when phase winding current is extinguished for commutation action. So the rapidly variation of radial force is repressed firstly to reduce vibrating force of SRM drive. This paper suggests the vibration reduction method, where SRM with unidirectional auxiliary winding is excited by a three stage commutation method at commutation period. This reduction effect of vibration is verified with the result obtained in the test of prototype machine.

파종기별 논콩재배의 수량 및 생태적 특성

조진웅,이석영,강순경,김충수 충남대학교 농업과학연구소 2006 농업과학연구 Vol.33 No.2

This study was conducted on a commerce silt loam soil at paddy field in the southwestern Korea (36˚N lat). In the study of planting time, seed were hand planted at 24 May, 14 June and 5 July, and at 24 May, 14 June and 5 July in 2005, respectively. Two seedlings plants per hill were taken prior to V3 stage. Fertilizer was applied prior to plant at a rate of 3.0-3.0-3.4 g (N-P-K) per square meter. Experimental design was a randomized complete block in a split plot arrangement with three replications. Yield was significantly affected by different of the planting times and cultivars. The seed yield in planting time was the highest on late in May 24 but was the lowest on July 5. Also, the plant time significantly affected on increasing pod and seed number and seed weight. The days from emergence to flowering and maturity was reducing tendency with late planting time.

정신분열병 입원 환자에서 단축형 증상관리 훈련의 효과:예비적 연구

최충식,채정호,우동원,최영희,함웅,이규항,장미화 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

연구목적: 정신분열병 환자에서의 재활치료는 개인의 극복 기술과 능력을 향상시키고 재발을 유발시킬 수 있는 스트레스의 부정적인 영향을 중화시킴으로써 질병의 만성화를 막고 사회기능을 호전시킬 수 있기에 점차 그 중요성이 대두되고 있다. 본 연구는 만성 정신분열병 입원 환자에서 재활치료의 하나인 단축형 증상관리 훈련이 정신장애에 대한 자기 인식에 미치는 효능을 알아보기 위하여 시행되었다. 방법: 정신분열병으로 진단받고 입원 중인 환자들에게 재발경고징후를 규명하는 것, 재발경고징후를 관리하는 것, 지속증상을 극복하는 것, 술과 불법 약물을 피하는 것 등으로 구성된 승인-UCLA 사회기술 및 독립적인 생활기술훈련 단위 중 증상관리단위를 기초로 한국실정에 맞게 축약한 증산관리 훈련을 주 1회, 60분씩, 4∼5주간 실시하였고 실시 전후에 전신장애 비인식 평가 척도(Scale to Assess Unawareness ofMental Disorder; 이하 SUMD)로 자신의 정신장애에 대한 인식을 평가하였으며 임상적 전반적 인상(Clinical Global Impression;이하 CGI)로 임상 상태를 조사하였고 각 인구학적 변인들을 조사하였다. 결과: 환자 30명이 훈련을 완수하였으며 이들의 평균 연령은 36.6±7.6세였고 남자가 14명(46.7%), 여자가16명(53.3%)이었다. SUMD 점수는 훈련 전 16.9±4.0점에서 훈련 후 12.9±4.2점으로 유의하게 줄어 정신장애에 대한 자기 인식 정도가 향상되었으며(p<0.01), CGI도 훈련전의 3.7±0.9점에서 훈련 후 2.8±0.8점으로 유의하게 호전되었다(p<0.01). 환자의 연령, 발병시 연령, 유병 기간, 입원 기간, 항정신병약물 사용 용량, 교육 정도, CGI로 평가한 임상 상태등은 정신장애의 자기 인식 정도와는 관련성이 없었다. 결론: 정신분열병 입원 환자에서 단축형 증상관리 훈련은 정신장애에 대한 자기 인식을 증가시킬 수 있는 방법이 될 가능성을 확인하였으며 이 방법이 정신분열병 재활치료의 중요한 요소가 될 수 있음을 알 수 있었다. Objectives : The purpose of this study was to examine whether Symptom Management Module-Korean Brief Version(SMM-B) is effective as a psychosocial treatment of the inpat-ients with chronic schizophrenia. We also questioned which of demographic and clinical characteristics could be predictors of differential treatment response. Methods : The subjects were composed of 30 inpatients with chronic schizophrenia, who were trained with weekly session of SMM-B for 5 weeks. Before and after the training, the level of psychopathology, knowledge about schizophrenia were assessed as dependent variables by using Clinical Global Impression(CGI) and Scale to Assess Unawareness of Mental Disorder(SUMD). Results : Overall, patients showed improvement over the treatment period on psychopath-ology as well as knowledge about psychosis. Total scores of SUMD were changed from 16.9±4.0 before training to 12.9±4.2 after training(p<0.01) and scores of CGI were improved from 3.7±0.9 to 2.8±0.8<p<0.01). Howver age, gender, years of education, age of onset, duration of illness, duration of admission, numbers of psychiatric admission, and clinical status evaluated by CGI were not correlated with unawareness of psychosis. Conclusion : These results suggest that SMM-B could be a reliable method to improve self-aw-areness of psychosis in patients whth chronic schizophrenia and one of important elements in rehabilitation.

