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윤성민,김춘철,서원일,황선영,이성훈,한경호,이우범 國立麗水大學校 環境問題硏究所 2004 環境硏究論文集 Vol.6 No.-
To detemine seasonal fluctuations in abundance and speices composition, polychaete samples were collected by Van Veen grab form March to November 2003 in Kangjin Bay. A total of 25,119.3 ind./㎡ polycaete were sampled and identified into 48 species. 25 families and 10 orders. Of the 10 orders. Phllodocida, Spionida, Eunicida and Sabellida accounted for approximately 79.9% of the polychaete fauna in this area. Phyllodocida, Nereidae, Nephtyidae ans Spionidae were dominant representing every moment 4 species. Of 48 species identified Neanthes japonica, Prionospio pinnate, Cirratulus cirratus and Palola siciliensis for 54.0% individuals collected. Season succession of dominant species was evident in study area: Neanthes japonica, Prionospio pinnata. Cirratulus cirratus. Nephtys oligobranchia in March, Neanthes japonica, Lumbrineris japonica. Cirratulus cirratus, Prionospio pinnata in May, Ncanthes japonica, Cirratulus cirratus, Lumbrineris nippnica. Lumbrineris japonica in August and Neanthes japonica, Prionospio pinnata, Laonice cirrata, Palola siciliensis in November, respectively. The diversity index was the highest value in March(H'=3.0059) and the lowest value in May(H'=2.7305). The eveness index was the highest in August(J=0.9184) and lowest in May(J=0.8524). The dominance index was the highest in May(D=0.3843) and the lowest in March(D=0.2275).
Woo Yeon Hwang,Chel Hun Choi,Kidong Kim,Moon-Hong Kim,Myong Cheol Lim,Banghyun Lee,Myounghwan Kim,Yun Hwan Kim,Seok Ju Seong,Jong-Min Lee 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.3
Objective We aimed to predict the risk of postoperative adjuvant therapy using preoperative variables in young patients with early stage cervical cancer. The predicted risk can guide whether ovarian transposition should be performed during surgery. Methods In total, 886 patients with stage IB1-IIA cervical cancer aged 20-45 years who underwent modified radical or radical hysterectomy between January 2000 and December 2008 were included. Preoperative variables, preoperative laboratory findings, International Federation of Gynaecology and Obstetrics stage, tumor size, and pathological variables were collected. Patients with high risk factors or those who met the Sedlis criteria were considered adjuvant therapy risk (+); others were considered adjuvant therapy risk (-). A decision-tree model using preoperative variables was constructed to predict the risk of adjuvant therapy. Results Of 886 patients, 362 were adjuvant therapy risk (+) (40.9%). The decision-tree model with four distinct adjuvant therapy risks using tumor size and age were generated. Specifically, patients with tumor size ≤2.45 cm had low risk (49/367; 13.4%), those with tumor size ≤3.85 cm and >2.45 cm had moderate risk (136/314; 43.3%), those with tumor size >3.85 cm and age ≤39.5 years had high risk (92/109; 84.4%), and those with tumor size >3.85 cm and age >39.5 years had the highest risk (85/96; 88.5%). Conclusion The risk of postoperative adjuvant therapy in young patients with early stage cervical cancer can be predicted using preoperative variables. We can decide whether ovarian transposition should be performed using the predicted risk.
CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer
Kim, Jihye,Cho, Young-Jae,Ryu, Ji-Yoon,Hwang, Ilseon,Han, Hee Dong,Ahn, Hyung Jun,Kim, Woo Young,Cho, Hanbyoul,Chung, Joon-Yong,Hewitt, Stephen M.,Kim, Jae-Hoon,Kim, Byoung-Gie,Bae, Duk-Soo,Choi, Chel Elsevier 2020 Gynecologic oncology Vol.156 No.1
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct link between the regulation of transcription and the cell cycle. Here, we investigated the clinical significance of CDK7 expression and its potential as a therapeutic target in epithelial ovarian cancer (EOC).</P> <P><B>Methods</B></P> <P>CDK7 expression was examined in 436 ovarian tissues including normal to metastatic ovarian tumors using immunohistochemistry, and its clinical implications were analyzed. Furthermore, we performed <I>in vitro</I> and <I>in vivo</I> experiments using CDK7 siRNA or a covalent CDK7 inhibitor (THZ1) to elucidate the effect of CDK7 inhibition on tumorigenesis in EOC cells.</P> <P><B>Results</B></P> <P>The patient incidence of high CDK7 expression (CDK7<SUP>High</SUP>) gradually increased from normal ovarian epithelium to EOC (<I>P</I> < 0.001). Moreover, CDK7<SUP>High</SUP> was associated with an advanced stage and high-grade histology (<I>P</I> = 0.035 and <I>P</I> = 0.011, respectively) in EOC patients and had an independent prognostic significance in EOC recurrence (<I>P</I> = 0.034). CDK7 inhibition with siRNA or THZ1 decreased cell proliferation and migration, and increased apoptosis in EOC cells, and this anti-cancer mechanism is caused by G0/G1 cell cycle arrest. In <I>in vivo</I> therapeutic experiments using cell-line xenograft and PDX models, CDK7 inhibition significantly decreased the tumor weight, which was mediated by cell proliferation and apoptosis.</P> <P><B>Conclusion</B></P> <P>Mechanistic interrogation of CDK7 revealed that it is significantly associated with an aggressive phenotype of EOC, and it has independent prognostic power for EOC recurrence. Furthermore, CDK7 may be a potential therapeutic target for patients with EOC, whether platinum sensitive or resistant.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CDK7 inhibition has an anti-cancer effect on platinum-sensitive EOC. </LI> <LI> CDK7 inhibition could induce responsiveness to platinum chemotherapy in platinum-resistant EOC. </LI> <LI> CDK7 overexpression had independent negative prognostic value for disease recurrence of EOC. </LI> <LI> CDK7 might play a critical role in EOC tumorigenesis, and it also serves as a possible therapeutic target in EOC. </LI> </UL> </P>
김정우,김성용,김철수,이승희,김수중 경북대학교 전자기술연구소 1993 電子技術硏究誌 Vol.14 No.1
A new approach to associative memory matrix is proposed far the purpose of optical neural network and pattern recognition Instead of digital computer to realize associative memory matrix, we use all optical system. This scheme can be realized by using 2-D magnifying operation and 2-D multimaging operation of a modes input. And the scheme for implementing recalling process also utilizes basically Hopfield model. Performance of this model will be demonstrated by computer simulation and optical experiment.
