마이크로그로브 형태에 따른 평활근 세포 운동 측정

유소영,박찬영,정석,김동익,이병붕,허세호,한동철,장준근 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2

Purpose: The spreading, orientation, and chemotaxis the gradient of a chemoattractant of smooth muscle cells (SMCs) were studied on the micro-grooved substrata by the light, fluorescence and scanning electron microscopy. Method: Vertical-walled grooves were produced in silicon wafers by the micromachining technique. All grooves were 4~20㎛ deep and 10~80㎛ wide, SMCs were cultured on each microgroove and examined under stereo-microscope. Result: Cell clusters were markedly oriented by all the grooved substrata examined. Tim-lapse images acquired from CCD (Charge Coupled Device) showed that the grooves directed the migration of SMCs. There was no prominent difference in the migration speed of SMCs according to the grooves. All the cytoskeletal fibers were reoragnized in the same direction with grooves. Especially the alignments of microtubule and intermediate filaments were distinguished in the SMCs on the micro grooves. Conclusion: These results could be applied to the analysis of vascular restenosis and the development of artificial blood vessels.

인슐린종에 음폐된 신경정신과적 증상 평가

유희정,이성동,김헌수,민병근,박인호 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.1

The authors experienced a patient with insulinoma presented with neuropsychiatric symptoms. It was demonstrated that Whipple's triad is highly suggestive of the presence of an insulinoma. Therefore physicians and/or psychiatrists, who refer patients with insulinoma to third institution, always have a alertness to neuropsychiatric symptoms of insulinoma and Whipple's triad. This case also illustrated the persistence and cooperation between psychiatric and medical teams including the involvement of a neurologist, endocrinologist, and surgeon for diagnosis and treatment planning of patient with insulinoma.

원심모형시험에 의한 사석재의 내부마찰각 추정

유남재,박병수,정길수,이종호 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

This paper is an experimental work of estimating friction angle of very coarse grained soil such as rubble mound by performing laboratory experiments. Two crushed rocks of rubble mound were used for tests. Triaxial compression tests with drained conditions were performed to measure friction angles of soils prepared by mixing the crushed soil having an identical coefficient of uniformity with different maximum grain size distribution. Centrifuge model experiments with those soils were also performed to measure angle of repose and to estimate friction angle of soil from measuring the slope of slip line in the active stress state. Model tests were carried out by changing the G-levels of 1G and 50G. From triaxial compression tests, the measured value of friction angle of soil is in the range of 41∼57˚. The measured value of repose angle is in the range of 32∼35˚. The values of friction angle are found not so sensitive to the maximum grain size of soil as long as the coefficient of uniformity is identical. Estimated value of friction angle from measuring the slope of slip line in the active stress state is in the range of 30~46˚. Thus, the estimated angle of friction are found to be greater in the order of the measured angle of repose, the estimated value from the slope of active state, and triaxial compression test results. On the other hand, the measured values of friction angle from triaxial tests were compared with empirical equations, based on the relation between friction angle and void ratio. Equations proposed by Helenelund(1966) and Hansen(1967) found to be relatively reliable to estimate friction angles of soil.

야간응급실로 내원한 급성 치통환자의 질환특성에 관한 임상적 연구

유재하,최병호,민연숙,오민성,이지응 연세대학교 원주의과대학 1999 원주의대논문집 Vol.12 No.1

포도종실 추출물이 Methylcellulose 필름 성질에 미치는 영향

유승모,박준서,정하열,심재용,김병호,박장우 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

The film with methylcellulose(MC) and grape seed extract(GSE) were prepared by casting their aqueous solution at 80℃ and drying at 23℃ for 48 hrs. Effect of grape seed extract(GSE) on the barrier permeabilities and the thermomechanical property of methylcellulose(MC) film was studied. The barrier permeabilities and the thermomechanical property of MC film containing various contents of GSE were evaluated in terms of water vapor, oxygen permeabilities, and dynamic mechanical analysis(DMA). The rate of water vapor permeability of MC film decreased with GSE contnets in the MC films. Also, the rate of oxygen permeability also decreased with GSE contents indicating higher oxygen barrier property of MC film. The results showed that GSE had a good miscibility with MC and acted as a plasticizer for MC film resuling in lowering the glass transition temperature of the film.

