Recent Epidemiology of Hip Fractures in South Korea

Boo-Seop Kim,Jae-Young Lim,하용찬 대한고관절학회 2020 Hip and Pelvis Vol.32 No.3

The aging of the Korean population is expected to result in an increase in the prevalence of hip fractures. The aim of this review is to evaluate potential hip-fracture trends in Korea during the last few decades. Data from a hip fracture-related epidemiology study informed by: (1) a cohort study; (2) hospital-based cohort study; and (3) claims database, were reviewed and summarized. The incidence of hip fractures rose from 159.1/100,000 in 2008 to 181.5/100,000 in 2012, and the total number of hip fractures is estimated to increase by 1.4 times over the next 10 years (35,729 in 2016 to 51,259 in 2025). The use of intramedullary nails has greatly surpassed the use of plates for the treatment of intertrochanteric fractures. The 1-year cumulative mortality rates in patients aged ≥50 years after hip fractures based on National Health Insurance Service data were 17.2% (3,575/20,849) in 2008 and 16.0% (4,547/28,426) in 2012; the decrease was mainly observed among women. In addition, the mean 1-year mortality rates were 21% for men and 15% for women, indicating that mortality was 1.4 times higher in men than in women. The number of hip fractures is rapidly increasing, and the incidence of hip fractures demonstrated a slightly increasing trend until 2012. Trends in the use of varying surgical options for treatments for femoral neck and intertrochanteric fractures follow global trends. Although the high mortality rate after hip fractures in Korea remains concerning, a decrease in these rates over the study period was observed.

Comparison of Single-Dose Toxicity by Intravenous Infusion or Bolus Injection with CKD-602, a Camptothecin Anticancer Agent in Rats (II): Hematological and Serum Biochemical, and Histopathological Changes

Kim, Choong-Yong,Yang, Byung-Chul,Kim, Joon-Kyum,Kim, Jong-Choon,Kim, Yong-Beom,Kang, Boo-Hyon,Han, Sang-Seop Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.20 No.4

The toxicity of CKD-602 was investigated at doses of 3, 9, and 27 mg/kg in rats, when the same total dose of CKD-602 was administered over 24 hr-continuous infusion or bolus injection. At 3 and 9 mg/kg, the 24-hr infusion group showed a more decreased WBC count on day 3, compared with the bolus group. Administration of CKD-602 caused more toxic effects such as the significant decreases of RBC counts, hematocrit, hemoglobin, and platelet count on day 7 post-administarion in the 24-hr infusion group than in the bolus group. Administration of CKD-602 also caused histopathological changes such as extramedullary hemopoiesis of liver and spleen, hyperplasia of femoral bone marrow, and caecal dilation. These toxic effects were more severe in the 24-hr infusion group than in the bolus injection group, indicating that the toxicity of CKD-602 may be dependant upon the duration of administration.

부하특성을 고려한 동계 강원지역 SPS 적용방안

김동현(Dong-Hyun Kim),김태옥(Tai-Ok Kim),김준연(Jun-Yun Kim),윤부현(Boo-Hyun Yoon),곽은섭(Eun-Seop Kwak),이석창(Seok-Chang Lee),이희찬(Heui-Chan Lee) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7(초록집)

간문맥혈전을 동반한 간암에서 경동맥화학색전 요법후 방사선조사 및 온열요법의 효과

최규용,김기태,배시현,김부성,박두호,최종영,박영민,오용석,윤승규,김창섭,방승호,김희열,윤세철 대한내과학회 1994 대한내과학회지 Vol.47 No.4

Primary Hepatocellular carcinoma (HCC) is well recognized as one of the most malignant tumors with a dismal prognosis Although surgical resection is effective in small solitary HCC, only 10%. of tumors are resectable. As a result, most HCC patients receive palliative therapy. Many efforts have been made in the treatment of the advanced HCC; systemic chemotherapy, transcatheter arterial chemo-embolization (TACE), percutaneous ethanol injection therapy (PEIT). The prognosis of HCC with main portal vein tumor thrombus is very poor due to limitation of treatment modality and poor results of treatment. Radiation therapy is known to be effective in the treatment of unresectable HCC and even in the case of portal vein tumor thrombus. Now we report three cases of advanced HCC with portal vein tumor thrombus or inferior vena cava thrombus that was treated with combined radiotherapy and hyperthermia after TACE.

