경기 서해안 무의도(舞衣島)민속의 해체

하정숙 중앙대학교 한국문화유산연구소(구 중앙대학교 한국민속학연구소) 2007 중앙민속학 Vol.- No.12

인천공항의 개발로 자연이 아름답고 마치 동남아 해변에 가 있는 듯 아름다운 섬으로 알려지기 시작하였다. 여기에 드라마, 영화의 촬영장소로 알려지면서 세트장을 보고픈 관광객들이 몰려들었다. 이 작은 섬만의 특유한 문화가 남아 있으리라는 기대를 가지고 조사를 하였지만, 옛날에는 이렇게 했었다는 이야기만 들을 수 있었다. 무의도는 작은 섬의 특징상 어업이 당연히 주 생업이었으며 인천에서 가까운 위치이기에 좋은 어장으로 근해에서도 고기가 많이 잡혔고, 멀리 연평도, 흑해에 까지 조기잡이, 홍어잡이를 다니기도 하였다. 이러한 훌륭한 어장이 개발로 인하여 없어지게 되면서 주민들의 생업은 변화하였고, 마을 공동체 구성으로 관광업이 성장한 반면, 마을신앙의 쇠퇴로 인한 민속문화가 거의 사라진 점이 조사되었다. 민속 문화의 해체는 섬 주민들을 지탱했던 사상과 신앙이 사라짐을 의미하는 것이고, 그 들만이 가진 아름다운 문화가 훼손되고 없어져 버렸다. 무의도라는 이름이 무색하게 기독교는 이 마을에 새로운 신앙으로 자리를 잡았고, 여기에 개발이라는 현대화가 모든 국토를 획일화 시켜, 눈앞에 보이는 경제화만 내다본다면 무의도는 이 섬만이 가진 우리의 미래가 큰 문제일 것이다. 자연환경과 특징을 살려 나가면서, 무의도 섬만의 전통문화를 지켜가는 개발이 이루어져야만 우리들의 후손에게 희망 있는 미래를 남겨주게 될 것이다. Mui-lsland became famous for its beautiful nature and the beach after the development of In-Chon International Airport. Since this Island was used in films and dramas many tourists came to visit. I expected to find some unique culture of this area but interviewing the locals about the past was all I could achieve. Mui-lslands main Industry was fishing. It has a good fishing grounds near In-chon and people who lived there went to yeon-peung Island and black sea to catch clams and skates. Because of the development, fishing grounds started to vanish and the residents living situation dramatically changed. Village people organized tourism however, Many village beliefs and folk culture has disappeared. After the disorganization of their folk culture, its natural beauty has damaged. Unlike its name Mui-Island Christianity became there new religion. Mui-lsland should keep there traditional culture to give hope to our next generation.

