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李恩英(Lee, Eunyoung) 국제언어문학회 2017 國際言語文學 Vol.- No.36
본 논문은 일제강점기 직전 관직에서 물러나 자정의 길을 택한 恥齋 李範世(1874~1940)의 생애와 교유에 대해 살펴본 것이다. 치재는 土門勘界使로 활약한 二雅堂 李重夏(1846~1917)의 외아들이다. 만 15세에 문과에 급제한 그는 을사늑약 직후부터 관직에서 물러날 때까지 관료로서의 저항적 삶을, 경술국치 후에는 독립자금 모금, 언론사와 신간회 활동을 통한 일제에 대한 투쟁 등 망국민으로서의 저항적 삶을 살았다. 치재는 교유했던 인물들에 대해 경술국치 전후를 기준으로 크게 두 가지 양상을 보인다. 하나는 함께 신학문을 공부하다 망명을 떠나 독립운동에 투신하는 인물들과 만나지 못해 그리워하는 모습이다. 또 하나는 직접적으로 독립운동에 투신하지 못하는 현실 속에서 국내에 남아 있던 인물들과 함께 망국에 대한 슬픔과 나라 잃은 백성들의 아픔을 시로 토로하는 모습이다. 그밖에 치재는 이상설을 비롯한 양명학자들과 교유를 가진 사실도 확인되었다. This paper is about the life and social intercourse of Chi-Jae, Bum-Se Lee(1874~1940), who had resigned from government service for self-regularity just before Japanese colonial period started. He is the only son of Yi-A-Dang, Jung-Ha Lee(1846~1917), who played a important role as a Tomungamgyesa. As a promising youth passing the examination aforementioned at the age of 15, his resistance came up to the surface right after the Ulsaneukyack. After the Kyungsulgukchi, he helped the independence with fund-raising and activity of Shinganhoe as a homeless race until his depth. He had 2 different attitudes to his acquaintances from Kyungsulgukchi. To the one group, who studied the new-learning with him, he felt sorrow at parting to the persons going into the independence movement in their exiled places. With the other group he wrote poems about the sorrow of the national ruin and the emotional injury of the ruined people in Korea. In addition, the fact is confirmed that he associated with the school of Wang Yang-ming including Sang-seol Lee.
[PE-0017] A Peanut Variety, ’Da-Ol’ with High Oleic Acid and Large Grain
Eunyoung Oh(Eunyoung Oh ),Sungup Kim(Sungup Kim),Jung In Kim(Jung In Kim),Min Young Kim(Min Young Kim),Sang Woo Kim(Sang Woo Kim),Jeongeun Lee(Jeongeun Lee),Eunsoo Lee(Eunsoo Lee),Rizwana Begum Syed N 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Lee Eunyoung,Park Sehee,Choi Jae-Phil,Kim Min-Kyung,Yang Eunmi,Ham Sin Young,Lee Seungjae,Lee Bora,Yang Jeong-Sun,Park Byoung Kwon,Kim Da Sol,Lee So-Young,Lee Joo-Yeon,Jang Hee-Chang,Jeon Jaehyun,Park 대한의학회 2023 Journal of Korean medical science Vol.38 No.8
Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group with nirmatrelvir/ritonavir therapy versus a control group with supportive care. Serial viral load and culture from the upper respiratory tract were evaluated for seven days, and clinical responses and adverse reactions were evaluated for 28 days. Results: A total of 51 patients were analyzed including 40 in the treatment group and 11 in the control group. Faster symptom resolution during hospitalization (P = 0.048) was observed in the treatment group. Only minor adverse reactions were reported in 27.5% of patients. The viral load on Day 7 was lower in the treatment group (P = 0.002). The viral culture showed a positivity of 67.6% (25/37) vs. 100% (6/6) on Day 1, 0% (0/37) vs. 16.7 (1/6) on Day 5, and 0% (0/16) vs. 50.0% (2/4) on Day 7 in the treatment and control groups, respectively. Conclusions: Nirmatrelvir/ritonavir against the omicron was safe and resulted in negative viral culture conversion after Day 5 of treatment with better symptomatic resolution.
