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주의력결핍 과잉행동장애 아동에 있어서 연속수행검사의 진단적 유용성
구본훈,박형배,이희정,송창진,김진성,이광헌 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6
서 론: 본 연구는 주의력결핍 과잉행동장애(이하 ADHD) 아동과 정상대조군의 연속수행검사(이하CPT) 결과 양상을 비교하여 CPT의 진단적 유용성을 알아보고자 하였다. 그리고, ADHD 아동의 연령과 성별, 지능, 그리고, 장애의 유형 등과 같은 변수에 따른 CPT의 결과양상을 비교하여, CPT가 ADHD의 어떤 특성을 잘 반영해주는가를 알아보고자 하였다. 대상 및 방법: DSM-Ⅳ의 진단기준에 의하여 진단이 내려진 ADHD 실험군 68명과 정상대조군 30명을 선정하였으며, 두 군간의 연령과 성별을 통제하였다. 실험군과 정상대조군 모두 환아의 부모가 ADHD 평가척도(ADDES-HV)를 작성하였으며, 환아에게 직접 CPT를 실시하였고 지적 능력을 평가하기 위해 K-ABC를 시행하였다. 결 과: 실험군과 정상대조군에서의 CPT 결과 양상을 비교하였을 때, 실험군과 정상대조군 사이에 민감도가 유의한 차이를 나타내었고, 반응 기준도 유의한 차이를 나타내었다(p<0.05). ADHD 아동을 대상으로 연령과 지능의 변화에 따른 CPT의 결과 양상을 비교하였을 때, 연령과 지능이 증가함에 따라 CPT각각의 결과들도 대체로 수행력이 호전되는 경향을 나타내었다. 주의력결핍 과잉행동 장애의 유형을 과잉행동을 동반한 군과 과잉행동을 동반하지 않은 군으로 나누어 비교분석을 한 결과, CPT 각각의 결과에서 유의한 차이는 나타나지 않았다. CPT 결과 양상에 있어서 남녀간 차이점을 비교하였을 때, 오경보오류와 정반응시간의 표준편차, 표준편차의 다양성, 그리고, 민감도가 유의한 차이를 나타내었다(p<0.05). CPT 각각의 8가지 결과 변수들에 대해 판별분석을 실시한 결과, 각각의 결과 변수들에 있어서 진단에 대한 전체 판별력이 모두 50%이상을 나타내었다. 그 중, 정반응시간의 표준편차와 표준편차의 다양성, 그리고, 민감도는 진단에 대한 전체 판별력이 모두 60%이상을 나타내었다. 결론 및 고찰: 이러한 결과들은 CPT가 ADHD의 진단에 있어서 어느 정도의 유용성을 가지고 있다는 점을 보여준다 하겠다. 즉, ADHD에 있어서 CPT는 비교적 선별검사와 같은 목적으로는 유용할 것으로 생각되며, 이는 또한 CPT가 장애의 진단에 있어서 보조적인 검사도구임을 나타낸다 하겠다. Objectives: The purpose of this study was to examine to diagnostic availability of CPT in children with ADHD, and what factors are affected to CPT results in the diagnosis of ADHD. Method: CPT, ADHD scales(ADDES-HV), K-ABC were administered to 68 ADHD patients and 30 normal elementary school students as the control group. Also, ages and sex are controlled between two groups. Results: In the differences of the results of CPT between ADHD patients and normal subjects, attentiveness and risk taking are significantly different(p<0.05). In the differences of the results of CPT between ages in ADHD patients, usually as more aged children are better performances in CPT. Also, in the differences of the results of CPT between intelligence in ADHD patients, usually as higher intelligent children are better performances in CPT. There are no differences of the results of CPT between types of ADHD in ADHD patients. In the differences of the results of CPT between sex in ADHD patients, commission error, hit reaction time standard error, variability of standard error, and attentiveness are significantly different between male and female patients(p<0.05). The correlations between ADHD scales and the results of CPT show that inattention subscale is significantly related to hit, omission error, hit reaction time standard error, and variability of standard error. In the discriminant ability between ADHD patients and normal children by the results of CPT, accuracy rates are more than 50% in all results of CPT. Especially, the accuracy rate of hit reaction time standard error, and the accuracy rate of variability of standard error, and also, the accuracy rate attentiveness are more than 60%. Conclusion: In this point of view, this study suggest that CPT is relatively valuable method in the diagnosis of ADHD. For instances, CPT is more likely to screen the ADHD from normal children, or to use as assisted method of diagnosis of ADHD in clinical settings.
