학교도서관과 MLA 연계를 위한 교육 온톨로지 모형 구축에 관한 연구

이혜원,Lee, Hye-Won 한국비블리아학회 2008 한국비블리아학회지 Vol.19 No.1

The advantage of ontology leads a new knowledge system through integrating existing knowledge system and descriptive element of the concept. This study based on the advantage of ontology, providing a modeling education ontology that considered educational circumstances and related objects-person, organization, educational resources and so forth. Therefore, this study developed the framework for education ontology that provided link between school library and MLA to practice teaching-learning activity, these characteristics of educational ontology were as follows : the first, utilizing the existing education metadata and ontology, the second, representing a concept of educational ontology, subsequently defining classes and properties of education domain, the third, adding new classes and properties to connect existing classes and properties.

이벤트 - 2005서울국제도서전

이혜원,Lee, Hye-Won 대한출판문화협회 2005 출판저널 Vol.356 No.-

서울국제도서전 결산과 과제

이혜원,Lee, Hye-Won 대한출판문화협회 2004 출판저널 Vol.344 No.-

무미양서류 꼬리 퇴화과정중 피부 상피조직의 세포사에 관한 조직화학적 및 미세구조적 연구

이혜원,문명진,Lee, Hye-Won,Moon, Myung-Jin 한국현미경학회 2009 Applied microscopy Vol.39 No.2

참개구리(Rana nigromaculata) 꼬리 퇴화과정에 따른 피부 상피조직의 분화와 세포자멸사에 의해 초래된 상피의 미세구조적 변화를 TUNEL 조직화학적 염색 및 고배율의 투과전자현미경 관찰을 통해 확인하였다. 꼬리의 퇴화가 시작되는 Shumway 31단계의 올챙이 피부에 발달되어 있던 점액층은 발생 32 단계를 거쳐 사라지고 상피는 비후되어 꼬리의 퇴화가 완료되는 발생 33 단계에 도달하면 성체인 개구리의 다층상피로 전환되었다. TUNEL 염색결과, 꼬리 퇴화과정중 apoptosis 세포의 출현은 원위부(distal region)의 꼬리에서 시작되어 몸통 쪽의 근위부(proximal region)로 이행되었고, 동일 상피층에서는 내강부로부터 기저부로 전이되는 특성을 보였다. 투과 전자현미경 관찰 결과, 세포자멸사에 의한 초기의 변형은 인접세포와의 세포간극이 사라지고 밀착된 후, 핵의 모양이 불규칙해지고 염색질이 응축되었다. 이어서 세포질에 다수의 자유 리보솜이 나타나고, 핵의 분절이 일어난 후, apoptotic body가 출현하며, 이들은 최종적으로 라멜라 구조를 지닌 잔여소체(residual body)를 형성하였다 The programed cell death of the cutaneous epithelial tissue during tail regression stages in anuran tadpoles of the blackspotted frog, Rana nigromaculata were visualized by the histochemical and transmission electron microscopic techniques. Metamorphotic changes in the tail regression during the period of the Shumway stage number 31 to 33 are characterized by the disappearance of mucous layer and formation of compound epithelium through cutaneous thickening. Following the TUNEL (terminal deoxynucleotidyl transferase-mediated biotinylated d-uridine triphosphate nick end labeling) staining technique, the apoptotic cells were detected at the distal region of the tail skin initially, but they can be seen at the proximal region according to their following development. It has been also revealed that the number of the TUNEL-positive cells gradually increased from apical to basal direction of the epithelial layers during the tail regressing stages. Following the TEM observation, the early apoptotic cells shown in the epithelium demonstrated condensation and margination of the chromatin material at the nuclear periphery. Another epithelial apoptotic cells were shown nuclear fragmentation, membrane blebbing and cytoplasmic condensation. Following the process of the apoptotic degradation, well preserved organelles and nuclear fragments can be identified in the cytoplasm of lysosome-rich cells, however they soon reduced to lysosomal residual bodies through the progressive degradation.