전기분사법을 이용한 키틴/키토산 미세입자의 제조

유용,박원호,민병무,이승진 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12

최근 의약학용 바이오 소재로 각광을 받고 있는 키틴과 키토산을 전기적인 힘을 이용하는 전기방사장치를 이용하여 미세입자 형태로 제조하였다. 키틴 또는 키토산 시료에 대하여 고분자 농도가 일정한 수준(사슬 간의 엉킴이 본격적 일어나는 농도) 이상에서는 초극세 섬유의 형태를 보였으며, 그 농도 이하에서는 비교적 균일하고 미세한 입자를 형성하였다. 키토산의 경우, 5% 초산 수용액에 녹여 4~5 wt%로 분사하였을 경우 200~400 ㎚ 크기의 미세입자를 제조할 수 있었다. 또한 농도가 증가할수록 입자의 크기가 커지면서 다소 불균일해지는 경향을 보였다. 수용성 글리콜 키토산은 분자량이 작기 때문에 높은 농도인 약 55 wt% 까지 미세입자가 생성되었다. 이 입자의 평균 크기는 약 300~500 ㎚ 정도를 나타내었다. 키토산을 초산 수용액에 녹여서 ???? 아세토산으로 ??????이 얻어진 N-아세틸화 키틴의 경우에는 ???????? ?????? 녹여 전기분사를 하였는데 7wt% 이하에서 균일한 미세입자가 생성되었다. 따라서, 키틴이나 키토산의 미세입자를 제조하기 위해서는 용매에 따라 일정한 농도와 점도와의 관계곡선으로부터 사슬 간의 엉킴현상에 의해 섬유상이 형성되지 않은 낮은 농도에서 전기분사를 실시하는 것이 무엇보다도 중요하다는 것을 알 수 있었다. Electrospray method is a new technique lo fabricate the polymer nanoparticles. Nanoparticles of chitin and chitosan were prepared by electrospray and characterized by scanning electron microscope (SEM). In general, the increase in the concentration of chitosan solution induced the increase in its solution viscosity. In addition, the solution viscosity increased rapidly at above the critical concentration, due to formation of entanglement between chitosan chains. From the plot of polymer concentration vs. solution viscosity, it was found that chitosan or chitin nanoparticles, with, particle size in the range of 200-600 nm, could be easily formed at below the critical concentration associated with the formation of chain entanglement. Therefore, we concluded that the plot of polymer concentration vs. solution viscosity was important to investigate the concentration range in which polymer nanoparticles could be prepared.

전국 가정의학과 전공의 수련내용

양병국,이행,윤영호,조은연,유태우,허봉렬 大韓家庭醫學會 1993 Korean Journal of Family Medicine Vol.14 No.4-5

새로운 알랄아민 항진균제의 합성과 생물학적 평가

정병호,박은주,문현주,유진철 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

Some allylamine compounds which are benzothiazole substituants in stead of naphthylring in naftifine, antifungal agents, were sythesized as potential antimycotics. The intermediate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines(5a-5d) after mrthylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes. showed no activity in 0.1∼100 μg/ml range.

관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

대사증후군 환자에서 고감도 C-반응 단백의 성별차이

이상호,정미홍,이순례,유병철,이용환 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2

Background: High-sensitivity C-reactive protein (hsCRP), the classic acute-phase reactant, is an extremely sensitive systemic marker of inflammation. A variety of factors seems to influence hsCRP levels. The aim of this study was to elucidate the gender differences in the association between hsCRP and features of the metabolic syndrome (MS) among Korean. Methods: The study population included 1,283 men and 3,265 women aged 40 years and over who were enrolled in Korean Health Examinee Cohort. They were examined in 10 General hospitals from November 2004 to September 2005. The height, weight, waist circumference, and systolic and diastolic blood pressure of the subjects were examined and on concentrations of fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, and hsCRP in peripheral venous blood were measured. Results: In both sexes, there were significant positive correlations between age, smoking, body mass index, waist circumference, systolic and diastolic blood pressure, triglyceride, and fasting glucose and hsCRP, whereas significant negative correlations were present between drinking, and HDL cholesterol and hsCRP. Mean concentrations of hsCRP in men with 0, 1, 2, 3, and ≥4 components of MS were 0.13, 0.16, 0.18, 0.20, and 0.22 mg/L, respectively. The respective mean concentrations of hsCRP for women were 0.08, 0.09, 0.12, 0.14 and 0.14 mg/L. Results of stratified analyses by the number of components of the metabolic syndrome of 0, 1, 2, 3, and ≥4 revealed that an increase in hsCRP concentrations was greater in men than women with an increased number of components of the MS. Conclusion: There was a difference in concentrations of hsCRP between men and women, and especially an increase in hsCRP concentrations associated with risk factor-clusteringof MS was more prnounced in men.