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      • 연 작업자들의 업종별 보건관리에 의한 건강수준의 변화

        정규,규동,이병국 순천향대학교 산업의학연구소 1996 순천향산업의학 Vol.2 No.1

        In order to evaluate the effect of industry type specific occupational health service on the health status of lead workers, total 39,203 record of 5 year accumulated data of workers from 1989 to 1993 in lead using industries which made special contract of group occupational health service with Soonchunhyang university, institute of industrial medicine were studied. Blood zinc protoporphyrin (ZPP) and 15 lead related symptoms were selected as a health indices and air concentration of lead (PbA) was selected as a environmental index of lead industries. Blood ZPP and symptoms survey were carried out twice a year for lead workers and once a year for non-lead office workers. Environmental measurements of lead in air were done twice a year in every lead using industries. Lead industries were divided into 4 group of lead industries arbitrarily such as storage battery industries for group I, secondary smelting, litharge making and related operation for group II, telecommunication for group III and primary smelting and crystal glass making for group IV. Data for group III only available for 3.5 years from 1990 to first half of 1993. Blood ZPP was measured with hematoflurometer (Aviv model 206). Fifteen questionnaire of lead related symptoms were provided to all workers and filled by themselves and confirmed by interview doctor at the site. The results obtained were as follows: 1. While the geometric means of lead in air of group I, II, IV in 1989 were 0.333, 0.353 and 0.113 ㎎/㎥, those in 1993 were decreased to 0.081, 0.162 and 0.037 ㎎/㎥ respectively. On the other hand the geometric means of lead in air of group III were always below 0.020 ㎎/㎥ throughout the study period. 2. While the geometric mean of lead in air in medium/large storage battery industries was 0.313 ㎎/㎥ in 1989, it was decreased to below 0.05 ㎎/㎥ since 1992, that in small storage battery industries was 0.395 ㎎/㎥ and it was still 0.101 ㎎/㎥ in 1993. This data suggested that the effect of group occupational health service were more effective in medium/large storage battery industries. 3. The overall percent of distribution of lead in air of below 0.05, 0.05-0.15 and over 0.15 ㎎/㎥ in group I for 5 years were 87.54%, 9.29% and 3.16% respectively. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96% 14.47%, 5.57% respectively. 4. The mean blood ZPP of male lead workers decreased from 52.61±68.67 ㎍/100ml in 1989 to 33.31±34.62 ㎍/100ml and those of female lead workers decreased from 84.01±79.06 ㎍/100ml in 1989 to 58.35±47.30 ㎍/100ml. While the mean blood ZPP of male lead workers for group I, II and IV in 1989 was 39.65±40.41, 132.9±121.1 and 32.9±55.51 ㎍/100ml, those in 1993 were 29.75±28.38, 77.35±64.48 and 31.41±21.35 respectively. The mean blood ZPP for group III were ranged from 13.11±8.53 to 26.43±8.83 ㎍/100ml for 3 and half years period. 5. The mean blood ZPP of male lead workers in medium/large and small storage battery industries in 1989 were 32.16, 82.53 ㎍/100ml in 1989 and those in 1993 were decreased to 25.69 and 76.22 ㎍/100ml respectively. Those of female lead workers in both industries in 1989 were 53.36, 126.3 ㎍/100ml and 43.68, 90.17 ㎍/100ml respectively. 6. The overall percent of distribution of blood ZPP of below 50, 50-99, 100-149 and over 150 for 5 years were 72.83% (male: 76.63%, female: 44.59%), 16.97% (male:15.23, femlae: 29.93%), 5.23% (male: 4.18%, female: 13.04%) and 4.96% (male: 3.96%, female: 12.44%) respectively. Among 4 groups, the percent of workers whose blood ZPP over 50 ㎍/100ml was highest in group II. 7. The mean of overall symptoms of male and female lead workers in 1989 were 5.2 and 4.9 and decreased to 4.6 and 4.3 in 1993 respectively. The mean of overall symptoms of male and female lead workers in medium/large storage battery industries in 1989 were 5.7, 5.9 and decreased to 4.8, 5.2 in 1993. Those in small storage battery industries in 1989 werer 4.8, 5.2 and 3.8, 3.2 respectively. 8. The most frequent symptom among 15 lead related symptom questionnaires for 5 year duration was 'generally fatigue' (male: 63%, female: 53%) and the least frequent symptom was 'acute abdominal pain around umbilicus' (male: 12%, femlae: 9%). Among male lead workers of 4 groups the prevalence of lead related symptoms was highest in group 4 and followed by group 3, 1 and 2 in descending order. Among female lead workers it was highest in group 3 and followed by group 1, 2, and 4 in descending order. 9. The prevalence of lead related symptoms were high in group whose blood ZPP below 100㎍/100ml than those with blood ZPP over 100 ㎍/100ml. The prevalence of lead related symptoms of male lead exposed workers were higher or same with male non-lead exposed workers in every symptoms except questionnaire 11. But for female workers the prevalence of lead related symptoms of lead exposed workers were lower than non-exposed lead workers except questionnaire 1, 4, 5, 6, 7, 8, 12, 15. 10. There was very similar pattern of symptom prevalence over the 5 years in lead exposed and non-exposed workers for both sex. 11. The prevalence of lead related symptoms was higher in young age group than old age group and there was no big difference of prevalence according to the work duration. With above results, group occupational health service for lead workers improved working condition of lead industries under special contract with Soonchunhyang university, institute of industrial medicine in term of decrease of lead in air, particularly more effective in medium/large storage battery industries. It also brought out the the decrease of lead burden of most lead workers in terms of blood ZPP of lead workers which is a good index of lead intoxication. But symptom servery did not give any clue of dose-response relationship between lead exposure and lead related symptoms with current symptom questionnaire. It is recommended to revise the way of questioning lead related symptoms from lead workers. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96%, 14.47%, 5.57% respectively.

