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한병현,최익수 대한비과학회 2018 Journal of rhinology Vol.25 No.2
Cholesterol granuloma is a disease in which cholesterol crystals act as a foreign substance in the surrounding tissues and causegranulomatous reaction and fibrosis within the chamber. It is found in various locations of the body, but the most common locationis the temporal bone associated with middle ear disease. Because the disease is associated with breathing disturbance,it may also occur in the paranasal sinus. However, it has been rarely reported since its first report by Graham and Michaels in1978. Recently, we experienced a case of cholesterol granuloma of the right maxillary sinus of a 63-year-old female patientwithout any nasal symptoms. We successfully managed this case with Caldwell-Luc operation. Also, we summarized the casesof cholesterol granuloma of the sinonasal region reported in Korea.
한병현,황귀서,Han Byong-Hyon,Hwang Gwi-Seo 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.1
This study was conducted to improve the current regulation guidelines for developing traditional Korean medicines with effectiveness and productivity, in order to cope with the upcoming ICH on specifications on oriental herbal drugs. Also, major purposes of this study are to motivate R&D and to pioneer foreign markets for domestic herbal drug companies. First, after examining concepts of traditional Korean medicines and comparing the numbers and differentiation of herbal drugs registered on Pharmacopeia among Korea, China, and Japan, the current new drug development requirements for traditional Korean medicines were reviewed in detail, followed by comparison of foreign regulation systems including USA, EU, China, and Japan. Second, empirical cases on failure of development for new traditional Korean medicines under the current regulation system in the domestic companies including Dong-A, Kwangdong, and Samchondang, were collected and analyzed. As a result, hanbangsaengyak, the new category for traditional Korean medicines was newly developed on the basis of scientification of data between saengyak and hanyak, from the perspectives of harmonization between oriental medicine and western medicine and of balance between food and drug, in terms of industrialization, publicity, modernization, and effectiveness of administration. In addition, the new regulation requirements for the new hanbangsaengyak preparations were discussed by establishing principles of reinforcing preclinical test and of simplifying clinical trials in Korea. Finally, the further researches to articulate the complete specifications for pre-clinical and clinical requirements for traditional Korean medicines were strongly suggested.