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부유대역 용융응고법으로 제조된 YBa_2Cu_3O_x 산화물초전도체의 미세구조와 전기적 특성
노태형,송정환,장규철,한이섭,김소정,구본급,김호기 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
The YBa_2Cu_3O_x-20 wt% Y_2BaCuO_5 composition designed in YBCO system was synthesized by solid state reaction method. The optimum condition of hot zone temperature and growth rate in floating-zone melt were 1080 ℃ and 2.5 mm/hour, respectively. In samples growth as these condition, the low angel boundaries in grain direction and small amount of amorphous phase known as decreasing characteristics of superconducting materials between grain boundaries in microstructure are investigated by polarized light microscopy on the whole. The critical current density(Jc) at 77k of sample using powder fabricated with no CeO_2 and doped 5 wt%CeO_2 were 8,000 A/㎠(Jc : 561A) and 12,000 A/㎠(Jc: 826A) at 0 T by direct current transport method, respectively.
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알록산 투여로 유발된 실험적 당뇨병에 대한 사인추출물의 치료 효과
노혜원,이지나,구본선,조정임,박진우,김형로 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2
연구배경:사인추출물이 알록산에 의한 당뇨 유발을 억제하는 효과가 있음을 이미 확인하였던 바 사인 추출물이 췌장 베타세포가 손상되어 유발된 당뇨병의 치료에 사용할 수 있는지의 가능성을 알아보았다. 방법:실험적 당뇨는 알록산(60㎎/㎏)을 생쥐 꼬리 정맥을 통해 주사하여 유발시켰다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 사인추출물의 영향을 관찰하기 위하여 사인추출물(2.5㎎/생쥐)을 하루에 두 번 생쥐 복강 내로 투여하였다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 생쥐에 사인추출물을 처리한 다음 혈당 및 혈청 인슐린 농도 변화 및 조직학적인 소견으로 확인하였다. 결과:생쥐에 알록산을 투여하면 췌장 베타세포가 파괴되어 고혈당 및 hypoinsulinemia가 유발되었다. 사인추출물을 알록산 투여 전 2일 동안 전처리하면 알록산에 의한 고혈당이 완전히 억제되었다. 뿐만 아니라 알록산에 의해 유발된 췌장 베타세포의 손상은 사인추출물의 투여로 현저히 개선되어 혈당 및 혈청 인슐린 농도가 거의 정상 수준으로 회복되었다. 알록산을 투여한 생쥐의 췌장 소도는 정상군에 비해 수가 현저히 감소되었을 뿐 아니라 남아있는 소도의 크기도 현저히 줄어들어 있었으나, 사인추출물을 처리하면 모두 회복되어 정상군과 유사한 양상을 보였다. 결론:사인추출물은 알록산에 의해 유발되는 당뇨병을 억제하는 방어 작용 뿐만 아니라, 알록산 투여로 이미 손상된 췌장 베타세포를 개선시킬 수 있는 치료 효과작용도 가지고 있음을 확인하였다. 이를 토대로 사인의 당뇨 개선 기전을 규명하면 당뇨병 치료제로서 이용할 수 있으리라 사료된다. Background : During the screening of natural products for potential antidiabetogenic components, a strong protective effect of Amomum xanthoides extract on alloxan-induced β-cell damage and in a mice diabetic model. In this study, the therapeutic effect of Amomum xanthoides extract was investigated after induction of diabetes by alloxan. Methods : Experimental diabetes was induced by the injection of alloxan(60mg/kg) to the mouse via the tail vein. To examine the effect the of Amomum xanthoides extract on diabetes, Amomum xanthoides extract (2.5mg/mouse) was admini-strated intraperitoneally. The effect of the Amomum xanthoides extract on alloxan-induced diabetes was observed by measuring the blood glucose and serum insulin level, and a histological examination. Results : Alloxan caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic β-cell. Pretreating the with an Amoumum xanthoides extract completely protected them from the hyperglycemia induced by alloxan. In addition, the Amomum xanthoides extract administe 3 days after the of alloxan injection significantly abolished the hyperglycemia and hypoinsulinemia induced by alloxan. The alloxan-treated mice showed a marked change of in the pancreatic islets: the number of islets was reduced and the size of the remaining islets also decreased. However these effects of alloxan were significantly recovered by a later administration of the Amomum xanthoides extract. Conclusion : The amomum xanthoides extract contains potentially effective components, which both protect and treat alloxan-induced diabetes. The identification and action mechanism of the effective components of the Amomum xanthoides extract requires further investigation and it is suggested that the Amomum xanthoides extract be used as a therapeutic drug for diabetes(J Kor Diabetes 26:126~133, 2002).