The Occurrence of Griffithsia okiensis (Ceramiaceae, Rhodophyta) from Korea on the Basis of Morphology and Molecular Data

Kim, Hyung-Seop,Yang, Eun Chan,Boo, Sung Min The Korean Society of Phycology 2006 ALGAE Vol.21 No.1

Despite continued studies on red algal flora in Korea, the taxonomy of the tiny ceramiaceous algae has received little attention. We report for the first time Griffithsia okiensis from Korea on the basis of morphology and molecular data. The species is small in thalli height (0.3-1.5 cm), and in diameter of vegetative cells (50-500 μm), and the ratio of cell length/breadth is 2-3 times. It has two carpogonial branches from the supporting cell of procarp. We generated psbA and rbcL sequences from ten specimens of G. okiensis isolated from Korea and Japan and from one G. japonica species isolated Japan. Eight specimens of G. okiensis from Korea were almost identical in both psbA and rbcL regions, nevertheless they differed from Japanese specimens by 4 ucleotides in psbA and 7 in rbcL. In all analyses of psbA, rbcL, and psbA + rbcL data sets, G. okiensis was determined to be a different species from G. japonica isolated from Japan, although both species showed a sister relationship. For all that extensive collection trips, we found no evidence for the occurrence of G. japonica in Korea.

교실 토론 상황에서 초등학생의 창의적 아이디어에 대한 교사의 인식과 피드백 유형 탐색

부은주(Boo, Eunjoo),김명섭(Kim, Myung-Seop),이선영(Lee, Seon-Young) 한국창의력교육학회 2020 창의력교육연구 Vol.20 No.3

본 연구의 목적은 교실 토론 상황에서 학생 아이디어의 독창성 및 관련성 수준에 따라 교사의 인식과 피드백이 어떻게 달라지는지를 확인하는 것이다. 이를 위하여 현직 초등교사 194명을 대상으로 사회, 과학 교실 토론 상황을 제시한 후 학생 응답의 독창성 및 관련성 수준에 따른 교사의 인식 및 피드백을 분석하였다. 연구 결과, 첫째, 교사들은 관련성이 높은 학생 응답을 관련성이 낮은 응답에 비하여 더 긍정적으로 인식하였다. 독창성이 높더라도 관련성이 낮은 응답은 독창성·관련성이 모두 낮은 응답과 유사하게 더 부정적으로 인식되었다. 둘째, 교사들은 독창성·관련성이 모두 높은 응답과 독창성은 낮고 관련성이 높은 응답에 칭찬, 인정과 같은 긍정 피드백을 더 많이 제공하였고, 독창성이 높고 관련성은 낮은 응답에는 부정 피드백을 더 많이 제공하였다. 셋째, 교사들은 독창성은 낮고 관련성이 높은 학생 응답에 대해 사고를 확장하는 피드백을 가장 많이 제공했지만, 독창성이 높고 관련성은 낮은 응답에 대해 사고를 확장하는 피드백을 가장 적게 제공하고 재고하라는 피드백을 더 많이 제공하는 경향이 있었다. 본 연구 결과를 학생의 창의적 잠재성 계발과 교사 교육 관점에서 논의하였다. The purpose of this study was to explore how teachers perceptions and feedback types vary according to the level of originality and relevance of student ideas in classroom discussion. A total of 194 elementary school teachers responded to a questionnaire that illustrated classroom discussion situations of Social Studies and Science subjects. Teachers perceptions and feedback were analyzed according to the level of originality and relevance of student responses. First, teachers perceived highly relevant student responses more positively than less relevant responses. Responses with high originality and low relevance were perceived more negatively, similar to those with low originality and low relevance. Second, teachers provided more positive feedback, such as praise and recognition, to responses with high originality and high relevance, and responses with low originality and high relevance, and more negative feedback to responses with high originality and low relevance. Third, teachers provided the most amount of thought-expanding feedback to responses with low originality and high relevance. In contrast, for the highly original but less relevant responses, teachers tended to give the least amount of thought-expanding feedback, but more feedback to reconsider. The results of this study were discussed in terms of creativity development and teacher education.

