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고양이에서 급성출혈성 쇽 및 수액소생시 대기 혹은 100% 산소가 소화관 점막 산소화에 미치는 효과
이유미,함경돈 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.4
Background : This study was purposed to study the effect of 100% oxygen on the oxygenation of gut mucosa in a feline model subjected to a hemorrhagic shock followed by reperfusion. Methods : Eighteen cats were divided into three groups : For group I, 6 cats were subjected to sham operation as a control group ; for group Ⅱ, 6 cats were subjected to a hemorrhagic shock for 2 hours prior to reperfusion and ventilated with air as a medical air group ; for group Ⅲ, 6 cats were ventilated with 100% oxygen, continued during the shock and reperfusion periods as a 100% oxygen group. Mesenteric PvO₂, mesenteric PaO₂, mesenteric venous arterial(v-a) lactate difference, mesenteric P(v-a)CO₂and mesenteric pH(a-v) were measured for every 30 minutes during the shock and reperfusion. Results : For group Ⅱ and group Ⅲ, the lactate(v-a) was increased during the shock. The values of pH(a-v) and P(v-a)CO₂ were increased during the shock but not retumed to the baseline value after reperfusion. For both pH(a-v) and P(v-a) CO₂, there were not statistically significant differences between group Ⅱ and group Ⅲ during the shock and reperfusion. For group Ⅲ, the PaO₂ was increase during the shock and reperfusion, there were statistically significant differences(p<0.05) between group Ⅱ and control, and between group Ⅲ and control. Conclusions : We conclude that the 100% oxygen does not improve the oxygenation of gut mucosa in the feline model undergone a hemorrhagic shock followed by reperfusion.
신경병증 통증모델에서 Edrophonium 과 Neostigmine 의 항이질통 효과
이동명,황재현,함경돈 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.1
Background : Peripheral nerve injury may produce a syndrome consisting of spontaneous pain, allodynia and hyperpathia. Cholinesterase inhibitors are known to have an antinociceptive effect in hot plate and tail flick tests and to be mediated by spinal muscarinic system. The purpose of the current study was to determine the effect of intrathecally(i.t.) administered edrophonium and neostigmine on the touch-evoked allodynia and to identify the antagonism of antiallodynia in a rat model of neuropathic pain. Methods : Sprague Dawley rats were prepared with tight ligation of left L5/L6 spinal nerves with 6∼0 black silk and chronic lumbar intrathecal catheters. After obtaining the baseline hindpaw withdrawal scores, edrophonium(3∼100ug) or neostigmine(0.3∼10ug) was administered intrathecally. Tactile allodynia was measured using von Frey filaments and allodynic threshold was calculated by updown method. Motor dysfunction was assessed by observing righting/stepping reflex responses and abnormal weight bearing. Toamine the reversal of antiallodynia, muscarinic receptor antagonist atropine(10ug) or nicotinic receptor antagonist mecamylamine(10ug) was injected intrathecally 5 min. prior to injection of edrophonium or neostigmine. Results : I.t. edrophonium and i.t. neostigmine produced a dose dependent antagonism of allodynic state but had moderate to severe effect on motor weakness at doses of 3 and 10 g of neostigmine. Pretreatment with i.t. atropine yielded a complete antagonism of antiallodynia in both drugs, but i.t. mecamylamine did not significantly reverse incresed allodynic threshold. Conclusions : These experiments suggest that i.t. edrophonium or i.t. neostigmine produces a dose dependent antagonism on touch-evoked allodynia at the spinal level and this antagonism is likely due to spinal muscarinic system. (Korean J Anesthesiol 1997; 33: 33∼40)
백서의 말초 신경병증성 통증모델에서 Capsaicin에 의한 역방향성 임펄스의 차단이 기계적 이질통의발현에 미치는 영향
이청,임중우,임정길,함경돈,박철호,구승우,최윤,신진우 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.01
Background: Nerve impulses that are generated in injured nociceptive fibers and enter the spinal cord are known to cause central sensitization leading to neuropathic pain. Injury-induced impulses that are transmitted antidromically into the peripheral terminals of nociceptive fibers may also cause nociceptors to be sensitized, thus contributing to neuropathic pain. However, this possibility has not yet been tested. The present study was designed to investigate the effects of antidromic impulses on the mechanical allodynic behavior seen in a rat model of neuropathic pain. Methods: Male Sprague-Dawley rats were assigned randomly into one of two groups, i.e., a capsaicin group or a vehicle group. Capsaicin group animals were treated with 1% capsaicin (4μl) in the stump of the distal nerve after severing the fifth left lumbar spinal nerve in order to inhibit delayed and continued antidromic impulses. The vehicle group was treated with same solution without capsaicin. The withdrawal threshold for mechanical allodynia was measured using von Frey hairs in terms of the bending force required to elicit hind-paw withdrawal. Threshold values were compared between the two groups. Results: The capsaicin group showed a statistically significant difference in terms of the paw withdrawal threshold as compared with the corresponding control from 12 days and this remained so until 32 days after treatment. Conclusions: Our results suggest that antidromic impulses developed by nerve injury are partly responsible for the development of mechanical allodynia.
미세침습 로봇 보조 심장수술 중 발생한 대량 이산화탄소 정맥색전증
최인철,신원정,이유미,함경돈,정용보 대한마취통증의학회 2006 Korean Journal of Anesthesiology Vol.50 No.1
A 37-year-old female was scheduled for minimally invasive mitral valve replacement and Maze operation using the robotically controlled camera (AESOP 3000, ComputermotionⓇ, USA). Thoracic incision and carbon dioxide insufflation was started. The end tidal carbon dioxide suddenly decreased with hypotension and an increase in central venous pressure to 70 mmHg. Then, cardiopulmonary bypass was started and large amount of gas was aspirated. Carbon dioxide embolism was suspected, carbon dioxide insufflation was discontinued. The aspiration of carbon dioxide embolus from cannulae for cardiopulmonary bypass confirmed our diagnosis. The gas flowed out from the peritoneal cavity following diaphragmatic incision, we suspected that the insufflating needle was placed into peritoneal cavity. The operation was completed uneventfully. No neurologic and cardiopulmonary sequelae were noted. We experienced a case of carbon dioxide embolism incidentally induced by carbon dioxide insufflation into closed intraperitoneal cavity. (Korean J Anesthesiol 2006; 50: 99~102)