Change of Anti-Inflammatory Activity of platycodon grandiflorum Extracts according to Steaming
Eunyoung Lee(이은영),Geum Soog Kim(김금숙),Dae Young Lee(이대영),Kyung Hye Seo(서경혜),Seung Eun Lee(이승은),Young Seob Lee(이영섭),Jae Won Lee(이재원),Doo Jin Choi(최두진),Hyung Don Kim(김형돈) 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2
이은영(Lee, Eunyoung) 국제언어문학회 2016 國際言語文學 Vol.- No.34
본 논문은 그동안 외교 능력가로 인정받아온 二雅堂 李重夏(1846~1917)의 문학적 자질에 대해 살펴본 것이다. 관료출신 이아당은 경술국치 전부터 일제에 대한 반감을 갖고 있었다. 그리고 경술국치 직후 70세를 바라보던 그는 은사금을 거부하고 양평 집으로 돌아가 은둔자정하며 엄격하게 일제와 거리를 두고 살다 여생을 마쳤다. 연로한 나이로 직접적 저항에 나설 수 없던 그는 당대 지식인들이 평생 익힌 신념에 따라 선택한 ‘處變三事’ 가운데 ‘自靖遂志’를 택했다. 그리고 그는 작품을 통해 자정적 삶을 고수한 정신과 일제에 대한 저항정신을 드러냈다. 젊어서 豪猛한 기운을 품고 있던 이아당의 시는 國難이라는 傷心의 시대를 맞이하면서 부화한 표현 없이 담백한 언어로 변화되었다. 그로인해 그의 시는『이아당집』 序文에서 밝혔듯이 ‘平淡典雅’ 그 자체가 되었다. 그러나 저항정신을 드러낸 시에서는 여전히 호맹한 기운이 엿보인다. 이처럼 문학적 역량이 풍부했던 이아당은 시대의 변화와 작품에 따라 자신의 정신을 담은 詩語를 함께 변화시키면서 문학적 자질을 유감없이 발휘한 시인이다. This paper is about the literary talent of Yiadang Jung-ha Lee known as his ability of the diplomacy. Yiadang standed against Japan even before the Gyeongsulgukchi. Yiadang returned to his house in Yang-peong and died in there refusing all bribes or contacts from Japan after Gyeongsulgukchi. He who could not resist directly because of his old age, chose keeping honor quietly in the three actions to respond to changes following the belief of elites at that time. He revealed the spirit of clean life and the will of resist against Japan with his literature. His poems show clear words without excessive adjectives in the era of lost country. Therefore, his poems become "Peaceful and elegant mind" itself as the introduction of 『Yiadang-jip』 said. But bravery is still in his poems showing the spirit of resist. With his literature talent, Yiadang revealed his gift changing the words in poems following the times.
[PB-0038] QTL-seq identified a locus controlling lignan content in sesame
Eunsoo Lee(Eunsoo Lee),Sungup Kim(Sungup Kim),Jeongeun Lee(Jeongeun Lee),Jung In Kim(Jung In Kim),Eunyoung Oh(Eunyoung Oh),Min Young Kim(Min Young Kim),Sang Woo Kim(Sang Woo Kim),Kwang-Soo Cho(Kwang-S 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Lee, Sukjun,Lim, Donghyun,Lee, Eunyoung,Lee, Nakyung,Lee, Hong-gun,Cechetto, Jonathan,Liuzzi, Michel,Freitas-Junior, Lucio H.,Song, Jin Sook,Bae, Myung Ae,Oh, Sangmi,Ayong, Lawrence,Park, Seung Bum American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.17
<P>New antimalarial agents that exhibit multistage activities against drug-resistant strains of malaria parasites represent good starting points for developing next-generation antimalarial therapies. To facilitate the progression of such agents into the development phase, we developed an image-based parasitological screening method for defining drug effects on different asexual life cycle stages of <I>Plasmodium falciparum</I>. High-throughput screening of a newly assembled diversity-oriented synthetic library using this approach led to the identification of carbohybrid-based 2-aminopyrimidine compounds with fast-acting growth inhibitory activities against three laboratory strains of multidrug-resistant <I>P. falciparum</I>. Our structure–activity relationship study led to the identification of two derivatives (<B>8aA</B> and <B>11aA</B>) as the most promising antimalarial candidates (mean EC<SUB>50</SUB> of 0.130 and 0.096 μM against all three <I>P. falciparum</I> strains, selectivity indices >600, microsomal stabilities >80%, and mouse malaria ED<SUB>50</SUB> values of 0.32 and 0.12 mg/kg/day, respectively), targeting all major blood stages of multidrug-resistant <I>P. falciparum</I> parasites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-17/jm5009693/production/images/medium/jm-2014-009693_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm5009693'>ACS Electronic Supporting Info</A></P>