      • KCI등재
      • 流域特性과 洪水到達時間과의 相關解析

        徐承德,林奎東 慶北大學校出版部 1987 慶北大農學誌 Vol.5 No.-

        The purpose of this study is to inquire and analyse the relation between trabeltime (Tc) and watershed physical characteristics surveyed such as river length (L), Lca, river main slope (s), base length of time area diagram, and storage constant (k). The results obtained in this study are as follows. The average widths of watersheds were with the range from 4.6 kilometers to 16.7 kilometers. The shape factors of main stream ranged from 0.08 to 0.37. The average slopes to main stream were within the range of 1.7 - 5.5 meters per kilometer. The relation between the base length and traveltime from S.C.S. method, Rational method, and RZIHA+KRAVEN method were derived Tc = 0.524X1.35^(c) (r=0.98), Tc = 0.628 ×1.339^(c), (r = 0. 98), Tc = 0.667×1.342^(c) (r = 0.97). The base length of the time-area diagram (c) for the IUH was derived as c=0.9 ◁수식 삽입▷ (원문을 참조하세요) and correlation coefficient was 0.98 which defined a high significance. The storage constant K, derived in this study was K = 8.32+0.0213◁수식 삽입▷ (원문을 참조하세요) with correlation coefficient (0.96). The relation between storage constant and conventional formula were figured out Tc = 0.0003 ×3.323^(k) (r = 0.97). Tc = 0.00045 ×3.286^(k) (r = 0.99)and Tc = 0.0004 ×3.26^(k) (r = 0.963). The base length (c) and storage constant (k) of time - Area Diagram were very important parts determinded traveltime for flood events. In the estimate of travel time for predicting flood volume, the formula of Tc = 0.524 ×1.35^(c) that would be available to apply the Nak - Dong river watershed area and homogeneous watershed characteristics was found.

      • 여성 연폭로 근로자들의 연폭로 지표와 자각증상에 관한 연구

        이금원,정규,규동,이병국 순천향대학교 1994 논문집 Vol.17 No.2

        The effect of lead on subjective symptoms of lead exposure was studied with 396 women lead workers in 6 storage battery factories as an exposed group to lead and 166 women workers in general manufacturing industries as a non-exposed group to lead. Zinc protoporphyrin in whole blood(ZPP) was selected as an indicator of lead exposure. SGOT and SGPT were also checked to observe the lead effect on liver function of lead workers. Questionnaires of 15 lead related symptoms were provided to all women workers and filled up by themselves and reconfirmed the symptoms answers by interviewing medical doctor. There was significant mean difference of blood ZPP between exposed group (90.0 ± 86.2 ug/dl) and non-exposed group (33.8 ± 29.9 ug/dl), but there was no differences of means of SGOT and SGPT between exposed and non-exposed group to lead. After age stratification, the symptom prevalences of exposed group were higher than non-exposed group in most cases. This trend was strong in the comparison of symptom prevalence of women worekrs whose ages were under 30 years. The symptom prevalence of women workers who worked in medium sized factories was higher than that of women workers working in small sized factories. While the symptom prevalence of all workers was not dose-dependent to ZPP increase in most symptoms category, there was weak trend of dose-respnse relationship of symptom prevalence with ZPP increase in women workers working in medium sized factories, but not statistically significant.

