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한병현,최익수 대한비과학회 2018 Journal of rhinology Vol.25 No.2
Cholesterol granuloma is a disease in which cholesterol crystals act as a foreign substance in the surrounding tissues and causegranulomatous reaction and fibrosis within the chamber. It is found in various locations of the body, but the most common locationis the temporal bone associated with middle ear disease. Because the disease is associated with breathing disturbance,it may also occur in the paranasal sinus. However, it has been rarely reported since its first report by Graham and Michaels in1978. Recently, we experienced a case of cholesterol granuloma of the right maxillary sinus of a 63-year-old female patientwithout any nasal symptoms. We successfully managed this case with Caldwell-Luc operation. Also, we summarized the casesof cholesterol granuloma of the sinonasal region reported in Korea.
한병현 대한약학회 2003 약학회지 Vol.47 No.4
Self-medication is a representative phenomenon in the domain of popular care, originated from perspective of medical pluralism and the pharmacy profession is said to be in the most appropriate position of health care professions to activate self-medication. As any healthcare reform impacts in a country, 2000 institutional separation between medicine and pharmacy implemented in Korea brought a lot of changes in behavior of drug use not only to physicians and pharmacists but also to consumers (patients). In this paper, the reality of self-medication since the institutional separation between medicine and pharmacy was analyzed, based on the empirical data which were collected by the Korea Institute for Health and Social Affairs in 2002. The major finding is that the domain of popular care including self-medication was significantly shrunk, while that of professional care was proportionally expanded. As a result, the following four points were strongly recommended for the purpose of promoting self-medication: i) upgrading the pharmacy education system from 4 year to 6 year level, ii) improvement of continuing education and introduction of GPP (Good Pharmacy Practice), iii) activating 'pharmacal encounter' (i.e., pharmacist-consumer relationship) and iv) promotion of socio-economic research activities and proactive participation in the international self-medication movement of pharmacists in Korea.
한병현,윤지민,최익수 대한이비인후과학회 2021 대한이비인후과학회지 두경부외과학 Vol.64 No.7
Background and Objectives Although studies of test-retest reliability of the standard polysomnographyhas been reported numerous times, studies of portable sleep devices have beenreported in very few cases to date. The purpose of this study is to investigate the test-retest reliabilityof level III devices, to examine the characteristics of patients with tendency of underestimationand to determine whether there are factors that can predict when retest is needed. Subjects and Method We enrolled 74 patients for this study from April 2014 to March2019. Two indicators were used to assess night to night variability. If the difference of apneahypopneaindex (AHI) score was less than 10 or there is no difference of severity of obstructivesleep apnea (OSA) between two nights, we decided that the results have a reliability. Results Seventeen out of 57 patients with an AHI difference of less than 10 showed unreliableresults based on severity, and 3 out of 17 patients with the AHI difference more than 10showed reliable results based on severity. Eight out of 74 patients were diagnosed at Night 2but not at Night 1. In other words, about 11% of the subjects needed retest. Based on thechange in severity of OSA, subjective sleep scores showed a statistically significant difference,indicating that the subjective sleep score should be considered when deciding a retest. AHI differed by more than 10 in about 23% of the subjects in this study, falling within “15%-32%,” which has been reported in the literature on the level I test. Conclusion This suggests that there is no significant difference in reliability between level Iand III.
한병현,황귀서,Han Byong-Hyon,Hwang Gwi-Seo 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.1
This study was conducted to improve the current regulation guidelines for developing traditional Korean medicines with effectiveness and productivity, in order to cope with the upcoming ICH on specifications on oriental herbal drugs. Also, major purposes of this study are to motivate R&D and to pioneer foreign markets for domestic herbal drug companies. First, after examining concepts of traditional Korean medicines and comparing the numbers and differentiation of herbal drugs registered on Pharmacopeia among Korea, China, and Japan, the current new drug development requirements for traditional Korean medicines were reviewed in detail, followed by comparison of foreign regulation systems including USA, EU, China, and Japan. Second, empirical cases on failure of development for new traditional Korean medicines under the current regulation system in the domestic companies including Dong-A, Kwangdong, and Samchondang, were collected and analyzed. As a result, hanbangsaengyak, the new category for traditional Korean medicines was newly developed on the basis of scientification of data between saengyak and hanyak, from the perspectives of harmonization between oriental medicine and western medicine and of balance between food and drug, in terms of industrialization, publicity, modernization, and effectiveness of administration. In addition, the new regulation requirements for the new hanbangsaengyak preparations were discussed by establishing principles of reinforcing preclinical test and of simplifying clinical trials in Korea. Finally, the further researches to articulate the complete specifications for pre-clinical and clinical requirements for traditional Korean medicines were strongly suggested.