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잣버섯 균사체로부터 분리한 단백다당체의 암종에 따른 선별적 항암작용
진미림(Mi Rim Jin),정규선(Kyu Sun Jung),김병각(Byong Kak Kim) 대한약학회 1998 약학회지 Vol.42 No.5
Many antitumor and immune modulating components have been isolated from fungal extracts. In this study, the authors isolated the proteoglycans from cultured mycelia of Lentinus lepideus, including especially the acidic polysaccharide fraction, named lepidan. It was obtained by extraction with hot water followed by purification using DEAE cellulose anion exchange. To elucidate antitumor effects against different type of tumor, the proteoglycans were tested on sarcoma 180, C3H MCA clone 16 and P388 leukemia in vivo. Lepidan showed 58.3% of tumor inhibition against solid form of sarcoma 180 and 58.6% against MCA clone 16. But lepidan did not affect life span of mice against P388 leukemia. Also when Lepidan was applicated to MTT assay, it did not show any direct cytotoxicity against various tumor cells in vitro.
잣버섯 균사체로부터 분리한 수용성 단백다당체 Lepidan의 면역증가작용
진미림(Mi Rim Jin),정규선(Kyu Sun Chung) 대한약학회 1999 약학회지 Vol.43 No.5
In this study, we investigated the immunopotent activities of lepidan, a water soluble proteolycan from Lentinus lepideus. To examine whether lepidan may affect nonspecific immune responses, we determined the effect on the production of nitric oxide (NO). Lepidan effectively increased the No production in IFN-gamma and LPS triggered RAW 264.7 cells. To further demonstrate the evidence that lepidan activates various immune cells, we determined the alkaline phosphatase activity, plaque-forming cell nember and secretion of interleukine-4 (IL-4) and granulocyte/macrophage-colony stimulating factor (GM-CSF) after lepidan treatment in murine splenocytes. The results showed that lepidan increased alkaline phosphatase activity and the number of plaque-forming cells, which indicates that lepidan can lead B lymphocytes to late stage of differentiation. Also, when the splenocytes were cultured with lepidan for 48hr, the level of IL-4 and GM-CSF in the supernatant dramatically increased. Taken together, these data suggest that lepidan is a biological response modulator that is able to activate immune responses.
비글견을 이용한 GST 추출물의 단회 경구투여 용량증가 독성시험
이철화,양원경,정인철,진미림,김승형,박양춘,Lee, Chul-wha,Yang, Won-kyung,Jung, In-chul,Jin, Mi-rim,Kim, Seung-hyeong,Park, Yang-chun 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.1
Objectives: To provide information on the safety of GST (Gami-Sasangja-tang), we carried out a single oral dose-increasing toxicity test of GST in beagle dogs.Materials and Methods: Six beagle dogs (three males and three females) were randomly assigned to two groups (experimental group: n=4, control group: n=2). The experimental group (two males, two females) was given oral doses of GST in increasing order (1,250, 2,500, and 5,000 mg/kg) at three-day intervals. After administration, the participants’ mortality, clinical signs, and body weight changes were monitored for two weeks. After two weeks, all dogs were sacrificed for autopsy.Results: Temporary vomiting was observed according to increasing dosage (n=1, 250 mg/kg; n=4, 2,500 and 5,000 mg/kg). Transient diarrhea was observed on the second and third dosing day (n=1, 2,500 mg/kg; n=2, 5,000 mg/kg). Temporary salivation was noted on the third dosing day (n=3, 5,000 mg/kg). Compound-colored stool was observed in all dogs fed the GST on all dosing days and also on the following days. We found no mortality and no abnormalities in the clinical signs, body weight, and gross findings in any of the dogs tested.Conclusions: The maximum tolerated dose was over 5,000 mg/kg for both male and female dogs.
김선영(Sun Young Kim),진미림(Mi Rim Jin),복진우(Jin Woo Bok),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1994 생약학회지 Vol.24 No.4
The hot water extract of the basidiocarps of Lentinus lepideus was purified and fractionated by DEAE-cellulose ion exchange column chromatography and Sepharose CL-4B gel filtration chromatography. The separated fractions were designated Frs. I, II, III, IV and V. When a dose of 50㎎/㎏/day was injected into ICR mice by i.p., the tumor inhibition ratio 81% of Fr. II against solid sarcoma 180 was the highest among the five fractions. To clarify mechanisms of its antitumor activity, it did not show any direct cytotoxicity against tumor cell when Fr. II was examined by MTT assay. But when examined for immunopotentiation activity, Fr. II increased the amount of the superoxide anion in activated macrophages to 1. 2 times and the number of the plaque forming cells to 2.0 times, respectively. And it restored the depressed response of DTH in tumor-bearing mice to the normal level. Fr. II was a proteinbound polysaccharide which was composed of 93.35% polysaccharide, 1.70% protein and 1.85% hexosamine. It was named lepidan.
박성미(Sung Mee Park),진미림(Mi Rim Jin),김진숙(Jin Sook Kim),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 대한약학회 1993 약학회지 Vol.37 No.5
To find antitumor components in the hot water extract from the basidiocarps of Hypsizigus mamoreus. protein-bound polysaccharides were purified and fractionated by DEAE-cellulose ion exchange column chromatography and Sepharose CL-4B gel filtration chromatography. When a dose of 20mg/kg/day was injected intraperitoneally into ICR mice. fraction IV of the component showed the highest inhibition ratio of 73.8% against the count of hemolytic plaque forming cells in mice to 3.2 times. when IV was about 30 KD and the fraction was composed of 76.1% polysaccharide and 4.9% protein. The hexosamine was detected in all the fractions, showing that the polysaccharide and protein moieties were bound each other.
GST의 Sprague-Dawley Rat를 이용한 단회 경구투여 독성시험 및 4주 반복 경구투여 용량결정시험
한종민,홍지희,이혜영,정인철,진미림,김승형,박양춘,Han, Jong-Min,Hong, Jee-Hee,Lee, Hye-Yeong,Jung, In-Chul,Jin, Mi-Rim,Kim, Seong-Hyeong,Park, Yang-Chun 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.4
Objectives : This study aimed to evaluate the single oral dose toxicity and four weeks repeated dose determination of Gamisasangja-tang (GST) in male and female Sprague-Dawley rats. Methods : In the single oral toxicity study, rats were orally administered a single dose of 0 and 5,000 mg/kg GST. There were 5 rats in each group. After single administration, mortality, clinical signs, body weight changes and gross pathological finding were observed for 14 days. In the 4-weeks repeated oral dose determination study, rats were orally administered a single dose of 0, 1,250, 2,500 or 5,000 mg/kg GST. There were 5 rats in each group. Mortality, clinical signs, body weight changes, food consumption and gross pathological finding were observed for 28 days. Organ weight, clinical chemistry and hematology were tested after 28 days. Results : There was no mortality in either of the two studies. There were also no significant differences in clinical sign, body weight, organ weights, hematological or serum chemical parameters between the GST and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of GST is over 5,000 mg/kg, so this finding would be expected to provide scientific evidence for the safety of GST.