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Coopersmith Self-Esteem Inventory(SEI)의 구성타당도 연구
최보가,전귀연 경북대학교 1992 논문집 Vol.24 No.-
The purpose of this study was to investigate the construct validity of the Coopersmith Self-Esteem Inventory(SEI) in a Korean setting. The 2,451 subjects were selected by random sample from grades 4, 5 and 6 of primary schools and the first and second grade of middle schools in the City of Taegu. Statistical analysis was by principal component factor analysis as foctor extraction model and varimax rotation, factor rotation through the SPSS computer program. The results were not in complete agreement with Coopersmith's dimensions; that is, construct validity was not found in the subareas of the SEI. However, 4 factors were found to account for self-esteem in all 5 grades of this study. The 7 items of Factor Ⅰ and the 3 items of factor Ⅱ can be used as the general self-esteem scale; the 4 items of Factor Ⅲ and the 4 items of Factor Ⅳ can be used as the home self-esteem and the social self-esteem scales, respectively.
Kim Hee‐Yeon,Jo Min Jeong,Nam So Yung,Kim Kwang Min,Choi Moon Bo,Lee Yong‐Ho 한국곤충학회 2020 Entomological Research Vol.50 No.5
Obese adipose tissue is characterized by adipocyte hypertrophy and a massive macrophage infiltration. The interaction between macrophages with mature adipocytes releases pro-inflammatory cytokines. This chronic inflammatory state can contribute to obesity-related complications, such as insulin resistance, type 2 diabetes and cardiovascular disease. Therefore, we can attempt to prevent and treat obesity-related diseases by inhibiting macrophage infiltration and blocking their interaction with adipocytes. Honey bee (Apis mellifera) venom (BV) has been reported to have anti-inflammatory effects. Although BV is used to treat chronic inflammatory diseases, few studies have addressed its use in obesity-associated inflammation. This study examines the inhibitory effects of BV on lipid accumulation in differentiating preadipocytes, inflammation, and insulin resistance in macrophages and adipocyte-macrophage co-culture system. We treated 3 T3-L1 preadipocytes with BV during differentiation. We later measured lipid accumulation and gene expression of master adipogenic transcription factors. After RAW264.7 and 3 T3-L1 cells were pretreated with BV, RAW264.7 cells were activated with LPS or co-cultured with pretreated 3 T3-L1 cells. Gene expression of pro-inflammatory cytokines and insulin sensitizing genes was measured in these cells. BV inhibited lipid accumulation and C/EBPα and PPARγ gene expression during intermediate and late 3 T3-L1 cell differentiation. BV also suppressed gene expression of pro-inflammatory cytokines (COX-2, iNOS, MCP-1, TNF-α, IL-1β and IL-6) in LPS-stimulated macrophages, and in co-culture of 3 T3-L1 adipocytes and RAW264.7 macrophages. However, adiponectin and GLUT-4 expression were both significantly increased by BV in co-culture. These findings demonstrate that BV attenuates adipocyte hypertrophy and improves obesity-related inflammation and insulin resistance in obese adipose tissue.
심문보,최연선 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1
Gear plays an important role for the power transmission of a machine. The rotation of driven gear should be that of the driving gear with the proportion of the gear ratio. However, the deviations between them are resulted from the deflections due to transmission error, which leads to vibrations and noise during gear meshing. Transmission error is defined as the difference of the rotation between driving and driven gear due to teeth deformation, which also causes an interference during meshing. The interference is one of severe causes of the vibration and noise of gear driving system. In this study, a tooth flank modification is suggested for the prevention of the interference by numerical simulation of gear meshing. The compliance of gear tooth and transmission error are calculated for the tooth modification. The interference due to transmission error is predicted numerically and the quantity of tooth flank modification is calculated to remove the interference.
Caffeine Inhibits Cell Proliferation and Regulates PKA/GSK3β Pathways in U87MG Human Glioma Cells
Bo Mi Ku,Yeon Kyung Lee,Joo Yeon Jeong,Jinhyun Ryu,Jungil Choi,Joon Soo Kim,Yong Woon Cho,Gu Seob Roh,Hyun Joon Kim,Gyeong Jae Cho,Wan Sung Choi,Sang Soo Kang 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.3
Caffeine is the most commonly ingested methylxanthine and has anti-cancer effects in several types of cancer. In this study, we examined the anti-cancer effects of caffeine on gliomas, both in vitro and in vivo. In vitro, caffeine treatment reduced glioma cell proliferation through G_0/G_1-phase cell cycle arrest by suppressing Rb phosphorylation. In addition, caffeine induced apoptosis through caspase-3activation and poly(ADP-ribose) polymerase (PARP) cleavage. Caffeine also phosphorylated serine 9 of glycogen synthase kinase 3 beta (GSK3β). Pretreatment with H89, a pharmacological inhibitor of protein kinase A (PKA), was able to antagonize caffeine-induced GSK3β^(ser9) phosphorylation,suggesting that the mechanism might involve a cAMP-dependent PKA-dependent pathway. In vivo, caffeine-treated tumors exhibited reduced proliferation and increased apoptosis compared with vehicle-treated tumors. These results suggest that caffeine induces cell cycle arrest and caspase-dependent cell death in glioma cells,supporting its potential use in chemotherapeutic options for malignant gliomas.