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쥐의 망막 미세구조에 미치는 급성 메탄올 중독에 대한 에탄올의 효과 관찰
이호경,유진형,구본술 인제대학교 1983 仁濟醫學 Vol.4 No.3
복강내 메탄올 주입으로 급성 메탄올 중독을 일으킨 쥐와 메탄올 주입 직후, 8시간 후 및 24시간 후에 에탄올을 투여한 쥐의 망막 미세구조를 관찰하여, 메탄올 주입 직후와 8시간 후에 에탄올을 투여한 쥐에서 메탄올에 의한 망막 조직 파괴가 경감되었음을 관찰하였다. Methanol is a widely-used chemical which can cause serious visual loss by accidental ingestion, and ethanol therapy has been considered effective in maintaining life as well as preserving vision, if performed appropriately. To provide histopathologic basis of ethanol therapy in acute methanol poisoning, which is still obscure, methanol was injected intraperitoneally to the rat and ethanol therapy was carried out immediately after, 8 hours after, and 24 hours after methanol injection. One month later, specimens of retina were obtained and examined using electron microscope, comparing with only methanol-injected case. The results were as follows. 1.Ultrastructural examination of retina of the only methanol·injected rat revealed such histologic changes as retinal ganglion cell degeneration, vacuole formation in nerve fiber layer, photoreceptor outer segment destruction, and separation of inter-pigment epithelial junction, which are compatible with clinically observed visual deterioration. 2.Retinal changes were much reduced in the rat which had received ethanol therapy immediately after methanol injection, but the reduction was not conspicuous in the 8 hour-interval ethanol treated rat. No differences were found between only methanol-injected rat and 24 hour-interval ethanol-treated case.
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마찰력과 열처리에 따른 아크용사 및 아크용접된 Fe-Cr-B 합금 피복층의 변화
이찬규,유인석,김강형,구본흔,박맹로 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-
Variations of arc thermal sprayed and arc welded Fe-Cr-B alloy coating with frictional loading and heat treatment were investigated by means of X-ray diffraction, optical microscopy, scanning electron microscopy, electron probe microanalysis and hardness test. The as-coated layers were shown to be crystalline state but peaks with the frictional loading largely disappeared in X-ray diffraction profiles. The splat is relatively wavy with the boundary in arc thermal spray coating. After heat treatment, the amount of porosity was found to be decreased and the intersplat distance was increased. As annealing temperature increased, interface layer for arc welding coating increased by the diffusion of Cr atoms. The wear type observed in arc thermal spray coatings is splat delamination. The hardness of the arc thermal spray coation layer was superior to that of the arc welding layer. Hardness of coated layer is reduced and microstructures become to be uniformed by the heat treatment.
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Purification and Spectroscopic Characterization of the Human Protein Tyrosine Kinase-6 SH3 Domain
(Bon Kyung Koo),(Min Hyung Kim),(Seung Taek Lee),(Weon Tae Lee) 생화학분자생물학회 2002 BMB Reports Vol.35 No.3
The human protein tyrosine kinase-6 (PTK6) polypeptide that is deduced from the cDNA sequence contains a Srchomology (SH) 3 domain, SH2 domain, and catalytic domain of tyrosine kinase. We initiated biochemical and NMR characterization of PTK6 SH3 domain in order to correlate the structural role of the PTK6 using circular dichroism and heteronuclear NMR techniques. The circular dichroism data suggested that the secondary structural elements of the SH3 domain are mainly composed of β-sheet conformations. It is most stable when the pH is neutral based on the pH titration data. In addition, a number of cross peaks at the low-field area of the proton chemical shift of the NMR spectra indicated that the PTK6 SH3 domain retains a unique and folded conformation at the neutral pH condition. For other pH conditions, the SH3 domain became unstable and aggregated during NMR measurements, indicating that the structural stability is very sensitive to pH environments. Both the NMR and circular dichroism data indicate that the PTK6 SH3 domain experiences a conformational instability, even in an aqueous solution.
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