TPCK 프레임워크를 기반으로 한 교과교사와 사서교사 간의 교수-학습 협력에 관한 연구

이혜원,Lee, Hye-Won 한국도서관정보학회 2008 한국도서관정보학회지 Vol.39 No.2

본 연구에서는 정보활용능력을 향상시키기 위해 학교도서관의 사서교사와 일반 교과의 교사들 간의 협력 방안을 제시하고자 하였다. 또한 교육의 또 다른 주체인 학생을 중심으로 한 부분을 확대함으로써 좀 더 효율적인 교수-학습이 이루어질 수 있도록 하였다. 무엇보다 교사와 학생들의 커뮤니케이션에서 직접적인 교환이 이루어지는 지식을 중심으로 주제, 교육학적인 배경, 정보기술의 활용 등을 고려한 모형을 제안하였다. In this study, collaboration of teacher librarians and subject teachers in school libraries has been investigated(tried, attempted, suggested) in order to improve the information literacy. The effective teaching-learning can be conducted by extending student's roles, which are essential elements in school education. Above all, the model. focused on direct exchange of knowledges in communications between teachers and students has been suggested with consideration of content knowledge, pedagogical knowledge, and technological knowledge.

가토 간내 선택적 담관결찰후 간부피의 변화에 대한 실험적 연구

이혜원,윤엽,고영태,최우석,임주원,오주형,임형택,김윤화,이석환,Lee, Hye Won,Yoon, Yup,Ko, Young Tae,Choi, Woo Suk,Lim, Joo Won,Oh, Joo Hyeong,Rim, Heyong Teck,Kim, Youn Wha,Lee, Seok Hwan 대한영상의학회 1998 대한영상의학회지 Vol.39 No.6

Purpose : To evaluate the role of bile duct obstuction in the development of atrophy of the liver, using ananimal model. Materials and Methods : Seven rabbits were divided into two groups : group 1(n=5), in which therewas selective bile duct ligation, and group 2(n=2), which underwent a sham operation. Each group was evaluatedusing CT for changes in hepatic volume after selective bile duct ligation or a sham operation. In group I, thediameter of dilated bile duct was measured 2, 4, 8, 12 and 16 weeks after bile duct ligation, while gross andhistologic change were evaluated in all cases. Results : In group 1, bile duct dilatation was seen on CT two weeksafter selective bile duct ligation, and did not change significantly during follow-up. In four of five cases, CTrevealed no evidence of significant atrophy of the involved segment. Pathologic specimens, however, revealeddilatation of the bile duct, periductal fibrosis, infiltration of chronic inflammatory cells, and periportalfibrosis. One of five cases showed segmental liver atrophy after selective bile duct ligation. In addion to theabove pathologic findings, there was obstruction of the portal vein by foreign body reaction. In group 2, noevidence of dilated bile duct or liver atrophy was revealed by CT or pathologic specimen after a sham operation.Conclusion : During long-term follow-up of 16 weeks, obstruction of the bile duct did not play a major role in thedevelopment of lobar atrophy in the rabbit.

음양곽으로부터 Icariin의 분리 및 함량분석

이혜원,황성원,고병섭,김호경,Lee, Hye-Won,Hwang, Seong-Won,Ko, Byoung-Seob,Kim, Ho-Kyoung 한국생약학회 2001 생약학회지 Vol.32 No.1

Epimedii Herba has been used for tonic, cardiotonic, impotency, amnestic and diuretic. Icariin, a main component was isolated from the Epimedii Herba and identified by the spectroscopic methods. In order to evaluate the quality of Epimedii Herba purchased from various regions of Korea, quantitative determination of icariin in Epimedii Herba using HPLC method has been conducted. Quantitative analysis showed the average amount of icariin in commercial 42 samples was 0.34% on the dry weight basis.

Nut류의 항산화 및 항균효과

이혜원,최무영,차배천,Lee, Hye-Won,Choi, Moo-Young,Cha, Bae-Cheon 한국생약학회 1998 생약학회지 Vol.29 No.1

It has been known that diseases related with aging or cancer result, at least in part, from free radicals, and antioxidants may reduce or prevent the abnormalities associated with free radical formation via its scavenging action. Thus, this study was carried out to investigate the antioxidative and antimicrobial activities of nut species for the purpose of developing antioxidant from natural products. Antioxidant activities of four kinds of nuts such as chestnut, groundnut, walnut and acorn were examined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The extracts from chestnut hull and acorn barnyard millet showed strong antioxidative activities among 10 samples tested. Because of their highest antioxidative activity among 10 samples, radical scavenging effects of 4 different extract compartments (Hexane, EtOAc, BuOH and $H_2O$ extracts) from chestnut hull and acorn barnyard millet, were further examined by DPPH method. EtOAc and BuOH extracts exhibited antioxidative activities similar to those of natural, tocopherol or synthetic antioxidants, BHA. These findings demonstrates that major fraction of the antioxidative activity of chestnut hull or acorn barnyard millet was the EtOAc and BuOH extract compartments. However, antimicrobial activities against food-related bacteria and yeasts was relatively weak.

