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Synthesis and Biological Evaluation of Decursinol Derivatives as FoxO-1 Inhibitors in HepG2 Cells
주정호,정선화,유국현,천혜경 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.8
Diabetes mellitus type 2 is caused by insulin resistance, often associated with increased hepatic gluconeogenesis. Forkhead box O-1 (FoxO-1) is known as a major transcription factor regulating hepatic gluconeogenesis, and the increased FoxO-1 expression and activity are mainly observed in type 2 diabetic patients. To discover new FoxO-1 inhibitors, the compounds were newly synthesized from decursinol, which is a molecule isolated from the Angelica gigas and proved to be safe. The compounds were evaluated for in vitro FoxO-1 inhibitory activity using FoxO-1 reporter assay in HepG2 cells. Among these, the compounds 2b and 2c exhibited FoxO-1 inhibitory activity with IC50 values of 98.9 and 123.7 ?M, respectively. Moreover, the blood glucose level reduction efficacy of synthesized compound 2b was found similar to that of glimepiride, a commercially available antidiabetic drug and used as a reference (21.6 vs. 21.4%), in alloxan-induced type 2 diabetes rats. These findings suggest that, the compound 2b has moderate inhibitory activity on FoxO-1 and possibly resulting in the amelioration of diabetic hyperglycemia.
Synthesis and In Vivo Evalution of Decursinol Derivatives as Antidiabetics
주정호,권호석,이재응,유국현 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.9
There are currently no diabetes drugs that can reduce blood glucose without causing adverse secondary effects. In this study, we report the synthesis of various compounds derived from decursinol, a molecule isolated from Angelica gigas with proven safety. The blood glucose reduction efficacy of synthesized compound 11 was equivalent to that of glimepiride, a commercially available diabetes drug used as a reference (21.6% vs. 21.4%), which was confirmed in rat and mouse models of diabetes. Compound 11 is a nonsulfonyl urea class substance that is predicted to be highly effective in reducing blood glucose while having few adverse effects, indicating that it is potential candidate drug for diabetes treatment that circumvents the limitations of existing therapeutics.
폐보조배터리로부터 황산과 D2EHPA를 사용한 망간 회수에 관한 연구
주정호,윤석표 한국폐기물자원순환학회 2023 한국폐기물자원순환학회지 Vol.40 No.5
This study aims to identify the optimal conditions for the wet recycling of Manganese (Mn) found in the cathode active material of waste mobile chargers. The best condition to extract the cathode active material using acid was a mix of 2 M sulfuric acid and 2% H2O2, L/S = 20, over an extraction duration of 2 h, resulting in an equilibrium pH of 2.56 for the extract. The ideal conditions for the liquid/liquid separation with D2EHPA to isolate Mn from the acid extract were A : O = 1 : 1, an extraction period of 15 min, and an initial pH of 2.5 (equilibrium pH 3.5). Following the acid extraction of the cathode active material using sulfuric acid, an organic solvent was introduced, forming a MnSO4-type precipitate, with Mn being recovered at close to 100%. The separation efficiency remained consistent, even when the organic solvent was reused twice.