      • SCOPUSKCI등재

        모 일산화 연 제조 업체 근로자들의 연 폭로에 관한 연구

        상복,정규,이성수,규동,이병국,Lim, Sang-Bok,Lim, Jung-Kyu,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook 대한예방의학회 1995 예방의학회지 Vol.28 No.4

        In order to investigate the level of lead exposure of workers in litharge making industry and to evaluate how lead exposure, personal habit such as smoking and drinking affect the prevalence of lead related symptoms and other study variables, we investigate 114 workers(24 office workers and 90 lead exposed workers) in a litharge making industry. Study variables chosen were blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), Hemoglobin(Hb), hematocrit (Hct), SGOT and SGPT symptom questionnaires which had 15 lead exposure related symptoms were provided to all workers and filled up by themselves and reconfirmed by physician. The results obtained were as follows; 1. The mean value of PbB, ZPP and SGOT in lead exposed group were higher than those of non-exposed group, and there were no differences of means in other study variables. 2. The smoking and drinking rate of study subjects were 65.8% and 71.0% as a whole. Smoking rates were lower in non-exposed group than exposed group, but drinking rate were not. 3. There were no differences of mean values of study variables between smoker and non-smoker in non-exposed and exposed group, but there was a difference of mean value of SGOT between drinker and lion-drinker in lead exposed group. 4. While the symptom prevalence of lead exposed group were higher in neuromuscular category than non-exposed group, those of non-exposed group were higher or same with exposed group in gastrointestinal and general symptom category. 5. The symptom prevalence of smoker were higher than non-smoker regardless of exposure. 6. The symptom prevalence of drinker were only higher in gastrointestinal symptom category than non-drinker. 7. In multiple stepwise regression analysis of lead related symptoms as dependent variable and blood lead, smoking habit, drinking habit and work duration as independent variables, drinking habit contributed to the gastrointestinal symptom category, whereas blood lead and smoking contributed to the neuromuscular symptom category. For the total symptoms work duration and smoking habit contributed significantly.

      • KCI등재

        Investigation of Hanwoo-specific structural variations using wholegenome sequencing data

        박장호,신원석,문세영,오만환,다정,오동엽,박영준,박종화,박용수,규동 한국유전학회 2019 Genes & Genomics Vol.41 No.2

        Background The total length of the cattle genome is approximately ~ 3 billion base pairs. About half of the bovine genome (46.5%) is composed of transposable elements (TEs). The TEs could be a major source of genomic structural variations (SVs) between cattle breeds. These SVs have led to genomic fluidity and rearrangements between interspecies. Objective TE-mediated insertion and deletion events could have a strong influence on the bovine genome. This study aimed to investigate TE-mediated deletion events that are common to 12 Hanwoo genome resequencing data. Results We compared 12 Hanwoo genome resequencing data with the cattle reference genome (Bos taurus_UMD_3.1.1) and six other open source data (2 Jersey, 2 Holstein, 2 Angus). By using BreakDancer program, the common SVs to the 12 Hanwoo genomes were detected. A total of 299 Hanwoo-specific SV candidates were detected. Among them, 56 Hanwoospecific TE-mediated deletion candidate loci were validated by PCR and Sanger sequencing. Finally, we identified one locus, DEL_96, which is an authentic Hanwoo-specific deletion. The DEL_96 event occurred by nonallelic homologous end-joining between LINE (BovB) and unique sequence with 1 bp microhomology. The 370 bp deletion event appeared to be only in the Hanwoo individuals after the divergence of Hanwoo and Holstein lineages. Conclusion Our study showed that one of the SVs, TE-mediated deletion, could be utilized as a molecular maker to distinguish between Hanwoo and Holstein.

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