Recombinant Human Epidermal Growth Factor (DWP401) 의 마우스를 이용한 피하투여 아급성독성시험

한상섭(Sang Seop Han),강진석(Jin Seok Kang),송시환(Si Whan Song),강부현(Boo Hyon Kang),신천철(Chun Chul Shin),김희연(Hee Yeun Kim),노정구(Jeong Koo Rho) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2

DWP401, a recombinant human epidermal growth factor, was subcutaneously administered to ICR mice at the dose levels of 0, 0.04, 0.2 and 1.0 ㎎/㎏/day (15rats/sex/group) in order to evaluate the subchronic toxicity. General observations, examinations for food and water consumption, ophthalmoscopy and urinalysis were carried out during the study. For the complete gross and microscopic examinations, 10 mice/ sex/group were sacrificed at the ends of the dosing period, and the remaining animals were sacrificed with a 5 week recovery period. Examinations for hematology and blood biochemistry were also carried out at the time of recovery period. Based on the results, it was thought that the target tissue or organs were mesothelial cell, injection site, spleen, adrenal gland, ovary and transitional epithelial cell of urinary tract, and no observed toxic level of DWP401 was 0.04 ㎎/㎏ while definite toxic dose level might be 0.2 ㎎/㎏.

Effects of Transportation on Hematological and Serum Biochemical Values in Cynomolgus Monkeys

Choong-Yong Kim,Su-Cheol Han,Jeong-Doo Heo,Hyun-Sook Lee,Chang-Su Ha,Boo-Hyon Kang,Myung-Sang Kwon,Sang-Seop Han 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4

Effects of transportation on hematological and serum biochemical values were investigated in five male cynomolgus monkeys imported from Japan. They were underwent air and ground travel-related stress in transport cages for a 15 hour-transit time. On arrival, body weight was found to have reduced. RBC count, hemoglobin concentration, and hematocrit values were significantly elevated immediately on arrival, and serum biochemical parameters such as creatinine, glucose, triglyceride, total bilirubin, inorganic phosphate, and sodium values were significantly higher immediately on arrival than during subsequent weeks. However, all hematological and serum biochemical values, except for blood urea nitrogen (BUN), total cholesterol, and chloride values, were within the Jimits of reference range data. Blood urea nitrogen (BUN), total cholesterol, and chloride values exceeded the normal reference range, and thus these changes were associated with the process of transportation. These changes should be considered when examining the health status of newly acquired animals during quarantine.

시험에 공시된 랫드의 생장기와 고정장기 중량비교

강부현(Kang Boo-Hyon),하창수(Ha Chang-Su),손화영(Son Hwa-Young),김정란(Kim Jeong-Ran),조계명(Cho Gye-Myung),한상섭(Han Sang-Seop) 한국실험동물학회 1992 Laboratory Animal Research Vol.8 No.1

Effects of Abdominal Massage for Preventing Acute Postoperative Constipation in Hip Fractures: A Prospective Interventional Study

Yong Gum Park,Boo Seop Kim,Kyu-Tae Kang,Yong-Chan Ha 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.4

Background: This prospective randomized controlled study aimed to determine the effects of abdominal massage on constipation management in elderly patients with hip fractures. Methods: From August 2017 to December 2018, patients aged above 65 years with hip fractures (n = 88) were randomly assigned to a massage group that received a bowel massage (n = 48) or a control group that did not receive a bowel massage (n = 40). Patients in the bowel massage group received a bowel massage from a trained caregiver after breakfast at approximately 9:00 AM for an hour. On admission, 5 days after surgery, and on the day of discharge, the patient’s normal and actual defecation pattern, stool consistency, and any problems with defecation were assessed through a structured interview. The questionnaire comprising the Bristol Stool Scale, patient assessment of constipation, time to defecation, medication for defecations, failure to defecate, cause of admission, admission period, and date of surgery were recorded. Statistical analyses were performed 5 days after surgery and on the day of discharge. Results: The mean age of the study cohort was 81.4 years (range, 65–99 years). The number of constipation remedies was significantly lower in the massage group than in the control group on postoperative day (POD) 5 and at discharge (9 vs. 15, p = 0.049 and 6 vs. 11, p = 0.039, respectively). The number of defecation failures was significantly lower in the massage group than in the control group (10 vs. 17, p = 0.028) on POD 5. However, the number of defecation failures at discharge was not significantly different between the two groups (p = 0.131). The development of postoperative ileus (p = 0.271) and length of hospital stay (p = 0.576) were not different between the groups. Conclusions: The number of constipation remedies was significantly lower in the massage group than in the control group on POD 5 and discharge, and the number of defecation failures was significantly lower in the massage group than in the control group on POD 5. Therefore, abdominal massage may be considered as an independent nursing initiative for constipation management.