Correlations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms

하정숙,김유경,정순일,정혜라,정인성 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.6

Background: This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). Methods: Clinical and hematologic features were reviewed for 103 MPN patients, including patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64 patients), and primary myelofibrosis (PMF, 17 patients). JAK2 V617F allele status and allele burdens were measured by allele-specific PCR and pyrosequencing, respectively. Results: The JAK2 V617F mutation was detected in 95.5%, 68.8%, and 52.9% of PV, ET, and PMF patients, respectively. JAK2 V617F-positive ET patients were significantly older and exhibited higher neutrophil fractions, a higher frequency of thrombotic events, and a higher myelofibrosis rate than JAK2 V617F-negative patients (P <0.05). PV patients carried the highest mean T allele burden (66.0%±24.9%) compared with ET (40.5%±25.2%) and PMF patients (31.5%±37.0%) (P =0.00). No significant correlations were detected between V617F allele burden and patient age, white blood cell count, Hb, Hct, or the platelet count for PV, ET, or PMF patients. ET patients with organomegaly had a higher JAK2 V617F allele burden (53.4%±23.7%) than patients without organomegaly (35.6%± 24.3%) (P =0.03). Conclusions: The JAK2 V617F mutational status and its allele burden correlate with the clinicohematologic phenotypes of ET patients, including older age, higher neutrophil count, and greater rates of organomegaly, thrombotic events, and myelofibrosis. For PV and PMF patients, larger-scale studies involving more MPN patients are needed. Background: This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). Methods: Clinical and hematologic features were reviewed for 103 MPN patients, including patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64 patients), and primary myelofibrosis (PMF, 17 patients). JAK2 V617F allele status and allele burdens were measured by allele-specific PCR and pyrosequencing, respectively. Results: The JAK2 V617F mutation was detected in 95.5%, 68.8%, and 52.9% of PV, ET, and PMF patients, respectively. JAK2 V617F-positive ET patients were significantly older and exhibited higher neutrophil fractions, a higher frequency of thrombotic events, and a higher myelofibrosis rate than JAK2 V617F-negative patients (P <0.05). PV patients carried the highest mean T allele burden (66.0%±24.9%) compared with ET (40.5%±25.2%) and PMF patients (31.5%±37.0%) (P =0.00). No significant correlations were detected between V617F allele burden and patient age, white blood cell count, Hb, Hct, or the platelet count for PV, ET, or PMF patients. ET patients with organomegaly had a higher JAK2 V617F allele burden (53.4%±23.7%) than patients without organomegaly (35.6%± 24.3%) (P =0.03). Conclusions: The JAK2 V617F mutational status and its allele burden correlate with the clinicohematologic phenotypes of ET patients, including older age, higher neutrophil count, and greater rates of organomegaly, thrombotic events, and myelofibrosis. For PV and PMF patients, larger-scale studies involving more MPN patients are needed.

조작활동과 수학동화를 활용한 뇌 기반 도형학습 프로그램이 경계선 지능아동, 학습장애 아동의 뇌 활성화에 미치는 효과

하정숙,김자경 한국특수아동학회 2022 특수아동교육연구 Vol.24 No.3

Purpose: In this study, we investigated the effects of a brain-based shape learning program that utilizes manipulative activities and mathematical assimilation on the shape performance, perceptual reasoning ability, and brain function index of borderline-intelligent children and children with learning disabilities. Method: For this purpose, eight children with borderline intelligence and five children with learning disabilities were selected from the 2nd grade of an elementary school students in J city and S county. We applied a pre-post design and verified the effect of the intervention. Results: First, the brain-based shape learning program that utilizes manipulative activities and mathematical assimilation showed significant differences in shape achievement in children with borderline intelligence but not in children with learning disabilities. Second, the brain-based shape learning program that utilizes manipulative activities and mathematical assimilation showed significant differences in the perceptual reasoning indicators of the perceptual reasoning ability of children with borderline intelligence, in weaving dirt curtains, and in finding common pictures. It was not significant for matrix reasoning. We found that the perceptual reasoning ability of children with learning disabilities was not significant. Third, the brain-based shape learning program that utilizes manipulative activities and mathematical assimilation showed significant differences in the activity index and brain function index in children with borderline intelligence. Children with learning disabilities were significant on the activity index but not on the Blaine index. Conclusion: Based on these results, we found that the brain-based shape learning program that utilizes manipulative activities and mathematical assimilation was more effective for children with borderline intelligence than for children with learning disabilities. 연구목적: 본 연구는 조작활동과 수학동화를 활용한 뇌 기반 도형학습 프로그램이 경계선 지능아동과 학습장애 아동의 도형학업성취도, 지각추론능력, 뇌 기능 지수에 미치는 효과를 알아보고자 하였다. 연구방법: 이를 위하여 J시와 S군에 있는 초등학교 2학년 아동을 대상으로 경계선 지능아동 8명, 학습장애 아동 5명을 선별하였다. 그들에게 사전-사후 설계를 적용하였고, 사전과 사후에 수집된 자료들의 효과성을 검증하였다. 연구결과: 첫째, 조작활동과 수학동화를 활용한 뇌 기반 도형학습 프로그램이 경계선 지능아동의 도형학업성취도에 유의한 차이를 나타내었지만 학습장애 아동은 유의하지 않았다. 둘째, 조작활동과 수학동화를 활용한 뇌 기반 도형학습 프로그램이 경계선 지능아동의 지각추론능력의 지각추론지표, 토막 짜기, 공통그림 찾기에는 유의한 차이를 나타내었지만 행렬추리에는 유의하지 않았다. 학습장애 아동의 지각추론 능력은 유의하지 않은 것으로 나타났다. 셋째, 조작활동과 수학동화를 활용한 뇌 기반 도형학습 프로그램이 경계선 지능아동의 뇌 기능 지수 중 활성지수와 브레인 지수에 유의한 차이를 나타내었다. 학습장애 아동은 활성지수에는 유의했지만 브레인 지수는 유의하지 않았다. 결론: 이러한 결과를 바탕으로 조작활동과 수학동화를 활용한 뇌 기반 도형 학습 프로그램이 학습장애 아동보다 경계선 지능 아동에게 더 효과가 있음을 알 수 있었다.