위암 조직에서 발현되는 새로운 유전자 Reg Ⅳ

김수령,서은영,이웅희,이증훈,이충식 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

A search for the genes expressed only in gastric cancer may help to define molecular alterations or aid in diagnosis of gastric cancer. Recently, suppression subtractive hybridization (SSH) has been used as an effective technique for detection of differentially expressed genes. We discovered a noble gene which belongs to the Reg family in stomach cancer tissue using the SSH technique. We identified and named the Reg Ⅳ gene that is highly expressed only in gastric tumor tissue. The Reg family gene has a lot of functions of the growth factor and gene regulation. The cathepsin L-12 gene, which is known to exhibit increased expression in breast cancer and some inflammatory conditions, is also expressed in stomach cancer. Expressions were verified by reverse Northern blot analysis and Northern blot analysis. We expect these genes to be used as an important tool for the diagnosis and/or understanding of the pathogenesis of gastric cancer.

치료 저항성 환청을 나타내는 만성 정신분열병 환자에서 측두두정부 반복 경두개자기자극의 효과

정경희,최충식,박진수,이규항,함웅,이승환,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on left and right temporopahetal cortex in schizophrenic patients with treatment-resistant auditory hallucination. Methods : Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly a1-located to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20 international system at 1 Hz for 20 minutes per day for 101reatment days. A Figure of eight TMS coil with a solid core was used for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment. Results : Ten days administration of l-Hz rTMS to temporopahetal cortex significant improved frequency (p<0.001) and attentional salience (p=0.038) of auditory hallucination, Positive (p<0.001) and negative symptom (p=0.02), and CGI-impro-vement (p<0.001). There were no significant differences between right and left side stimulations. Conclusion : These results suggest that the low frequency rTMS on temporopahetal cortex may be useful in treating Schizo-phrenic patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option.

Comparison of Effectiveness between Abdominal Vibration Stimulation and Walking Exercise for Bowel Cleansing before Therapeutic Colonoscopy

Choong-Kyun Noh,In Sung Kim,Gil Ho Lee,Jin Woong Park,Eunyoung Lee,Bumhee Park,Hye Jeon Hong,Sun Gyo Lim,Sung Jae Shin,Jin Hong Kim,Kee Myung Lee 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4

Background/Aims: Adequate bowel preparation is important for successful colonoscopy. We aimed to evaluate the clinical feasibility and effectiveness of abdominal vibration stimulation in bowel preparation before therapeutic colonoscopy. Methods: A single center, prospective, randomized, investigator-blinded study was performed between January 2016 and December 2016. Patients for therapeutic colonoscopy were prospectively enrolled and assigned to either the vibrator group or walking group. Patients who refused to participate in this study as part of the experimental group consented to register in the control group instead. During the preparation period, patients assigned to the walking group walked ≥3,000 steps, whereas those assigned to the vibrator group received abdominal vibrator stimulation and restricted walking. All patients received the same colon cleansing regimen: 4-L split-dose polyethylene glycol (PEG) solution. Results: Three hundred patients who received PEG solution for therapeutic colonoscopy were finally enrolled in this study (n=100 per group). Bowel cleansing with abdominal vibration stimulation showed almost similar results to that with walking exercise (Boston Bowel Preparation Scale score for the entire colon: vibrator vs walking vs control, 7.38±1.55 vs 7.39±1.55 vs 6.17±1.15, p<0.001). There were no significant differences between the vibrator group and walking group regarding instances of diarrhea after taking PEG, time to first diarrhea after taking PEG, total procedure time, and patient satisfaction. Conclusions: This study indicates that, compared with conventional walking exercise, abdominal vibration stimulation achieved similar rates of bowel cleansing adequacy and colonoscopy success without compromising safety or patient satisfaction.

Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis

Lee, Sangmin,Kang, Sun-Woong,Ryu, Ju Hee,Na, Jin Hee,Lee, Dong-Eun,Han, Seung Jin,Kang, Choong Mo,Choe, Yearn Seong,Lee, Kyo Chul,Leary, James F.,Choi, Kuiwon,Lee, Kyung-Han,Kim, Kwangmeyung American Chemical Society 2014 Bioconjugate chemistry Vol.25 No.3

<P>Imaging techniques including computed tomography, magnetic resonance imaging, and positron emission tomography (PET) offer many potential benefits to diagnosis and treatment of cancers. Each method has its own strong and weak points. Therefore, multimodal imaging techniques have been highlighted as an alternative method for overcoming the limitations of each respective imaging method. In this study, we fabricated PET/optical activatable imaging probe based on glycol chitosan nanoparticles (CNPs) for multimodal imaging. To prepare the dual PET/optical probes based on CNPs, both <SUP>64</SUP>Cu radiolabeled DOTA complex and activatable matrix metalloproteinase (MMP)-sensitive peptide were chemically conjugated onto azide-functionalized CNPs via bio-orthogonal click chemistry, which was a reaction between azide group and dibenzyl cyclooctyne. The PET/optical activatable imaging probes were visualized by PET and optical imaging system. Biodistribution of probes and activity of MMP were successfully measured in tumor-bearing mice.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bcches/2014/bcches.2014.25.issue-3/bc500020g/production/images/medium/bc-2014-00020g_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bc500020g'>ACS Electronic Supporting Info</A></P>

In Vivo Mapping and Quantification of Creatine Using Chemical Exchange Saturation Transfer Imaging in Rat Models of Epileptic Seizure

Lee, Dong-Hoon,Lee, Do-Wan,Kwon, Jae-Im,Woo, Chul-Woong,Kim, Sang-Tae,Lee, Jin Seong,Choi, Choong Gon,Kim, Kyung Won,Kim, Jeong Kon,Woo, Dong-Cheol Springer-Verlag 2019 Molecular imaging and biology Vol.21 No.2