만삭 전 조기양막파수에서 분만 잠복기에 따른 주산기 예후에 관한 연구
김우선 ( Woo Sun Kim ),최철훈 ( Chel Hun Choi ),이수호 ( Su Ho Lee ),최석주 ( Suk Joo Choi ),김지운 ( Ji Un Kim ),이은실 ( Eun Sil Lee ),손영수 ( Young Soo Son ),김종화 ( Jong Hwa Kim ),노정래 ( Cheong Rae Roh ) 대한주산의학회 2004 Perinatology Vol.15 No.4
목적 : 조기양막파수 산모에서 양막파수에서 분만까지의 기간(잠복기)이 주산기 예후에 미치는 영향을 조사하기 위하여 본 연구를 시행하게 되었다. 방법 : 1996년 1월부터 2003년 10월까지 조기양막파수로 34주 이전에 분만한 223명을 대상으로 분만 잠복기에 따라 6군(I군 : 6시간 이하, II군 : 6시간~2일, III군 : 2~4일, IV군 : 4~7일, V군 : 7~12일, VI군 : 12일 이상)으로 구분한 후 각 군의 임상 양상과 주산기 예후를 관찰하였다. 결과 : 전체 산모의 입원 시 평균 임신 주수는 29.6±2.6주이었고 양막파수 당시 평균 양수지수는 7.3±5.0 이었다. 평균 분만 주수는 30.6±2.4주였고, II군과 III군에서 유의하게 높았다(p=0.0017). 중앙 잠복기는 전체 산모에서 102시간(4일 6시간)이었고 67%의 산모가 1주 이내에 분만하였다. 분만 잠복기는 양막파수 당시 주수가 30주 이하일 때(175시간 vs. 76시간, p=0.001) 연장되었고, 자궁 수축 억제제를 사용했을 때(131시간 vs. 33시간, p=0.001) 분만 잠복기는 유의하게 증가하였다. 양막파수 당시 양수지수는 잠복기에 영향을 미치지 않았다(p>0.05). 분만 주수를 보정하였을 경우 V군에서 조직학적 융모양막염이 유의하게 많이 발생하였고(60%), 분만 잠복기가 증가함에 따라 신생아 중환자실 재원 기간이 증가하였다. 신생아 호흡곤란 증후군은 II군과 IV군에서 I군에 비해 유의하게 적게 발생하였다(12%, 16% vs. 69%). 신생아 사망률은 I군이 18%로 가장 높았고, 분만 주수를 보정하였을 때에도 같은 결과를 보였으나 I군을 제외한 다른 군들 간에는 유의한 차이가 없었다. 그 외 다른 신생아 합병증은 각 군간 유의한 차이가 없었다. 결론 : 만삭 전 조기양막파수에서 즉각적인 분만보다는 적극적인 관찰요법을 통하여 분만 잠복기를 연장시키는 것이 신생아 사망이나 신생아 호흡곤란 증후군의 빈도를 줄이는데 도움이 되나 7일 이상 지연시키는 것은 주산기 예후의 향상과는 관계없이 감염성 합병증을 증가시키는 것으로 보인다. Objective : To evaluate the clinical characteristics and perinatal outcomes in relation to the latency period after preterm premature rupture of membrane (PPROM). Methods : We analyzed retrospectively the 223 pregnant women with PPROM who delivered before 34 weeks of gestation in Samsung Seoul Hospital from January 1996 to October 2003. The study population was divided into six groups according to the larency from membrane rupture and delivery (group I : shorter than 6 hours, group II : 6~48 hours, group III: 2~4 days, group IV : 4~7 days, group V : 7~12 days, group VI : beyond 12 days). Results : The mean gestational age (GA) at rupture was 29.6±2.6 weeks and the mean GA at delivery was 30.6±2.4 weeks. The median latency was 102 hours and 67% of patients delivered within 7 days. The latency was prolonged with GA at rupture before 30 weeks and used of tocolytics. After adjustment of GA at delivery, pathologic chorioamnionitis occurred more frequently in group V than group I. Respiratory distress syndrome occurred less frequently in group II and group IV than group I. Neonatal mortality rate was highest in group I, but the other neonatal morbidities were not significant differences. Conclusion : In PPROM with delivery before 34 weeks, prolongation of the latency longer than 6 hours seems to be beneficial for reducing neonatal RDS and mortality, but infectious morbidity seems to increase when the latency was prolonged longer than 7 days without any benefits for perinatal outcomes.
Clinical Outcome of Lymphoepithelioma-Like Carcinoma of the Uterine Cervix (초)
이우석 ( Woo Seok Lee ),( Jeong Won Lee ),( Ha Jeong Kim ),( Hwang Shin Park ),( Tae Jong Song ),( Min Kyu Kim ),( Yoo Young Lee ),( Chel Hun Choi ),( Tae Joong Kim ),( Byoung Gie Kim ),( Je Ho Lee ),( D 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-