Calreticulin Exon 9 Mutations in Myeloproliferative Neoplasms

하정숙,김유경 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.1

Background: Calreticulin (CALR) mutations were recently discovered in patients with myeloproliferative neoplasms (MPNs). We studied the frequency and type of CALR mutations and their hematological characteristics. Methods: A total of 168 MPN patients (36 polycythemia vera [PV], 114 essential thrombocythemia [ET], and 18 primary myelofibrosis [PMF] cases) were included in the study. CALR mutation was analyzed by the direct sequencing method. Results: CALR mutations were detected in 21.9% of ET and 16.7% of PMF patients, which accounted for 58.5% and 33.3% of ET and PMF patients without Janus kinase 2 (JAK2) or myeloproliferative leukemia virus oncogenes (MPL) mutations, respectively. A total of five types of mutation were detected, among which, L367fs*46 (53.6%) and K385fs*47 (35.7%) were found to be the most common. ET patients with CALR mutation had lower leukocyte counts and ages compared with JAK2-mutated ET patients. Conclusion: Genotyping for CALR could be a useful diagnostic tool for JAK2-or MPL-negative ET or PMF patients. CALR mutation may be a distinct disease group, with different hematological characteristics than that of JAK2-positive patients.

Repetitive Pregnancy Loss in inv(22)(p13q12) Carrier

하정숙,김도훈,이정호 대한의학유전학회 2010 대한의학유전학회지 Vol.7 No.1

Pericentric inversion is not rare in humans and is usually benign. However, pericentric inversion can lead to production of an unbalanced recombinant and might be a cause of repetitive pregnancy loss. Pericentric inversion of chromosome 22 is rare and only a few cases have been reported. We report a case of inv(22)(p13q12) carrier who had history of repetitive pregnancy loss including three spontaneous abortions and one fetal hydrops in which the chromosomal complement was rec(22)dup(22q) inv(22)(p13q12)mat. The maternal inv(22) and fetal rec(22) were confirmed by fluorescence in situ hybridization using region-specific probes (TUPLE1 on 22q11.2 and ARSA on 22q13). Because the identification of inv(22) or rec(22) in conventional karyotyping might be easily overlooked, great attention and additional molecular tests are required for accurate diagnosis of inv(22) and rec(22).

당뇨병 치료 이런 약물이 한다

하정숙 사단법인 한국당뇨협회 1994 당뇨 Vol.55 No.-

ABO 불일치를 나타낸 다발성 골수종 3예

하정숙,김은진,전효진,김재룡,전동석 大韓輸血學會 1998 大韓輸血學會誌 Vol.9 No.2

SnO₂ nanowire logic devices on deformable non-planar substrates

하정숙 한국고분자학회 2012 한국고분자학회 학술대회 연구논문 초록집 Vol.2012 No.10

식도암과 동반된 원발성 형질세포성 백혈병 1예

하정숙,김은진,전효진,김재룡,전동석,송홍석 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.4

日蓮佛法과 양명학

하정숙 한국양명학회 2013 한국양명학회 학술대회 논문집 Vol.2013 No.10