참개구리(Rana nigromaculata) 유생기 상피 세포사의 미세구조

이혜원,문명진,Lee, Hye-Won,Moon, Myung-Jin 한국현미경학회 2010 Applied microscopy Vol.40 No.2

변태중인 참개구리(Rana nigromaculata) 유생의 상피에서 세포자멸사가 초래된 세포를 확인하고 이들의 핵과 세포질에서 나타나는 퇴행과정의 미세구조 변화를 TUNEL 염색법과 투과전자현미경 관찰을 통해 분석하였다. 꼬리의 퇴화가 진행되는 Shumway 발생단계 31기부터 33기까지의 유생 상피는 다층의 입방형세포로 이루어져 있었고, TUNEL 염색으로 관찰한 결과, 상피 전역에 걸쳐 광범위한 세포자멸사가 진행되고 있음을 확인할 수 있었다. 자멸사에 의해 초래되는 상피세포의 초기 변형은 먼저 핵에서 관찰되었는데, 염색질이 응축되어 핵막 주변부로 편재되었고 핵의 분절과 세포질의 응축, 그리고 세포막의 변형이 뒤따르는 것으로 확인되었다. 이어서 세포질의 분절에 의해 자멸소체가 형성되었는데 막으로 둘러싸인 소체 내부에서는 비교적 잘 보존된 형태의 세포소기관들이 관찰되었다. 자멸사가 초래된 세포들은 상피내 대식세포(intraepithelial macrophage)로 추정되는 인접 세포들에 의해 탐식되어 잔여소체를 형성하였으며, 급속한 퇴화과정을 거쳐 층판구조를 지닌 소포의 형태로 변형된 후 세포질에서 소멸됨이 확인되었다. The fine structural characteristics of the apoptotic cells in the cutaneous epithelium of the anuran tadpole of the black-spotted frog, Rana nigromaculata was examined using the TUNEL (Terminal deoxynucleotidyl transferase-mediated biotinylated d-Uridine triphosphate Nick End Labeling) staining technique and TEM (transmission electron microscopy) observations. The cutaneous epithelium of the tadpole was composed of stratified cuboidal cells and the apoptotic cell death was observed continuously during the tail degeneration stages from the Shumway stage number 31 to 33. The early apoptotic cells shown in the epithelium demonstrated condensation and margination of the chromatin material at the nuclear periphery, and nuclear breakdown and cytoplasmic condensation were followed. Subsequent cytoplasmic degeneration of the apoptotic cell were produced by membrane-bounded cell fragments with relatively well preserved organelles. Following the processes of autophagic degradation, the late apoptotic cells being phagocytosed by other surrounding cells. These nearby cells, presumptive intraepithelial macrophages, contain a variety of lysosomal residual bodies which fuses with other cell organelles or other cytoplasmatic material to form secondary lysosomes. They are soon transformed into lamellar shaped vesicles and finally disappeared during the process of degradation.

매쉬업을 적용한 기관 내 정보검색시스템 통합 방안 연구 - 국사편찬위원회 정보시스템을 중심으로 -

이혜원,윤소영,Lee, Hye-Won,Yoon, So-Young 한국과학기술정보연구원 과학기술정보센터 2011 Journal of Information Science Theory and Practice Vol.42 No.1

본 연구에서는 실시간으로 질의를 처리하고, 이용자의 요구에 보다 동적으로 응답한다는 장점을 가진 매쉬업을 이용하여 기관 내부 정보시스템을 통합검색하고자 하였다. 국사편찬위원회 기관 내부의 정보시스템 각각은 개별 도서관시스템에 준하는 정보의 양을 보여주고 있다. 기관 내부의 여러 시스템에 대한 통합검색서비스 또한 매쉬업 등 웹 2.0 기술을 적용하여 기관 외부 정보와 연계하는 통합검색 시도와 같은 맥락에서 볼 수 있다. 본 연구에서는 기관 내부에서 검색서비스를 제공하는 것을 전제로 하여 역사콘텐츠를 위한 국사편찬위원회 OpenAPI를 설계하고 메타데이터 형식 및 내용을 제안하였다. Mashup service provides results by query in real time and responds to users' request in dynamic. In terms of size, each of NIKH(National Institute of Korean History)'s internal Information Systems is equal to individual library system. As adapting mashup for information convergence with external resources, it was accepted for internal integrated search in the same context. This study designated NIKH OpenAPI and proposed metadata format for internal integrated search of historical contents.