Lee, Yun-Gyoo,Kim, Inho,Lee, Eunyoung,Bang, Soo-Mee,Kang, Chang Hyun,Kim, Young Tae,Kim, Hak Jae,Wu, Hong-Gyun,Kim, Young Whan,Kim, Tae Min,Lee, Keun-Wook,Lee, Se-Hoon,Kim, Dong-Wan,Heo, Dae Seog F. K. Schattauer 2014 Thrombosis and Haemostasis Vol.111 No.6
<P>Although the overall risk of venous thromboembolism (VTE) is high in patients with non-small cell lung cancer (NSCLC), risk identification is limited. The goal of this study was to estimate the incidence, risk factors and prognostic implications of VTE, and to evaluate a genetic link between oncogenes and the risk of VTE in Asian patients with NSCLC. A total of 1,998 consecutive patients with NSCLC were enrolled and analysed retrospectively. Since the effects of therapeutics on VTE development were modified by stage, stratified analyses were performed. When comparing overall survival in terms of VTE development, a propensity score-matching method was adopted to minimise potential confounding. The six-month and two-year cumulative incidences of VTE were 4.2% and 6.4%, respectively. The risk of VTE increased 2.45-fold with each advancing stage in NSCLC (p<0.001). The independent predictors of VTE were advanced age, pneumonectomy and palliative radiotherapy in localised NSCLC and ineligibility for surgery and palliative radiotherapy in locally advanced NSCLC. Adenocarcinoma histology (vs squamous cell) and former/current smoking status were significant predictors of VTE in metastatic NSCLC. A significant association between VTE and decreased survival was observed only among patients with localised NSCLC. EGFR mutations (p=0.170) and ALK rearrangements (p=0.159) were not associated with VTE development in lung adenocarcinoma. In conclusion, the two-year cumulative incidence of VTE is 6.4% in Asian patient with NSCLC. The significant predictors of VTE are different across stages of NSCLC. The prognostic impact of VTE on poor survival was limited to localised NSCLC.</P>
Chromothripsis in Treatment Resistance in Multiple Myeloma
Lee, Kyoung Joo,Lee, Ki Hong,Yoon, Kyong-Ah,Sohn, Ji Yeon,Lee, Eunyoung,Lee, Hyewon,Eom, Hyeon-Seok,Kong, Sun-Young Korea Genome Organization 2017 Genomics & informatics Vol.15 No.3
Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, ${\beta}$-2 microglobulin, and albumin. Recently, the term chromothripsis has emerged, which is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event. Many studies have shown an association of chromothripsis with the prognosis in several cancers; however, few studies have investigated it in MM. Here, we studied the association between chromothripsis-like patterns and treatment resistance or prognosis. First, we analyzed nine MM cell lines (U266, MM.1S, RPMI8226, KMS-11, KMS-12-BM, KMS-12-PE, KMS-28-BM, KMS-28-PE, and NCI-H929) and bone marrow samples of four patients who were diagnosed with MM by next-generation sequencing-based copy number variation analysis. The frequency of the chromothripsis-like pattern was observed in seven cell lines. We analyzed the treatment-induced chromothripsis-like patterns in KMS-12-BM and KMS-12-PE cells. As a result, breakpoints and chromothripsis-like patterns were increased after drug treatment in the relatively resistant KMS-12-BM. We further analyzed the patients' results according to the therapeutic response, which was divided into sensitive and resistant, as suggested by the International Myeloma Working Group. The chromothripsis-like pattern was more frequently observed in the resistant group. In the sensitive group, the frequency of the chromothripsis-like pattern decreased after treatment, whereas the resistant group showed increased chromothripsis-like patterns after the treatment. These results suggest that the chromothripsis-like pattern is associated with treatment response in MM.